Carbon atom aza compounds. Medical search. Frequent questions

In one study, a [4.5.5.5]fenestrane was synthesized with one carbon atom replaced by nitrogen because aza- compounds and their salts are more likely to form crystalline compounds suitable for X-ray analysis than low-molecular-weight alkanes. (wikipedia.org)
Organic chemicals where carbon atoms have been replaced by nitrogen atoms. (nih.gov)

This drug is a cytidine analog, where a nitrogen atom replaces Carbon 5. (worldmedicinefoundation.com)
The presence of the nitrogen atom in between the radical centre and the triple bond could facilitate the 4-exo-dig cyclization by bringing the reacting centres in proximity, polarizing the triple bond and stabilizing the resulting vinyl radical (Fig. 1c ). (nature.com)
b Carbon atom vs nitrogen atom. (nih.gov)
These compounds crosslink DNA by adding an alkyl group (C n H 2n+1 ) to the guanine base of DNA, at the number seven nitrogen atom of the imidazole ring. (medscape.com)
Progress in the synthesis and application of the cyclopalladated derivatives of ferrocene with a donor nitrogen atom in the directing group is surveyed including the planar chirality and enantioselective catalysis of organic reactions and rearrangements. (sioc-journal.cn)
Direct synthesis of the hydroxymethylated arene derivatives via ruthenium(Ⅲ)-catalyzed nitrogen atom directed C-H activation is described. (sioc-journal.cn)
This approach demonstrates that the presence of a methyl group at the stereogenic center at the alpha-position relative to the nitrogen atom does not slow down the polymerization as compared with the polycondensation of a related achiral monomer. (univ-amu.fr)

Pyrrole is a heterocyclic aromatic organic compound, a five-membered ring with the formula C₄H₄NH. (patsnap.com)
The compound is composed of a five-membered ring of. (benchchem.com)

Perhaps both teams can agree on structure B. Christl & Engels dismiss it as such because the C4 atom carries a double negative charge but nevertheless see possibilities for it as a ligand to a strongly electron-withdrawing transition metal. (vander-lingen.nl)
The title compound, [Pd2(C18H54Cl2N4P2Si6)2Cl2]·2C4H10O, features a dinuclear chloride-bridged palladium complex bearing two equivalents of the novel monoanionic mixed valent (λ3-P)-N-(λ5-P) ligand. (tib.eu)
This article reports on the singlet quenching of 5, 10, 15, 20-tetraphenylporphyrin (H₂TPP) and its magnesium(II) and zinc(II) derivatives (MgTPP and ZnTPP) by a series of iron(III) coordination compounds bearing different ligand systems. (unt.edu)
Comparison with the μ-oxido dinuclear complex of an unsubstituted ligand of the same size demonstrates that the methyl groups of 4,11-dimethyl-1,4,8,11-tetra-aza-bicyclo-[6.6.2]hexa-decane prevent dimerization upon oxidation. (worktribe.com)
GAVKIS consists of a tricyclic aza-ether ligand or cryptand wrapping a potassium atom in the centre, the overall unit having no charge. (imperial.ac.uk)
There are also tiny amounts of (negative) spin density on the ligand atoms. (imperial.ac.uk)

In view of their atom and step economies, direct asymmetric C-H bond functionalization is the most concise and powerful method for the construction of planar chiral ferrocenes compared with traditional approaches. (sioc-journal.cn)
This review summarizes recent progress on the development of novel methods to synthesize planar chiral compounds via transition- metal (Cu-, Pd-, Ir-, Rh-, Au-, Pt-) catalyzed asymmetric C-H bond functionalization. (sioc-journal.cn)

Thus, the assembly of the molecular framework will depend in part on the structure and functionality of available starting materials, the selectivity (regio and stereo) of the various reactions that may be used to stitch them together, and the loss or relocation of functional groups in the intermediate compounds formed on the way to the final product. (msu.edu)
Indeed, new synthetic routes to known compounds continue to be reported, particularly as new reactions are developed and applied to difficult transformations. (msu.edu)
For all but the simplest of these, a majority of the reactions in the synthesis involve functional group modification, preceding or following a smaller number of carbon-carbon bond forming reactions. (msu.edu)

7. The starting compounds and reagents for a synthesis must be purchased, so economic considerations are often significant. (msu.edu)

