• neuronal
  • The cannabinoid CB1 receptor is expressed in different neuronal subpopulations, and is engaged in fine-tuning excitatory and inhibitory neurotransmission. (jneurosci.org)
  • These data reveal that CB1 receptor in dorsal telencephalic glutamatergic neurons plays a sufficient role to control neuronal functions that are in large part hippocampus-dependent, while it is insufficient for proper amygdala functions, suggesting an unexpectedly complex circuit regulation by endocannabinoid signaling in the amygdala. (jneurosci.org)
  • The underlying cellular mechanisms have been intensively investigated, but the causal relationships between CB1 receptor signaling and neuronal circuit functions have been only partially addressed. (jneurosci.org)
  • However, the anatomical organization of the neuronal substrates that express 2-AG/CB1 signaling system-related molecules associated with selective Ca(2+)-binding proteins (CaBPs) is still unknown. (sigmaaldrich.com)
  • The identification of anatomically related-neuronal substrates that expressed 2-AG/CB1 signaling system and selective CaBPs should be considered when analyzing the cannabinoid signaling associated with hippocampal functions. (sigmaaldrich.com)
  • In a search for best neurological drugs that protect neuronal cells and stimulate neurogenesis with no side effects, cannabinoids proved to be a strong group of substances having many beneficial properties. (deepdyve.com)
  • novel
  • A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. (rsc.org)
  • Hence, we investigated the role of cannabinoid receptors, CB1 and CB2, as novel therapeutic targets against NSCLC. (aacrjournals.org)
  • These results suggest that CB1 and CB2 could be used as novel therapeutic targets against NSCLC. (aacrjournals.org)
  • Recently, CB1 and CB2 have been shown to be overexpressed on tumor cells compared with normal cells in various types of cancers, such as breast ( 11 ) and liver cancers ( 12 ), and therefore could be used as novel targets for cancer. (aacrjournals.org)
  • neurons
  • Studies using conditional knock-out mice revealed necessary roles of CB1 receptor expressed in dorsal telencephalic glutamatergic neurons in synaptic plasticity and behavior, but whether this expression is also sufficient for brain functions is still to be determined. (jneurosci.org)
  • We applied a genetic strategy to reconstitute full wild-type CB1 receptor functions exclusively in dorsal telencephalic glutamatergic neurons and investigated endocannabinoid-dependent synaptic processes and behavior. (jneurosci.org)
  • These features coincided with a rescued hippocampal depolarization-induced suppression of excitation (DSE), a CB1 receptor-dependent form of synaptic plasticity at glutamatergic neurons. (jneurosci.org)
  • By comparison, the rescue of the CB1 receptor on dorsal telencephalic glutamatergic neurons prolonged the time course of DSE in the amygdala, and impaired fear extinction in auditory fear conditioning. (jneurosci.org)
  • The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized collectively comprise the endocannabinoid system. (wikipedia.org)
  • Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1-OX1 receptor heterodimer. (wikipedia.org)
  • CB1 has also been noted to form a functional human receptor heterodimer in orexin neurons with OX1, the CB1-OX1 receptor, which mediates feeding behavior and certain physical processes such as cannabinoid-induced pressor responses which are known to occur through signaling in the rostral ventrolateral medulla. (wikipedia.org)
  • anandamide
  • An example of this is the lipid signaling system involving transient receptor potential channels (TRP), which interact with N-acyl amides such as N-arachidonoyl ethanolamide (Anandamide), N-arachidonoyl dopamine and others in an opportunistic fashion. (wikipedia.org)
  • In the 1990s, the relation between anandamide and PEA was described, and the expression of receptors sensitive for those two molecules on mast cells was first demonstrated by the group of Nobel prize winner Rita Levi-Montalcini. (wikipedia.org)
  • behavior
  • Although CB1 receptor blockade is generally ineffective in reducing the self-administration of cocaine in rodents and primates, it reduces the reinstatement of extinguished cocaine-seeking behavior produced by cocaine-associated conditioned stimuli and cocaine priming injections. (cannabis-marijuana.com)
  • Similarly, CB1 receptor blockade is effective in reducing nicotine-seeking behavior induced by re-exposure to nicotine-associated stimuli. (cannabis-marijuana.com)
  • Density of expression varies based on species and correlates with the efficacy that cannabinoids will have in modulating specific aspects of behavior related to the site of expression. (wikipedia.org)
  • highly selective
  • The aim of this study was to evaluate the impact of ACEA (arachidonyl-2′-chloroethylamide-a highly selective cannabinoid CB1 receptor agonist) combined with a classical antiepileptic drug sodium valproate (VPA) on neural precursor cells׳ proliferation and differentiation in the mouse brain. (deepdyve.com)
