Carbapenem resistant enterobacteriaceae. Medical search. Frequent questions

Some bacteria in this family are resistant to nearly all antibiotics, leaving more toxic or less effective treatment options. (cdc.gov)
Carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae (CPE) are Gram-negative bacteria that are resistant to the carbapenem class of antibiotics, considered the drugs of last resort for such infections. (wikipedia.org)
People most likely to acquire carbapenem-resistant bacteria are those already receiving medical attention. (wikipedia.org)
revealed that exposure to antibiotics, especially fluoroquinolones and previous hospitalization dramatically increased the risk of acquisition carbapenem-resistant bacteria. (wikipedia.org)
Regions are considering the use of electronic registries to track patients that carry antibiotic-resistant bacteria including carbapenem-resistant Enterobacteriaceae (CRE). (amr-insights.eu)
Following the initial remarkable success of antibiotics, the emergence and spread of human pathogenic bacteria resistant to antibiotics has become a major phenomenon in the past fifty years. (europa.eu)
The work package focusing on molecular studies generated new evidence about the changes effected by antibiotic therapy on commensal organisms or opportunistic pathogens in the oropharyngeal, nasal and gastro-intestinal flora and study AMR mechanisms and the dissemination of successful clones of fluoroquinolone-resistant, carbapenem-resistant or extended-spectrum beta-lactamase harboring Gram-negative bacteria, MRSA and fluoroquinolone-resistant viridans streptococci. (europa.eu)
The emergence and spread of human pathogenic bacteria resistant to antibiotics has become a major problem in the past fifty years. (europa.eu)
Also, SATURN had as mission to improve methodological standards and conduct research to better understand the impact of antibiotic use on acquisition, selection and transmission of antibiotic-resistant bacteria (ARB) in different environments, by combining state-of-the-art analyses of molecular, ecologic and individual patient-level data. (europa.eu)
Multi-resistant hospital bacteria linked to India and Pakistan. (cdc.gov)
Carbapenem antibiotics are typically reserved to treat multidrug-resistant bacterial infections, so when bacteria develop resistance to them, treatment options can be extremely limited. (floridahealth.gov)
A Nevada woman has died from a "superbug," an antibiotic-resistant strain of bacteria. (ajc.com)
Once mutated, drug-resistant bacteria can pass on their resistance to others. (ajc.com)
The gene makes bacteria resistant to antibiotics. (medicalnewstoday.com)
Carbapenem antibiotics are extremely powerful drugs that can counter the activity of highly resistant bacteria for which other antibiotics have not been effective. (medicalnewstoday.com)
Medical scopes called duodenoscopes-used to treat gallstones, cancers and other problems in the digestive system-can be difficult to disinfect, and these devices appear to have carried a drug-resistant strain of bacteria to almost 200 patients, reports the Los Angeles Times . (smithsonianmag.com)
At least the White House's proposed 2016 budget plan recognizes the need to combat antibiotic-resistant bacteria. (smithsonianmag.com)
From an infection control perspective, C. auris acts more like a multidrug-resistant, healthcare-associated bacteria than like a typical yeast. (mdlinx.com)
In addition to the 2 deaths, 5 other patients have tested positive for the drug-resistant bacteria, and 179 additional individuals may have been exposed. (sokolovelaw.com)
When patients are exposed to bacteria that have become resistant to even the most potent antibiotics, the results can be deadly. (sokolovelaw.com)
