• These 2 theranostic approaches, as well as the therapy of osseous metastases of prostate cancer with 223 Ra ( 4 , 9 , 10 ), have unequivocally demonstrated that radionuclide therapy can be applied not only to thyroid cancer but also to other solid tumors. (snmjournals.org)
  • The complexity of the human bone marrow, with context to haematological malignancies, is more difficult to elucidate with the present strategies compared to the niche of solid tumors. (fortunejournals.com)
  • There can, however, be few similarities between the two, as the bone marrow is a common site of metastasis of solid tumors too [6]. (fortunejournals.com)
  • Relevant information has now been established on solid tumors and their micro-environments, which include immune, endothelial and mesenchymal cells. (fortunejournals.com)
  • The present invention discloses a pharmaceutical composition containing antibodies or antigen-binding fragments of antibodies that bind to SSEA3, SSEA4, and globo H. It also describes methods for using the composition. (patentpc.com)
  • Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates , however they are not considered lectins . (lookformedical.com)
  • Transmembrane or otherwise tumor-associated polypeptides specifically expressed on the surface of cancer cells as compared to normal, non-cancerous cell(s) have been identified as cellular targets for cancer diagnosis and therapy with antibodies. (justia.com)
  • CAR4-DNTs effectively infiltrated tumors, delayed tumor progression, and prolonged the survival of T-ALL and PTCL xenografts. (bvsalud.org)
  • In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
  • In accordance, attempts have been made to establish a link between the immune system and the tumor microenvironment, to comprehend tumor progression and achieve effective therapeutic approaches. (fortunejournals.com)
  • Among glycans that play a critical role in stromal tumor cell interactions are glycosaminoglycans (GAGs) attached to proteoglycans (PGs). (biomedcentral.com)
  • Glycan is also a general term used to refer to the carbohydrate portion of Glycoproteins , Glycolipids and Proteoglycans . (glycop.com)
  • Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
  • No. 4,975,278) allows targeted delivery of the drug moiety to tumors, and intracellular accumulation therein, where systemic administration of these unconjugated drug agents may result in unacceptable levels of toxicity to normal cells as well as the tumor cells sought to be eliminated (Baldwin et al (1986) Lancet pp. (justia.com)
  • The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight. (lookformedical.com)
  • Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. (lookformedical.com)
  • The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. (lookformedical.com)
  • Proteins that share the common characteristic of binding to carbohydrates . (lookformedical.com)
  • PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). (lookformedical.com)
  • Although most patients with localized tumors can be cured with surgical therapies, 20-30 % of the patients without any evidence of metastasis will develop relapse and/or metastatic RCC in the future [ 3 ]. (biomedcentral.com)
  • In recent years, however, theranostics has been successfully applied to a whole range of other malignancies, including neuroendocrine tumors (NETs) and prostate cancer in particular. (snmjournals.org)
  • The use of chimeric antigen receptor (CAR)-T cell therapy for T-cell malignancies is challenging due to possible blast contamination of autologous T-cell products and fratricide of CAR-T cells targeting T-lineage antigens. (bvsalud.org)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • Current research in theranostics is addressing new targets but-equally important-the optimization of radiopharmaceutical doses and dose schedules, investigation of combination therapies, and treatment at earlier tumor stages. (snmjournals.org)
  • Identification of such tumor-associated cell surface antigen polypeptides, i.e. tumor associated antigens (TAA), allows specific targeting of cancer cells for destruction via antibody-based therapies. (justia.com)
  • Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. (lookformedical.com)
  • This "depot" was formed by associating the antigen with substances able to persist at the injection site, such as aluminum salts or emulsions. (mdpi.com)
  • It encodes carbohydrates precursor substances in RBCs. (labpedia.net)
  • The oligosaccharide chains of glycoprotein and glycolipid are often terminated by sialic acids, which play intensely important role in regulating physiologically and pathologically interactions with ligands [ 9 ]. (biomedcentral.com)
  • Tumor-associated glycans play a significant role in promoting aggressive and metastatic behavior of malignant cells [ 1 - 5 ], participating in cell-cell and cell-extracellular matrix interactions that promote tumor cell adhesion and migration. (biomedcentral.com)
  • Intramolecular carbohydrate-protein interactions. (musicastorrent.com)
  • Their response involves antigen capture, enhancing their MHC-II presentation receptors and production of chemokines and/or cytokines at the site of inflammation [9]. (fortunejournals.com)
  • There are two classes of antigen-recognizing receptors, one set expressed on B cells and referred to as B cell receptors (BCRs), and the other mtt expressed on T cells and referred to as T cell receptors (TCRs). (top5binarybrokers.com)
  • Aberrant sialylated carbohydrate synthesis is frequently noted in various cancers. (biomedcentral.com)
  • Tandem galectins contain at least two distinct carbohydrate recognition domains (CRD) within one polypeptide, thus are considered intrinsically divalent. (wikipedia.org)
