Hydroxyprogesterone Caproate Injection, USP is a sterile, long-acting preparation of the caproate ester of the naturally-occurring progestational hormone, hydroxyprogesterone, in an oil solution for intramuscular use. (nih.gov)
In advanced adenocarcinoma of the uterine corpus, Hydroxyprogesterone Caproate Injection in a dosage of 1,000 mg or more, one or more times each week, often induces regressive changes. (nih.gov)
Hydroxyprogesterone caproate injection is used to prevent premature labor in pregnant women in order to reduce the risk of giving birth too early (preterm birth). (moruflifesciences.com)
Hydroxyprogesterone caproate injection is administered only by or under the supervision of a doctor. (moruflifesciences.com)
Like other drugs, this Hydroxyprogesterone caproate injection also shows interactions with many other medications which are used to treat other health issues, and these drugs include anti-epilepsy, painkillers, antidiabetics, HIV drugs, and anti-fungal medications. (moruflifesciences.com)
There are names f certain medications that can be harmful if used with Hydroxyprogesterone caproate injection. (moruflifesciences.com)
Before applying this Hydroxyprogesterone caproate injection the doctor or professional nurse should read the label information or instructions of the doctor for use. (moruflifesciences.com)
Injection10
Side effects of gestonorone caproate include worsened glucose tolerance, decreased libido in men, and injection site reactions. (wikipedia.org)
Side effects of gestonorone caproate have been reported to include worsened glucose tolerance, decreased libido in men, and local injection site reactions such as irritation. (wikipedia.org)
It is approximately 20 to 25 times more potent than progesterone or hydroxyprogesterone caproate in animal bioassays when all are given by subcutaneous injection. (wikipedia.org)
Gestonorone caproate is administered by intramuscular injection, and acts as a long-lasting depot by this route. (wikipedia.org)
After an intramuscular injection, gestonorone caproate is completely released from the local depot and is highly bioavailable. (wikipedia.org)
A single intramuscular injection of 25 to 50 mg gestonorone caproate in oil solution has been found to have a duration of action of 8 to 13 days in terms of clinical biological effect in the uterus in women. (wikipedia.org)
At high doses, the duration of action of gestonorone caproate by intramuscular injection has been found to be at least 21 days. (wikipedia.org)
Following a single intramuscular injection of 200 mg radiolabeled gestonorone caproate in 1 mL of solution in men with prostate cancer, maximal levels of gestonorone caproate occurred after 3 ± 1 days and were 420 ± 160 ng/mL. (wikipedia.org)
Peak serum levels of hydroxyprogesterone caproate appeared after 3 to 7 days in non-pregnant female subjects following a single intramuscular injection of 1,000 mg hydroxyprogesterone caproate. (nih.gov)
Hydroxyprogesterone Caproate IP 500mg For Injection will be given to you under the skin as an Powder For Injection in a hospital or clinic by a doctor or nurse. (sterisonline.com)
Makena2
The progesterone shot (sometimes called "17P" for the drug name [17 alpha-hydroxyprogesterone caproate] or its brand name, Makena) can help prevent an early birth. (kidshealth.org)
WASHINGTON, D.C. - Covis Pharma announced late Tuesday that it plans to voluntarily withdraw Makena (hydroxyprogesterone caproate) for prevention of preterm birth from the market. (citizen.org)
Alpha-hydroxyprogesterone caproate5
OBJECTIVE: To estimate whether administration of 17 alpha-hydroxyprogesterone caproate can prevent neonatal morbidity in multiple pregnancies by reducing the preterm birth rate. (maastrichtuniversity.nl)
Women with a multiple pregnancy were randomized to weekly injections of either 250 mg 17 alpha-hydroxyprogesterone caproate or placebo, starting between 16 and 20 weeks of gestation and continuing until 36 weeks of gestation. (maastrichtuniversity.nl)
The mean gestational age at delivery was 35.4 weeks for the 17 alpha-hydroxyprogesterone caproate group and 35.7 weeks for the placebo group (P =.32). (maastrichtuniversity.nl)
CONCLUSION: 17 alpha-hydroxyprogesterone caproate does not prevent neonatal morbidity or preterm birth in multiple pregnancies. (maastrichtuniversity.nl)
Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. (medscape.com)
Allyl1
Ashapura Aromas Pvt Ltd offers wide range of flavors which includes Allyl Caproate. (ingredientsnetwork.com)
Gestonorone caproate14
