• domain 3 (residues 175-191) is highly hydrophobic and acts as a signal sequence for E1 envelope protein. (wikipedia.org)
  • Crystal structure of the N-terminal domain of the effector protein SidI of Legionella pneumophila reveals a glucosyl transferase domain. (resist-cluster.de)
  • citation needed] The proteins of this virus are arranged along the genome in the following order: N terminal-core-envelope (E1)-E2-p7-nonstructural protein 2 (NS2)-NS3-NS4A-NS4B-NS5A-NS5B-C terminal. (wikipedia.org)
  • NS1 (p7) protein is dispensable for viral genome replication but plays a critical role in virus morphogenesis. (wikipedia.org)
  • The genome terminal regions were maintained in a form able to sustain viral replication, while the internal region was clipped to include only the left-side genetic set, containing the coding sequence for the functional NS1 protein. (bvsalud.org)
  • This is why on publicly available databases, such as the European Bioinformatics Institute, the viral proteome only consists of 2 proteins. (wikipedia.org)
  • citation needed] At the 5′ and 3′ ends of the RNA are the untranslated regions (UTR), that are not translated into proteins but are important to translation and replication of the viral RNA. (wikipedia.org)
  • The large pre-protein is later cleaved by cellular and viral proteases into the 10 smaller proteins that allow viral replication within the host cell, or assemble into the mature viral particles. (wikipedia.org)
  • The mature nonstructural proteins (NS2 to NS5B) generation relies on the activity of viral proteinases. (wikipedia.org)
  • Further, the B19V minigenome was able to complement B19-derived, NS1-defective genomes, restoring their ability to express viral capsid proteins. (bvsalud.org)
  • In addition, we found that a smaller proportion of cells supported miR-122-independent replication compared a population of cells supporting miR-122-dependent replication, while viral protein levels per positive cell were similar. (bvsalud.org)
  • Epidemiological studies in humans and experimental studies in animal have shown that viral infections can induce or protect from autoimmunopathologies depending on several factors including genetic background, host-elicited immune responses, type of virus strain, viral load, and the onset time of infection. (mdpi.com)
  • Following transfection in UT7/EpoS1 cells, this minigenome still proved competent for replication, transcription and production of NS1 protein. (bvsalud.org)
  • This single open reading frame is translated to produce a single protein product, which is then further processed to produce smaller active proteins. (wikipedia.org)
  • In conclusion, we presented SUMO fusion for the enhanced expression in E. coli and purification of active recombinant 3ABC protein using non-denaturing conditions without refolding steps. (bvsalud.org)
  • HVR1 helps E2 shield the virus from the immune system. (wikipedia.org)
  • It prevents CD81 from latching onto its respective receptor on the virus. (wikipedia.org)
  • The detection of antibody to non-structural protein (NSP) of Foot-and-mouth disease virus (FMDV) is the reliable diagnostic method for differentiating infected from vaccinated animals (DIVA). (bvsalud.org)
  • For this purpose, the detection of antibodies to non-structural 3ABC protein is suitable for identification of virus activity in the animals exposed to FMDV infection. (bvsalud.org)