Imatinib mesylateEtoposideCapecitabineEribulinPaclitaxelMetastaticRegimenVincristineTumorsDoxorubicinMulticenterGleevecTrametinibInjectionMetastasesEfficacyAdult patientsPediatric patientsStudyMelanomaMutationsMalignantRadiationRegimensSCLCTreatmentRetrospectiveDrugsSmall Cell LLungCyclesBreast cancerBiomarkersNeutropenicOncologyReceiveToxicityMonthsPhysicianTumorTherapyExtensive-stagePrognosisTrialAcuteGenesMethodsCancer patientsDisease
Imatinib mesylate3
- Patients receive oral imatinib mesylate twice daily on days 1-28. (knowcancer.com)
- Safety of Zileuton (Zyflo) in Combination With Imatinib Mesylate (Gleevec) in CML. (druglib.com)
- Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. (nature.com)
Etoposide1
- A German multicenter, randomized phase III trial comparing irinotecan-carboplatin with etoposide-carboplatin as first-line therapy for extensive-disease small-cell lung cancer. (trillium.de)
Capecitabine1
- 12 months, paclitaxel or nab-paclitaxel If prior taxane and DFI ≤ 12 months: capecitabine, carboplatin, or eribulin. (withpower.com)
Eribulin7
- BACKGROUND: Eribulin methylate (eribulin) improved the overall survival (OS) of eribulin-treated patients with HER2-negative advanced breast cancer (ABC) in prospective and retrospective studies. (bvsalud.org)
- However, the effect of eribulin on OS as first-line chemotherapy and the characteristics of the patients who benefited from eribulin remain unclear. (bvsalud.org)
- RESULTS: We identified 172 patients (119 estrogen receptor-positive [ER+], 47 ER-, 6 unknown) who received eribulin (eribulin group) and 129 patients (92 ER+, 31 ER-, 6 unknown) who did not receive eribulin (non-eribulin group). (bvsalud.org)
- CONCLUSIONS: This study successfully identified subgroups of HER2- ABC patients with improved OS by eribulin therapy. (bvsalud.org)
- Selecting patients according to their background and line of treatment will maximize the efficacy of eribulin therapy. (bvsalud.org)
- OBJECTIVES: This pharmacokinetic/pharmacodynamic (PK/PD) study was conducted to establish the effect of different G-CSF regimens on neutropenia's incidence for patients treated by eribulin, to propose an optimal G-CSF dosing schedule. (bvsalud.org)
- METHODS: A population PK/PD model was developed to describe absolute neutrophil counts' (ANC) time course in 87 cancer patients receiving eribulin. (bvsalud.org)
Paclitaxel2
- The aim of this study is to investigate the feasibility and determine the pharmacokinetics of low-dose paclitaxel in cancer patients with severe hepatic dysfunction. (ucy.ac.cy)
- Purpose: To evaluate the activity and toxicity of the combination of paclitaxel given by three-hour infusion, and carboplatin as first- line chemotherapy in patients with advanced breast cancer (ABC). (ucy.ac.cy)
Metastatic5
- Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. (nature.com)
- Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette smoking, with patients often presenting with metastatic disease at the time of diagnosis. (ersjournals.com)
- Tagrisso (osimertinib) is a kinase inhibitor indicated for the treatment of patients with metastatic epidermal growth factor receptor ( EGFR ) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, who have progressed on or after EGFR TKI therapy. (rxlist.com)
- TAGRISSO is indicated for the first-line treatment of adult patients with metastatic NSCLC whose tumors have EGFR exon 19 deletions or exon 21 L858R mutations, as detected by an FDA-approved test [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
- TAGRISSO is indicated for the treatment of adult patients with metastatic EGFR T790M mutationpositive NSCLC, as detected by an FDA-approved test, whose disease has progressed on or after EGFR tyrosine kinase inhibitor (TKI) therapy [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
Regimen1
- This staging system was used to select the appropriate treatment regimen: chemotherapy in combination with thoracic radiotherapy in patients with LS-SCLC, and chemotherapy alone in patients with ES-SCLC. (ersjournals.com)
Vincristine1
- A study of the drugs selumetinib verus carboplatin/vincristine in patients with neurofibromatosis and low-grade glioma. (medscape.org)
Tumors4