As part of his work and expertise in molecular epidemiology of antimicrobial resistant bacteria, Dr. Adler was appointed as consultant for the European Center for Disease Control (ECDC) and he is the secretary of the Advisory Committee for Laboratory Standards of the Israeli National Center of Infection Control. (tau.ac.il)
Bacteria harbouring this NDM gene are commonly resistant to multiple antimicrobials, limiting therapeutic options and rendering severe clinical infections difficult to treat. (gov.hk)
Rochester, Minnesota - The gene that makes bacteria highly resistant to a last-resort class of antibiotics is in the U.S. A report published in Antimicrobial Agents and Chemotherapy says the colistin-resistant mcr-1 E. coli has been discovered in a woman in Pennsylvania. (imperialvalleynews.com)
In its blog, HHS states, "Although the findings suggest that mcr-1-mediated colistin resistance might be rare, HHS and USDA remind consumers that cooking all meat, poultry and fish to its proper internal temperature kills bacteria, viruses and other foodborne pathogens, whether or not they are antibiotic-resistant. (imperialvalleynews.com)
Extended-spectrum beta-lactamase produc- ing Enterobacteriaceae was found in 37.5% (54) isolates and carbapenem resistant bacteria were identified in 27.8% of patients. (who.int)
Age 65 years, presence of septic shock, and presence of carbapenem-resistant bacteria were independently associated with in- creased in-hospital mortality. (who.int)
Conclusion High number of resistant microorganisms was isolated, and increased mortality was documented from infections caused by carbapenem-resistant bacteria. (who.int)
Carbapenem-resistant gram-negative bacteria, namely, carbapenem-resistant Enterobacteriaceae (CRE) (for example, Klebsiella pneumoniae, Escherichia coli), Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPsA), are a matter of national and international concern as they are an emerging cause of. (bvsalud.org)
Tigecycline is effective against many resistant bacteria, including those with resistance to tetracyclines. (msdmanuals.com)
View of How can we ?ght against antimicrobial-resistant bacteria in the World Health Organization Western Paci?c Region? (who.int)
The public health community is faced with the global challenge posed by antimicrobial-resistant bacteria, including meticillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum β-lactamases (ESBLs)-producing enterobacteriaceae. (who.int)
In today's world of international travel, the globalization of drug-resistant bacteria is a pressing issue for public health professionals. (who.int)
In the World Health Organization (WHO) Western Pacific Region, as well as other regions in the world, more and more new types of antimicrobial-resistant bacteria have come to the forefront. (who.int)
In this perspective article, we consider four focus areas for countries in the Western Pacific Region to consider when strategizing their response to antimicrobial resistant bacteria. (who.int)
Constructing a standardized surveillance system in the Region would provide useful data to monitor and assess the pattern and frequency of resistant bacteria. (who.int)
Such a network would assist countries, especially when dealing with cross-border outbreaks of resistant bacteria. (who.int)
The WHO South-East Asia and the Western Pacific Regional Offices are collaborating to build up standard laboratory methods and surveillance systems to monitor resistant bacteria in both regions. (who.int)
Basic research of drug-resistant bacteria, such as identifying responsible genes and enzymes, is crucial to understanding the mechanism of antimicrobial resistance and transmission. (who.int)