Most of the title compounds readily react with carbon dioxide to provide stable adducts, although the formation of the Lewis acid/base adducts was observed in the solid state. (uni-paderborn.de)
Although photo redox catalysis has been widely used over the past 40 years in the domains of water splitting, carbon dioxide reduction and the creation of innovative solar cell materials, its potential to be used for organic synthesis has only lately began to be fully understood. (tsijournals.com)

Although the formation of the Lewis acid/base adduct is observed in the solid state, which at first glance leads to formally quenched FLP reactivity, we show that the title compound readily reacts with non-aqueous ammonia thermoneutrally and splits the N-H bond reversibly at ambient temperature. (uni-paderborn.de)
The title compound, C24H22N2O2P2, contains a diphosphazane backbone, as well as a hydrazine entity. (tib.eu)
The title compound, C24H22N2OP2, is an asymmetrically substituted hydrazine derivative bearing a phosphoryl and a phosphanyl substituent. (tib.eu)
The title compound, [FeCl₂(C₁₄H₃₀N₄)]PF₆, contains Fe³⁺ coordinated by the four nitro-gen atoms of an ethyl-ene cross-bridged cyclam macrocycle and two cis chloride ligands in a distorted octa-hedral environment. (worktribe.com)

In an extreme case[clarification needed] the central carbon atom, which would ordinarily have tetrahedral molecular geometry for its four bonds gets completely flattened. (wikipedia.org)
citation needed] One of the most highly strained fenestranes to have been isolated is a [4.4.4.5]fenestrane with bond angles at the central carbon atom of around 130° (based on X-ray crystallography), as compared to the 109.45° standard for tetrahedral atoms. (wikipedia.org)
Whereas the C-C bond in ethane is 155 pm, in this fenestrane, the bonds extending from the central carbon atom are shortened to 149 pm while those at the perimeter are lengthened to 159 pm. (wikipedia.org)
In this type of compound a central carbon atom is connected to two other carbon atoms through a double bond. (vander-lingen.nl)

Benzo-15-crown-5 (also known as benzo-15-crown ether) is a cyclic polyether compound that has a broad range of applications in organic and inorganic chemistry. (benchchem.com)

Highly Enantioselective Synthesis of 3a-Fluorofuro[3,2-b]indolines via Organocatalytic Aza-Friedel-Crafts Reaction/Selective C-F Bond Activation. (acs.org)
A general and efficient Cu-assisted cycloisomerization of alkynyl imines enables an efficient synthesis of pyrroles and various types of fused heteroaromatic compounds. (organic-chemistry.org)
Synthesis and Reaction of Hydroaluminum Compounds with Bulky Rind Groups (Fac. (csj.jp)

The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. (justia.com)
More particularly the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28. (justia.com)

They test for Carbon Monoxide in your home while there. (richhomeline.ru)

In the molecular orbital picture for the resulting square planar geometry of methane, two of a total of three sp2-hybridized carbon atomic orbitals form regular bonds with two of the hydrogen atoms as in a planar alkene. (wikipedia.org)
The third sp2 orbital interacts in a three-center two-electron bond with the two remaining hydrogen atoms utilizing only the hydrogen electrons. (wikipedia.org)
Article on rate coefficients for the hydrogen atom + ammonia reaction over a wide temperature range. (unt.edu)

64] "A crystalline aluminium-carbon-based ambiphile capable of activation and catalytic transfer of ammonia in non-aqueous media" Felix Krämer, Jan Paradies, Israel Fernández, Frank Breher*, Nature Chemistry, DOI:10.1038/s41557-023-01340-9. (uni-paderborn.de)

Polycyclic aromatic hydrocarbons (PAHs) are important compounds in materials chemistry, particularly for optoelectronic applications. (bvsalud.org)
A strong argument in favor of the allenic structure according to Bertrand is pyramidalization of the nitrogen atoms which would disrupt aromatic stabilization of the zwitterion. (vander-lingen.nl)
Friedel, R. A. and M. Orchin (1951) Ultraviolet Spectra of Aromatic Compounds. (photochemcad.com)