- All of these are considered standard of care for recurrent tumors (which is important for insurance reasons), and can legally also be used for newly diagnosed patients as well. (gotomydoctor.com)
- TAGRISSO is indicated as adjuvant therapy after tumor resection in adult patients with non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R mutations, as detected by an FDA-approved test [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
- Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)
- Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)
Doxorubicin1
- Combined chemotherapy with doxorubicin, carboplatin and cyclophosphamide was applied for two cycles but ineffective. (bvsalud.org)
Multicenter1
- Selumetinib in paediatric patients with BRAF -aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicenter, phase 2 trial. (medscape.org)
Gleevec1
- To determine the frequency and severity of adverse effects of Gleevec in this cohort of patients as assessed by CTC. (knowcancer.com)
Trametinib1
- Trametinib in pediatric patients with neurofibromatosis type 1-associated plexiform neurofibroma: a phase I/II study. (medscape.org)
Injection1
- Patients are generally advised to call their doctor in case of fever, symptoms of infection or painful injection sites, as these may progress severely without adequate medical attention. (the-medical-dictionary.com)
Metastases1
- The International Association for the Study of Lung Cancer defines limited-stage SCLC (LS-SCLC) as: "disease restricted to one hemithorax with regional lymph node metastases, including hilar, ipsilateral and contralateral mediastinal, and ipsilateral and contralateral supraclavicular nodes and should also include patients with ipsilateral pleural effusion independent of whether cytology is positive or negative" 2 . (ersjournals.com)
Efficacy1
- Efficacy, effectiveness and safety of long-acting granulocyte colony-stimulating factors for prophylaxis of chemotherapy-induced neutropenia in patients with cancer: A systematic review. (trillium.de)
Adult patients2
- 3 . Aapro MS et al: 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours. (trillium.de)
- Used in pediatric and adult patients with age ≥ 1 year. (oklahoma.gov)
Pediatric patients1
- It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
Study1
- All patients enrolled in this study will receive some form of active treatment. (withpower.com)
Melanoma2
- If a patient is diagnosed with a melanoma, examine all lymph node groups. (medscape.com)
- Medical management is reserved for adjuvant therapy in patients with advanced melanoma. (medscape.com)
Mutations1
- However, 25% to 30% of patients with EGFR -activating mutations show intrinsic resistance, and the responders invariably acquire resistance to gefitinib. (aacrjournals.org)
Malignant1
- Small cell lung cancer (SCLC) is an aggressive malignant disease, with the majority of patients presenting with distant metastasis at diagnosis. (ersjournals.com)
Radiation2
- Median survival has been about a year, which is 2-3 months longer than for patients receiving radiation alone without chemotherapy. (gotomydoctor.com)
- Fortunately, as will be discussed in the next section, the past ten years has produced a new "gold standard" of treatment for newly diagnosed patients: the combination of radiation with a new chemotherapy agent, temozolomide (trade name temodar in the USA and temodal elsewhere in the world). (gotomydoctor.com)
Regimens1
- However, some drugs have a better side-effect profile than others, enabling doctors to adjust treatment regimens to the advantage of patients in certain situations. (wikidoc.org)
SCLC5
- Patients with SCLC who do not fit this definition are considered to have extensive-stage SCLC (ES-SCLC). (ersjournals.com)
- Recently, prophylactic cranial irradiation (PCI) has been shown to improve outcome in patients with ES-SCLC 4 , but only small advances have been made otherwise. (ersjournals.com)
- If left untreated, patients with SCLC rarely survive longer than a few months 5 , but chemotherapy dramatically prolongs survival compared to the best supportive care 6 . (ersjournals.com)