Carbapenem-resistant Enterobacteriaceae (CRE) have been defined as carbapenem-nonsusceptible and extended-spectrum cephalosporin-resistant Escherichia coli, Enterobacter aerogenes, Enterobacter cloacae complex, Klebsiella pneumoniae, or Klebsiella oxytoca. (wikipedia.org)
Infections with carbapenem-resistant Klebsiella pneumoniae were associated with organ/stem cell transplantation, mechanical ventilation, exposure to antimicrobials, and overall longer length of stay in hospitals. (wikipedia.org)
Carbapenems continue to have the best activity against E cloacae, E aerogenes, (now known as Klebsiella aerogenes ) and other Enterobacter species. (medscape.com)
Persistence of Klebsiella pneumoniae ST258 as the predominant clone of carbapenemase-producing Enterobacteriaceae in post-acute-care hospitals in Israel, 2008-13. (tau.ac.il)
ABSTRACT The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the blaKPC gene that encodes for carbapenemase production have complicated the management of patient infections. (who.int)
RÉSUMÉ L'émergence et la propagation rapide des souches de Klebsiella pneumoniae résistantes aux antibiotiques et porteuses du gène blaKPC codant la production de carbapénèmases ont compliqué la prise en charge des infections des patients. (who.int)

In 1985, the first OXA-encoding gene was found in an isolate from the United Kingdom and designated or carried both isolate coexpressing three carbapenemases, KPC-2, NDM-1, and IMP-4, which was recognized in 2017, and the plasmids comprising these three resistance genes have emerged in most additional members of the family Enterobacteriaceae, including varieties (Wang et al. (biopaqc.com)
In August 2017, meropenem/vaborbactam (Vabomere) was approved for complicated urinary tract infections (cUTIs), including pyelonephritis, caused by susceptible Enterobacteriaceae: E coli, K pneumoniae, and E cloacae species complex. (medscape.com)
Effective January 2017, Washington State Department of Health and Public Health Laboratories have expanded surveillance for antibiotic resistant organisms. (wa.gov)

Serious concur- fromaroundtheworldpublishedbeforeApril9,2012.At- rent conditions ( 3 , 4 , 19 - 22 ) and prior use of fluoroquino- tributabledeathwasdefinedasthedifferenceinall-cause lones ( 20 , 23 , 24 ), carbapenems ( 22 , 25 ), or broad-spectrum deaths between patients with carbapenem-resistant infec- cephalosporins ( 20 , 22 ) have been independently associated tions and those with carbapenem-susceptible infections. (cdc.gov)
Beta-lactam antibiotics include Cephalosporins, Penicillins, monobactams and Carbapenems. (clickpress.com)
Serious concurrent conditions and prior use of fluoroquinolones, carbapenems, or broad-spectrum cephalosporins have been independently associated with acquisition of infections caused by CRE. (cdc.gov)
The antimicrobials most commonly indicated in Enterobacter infections include carbapenems, fourth-generation cephalosporins, aminoglycosides, fluoroquinolones, and TMP-SMZ. (medscape.com)
Cefiderocol was well tolerated, and its safety profile was consistent with that of other cephalosporins and/or carbapenems. (dutchnews.nl)
Strain WCHECl-1060 belongs to a new sequence type, ST410, and was resistant to carbapenems and colistin but was susceptible to third-generation cephalosporins. (medscape.com)

A few infections caused by carbapenem-resistant Enterobacteriaceae outside the bowel include wound infection, urinary tract infection (UTI) and pneumonia. (clickpress.com)
People admitted to any healthcare setting for medical care are more prone to infection and to go for Carbapenem-resistant enterobacteriaceae testing than healthy people. (clickpress.com)
Growing awareness about prevention of Carbapenem resistance and increased efforts by governments through the implementation of infection prevention and control measures might hinder the growth of the Carbapenem-resistant enterobacteriaceae testing market during the forecast period. (clickpress.com)
Leaders in infectious disease and infection control can use this toolkit to develop interventions to control carbapenem-resistant Enterobacteriaceae (CRE). (ahrq.gov)
Clinical Trial for Blood Stream Infections, Ventilator Associated Pneumonia, Healthcare Associated Infection, Carbapenem-Resistant Enterobacteriaceae Infection and Hospital-acquired Pneumonia. (pfizerclinicaltrials.com)
The primary hypothesis is that these interventions will lead to improved clinical outcomes amongst patients with hospital-acquired bloodstream infection, hospital-acquired pneumonia or ventilator-associated pneumonia due to carbapenem non-susceptible Pseudomonas aeruginosa or Enterobacterales, compared to standard antibiotic susceptibility testing. (pfizerclinicaltrials.com)
Both community and hospital settings should be considered in future research addressing pediatric ESC-R Enterobacteriaceae infection. (elsevierpure.com)
Current CDC infection control guidance for carbapenem-resistant Enterobacteriaceae also is appropriate for NDM-1--producing isolates ( 5 ). (cdc.gov)
Laboratory identification of the carbapenem- resistance mechanism is not necessary to guide treatment or infection control practices but should instead be used for surveillance and epidemiologic purposes. (cdc.gov)
Infection control interventions aimed at preventing transmission, as outlined in current guidance ( 5 ), should be implemented when NDM-1--producing isolates are identified, even in areas where other carbapenem-resistance mechanisms are common among Enterobacteriaceae . (cdc.gov)
Meropenem/Vaborbactam in Patients with Carbapenem-resistant Enterobacteriaceae Gram-negative Blood Stream Infection: A Case Series, S. Alosaimy et al. (globenewswire.com)
Horizontal Infection Control Strategy Decreases Methicillin-Resistant Staphylococcus aureus Infection and Eliminates Bacteremia in a Surgical ICU Without Active Surveillance. (tuftsmedicalcenter.org)