Two additional carbon valence electrons are situated in a p orbital perpendicular to the plane of the molecule. (wikipedia.org)
These centroids normally coincide with the two-centre basins (bonds) and one-centre basins (lone pairs, inner shell electrons) in normal molecules, both being close to nuclear centres (atoms). (imperial.ac.uk)
For GAVFIS, two unexpected one-centre basins are found close to the two nitrogen atoms in the molecule, each with a population of 0.48 electrons, along with regular one-centre "lone pair" basins pointing inwards to the potassium (2.38 electrons each). (imperial.ac.uk)

The latter compound is accessed using a short sequence involving the use of two strained cyclic alkynes, benzyne and a 3,4-piperidyne, in Diels-Alder cycloaddition sequences. (bvsalud.org)
Additionally, knowledge of their pharmacokinetics is very limited, and in some cases even the concept of a compound being (or not) a toxin itself requires further research (i.e., cyclic imines or yessotoxin). (mdpi.com)
In organic chemistry, Fatty Acyls are a class of organic compounds in the lipids and lipid-like molecules superclass , synthesized by chain elongation of an acetyl-CoA primer with malonyl-CoA (or methylmalonyl-CoA) groups that might contain a cyclic functionality and/or are substituted with heteroatoms . (wellnessadvantage.com)
Benzo-12-crown 4-ether, also known as B12C4E, is a cyclic ether compound with a molecular formula of C12H24O4. (benchchem.com)
It is an important member of the family of crown ethers, which are cyclic polyethers with oxygen atoms arranged in a ring. (benchchem.com)

1. Constructing the carbon framework or skeleton of the desired molecule. (msu.edu)
So even when the "empty space" is infinitely large, the shape of the electride anion is nevertheless quite specific, but a holistic function of the shape of the entire molecule rather than its component atoms. (imperial.ac.uk)

Results on the YIII analogue Y2 (μ-N2 3− ) and the parent compound Tb2 (μ-N2 2− ) (showing no SMM features) are also reported. (pdfhost.io)
The results on the parent compound include the ﬁrst direct determination of the lanthanide-lanthanide exchange interaction in a molecular cluster based on inelastic neutron scattering. (pdfhost.io)

Natural products and relevant compounds with biological and pharmaceutical activity are often characterized by complex molecular structures. (frontiersin.org)
or a molecular compound such kakım polymeric sulfur nitride. (name.tr)
Multiple bonding analysis approaches, including molecular orbital analysis, the natural bond orbital analysis, electron localization function, adaptive natural density partitioning analysis, and quantum theory of atoms in molecules, have unambiguously revealed one two-center two-electron σ covalent bond between two Lu ions in fullerenes. (aip.org)

A fenestrane in organic chemistry is a type of chemical compound with a central quaternary carbon atom which serves as a common vertex for four fused carbocycles. (wikipedia.org)
In organic chemistry, photoredox catalysis has emerged as a potent method for activating tiny compounds. (tsijournals.com)

We report a comparative study of the well-known fluorophore 9,10-diphenylanthracene with an aza analog. (bvsalud.org)

A general, selective, and atom economic metal-catalyzed conversion of primary diols and amines to highly valuable 2,5-unsubstituted pyrroles is catalyzed by a stable manganese complex in the absence of organic solvents. (organic-chemistry.org)

If the central carbon were to be tetrahedral, it would have the form of spiropentadiene, but with additional bonds between the two cyclopropyl rings rather than double-bonds within them. (wikipedia.org)
The ability of photo redox catalysis to quickly build novel reaction pathways is highlighted in this perspective, with a focus on multicatalytic techniques that make it possible to create difficult carbon and carbon-heteroatom bonds. (tsijournals.com)
In lipid science , Glycerolipids , aka Acylglycerols , are a class of organic compounds in the lipids superclass , formed by joining fatty acids to glycerol by ester bonds, composed mainly of mono-, di- and tri-substituted glycerols (glycerins) . (wellnessadvantage.com)
Suprafacial endo addition fixes the relative configuration of the three stereogenic centers as two new carbon-carbon bonds are formed. (msu.edu)

This new catalytic process employs challenging but synthetically ideal free amino functionality to achieve alkenyl C-H activation with sulfoxonium ylides as one-carbon coupling partners. (acs.org)
65] "Quo Vadis CO2 activation: Catalytic Reduction of CO2 to Methanol Using Aluminum and Gallium/Carbon-based Ambiphiles" Felix Krämer, Jan Paradies, Israel Fernández* and Frank Breher* Chem. (uni-paderborn.de)
The resulting highly Lewis acidic boron compounds were used for catalytic C-F and S-F bond activation. (uni-paderborn.de)