- This has important clinical implications as, in contrast to advanced-stage NSCLC, chemotherapy can also be offered to patients with SCLC and a poor or bad performance status (World Health Organization performance status of 2-3), since a rapid amelioration of the patient's symptoms and general condition can be expected together with an improved outcome 7 . (ersjournals.com)
- Conclusion: Double-cycle, high-dose ICE therapy followed by PBSCT is tolerable and feasible even after conventional chemotherapy or chemoradiotherapy in patients with SCLC. (the-medical-dictionary.com)
Treatment12
- Obatoclax mesylate, also known as GX15-070, is an experimental drug for the treatment of various types of cancer. (wikipedia.org)
- Clinical trial results have been published for treatment of acute myeloid leukemia, small cell lung cancer, Hodgkin's lymphoma, myelodysplastic syndromes, Teva halted a phase III trial in patients with lung cancer before it had begun, citing "business decisions" as the reason. (wikipedia.org)
- She has a deep passion for patient care, which includes helping patients and their families search for treatment options at the top mesothelioma cancer centers. (mesotheliomaguide.com)
- She finds the balance between encouraging patients to receive the best treatment possible while enjoying their time with loved ones and friends. (mesotheliomaguide.com)
- Karen is a valuable asset for patients due to her knowledge of mesothelioma, compassion for the victims of this disease and dedication to guiding patients through their treatment journey. (mesotheliomaguide.com)
- The Foundation is able to help patients receiving treatment for indications for which we currently have an open fund. (healthwellfoundation.org)
- The patient must receive treatment in the United States. (healthwellfoundation.org)
- Although this discussion is intended to be primarily descriptive of the recent development of new treatment options, it is motivated by my belief that single-agent treatment protocols are unlikely to be successful, and patients are best served if they utilize multiple treatment modalities, and go beyond the "certified" treatments that too often are the only treatment options offered. (gotomydoctor.com)
- As a result it is common that any given 'effective' treatment agent will benefit only a minority of patients, often in the range of 10-35%, but do little if anything for the majority. (gotomydoctor.com)
- Antibody therapy has been established for the targeted treatment of patients with cancer, immunological and angiogenic disorders. (justia.com)
- Blood Manuscript describes a phase II trial of tipifarnib for the treatment of patients with multiple myeloma. (hsp90-inhibitors.com)
- Most patients with extensive disease respond well to treatment, yet the median survivals remain around 10 - 12 months. (oncolink.org)
Retrospective1
- Pegfilgrastim prophylaxis is associated with a lower risk of hospitalization of cancer patients than filgrastim prophylaxis: A retrospective United States claims analysis of granulocyte colony-stimulating factors (G-CSF). (trillium.de)
Drugs1
- When patients develop resistance, multiple drugs with different pathways of entry and different cellular targets are used. (savedelicious.com)
Small Cell L2
- Surgery offers the best chance for longer survival, but around 1 in 4 non-small-cell lung cancer patients are eligible for lung cancer surgery. (mesotheliomaguide.com)
- Two hundred ten patients with extensive stage small cell lung cancer (SCLCa) were enrolled onto this prospective trial, which was partially randomized. (oncolink.org)
Lung1
- Overall prognosis nonetheless stays grim, and for most patients, candidacy for lung transplantation must be evaluated [url=https://archives.gov.pk/rx-pharmacy/buy-online-haldol-cheap-no-rx/] medications bad for your liver buy 10 mg haldol[/url]. (ehd.org)
Cycles2
- PE chemotherapy x 4 more cycles alone.Only 109 patients met criteria to be randomized. (oncolink.org)
- Patients with limited disease (LD) concurrently received 50 Gy of irradiation with the last two cycles of PE. (the-medical-dictionary.com)
Breast cancer1
- Radiotherapy also assures a longer life for breast cancer patients, and to remain cancer free longer than patient who doesn't receive it. (breastscancersymptoms.com)
Biomarkers1