Carbapenems are strong antibiotics that are commonly used to treat serious infections. (clickpress.com)
Increase in the number of people requiring inpatient medical assistance, growing number of healthcare facilities, increased number of complex surgeries, multiple use of several antibiotics and rise in use of medical devices in the body, such as urinary catheters, intravenous catheters and ventilators, are few of the major factors responsible for growth in the Carbapenem-resistant enterobacteriaceae testing market. (clickpress.com)
Timely identification of carbapenem-resistant organisms is crucial to orient antibiotics and save lives. (biomerieuxconnection.com)
Apart from empirical treatment, the antibiotics used for treatment might be less effective against carbapenem-resistant infections as well. (cdc.gov)
For example, some Enterobacteriaceae can produce enzymes called carbapenemases that break down antibiotics including carbapenems, making the drugs ineffective. (floridahealth.gov)
New Delhi Metallo-beta-lactamase (NDM): A less common carbapenemase in the United States but concerning because it can be resistant to even more antibiotics than KPC. (floridahealth.gov)
A carbapenemase is an enzyme that breaks down carbapenem antibiotics and can be transferred between organisms. (floridahealth.gov)
A bacterial strain that carries NDM-1 will be resistant to even some of the strongest antibiotics. (medicalnewstoday.com)
Carbapenems are among the most powerful antibiotics. (medicalnewstoday.com)
A bacterium with a plasmid containing the NDM-1 protein product has the potential to be resistant to many current antibiotics, as well as newer antibiotics that could become available in the near future. (medicalnewstoday.com)
The drug-resistant bugs have an enzyme that can break down common antibiotics such as penicillin and amoxicillin, reports ABC News . (smithsonianmag.com)
CRE, which stands for carbapenem-resistant Enterobacteriaceae, is highly resistant to antibiotics and can kill up to 50% of infected patients. (latimes.com)
In addition, frequent hospitalizations and receipt of multiple courses of very broad-spectrum antibiotics, like carbapenems, stand out as risk factors for C. auris colonization," noted Dr. Vallabhaneni and coauthors. (mdlinx.com)
Mayo Clinic infectious diseases specialist Dr. Pritish Tosh says, "The issues we are encountering regarding antibiotic resistant organisms continue to worsen, in large part are due to inappropriate use of antibiotics in the hospital and in outpatient settings. (imperialvalleynews.com)

They are resistant because they produce an enzyme called a carbapenemase that disables the drug molecule. (wikipedia.org)
Carbapenemases are a class of enzymes that can confer earchbasic) databases on April 9, 2012, by using the fol- resistance to carbapenems and other -lactam antibiotic lowing search terms: carbapenem-resistant or carbapen- drugs, but not all carbapenemase-producing isolates are emase-producing or KPC and outcome or mortality. (cdc.gov)
Carbapenemase production in the Enterobacteriaceae was unknown until early 2000s. (unboundmedicine.com)
Carbapenemases are a class of enzymes that can confer resistance to carbapenems and other Beta-lactam antibiotic drugs, but not all carbapenemase-producing isolates are carbapenem-resistant. (cdc.gov)
Carbapenem resistance and carbapenemase production conferred by bla NDM-1 is detected reliably with phenotypic testing methods currently recommended by the Clinical and Laboratory Standards Institute ( 3 ), including disk diffusion testing and the modified Hodge test ( 4 ). (cdc.gov)
Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities. (cdc.gov)
Carbapenemase renders many preferred types of antibiotic ineffective, including carbapenems. (medicalnewstoday.com)
Some of these patients were also colonized or infected with carbapenemase-producing, carbapenem-resistant Enterobacteriaceae . (mdlinx.com)
The Public Health Laboratory Services Branch (PHLSB) of the Centre for Health Protection (CHP) of the Department of Health confirmed a case of New Delhi metallo- ]-lactamase-1 (NDM-1) Carbapenemase-producing Enterobacteriaceae in a 26-year-old woman. (gov.hk)
The patient's rectal swab grew NDM-1 Carbapenemase-producing Enterobacteriaceae, as confirmed by the PHLSB. (gov.hk)
This is the 19th detected case of NDM Carbapenemase-producing Enterobacteriaceae in Hong Kong. (gov.hk)
bla IMI is a carbapenemase gene mediating resistance to carbapenems but has not been commonly found. (medscape.com)
To our knowledge, this is the first report of an IMI-1 carbapenemase-producing colistin-resistant E. cloacae in China. (medscape.com)

