• genomic
  • The capsid encapsulates the two genomic RNAs. (uniprot.org)
  • Based on the Baltimore classification system, Entebbe Bat Virus is a (+)ssRNA genomic virus that doesn't need a DNA intermediate to create viral proteins (Flint). (wikipedia.org)
  • The basic MCP1 protein forms a core around which the genomic dsDNA is wrapped, whereas MCP2 interacts with the genome with its basic N-terminal region and the hydrophilic C-terminal domain is embedded into the lipid envelope Genomes are linear, up to 40 kb in length. (wikipedia.org)
  • virion
  • Atomic structure of the major capsid protein of rotavirus: implications for the architecture of the virion. (ebi.ac.uk)
  • Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. (uniprot.org)
  • The virion is made up of 180 copies of a single viral capsid protein. (wikipedia.org)
  • After binding to molecules on the cell surface, the virion is endocytosed and enters the endoplasmic reticulum - a behavior unique among known non-enveloped viruses - where the viral capsid structure is likely to be disrupted by action of host cell disulfide isomerase enzymes. (wikipedia.org)
  • It has been frequently reported that an intact, albeit distorted, virion particle is released from the endoplasmic reticulum into the cell cytoplasm, where the genome is released from the capsid, possibly due to the low calcium concentration in the cytoplasm. (wikipedia.org)
  • L2 minor capsid proteins enter the nucleus twice during infection: in the initial phase after virion disassembly, and in the productive phase when it assembles into replicated virions along with L1 major capsid proteins. (wikipedia.org)
  • packaging the viral
  • for example, in JC virus both VP2 and VP3 seem to be essential for packaging the viral chromosome into the capsid, while absence of these proteins in SV40 prevents successful entry into new host cells, with variable effects on packaging reported. (wikipedia.org)
  • Sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • Following assembly, some viral shells pass through a sequence of coordinated maturation steps that progressively strengthen the capsid. (asknature.org)
  • The C-terminus also contains a basic nuclear localization sequence, while the N-terminus - which is oriented toward the center of the assembled capsid - contains basic residues that facilitate non-sequence-specific interactions with DNA. (wikipedia.org)
  • the proteins contain a leucine zipper sequence of amino acids which allow them to adhere to each other. (wikipedia.org)
  • The result of this genetic encoding is three proteins that share a common N-terminal sequence, forming a protein domain called the J domain which has sequence homology to DnaJ molecular chaperone proteins. (wikipedia.org)
  • binds
  • p>This subsection of the 'Function' section indicates at which position the protein binds a given metal ion. (uniprot.org)
  • MPyV capsid protein VP1 binds to sialic acids of gangliosides GD1a and GT1b on the cell surface. (wikipedia.org)
  • For example, MTag binds and activates Src-family protein tyrosine kinases in a PP2A-dependent manner, and in turn is phosphorylated by Src on tyrosine residues in the MTag C-terminus. (wikipedia.org)
  • Gene
  • The protein is commonly referred to as the HSV-1 UL-6 protein because it is the transcription product of Herpes gene UL-6. (wikipedia.org)
  • A somewhat more common tumor antigen variant, an overprinted gene encoding a protein called ALTO, may be evolutionarily related to MTag. (wikipedia.org)
  • MTag plays a role in viral DNA replication and in the transition from early to late gene expression, and its absence can cause defects in viral capsid assembly. (wikipedia.org)
  • outer
  • This protein is responsible for binding the capsid (outer coat) of the SARS (severe acute respiratory syndrome) coronavirus to the virus's RNA (ribonucleic acid), which holds its genetic code. (sciencephoto.com)
  • Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. (uniprot.org)
  • replication
  • The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. (uniprot.org)
  • The viral protein gp2 plays an essential role in viral DNA replication. (wikipedia.org)
  • These proteins serve to manipulate the host's cell cycle - dysregulating the transition from G1 phase to S phase, when the host cell's genome is replicated - because host cell DNA replication machinery is needed for viral genome replication. (wikipedia.org)