Structures within this class of chemicals can be named according to the number of atoms in each ring in addition to the systematic nomenclature of IUPAC naming rules. (wikipedia.org)

Strikingly, 0.3-3.0 mol% of the reported aluminum and gallium/carbon-based ambiphiles catalyze the reduction of CO 2 to methanol with satisfactory high selectivity and yields using pinacol borane as stoichiometric reduction equivalent. (uni-paderborn.de)

This proof-of-principle study is expected to initiate further activities in utilizing N-H-activated ammonia as a readily available, atom-economical nitrogen source. (uni-paderborn.de)

1963) Tables of Spectrophotometric Absorption Data of Compounds Used for the Colorimetric Determination of Elements. (photochemcad.com)

4'-Acetylbenzo-15-crown-5 ether (4'-AB15C5E) is a synthetic, organic compound that has a wide range of applications in scientific research. (benchchem.com)

Hirayama, K. (1967) Handbook of Ultraviolet and Visible Absorption Spectra of Organic Compounds. (photochemcad.com)

The term atom efficiency has been coined to reflect the latter point. (msu.edu)

Nucleoside-like compounds, the earliest type of methylation inhibitors, have found applications in cancer treatment. (worldmedicinefoundation.com)
4'-Acetylbenzo-18-crown-6-ether, also known as 4-AB-18-C6, is an organic compound and a type of crown ether. (benchchem.com)

Carbon-Carbon Bond Cleavage for Late-Stage Functionalization. (acs.org)

Breit B , Schmidt J. Rhodium-Catalyzed Cyclisation of Terminal and Internal Allenols: An Atom Economic and Highly Stereoselective Access Towards Tetrahydropyrans Johannes P. Schmidt, Bernhard Breit. (academictree.org)

Compounds of general formula (I) are CD80 antagonists. (justia.com)

The P-N-P diphosphazane unit and the N-amine N atom are almost coplanar, and the O atoms of the Ph2P(O) units are oriented trans to each other with respect to the P...P axis. (tib.eu)
They include, for example, NaCd2, with 348 sodium atoms and 768 cadmium atoms in the unit cell. (name.tr)

In terms of resonance structures Bertrand not only considers allene A but also 4-electron donor B which can be considered a carbodicarbene with a divalent carbon(0) center. (vander-lingen.nl)
HN - 2008(2004) BX - Acetogenin Compounds MH - Acridones UI - D054831 MN - D3.132.32 MN - D3.494.46.109 MS - Compounds based on acridone, which have three linear rings, with the center ring containing a ring nitrogen and a keto oxygen opposite to each other. (nih.gov)

Create an account below to get 6 C&EN articles per month, receive newsletters and more - all free. (acs.org)

Applications of Bioisosteres in the Design of Biologically Active Compounds. (acs.org)

Over the course of the past hundred years, a very large number of syntheses for a wide variety of compounds have been recorded. (msu.edu)

CRC Atlas of Spectral Data and Physical Constants for Organic Compounds. (photochemcad.com)

Journal of Labelled Compounds and Radiopharmaceuticals. (illinois.edu)

The most frequent ways for photocatalysts to activate specific molecules while also converting light into chemical energy are I energy transfer, organometallic excitation, light induced atom transfer and photo redox catalysis, all of which will be covered in depth in this special issue. (tsijournals.com)

2. Introducing, removing or transforming functional groups in a fashion that achieves the functionality of the desired compound. (msu.edu)

The carbon-carbon bond-lengths deviate from those of normal alkanes as well. (wikipedia.org)

Anatomy6

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Chemicals and Drugs123

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Phenomena and Processes52

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Replaced by nitrogen2

Nitrogen atom7

Five-membered2

Ligand6

Chiral2

Reactions3

Reagents1

Dioxide2

Title compound4

Central carbon atom4

Inorganic Chemistry1

Synthesis3

Invention relates2

Monoxide1

Hydrogen3

Crystalline1

Aromatic3

Electrons3

Cyclic5

Molecule2

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Organic chemistry2

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Bonds4

Activation3

Chemicals1

Reduction1

Ammonia1

Determination1

Synthetic1

Absorption1

Term1

Type2

Functionalization1

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General formula1

Unit2

Center2

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