Colistin, introduced in the 1950s, is used to treat multidrug resistant bacterial infections known as carbapenem-resistant Enterobacteriaceae (CRE). (imperialvalleynews.com)

According to The Centers for Disease Control and Prevention (CDC), around 2 million people are infected by antibiotic-resistant organisms every year, which further leads to approximately 23,000 deaths annually. (clickpress.com)
Used for pseudomonal infections and infections due to multidrug-resistant gram-negative organisms. (medscape.com)
In the United Kingdom, where these organisms are increasingly common, carriage of Enterobacteriaceae containing bla NDM-1 has been closely linked to receipt of medical care in India and Pakistan ( 2 ). (cdc.gov)
It is a new bug using old tricks mastered by some well-known, multidrug resistant organisms," Dr. Vallabhaneni and coauthors observed. (mdlinx.com)
Which antibiotic resistant organisms are reportable to public health and requested for submission to the Washington State Public Health Laboratory? (wa.gov)
Please refer to the Antibiotic Resistant Organisms Elaborations newsletter article for detailed information about this increased surveillance. (wa.gov)
Multi-center studies should be done to determine the extent of resistant organisms in health facilities throughout the country.epidemiology, and the findings should be factored into clinical decision making and program design for disease prevention, screening, and treatment. (who.int)

2019 ) Survey of US wastewater for carbapenem-resistant Enterobacteriaceae. (academictree.org)

Evaluation of the spread of methicillin-resistant Staphylococcus aureus in the Dermatology. (usp.br)
The NDM-1 protein is different from the protein product that characterizes methicillin-resistant Staphylococcus aureus ( MRSA ), another superbug. (medicalnewstoday.com)
MRSA, or methicillin-resistant Staphylococcus aureus , in particular has garnered a lot of attention . (smithsonianmag.com)
Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Israel: dissemination of global clones and unique features. (tau.ac.il)
Adler A , Givon-Lavi N, Moses AE, Block C, Dagan R. Carriage of community-associated methicillin-resistant Staphylococcus aureus in a cohort of infants in southern Israel: risk factors and molecular features. (tau.ac.il)

KPC and NDM are enzymes that break down carbapenems and make them ineffective. (wikipedia.org)

We performed a systematic search in the PubMed arbapenem-resistant strains have emerged among spe- (http://www.ncbi.nlm.nih.gov/pubmed/) and Scopus cies belonging to the Enterobacteriaceae family ( 1 , 2 ). (cdc.gov)
Carbapenem-resistant strains have emerged among species belonging to the Enterobacteriaceae family. (cdc.gov)

In contrast, infections caused by ESC-R or CR K pneumoniae were more likely than those caused by resistant E coli to be healthcare- or hospital-associated and to occur in patients with an indwelling device (P ≤ .003 for any differences, multivariable logistic regression). (elsevierpure.com)

Epidemiology and Outcomes of Carbapenem Resistance Among Patients with Hospital-Acquired and Ventilator-Associated Pneumonia, M. Zilberberg et al. (globenewswire.com)

NDM is an enzyme which can inactivate carbapenems and other beta-lactams such as penicillins. (gov.hk)