Gestonorone caproate, also known as gestronol hexanoate or norhydroxyprogesterone caproate and sold under the brand names Depostat and Primostat, is a progestin medication which is used in the treatment of enlarged prostate and cancer of the endometrium. (wikipedia.org)
Gestonorone caproate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. (wikipedia.org)
Gestonorone caproate was discovered in 1960 and was introduced for medical use by 1973. (wikipedia.org)
Gestonorone caproate is used in the palliative treatment of benign prostatic hypertrophy and endometrial cancer. (wikipedia.org)
In humans, 100 or 200 mg intramuscular gestonorone caproate has been said to be equivalent to 1,000 mg intramuscular hydroxyprogesterone caproate. (wikipedia.org)
Hence, gestonorone caproate is approximately 5- to 10-fold more potent than hydroxyprogesterone caproate in humans. (wikipedia.org)
The biological effects of gestonorone caproate in women have been studied. (wikipedia.org)
Like other potent progestins, gestonorone caproate possesses potent antigonadotropic activity and is capable of markedly suppressing the gonadal production and circulating levels of sex hormones such as testosterone and estradiol. (wikipedia.org)
In accordance with its lack of glucocorticoid activity, gestonorone caproate has no anticorticotropic effects, and does not influence the secretion of adrenocorticotropic hormone. (wikipedia.org)
Of a variety of different esters, the caproate (hexanoate) ester was found to have the strongest progestogenic activity, and this formed the basis for the development of gestonorone caproate, as well as other caproate progestogen esters such as hydroxyprogesterone caproate. (wikipedia.org)
Gestonorone caproate has been found to decrease the weights of the prostate gland and seminal vesicles by 40 to 70% in adult male rats. (wikipedia.org)
Gestonorone caproate decreases the uptake of testosterone into the prostate gland. (wikipedia.org)
Gestonorone caproate has been reported to act to some extent as a 5α-reductase inhibitor, similarly to progesterone. (wikipedia.org)
Clinical studies have found gestonorone caproate to be satisfactorily effective as a progestogen when injected once a month, whereas it was poorly effective as an injectable contraceptive when it was injected once every two months. (wikipedia.org)
Preterm Delivery1
17alpha-hydroxyprogesterone caproate (17P) administration reportedly improves outcome for women with a previous spontaneous preterm delivery. (biomedcentral.com)
Vitro1
In vitro data indicate that the metabolism of hydroxyprogesterone caproate is predominantly mediated by CYP3A4 and CYP3A5. (nih.gov)
Benzyl1
Each 5 mL multiple-dose vial contains hydroxyprogesterone caproate, 250 mg/mL, in castor oil (28.6% v/v) and benzyl benzoate (46% v/v) with the preservative benzyl alcohol (2% v/v). (nih.gov)
Acetate1
User sabrinaamorgan uploaded this Appetite - Hydroxyprogesterone Caproate Medroxyprogesterone Acetate Progestin Progestogen PNG PNG image on September 28, 2023, 3:31 pm. (favpng.com)
Pharmacokinetics3
The pharmacokinetics of the 250 mg dose of hydroxyprogesterone caproate has not been evaluated in a study. (nih.gov)
The effect of hepatic impairment on the pharmacokinetics of hydroxyprogesterone caproate has not been evaluated. (nih.gov)
The effect of renal impairment on the pharmacokinetics of hydroxyprogesterone caproate has not been evaluated. (nih.gov)
Crystalline2
Hydroxyprogesterone caproate exists as white to creamy white crystalline powder. (nih.gov)
Sodium gluconate is a kind of sodium polyhydroxy carboxylic acid, which is also known as sodium hydroxy caproate, which is white or light yellow crystalline granule or powder, easily soluble in water, slightly soluble in alcohol, and insoluble in eth. (mis-asia.com)
Women1
Hydroxyprogesterone caproate is contraindicated in women with a history of hypersensitivity to a progestin. (nih.gov)
Include1
Her research interests include 17-hydroxyprogesterone caproate supplementation for preeclampsia management. (umc.edu)
Reduce1
Hydroxyprogesterone caproate is extensively metabolized and hepatic impairment may reduce the elimination of hydroxyprogesterone caproate. (nih.gov)
Trial1
Study Design We performed a secondary analysis of a randomized controlled trial evaluating 17-α-hydroxyprogesterone caproate in twins. (thieme-connect.com)
Patients1
Hydroxyprogesterone caproate is also contraindicated as a diagnostic test for pregnancy and in patients with current or history of thrombotic or thromboembolic disorders. (nih.gov)