MiostatStimulation with carbacholLowers intraocular pressureCARBASTATAgonistsOphthalmicCataract surgeryContractionIntraocularBrimonidineChlorideParasympathomimeticInjectionVitroGlaucomaHistamineCalciumMuscarinic receptorsInhibitionRatsPotassiumEffectsNeuronsPupilResponsesAdditionHoursResponseGroupSECTIONTreatActivationApplication
Miostat3
- Carbachol, also known as carbamylcholine and sold under the brand name Miostat among others, is a cholinomimetic drug that binds and activates acetylcholine receptors. (wikipedia.org)
- carbachol (Miostat) or pilocarpine (Isopto Carpine, Salagen). (nih.gov)
- and eye drops such as acetylcholine chloride (Miochol E) and carbachol (Miostat, Isopto Carbachol). (medlineplus.gov)
Stimulation with carbachol1
- Concurrent stimulation with carbachol and morphine promoted MOP receptor internalization, desensitization and down-regulation and this facilitation was not dependent on PKC activation. (gla.ac.uk)
Lowers intraocular pressure2
CARBASTAT2
- CARBASTAT ® (Carbachol Intraocular Solution, USP) 0.01% is a sterile balanced salt solution of carbachol for intraocular injection. (nih.gov)
- In addition, Carbastat ® (Carbachol Intraocular Solution USP) reduces the intensity of intraocular pressure elevation in the first 24 hours after cataract surgery. (nih.gov)
Agonists3
- Use of carbachol, as well as all other muscarinic receptor agonists, is contraindicated in patients with asthma, coronary insufficiency, gastroduodenal ulcers, and incontinence. (wikipedia.org)
- Because there is a direct relationship between phosphatidylinositol (PI) metabolism and airway smooth muscle contraction induced by muscarinic agonists, the authors examined the effects of carbachol (CCh), norepinephrine (NE), and hypocapnia on PI turnover in the airway smooth muscle. (silverchair.com)
- IP3-mediated Ca2+ release also was observed in the presence of the metabotropic agonists t-ACPD and carbachol when backpropagating spikes were generated. (nih.gov)
Ophthalmic2
- Carbachol is primarily used in the treatment of glaucoma, but it is also used during ophthalmic surgery. (wikipedia.org)
- No information is available on the use of carbachol ophthalmic drops during breastfeeding. (nih.gov)
Cataract surgery1
- Carbachol is a prescription medication used to constrict the pupil and lower eye pressure during surgery as well as reduce the pressure elevation in the eye after cataract surgery. (rxwiki.com)
Contraction1
- Response was measured as a percent of maximal carbachol contraction. (cdc.gov)
Intraocular3
- Carbachol is not easily metabolized by cholinesterase, it has a 2 to 5 minute onset of action and its duration of action is 4 to 8 hours with topical administration and 24 hours for intraocular administration. (wikipedia.org)
- Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. (nih.gov)
- Intraocular carbachol 0.01% should be used with caution in patients with acute cardiac failure, bronchial asthma, peptic ulcer, hyperthyroidism, G.I. spasm, urinary tract obstruction and Parkinson's disease. (nih.gov)
Brimonidine5
- To evaluate safety and efficacy, Dr Abdelkader compared the combination of carbachol and brimonidine with placebo in two groups of patients with emmetropic presbyopia. (medscape.com)
- In the first group, the nondominant eye of 30 patients was treated with a combination of 2.25% carbachol plus 0.2% brimonidine, and of 18 patients was treated with placebo. (medscape.com)
- In the second group, 10 patients received 3% carbachol, 0.2% brimonidine, a combination of the two, or placebo. (medscape.com)
- From these results, Dr Abdelkader determined that the optimal formula is a combination of carbachol and brimonidine. (medscape.com)
- The people who received the carbachol and brimonidine combination said they liked it and would use it as a therapy if it were available. (medscape.com)
Chloride3
- Since carbachol is poorly absorbed through topical administration, benzalkonium chloride is mixed in to promote absorption. (wikipedia.org)
- A recent review indicates that carbachol is a strong promoter of ICC activity, which is mediated through the calcium-activated chloride channel, anoctamin 1. (wikipedia.org)
- Results The cumulative chloride secretory response of ΔI sc,carbachol , ΔI sc,cAMP/forskolin and ΔI sc,histamine was the best diagnostic ICM parameter (cut-off 34 μA/cm 2 between patients with known PS-CF and controls), differentiating patients with questionable CF into PS-CF (n=6) and 'CF unlikely' (n=55) groups. (bmj.com)
Parasympathomimetic1
- Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. (wikipedia.org)
Injection2
- Carbachol is also available as an injection and is given into the eye during the eye procedure. (rxwiki.com)
- Notably, retinas from rats treated with a single subcutaneous injection of 100 mg/kg fenthion showed decreases in carbachol-stimulated release of inositol phosphate, an indicator of cholinergically-mediated intracellular second messenger systems. (epa.gov)
Vitro1
- The cholinergic agonist carbachol, after 24 h in vitro, increased the length of the axon, without affecting the length of minor neurites. (nih.gov)
Glaucoma2
- Carbachol eyedrops are used to decrease the pressure in the eye for people with glaucoma. (wikipedia.org)
- Carbachol is also used to treat glaucoma. (rxwiki.com)
Histamine1
Calcium1
- Bronchospasms occur in instances of high levels of carbachol or potassium, which are able to cause tracheal tissue contractions by simultaneously opening L-type calcium channels and stimulating muscarinic receptors. (discovermagazine.com)
Muscarinic receptors1
- The effect of carbachol was mediated by the M(1) subtype of muscarinic receptors. (nih.gov)
Inhibition1
- C7/3-phth also produced supra-additive inhibition of the negative inotropic effects of carbachol when combined with NMS. (aspetjournals.org)
Rats1
- 8. Carbachol alleviates myocardial injury in septic rats through PI3K/AKT signaling pathway. (nih.gov)
Potassium3
- Moreover, cardamom extracts were observed to relax carbachol- and potassium-induced contractions in tracheal tissues [2], effectively relieving bronchospasms in asthma attacks. (discovermagazine.com)
- carbachol and potassium interaction with these signaling pathways leads to airway constrictions. (discovermagazine.com)
- In the study, cardamom showed inhibitory effects against carbachol and potassium, enabling relaxation of the contracted tissues. (discovermagazine.com)
Effects4
- Side effects such as flushing, sweating, epigastric distress, abdominal cramps, tightness in urinary bladder, and headache have been reported with topical or systemic application of carbachol. (nih.gov)
- Serious side effects have been reported with carbachol. (rxwiki.com)
- This is not a complete list of carbachol side effects. (rxwiki.com)
- Effects of in vivo ischemia on contractile responses of rabbit bladder to field stimulation, carbachol, ATP and KCl. (upstate.edu)
Neurons2
- The main differences between waves in neocortical neurons and in previously described hippocampal pyramidal neurons were, (a) Ca2+ waves in L5 neurons could be evoked further out along the main shaft, (b) Ca2+ waves extended slightly further out into the oblique dendrites and (c) higher concentrations of bath-applied t-ACPD and carbachol were required to generate Ca2+ release events by backpropagating action potentials. (nih.gov)
- Carbachol-induced axonal growth was also observed in pyramidal neurons from the neocortex but not in granule neurons from the cerebellum. (nih.gov)
Pupil1
- Carbachol constricts the pupil during medical procedures. (rxwiki.com)
Responses1
- During either generalized forebrain activation or selective thalamic activation caused by carbachol infusion in the VPM, the responses to AWs enhance so that VPM receptive fields become much larger. (nih.gov)
Addition1
- In addition, down-regulation of ERK1/2 with small interfering RNA abolished the neuritogenic effect of carbachol. (nih.gov)
Hours1
- Patients who received carbachol monotherapy experienced a drop to a little above 5 in the first hour, which rose to just above 7 at 8 hours. (medscape.com)
Response1
- IL instilled mebeverine (1 × 10 -6 M) inhibited the carbachol dose response of the ileal and colonic segments more than an equivalent dose of mebeverine infused IA. (annals.edu.sg)
Group2
- A "mild burning sensation" was reported by some subjects in each of the groups, including the placebo group, but most frequently in the carbachol monotherapy group. (medscape.com)
- Carbachol belongs to a group of medications called cholinergics. (rxwiki.com)
SECTION1
- See "Carbachol Precautions" section. (rxwiki.com)
Treat1
- Carbachol can also be used to stimulate bladder emptying to treat the condition of underactive bladder. (wikipedia.org)
Activation1
- Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs). (wikipedia.org)
Application1
- Inward cationic current was activated by the application of 50 pM carbachol (I(CCh)) at a holding potential of -60 mV with the same CsCl-rich solution in both pipette and bath. (ewha.ac.kr)