- The future of tipifarnib lies in achieving a better understanding of the mechanism of clinical response and the use of predictive biomarkers for patient selection. (hsp90-inhibitors.com)
Neutropenic1
- Predicting individual risk of neutropenic complications in patients receiving cancer chemotherapy. (trillium.de)
Oncology1
- Prophylaxis of infectious complications with colony-stimulating factors in adult cancer patients undergoing chemotherapy - evidence-based guidelines from the Infectious Diseases Working Party AGIHO of the German Society for Haematology and Medical Oncology (DGHO). (trillium.de)
Receive1
- Fifteen patients could receive high-dose ICE followed by PBSCT twice, and 3 patients could receive it once. (the-medical-dictionary.com)
Toxicity1
- However, the risk of toxicity is greater in this group than in patients with good performance status. (ersjournals.com)
Months2
- Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter. (knowcancer.com)
- In patients with limited disease (LD), the CR rate is 16 to 18%, with a median survival of 11.7 to 12.4 months. (the-medical-dictionary.com)
Physician3
- B. SCOPE OF THE SURVEY The basic sampling unit for the NAMCS is the physician-patient encounter or visit. (cdc.gov)
- The physician universe, sample size, and response rates by physician specialty are shown in table I. Of the participating physicians, 254 saw no patients during their assigned reporting period because of vacations, illness, or other reasons for being temporarily not in practice. (cdc.gov)
- D. SAMPLE DESIGN The 1993 NAMCS utilized a multistage probability design that involved probability samples of primary sampling units (PSU's), physician practices within PSU's, and patient visits within practices. (cdc.gov)
Tumor2
- Some information has been contributed by others to various online brain tumor patient support groups, which I have followed up on, and some is from direct communications with various physicians conducting the treatments that are described. (gotomydoctor.com)
- Farnesyltransferase inhibitor tipifarnib is well leurocristine tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic tumor survival pathways in patients with advanced multiple myeloma. (hsp90-inhibitors.com)
Therapy2
- We do not know yet how to select patients for this therapy and how to move it from life extension to cure. (aacrjournals.org)
- Reauthorization may be granted if the patient does not show evidence of progressive disease while on everolimus therapy. (oklahoma.gov)
Extensive-stage1
- The results of this trial suggest that a certain subset of extensive stage patients may benefit from TRT in regards to survival, as is the case in limited stage SCLCa. (oncolink.org)
Prognosis1
- However, it has a favorable prognosis because the majority of patients present at an early stage, resulting in only 4% of cancer deaths in women. (medscape.com)
Trial2
- Phase II trial of pegylated interferon alfa-2b in young patients with neurofibromatosis type 1 and unresectable plexiform neurofibromas. (medscape.org)
- A large intergroup trial has demonstrated that AHFRT over standard fractionation TRT seems to further benefit patients with limited disease SCLCa.4 Most of the literature to date has not demonstrated an advantage in treating extensive disease with TRT in regards to response or survival. (oncolink.org)
Acute1
- Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. (trillium.de)
Genes1
- This is an autosomally dominant germline mutation in DNA mismatch repair (MMR) genes (MSH1, MSH2, MSH6) and accounts for 9% of patients younger than 50 years with endometrial cancer. (medscape.com)
Methods1
- METHODS: Between January 2011 and December 2016, 301 patients with HER2-negative ABC who started first-line chemotherapy at 3 institutions were retrospectively evaluated for OS from the initiation of first-line chemotherapy. (bvsalud.org)
Cancer patients3
- Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. (trillium.de)
- Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: A systematic review. (trillium.de)
- In recent times, the number of cancer patients is multiplying rapidly across the globe. (pharmika.co.in)
Disease1
- HealthWell estimates that patients use an average of $3,600 during their 12-month grant period for this disease area. (healthwellfoundation.org)