• tryptamine
  • The structure of β-carboline is similar to that of tryptamine, with the ethylamine chain re-connected to the indole ring via an extra carbon atom, to produce a three-ringed structure. (wikipedia.org)
  • Rearrangements enable the formation of a Schiff base from tryptamine, which then reacts with pyruvate in II to form a β-carboline carboxylic acid. (wikipedia.org)
  • anxiolytic
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  • Abecarnil (ZK-112,119) is an anxiolytic drug from the β-Carboline family. (wikipedia.org)
  • derivatives
  • The direct conversion of various amides to isoquinoline and β-carboline derivatives via mild electrophilic amide activation, with trifluoromethanesulfonic anhydride in the presence of 2-chloropyridine followed by cyclodehydration upon warming provides the desired products with short overall reaction times. (organic-chemistry.org)
  • A group of β-carboline derivatives, termed eudistomins were extracted from ascidians (marine tunicates of the family Ascidiacea), like Ritterella sigillinoides, Lissoclinum fragile or Pseudodistoma aureum. (wikipedia.org)
  • A series of novel β-carboline-based hydroxamate derivatives ( 8a-n ) as HDAC inhibitors have been designed and synthesized. (rsc.org)
  • Together, our findings suggest that these novel β-carboline-based hydroxamate derivatives may provide a new framework for the discovery of novel antitumor agents for the intervention of human carcinoma cells. (rsc.org)
  • serotonin
  • Comparison of the inhibition kinetics of tetrahydro-β-carbolines for serotonin and epinephrine reuptake to that of the platelet aggregation response to these amines has shown that 5-hydroxymethtryptoline, methtryptoline, and tryptoline are poor inhibitors of reuptake. (wikipedia.org)
  • Indoles
  • A wide range of functionalized β-carbolines and γ-carbolines can be prepared from readily accessible indoles and nitriles in good to excellent yields under the optimal conditions. (rsc.org)
  • An enantioselective aza-Friedel-Crafts alkylation reaction of indoles with 1-trifluoromethyl-3,4-dihydro-β-carbolines catalyzed by a chiral spirocyclic phosphoric acid has been realized. (rsc.org)
  • presence
  • As a result of the presence of β-carbolines in the cuticle of scorpions, their skin is known to fluoresce when exposed to certain wavelengths of ultraviolet light such as that produced by a blacklight. (wikipedia.org)
  • structure
  • Different levels of saturation are possible in the third ring, which is indicated here in the structural formula by colouring the optionally double bonds red and blue: Some of the more important β-carbolines are tabulated by structure below. (wikipedia.org)
  • route
  • This methodology provides a facile route to 1-trifluoromethyl-1-indole-substituted tetrahydro-β-carbolines featuring a CF 3 -containing quaternary stereocenter in considerable yields and good enantioselectivities. (rsc.org)