  • In Canine minute virus NP1 has been shown to be essential for an early step in viral replication and is also required for the read through of an internal polyadenylation site that is essential for expression of the capsid proteins. (wikipedia.org)
  • A late protein is a viral protein that is formed after replication of the virus. (wikipedia.org)
  • VP0, which is further cleaved into VP2 and VP4, VP1 and VP3, proteins of the viral capsid After translation, transcription and genome replication which involve a single process (synthesis of (+) RNA) is realized. (wikipedia.org)
  • The primer for both (+) and (−) strand synthesis is the small protein VPg, which is uridylylated at the hydroxyl group of a tyrosine residue by the poliovirus RNA polymerase at a cis-acting replication element located in a stem-loop in the virus genome. (wikipedia.org)
  • similarity
  • Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma (By similarity). (uniprot.org)
  • After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (By similarity). (uniprot.org)
  • Heterohexamer of three sigma-3 and three Mu-1 proteins (By similarity). (rcsb.org)
  • trimers
  • In flavivirus virions, the fusion peptide is buried in dimmers of the fusion glycoprotein E. At low pH, the dimmers are disrupted, the proteins rotate to form trimers, and the fusion peptide is directed toward the cell membrane The viral envelope protein E attaches to host receptors, which mediates receptor-mediated endocytosis. (wikipedia.org)
  • capsomeres
  • The unique, single protein, trumpet-shaped capsomeres of Gyrovirus are arranged into 12 pentomers yielding a capsid 60 units in size. (wikipedia.org)
  • The number and arrangement of capsomeres in an icosahedral capsid can be classified using the "quasi-equivalence principle" proposed by Donald Caspar and Aaron Klug. (wikipedia.org)
  • amino acid
  • The weak forces at work include attraction or repulsion between electrostatic charges, water solubility, and constituent amino acid structures in various parts of the capsid. (asknature.org)
  • These proteins share 38.8%, 40.3%, and 32.2% amino acid identities between their homologs in the CAV. (wikipedia.org)
  • Interacts
  • Once phosphorylated, MTag interacts with and activates downstream signaling pathways through Shc, 14-3-3 proteins, phosphoinositide 3-kinase, and phospholipase Cγ1. (wikipedia.org)
  • bind
  • The minor components are VP2 and VP3, which bind in the interior of the capsid. (wikipedia.org)
  • Entebbe Bat Virus is an enveloped virus, which means that it has to bind its envelope proteins to a cell surface protein on the cell that it's going to infect. (wikipedia.org)
  • L1 capsid proteins can bind via its nuclear localisation signal (NLS) to karyopherins Kapbeta(2) and Kapbeta(3) and inhibit the Kapbeta(2) and Kapbeta(3) nuclear import pathways during the productive phase of the viral life cycle. (wikipedia.org)
  • Each coat protein on the interior of the helix bind three nucleotides of the RNA genome. (wikipedia.org)
  • pentamer
  • VP2 and VP3 assemble inside the capsid in contact with VP1, with a stoichiometry of one VP2 or VP3 molecule to each pentamer. (wikipedia.org)
  • Refinements to the electron microscopy in 2007 allowed finding that the portal is a twelve (12)-unit polymer present at one of the twelve capsid vertices instead of the UL-19 pentamer found at non-portal vertices. (wikipedia.org)
  • each pentamer of VP1 is associated with one molecule of one of the other two capsid proteins, VP2 or VP3. (wikipedia.org)
  • Chromosome
  • All three capsid proteins are expressed from alternative start sites on a single transcript of the "late region" of the circular viral chromosome (so named because it is transcribed late in the process of viral infection). (wikipedia.org)
  • interaction
  • In order to better understand the context of the capsid/restriction factor interaction, cell biology studies using live-cell microscopy were initiated. (bl.uk)
  • Like STag, MTag has no enzymatic activity of its own, but has a number of protein-protein interaction sites that mediate interactions with proteins in the host cell. (wikipedia.org)
  • however, MTag preferentially performs other protein-protein interactions that compete with the Hsc70 interaction. (wikipedia.org)