In this report, we aim to describe the epidemiology of extended-spectrum cephalosporin-resistant (ESC-R) and carbapenem-resistant (CR) Enterobacteriaceae infections in children. (elsevierpure.com)
The epidemiology of ESC-R and CR Enterobacteriaceae varied according to hospital and species (E coli vs K pneumoniae). (elsevierpure.com)
The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace. (nih.gov)
She has particular interest in carbapenem-resistant Enterobacteriaceae transmission in the hospital environment, including outbreak management, and transmission and epidemiology of Clostridium difficile. (hopkinsmedicine.org)

Carbapenem resistant Enterobacteriaceae colonization in patients admitted to the. (usp.br)

In 2016, 490 000 people developed multi-drug resistant TB globally, and drug resistance is starting to complicate the fight against HIV and malaria, as well. (paho.org)

During January--June 2010, three Enterobacteriaceae isolates carrying a newly described resistance mechanism, the New Delhi metallo-beta-lactamase (NDM-1) ( 1 ), were identified from three U.S. states at the CDC antimicrobial susceptibility laboratory. (cdc.gov)
This is the first report of NDM-1 in the United States, and the first report of metallo-beta-lactamase carriage among Enterobacteriaceae in the United States. (cdc.gov)

This study found that carbapenem-resistant acquisition has a significantly higher mortality rate and poorer clinical response compared to that of the ertapenem-resistance acquisition. (wikipedia.org)
The objective of the current ering new classes of antimicrobials and the increasing study was, therefore, to assess the bacteriologic pro- emergence and reemergence of resistant pathogens, file, resistance pattern, and patient's outcome in Lan- mortality from infectious disease is increasing [1]. (who.int)

Predicting Carbapenem Resistance Among Gram-Negative Pathogens in Complicated Urinary Tract Infections, M. Zilberberg Et Al. (globenewswire.com)

Epidemiological and microbiological characteristics of an outbreak caused by OXA-48-producing Enterobacteriaceae in a neonatal intensive care unit in Jerusalem, Israel. (tau.ac.il)
A rapid matrix-assisted laser desorption ionization-time of flight mass spectrometry-based method for single-plasmid tracking in an outbreak of carbapenem-resistant Enterobacteriaceae. (nih.gov)
This plasmid peak was present in spectra from retrospectively analyzed K. pneumoniae outbreak isolates, concordant with results from whole-genome sequencing, and absent from a diverse control set of bla(KPC)-negative clinical Enterobacteriaceae isolates. (nih.gov)

Carbapenem-resistant Enterobacteriaceae (CRE) are a major concern for patients in healthcare facilities. (cdc.gov)
DeathsAttributabletoCRE Enterobacteriaceae with susceptible isolates) were excluded, as were studies Statistical Analysis that compared patients who had carbapenem-resistant in- We calculated pooled risk ratios (RRs) and 95% CIs fections with patients who were not infected. (cdc.gov)
0.10 was for infected patients from those for colonized patients and defined to indicate the presence of heterogeneity) and studies that reported on isolates resistant to a carbapenem the I 2 index (for assessing the degree of heterogeneity) other than imipenem, meropenem, or doripenem. (cdc.gov)
Carbapenem of choice for meningitis and for patients at risk for seizures. (medscape.com)
This includes recognizing carbapenem-resistant Enterobacteriaceae when cultured from clinical specimens, placing patients colonized or infected with these isolates in contact precautions, and in some circumstances, conducting point prevalence surveys or active-surveillance testing among other high-risk patients. (cdc.gov)
Clinicians should be aware of the possibility of NDM-1--producing Enterobacteriaceae in patients who have received medical care in India and Pakistan, and should specifically inquire about this risk factor when carbapenem-resistant Enterobacteriaceae are identified. (cdc.gov)
CDC asks that carbapenem-resistant isolates from patients who have received medical care within 6 months in India or Pakistan be forwarded through state public health laboratories to CDC for further characterization. (cdc.gov)
The cost of health care for patients with resistant infections is higher than care for patients with non-resistant infections due to longer duration of illness, additional tests and use of more expensive drugs. (paho.org)