  • The galectin carbohydrate recognition domain (CRD) is constructed from beta-sheet of about 135 amino acids. (wikipedia.org)
  • The strength of ligand binding is determined by a number of factors: The multivalency of both of ligand and the galectin, the length of the carbohydrate and the mode of presentation of ligand to carbohydrate recognition domain. (wikipedia.org)
  • They cannot bind to other sugars such as mannose because this sugar will not fit inside the carbohydrate recognition domain without steric hindrance. (wikipedia.org)
  • However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition. (lookformedical.com)
  • Change in the structure of glycan chains is one of the most shared features of the malignant transformation [ 8 ]. (biomedcentral.com)
  • The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). (lookformedical.com)
  • The concave side forms a groove in which the carbohydrate ligand can bind, and which is long enough to hold about a linear tetrasaccharide. (wikipedia.org)
  • Since the pioneering use of 131 I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177 Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. (snmjournals.org)
  • More recently, the prostate-specific membrane antigen (PSMA) has been established as a theranostic target for prostate cancer. (snmjournals.org)
  • these 2 genes decide which ABO antigens are present on the RBC membrane. (labpedia.net)
  • They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. (wikipedia.org)
  • Carbohydrate binding is calcium independent, unlike C-type lectins. (wikipedia.org)
  • CD BioGlyco can process patient-derived tumor samples provided by customers and provide personalized model building and precision treatment strategy screening services based on the MOPCGM platform. (bioglyco.com)
  • CD BioGlyco has professional glycomedicine development teams with multiple world-leading technologies to help customers comprehensively promote the development of carbohydrate-based anticoagulant glycomedicine. (bioglyco.com)
  • As a leading resource provider in the glycobiology field, CD BioGlyco has various systematic services for the synthesis, modification, analysis, and activity detection of carbohydrate-based anticoagulant glycomedicine. (bioglyco.com)
  • With a first-class carbohydrate-based glycomedicine development platform and professional research teams, CD BioGlyco is committed to ensuring customer the highest level of satisfaction. (bioglyco.com)
  • The mechanism by which vaccine adjuvants enhance immune responses has historically been considered to be the creation of an antigen depot. (mdpi.com)
  • From here, the antigen is slowly released and provided to immune cells over an extended period of time. (mdpi.com)
  • This theranostic principle has acquired greater importance in personalized medicine in recent years, particularly in oncology, where advanced tumors can be treated effectively with low side effects. (snmjournals.org)
  • Molecular alterations in malignant disease result in the expression or upregulations of various targets that can be used for imaging and treatment with radiopharmaceuticals. (snmjournals.org)
  • The identification of Pathogen-Associated Molecular Patterns (PAMPs) has greatly advanced our understanding of how adjuvants work beyond the simple concept of extended antigen release and has accelerated the development of novel adjuvants. (mdpi.com)
  • The yak rumen fibroblast cell line (SV40T-YFB) was immortalized by introducing simian virus 40 large T antigen (SV40T) by lentivirus-mediated transfection. (bvsalud.org)
  • Transient transfection of the human breast cancer cell line MDA-MB-231 with the siRNAs for carbohydrate (chondroitin 4) sulfotransferase-11 ( CHST11 ) and chondroitin sulfate proteoglycan 4 ( CSPG4 ) was used to investigate the involvement of these genes in expression of surface P-selectin ligands. (biomedcentral.com)
  • Enzymatic removal of tumor-cell surface CS-GAGs significantly inhibited lung colonization of the 4T1 murine mammary cell line ( P = 0.0002). (biomedcentral.com)
  • It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. (lookformedical.com)
  • Tests for the ABH secretion may help establish the true ABO group of an individual whose red blood cell antigens are poorly developed. (labpedia.net)
  • Glioblastoma Multiforme (GBM) is the most aggressive form and most common primary brain tumour in adults. (patentpc.com)
  • MCPyV integrates into the host genome, resulting in expression of oncoproteins including a truncated form of the viral large T antigen (LT) in infected cells. (bvsalud.org)
  • The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer (Lambert, J. (2005) Curr. (justia.com)
  • ABO genes do not actually code for the production of ABO antigens but rather produce specific glycosyl-transferases that add sugars to the basic precursor substance. (labpedia.net)
  • The basic material is a glycoprotein or glycolipids that are the backbone to which sugars are added in response to specific enzyme transferases shown by inherited parents' genes. (labpedia.net)
  • Our professional research teams provide customers with high-quality carbohydrate-based anticoagulant glycomedicine development services according to their needs. (bioglyco.com)
  • Blood grouping is done based on the presence of antigens on the surface of RBCs. (labpedia.net)
  • So the basic principle of blood donation is that there should be no antibody to match the RBCs' surface antigen. (labpedia.net)
  • In addition, CSPG4 and CHST11 were over-expressed in tumor-containing clinical tissue specimens compared with normal tissues. (biomedcentral.com)
  • It has, rather, been used for decades for the therapy of benign and malignant thyroid diseases ( 2 , 3 ). (snmjournals.org)