• pontine
  • In the cat and rat , carbachol is well known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. (wikipedia.org)
  • response
  • The resultant response in respiratory impedence was investigated in nine normal volunteers, and compared with the response to increasing doses of inhaled carbachol. (ersjournals.com)
  • The percentage changes in R0 following pneumatic trouser inflation highly correlated those induced by inhalation of 125 micrograms carbachol (r = 0.98) Our data demonstrate that, even in normal subjects, pneumatic trouser inflation causes an increase in respiratory resistance, which can be predicted by the response to a low dose of carbachol. (ersjournals.com)
  • evoked action
  • Our results show that carbachol produced a significant decrease in the spontaneous and evoked action potential (AP) firing frequency of RA projection neurons, accompanying a hyperpolarization of the membrane potential, an increase in the evoked AP latency, afterhyperpolarization (AHP) peak amplitude, and AHP time to peak, and a decrease in the membrane input resistance, membrane time constant, and membrane capacitance. (hindawi.com)
  • guinea
  • Are the pA2 values of selective β‐adrenoceptor antagonists valid when obtained on guinea‐pig tracheal preparations contracted with carbachol? (edu.au)
  • O'DONNELL S.R. and WANSTALL J.C. (1980) Are the pA2 values of selective β‐adrenoceptor antagonists valid when obtained on guinea‐pig tracheal preparations contracted with carbachol? (edu.au)
  • topical
  • Carbachol is not easily metabolized by cholinesterase , it has a 2 to 5 minute onset of action and its duration of action is 4 to 8 hours with topical administration and 24 hours for intraocular administration. (wikipedia.org)
  • Since carbachol is poorly absorbed through topical administration, benzalkonium chloride is mixed in to promote absorption. (wikipedia.org)
  • activity
  • These inhibitors had no direct effect on MLCK activity.Thus unlike previously reported for isolated muscle cells where CaMKII and ERK1/2 are notinvolved in contraction, we conclude that the regulation of carbachol-induced contractionin innervated longitudinal muscle strips involves the interplay of Rho kinase, ERK1/2,CaMKK/AMPK, and CAMKII. (nih.gov)
  • Carbachol increases ICC activity through ANO1 activation. (wikipedia.org)
  • significant
  • 0.05 significant inhibition of CCh-induced contraction.The inset illustrates an original tracing showing abolition of carbachol-inducedcontraction by 1 µM 4-DAMP but not by 1 µM tetrodotoxin (TTX) or 1 µM methoctramine. (nih.gov)
  • study
  • Difference between basal release and carbachol-induced secretion achieved statistical significance as to all the proteins/peptides under study but for statherin. (unica.it)