[ 70 ] Doripenem, approved in the United States in 2007, appears to be as effective as the other carbapenems. (medscape.com)

People prone to Carbapenem-resistant enterobacteriaceae include people admitted to hospitals or other healthcare settings. (clickpress.com)
Healthcare settings, such as nursing homes and acute care centers, where constant medical care is required for a longer duration of time are more prone to CRE and thus, the demand for Carbapenem-resistant enterobacteriaceae testing is higher in these settings. (clickpress.com)
Carbapenem-Resistant Enterobacteriaceae: Analyzing Knowledge and Practice in Healthcare Providers. (tuftsmedicalcenter.org)
Carbapenem resistance among the Enterobacteriaceae is a serious healthcare challenge. (medscape.com)

The "superbug" is scientifically known as a carbapenem-resistant Enterobacteriaceae (CRE). (sokolovelaw.com)

Several outbreaks caused by carbapenem-resistant Italian, Spanish, or Greek were not evaluated. (cdc.gov)
Moreover, the sporadic outbreaks of VIM-producing Enterobacteriaceae are globally reported (Walsh et al. (biopaqc.com)
Several outbreaks caused by carbapenem-resistant Enterobacteriaceae , or CRE, have been recorded in health care facilities around the world, and in some places, CRE have become endemic. (cdc.gov)

Microbiological laboratories should be aware of the unusual carbapenem-resistant but third-generation cephalosporin-susceptible profiles of these IMI-producing isolates. (medscape.com)

Meropenem/Vaborbactam versus Ceftazidime/Avibactam for Treatment of Carbapenem-resistant Enterobacteriaceae Infections, R. Ackley et al. (globenewswire.com)

Carbapenem-resistant Enterobacteriaceae (CRE) have spread globally and represent a serious and growing threat to public health. (nih.gov)
Antimicrobial resistant microorganisms are found in people, animals and the environment and can spread globally. (who.int)

Carbapenem-resistant enterobacteriaceae testing includes disc diffusion or automated systems, selective agar Carbapenem-resistant enterobacteriaceae testing, minimal inhibitory concentration (MIC) for Carbapenem-resistant enterobacteriaceae testing, synergy Carbapenem-resistant enterobacteriaceae testing, modified Hodge tests, whole genome sequencing, spectrometrics and various other molecular methods. (clickpress.com)

Sequence analysis demonstrates the presence of this gene in other bla(KPC) Tn4401-containing plasmids and suggests that this signature MS peak may be useful in tracking other plasmids conferring carbapenem resistance. (nih.gov)

NDM-producing Enterobacteriaceae was first reported in a Swedish patient of Indian origin who travelled to New Delhi, India, in 2008. (gov.hk)
An important example is New Delhi Metallo-β-lactamase 1 (NDM-1)-carrying enterobacteriaceae, which attracted attention in Europe in 2010 as imported cases associated with health care contact in India and Bangladesh. (who.int)

Almost all carbapenem-resistant isolates were sporadic cases of hyperproduction of a beta-lactamase (AmpC or ESBL) combined with porin loss. (unboundmedicine.com)

According to The Centers for Disease Control and Prevention (CDC), by 2013 Carbapenem-resistant enterobacteriaceae was found in almost 42 states. (clickpress.com)
1995). At present, IMP-producing Enterobacteriaceae were found in Japan and Taiwan, China with the highest rate of recurrence (Nordmann et al. (biopaqc.com)

Carbapenem-resistant Enterobacteriaceae (CRE) have spread rapidly all over the world before couple of years, posing great challenges to individual health. (biopaqc.com)

Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
The Centers for Disease Control and Prevention (CDC) has expanded its guidelines for preventing the spread of carbapenem-resistant Enterobacteriaceae (CRE). (medscape.com)

Enterobacteriaceae are common commensals and infectious agents. (wikipedia.org)

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