  • It is highly selective for the CB1 receptor over CB2, with a Kd at CB1 of 1.5nM vs over 7000nM at CB2, has good blood-brain barrier penetration, and can be conveniently radiolabelled with either 11C or 18F, making it useful for mapping the distribution of CB1 receptors in the brain. (wikipedia.org)
  • FAAH
  • For this purpose, we used double-label immunofluorescence and confocal laser scanning microscopy for the characterization of the expression of the 2-AG/CB1 signaling system (CB1 receptor, DAGLα, MAGL, and FAAH) and the CaBPs calbindin D28k, calretinin, and parvalbumin in the rat hippocampus. (sigmaaldrich.com)
  • By using FAAH mutant mice and both intraperitoneal and intracerebroventricular administration of the FAAH inhibitor (3′-(aminocarbonyl)[1,1′-biphenyl]-3-yl)-cyclohexylcarbamate (URB597), we found that enhanced AEA signaling reversed, via central cannabinoid CB1 receptors (CB1Rs), the anxious phenotype of mice exposed to social defeat stress. (aspetjournals.org)
  • We also provided some physiological indications that striatal CB1Rs regulating GABA synapses are not the receptor targets of FAAH inhibition, which rather resulted in the stimulation of striatal CB1Rs regulating glutamate transmission. (aspetjournals.org)
  • Collectively, our findings suggest that preservation of cannabinoid CB1 receptor function within the striatum is a possible synaptic correlate of the antianxiety effects of FAAH inhibition. (aspetjournals.org)
  • These findings selectively implicate striatal CB1Rs (GABA) in emotional control and suggest that FAAH inhibition exerts antianxiety and antidepressant effects by activating these receptors. (aspetjournals.org)
  • molecules
  • 2) The interaction of the molecules with the hCB1 and hCB2 receptors seems to be highly complex and mainly orbital controlled. (hindawi.com)
  • Cannabinoids include the active constituents of Cannabis or are molecules that mimic the structure and/or function of these Cannabis -derived molecules. (frontiersin.org)
  • Involvement
  • Durnett-Richardson J, Aanonsen L, Groves N, Jackson D, Hargreaves K (1995) Involvement of the spinal cannabinoid receptor in nociception. (springer.com)
  • The data also show that noladin ether-induced enhancement of outflow facility is mediated through the trabecular meshwork CB1 receptor, with an involvement of p42/44 MAP kinase signaling pathway and changes in actin cytoskeletons. (arvojournals.org)
  • hippocampal
  • CB1, DAGLα, and MAGL labeling was mainly localized in fibers and neuropil, which were differentially organized depending on the hippocampal CaBPs-expressing cells. (sigmaaldrich.com)
  • therapeutic
  • Cannabinoids are well known for their psychotropic properties, as well as for their therapeutic potential. (arvojournals.org)
  • Obtaining a comprehensive understanding of the diverse mechanisms of cannabinoid action may lead to the design and development of therapeutic agents with greater efficacy and specificity for their cellular targets. (frontiersin.org)
  • affinities
  • 1) We obtained statistically significant equations relating the variation of hCB1 and hCB2 receptor binding affinities with the variation of definite sets of local atomic reactivity indices. (hindawi.com)
  • phenotype
  • Using this approach, we partly restored the phenotype of global CB1 receptor deletion in anxiety-like behaviors and fully restored hippocampus-dependent neuroprotection from chemically induced epileptiform seizures. (jneurosci.org)
  • peripheral
  • 1 2 CB1 receptors are located in the central nervous system (CNS) as well as in the periphery, whereas CB2 receptors are mainly located in the peripheral tissues, such as immune cells. (arvojournals.org)
  • Enzo Life Sciences Win 55,212-2 Data Sheet The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. (wikipedia.org)
  • derivative
  • WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. (wikipedia.org)
  • O-1238 is a drug which is a cannabinoid derivative that is used in scientific research. (wikipedia.org)
  • psychoactive
  • Marijuana consists of a mixture of leaves, stems, and flowering tops of Cannabis plants selectively bred to produce high levels of Δ 9 -tetrahydrocannabinol (THC or (−)-trans-Δ 9 -THC) and several other psychoactive cannabinoids. (hindawi.com)
  • inhibition
  • The G-protein-coupled central cannabinoid receptor (CB1) has been shown to be functionally associated with several biological responses including inhibition of adenylate cyclase, modulation of ion channels and induction of the immediate-early gene Krox-24. (biochemj.org)
  • molecular
  • Comparison of Cannabinoid CB 1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [ 18 F]MK-9470," International Journal of Molecular Imaging , vol. 2011, Article ID 548123, 11 pages, 2011. (hindawi.com)
  • mechanism
  • This coupling of CB1 subtype and mitogenic signal pathway, also observed in the human astrocytoma cell line U373 MG, may explain the mechanism of action underlying cannabinoid-induced Krox-24 induction. (biochemj.org)
  • cerebellum
  • For example, in rodents, the highest concentration of cannabinoid binding sites are in the basal ganglia and cerebellum, regions of the brain involved in the initiation and coordination of movement. (wikipedia.org)
  • pathway
  • One explanation for this association comes from experiments with transfected astrocytoma cells, where a high CB receptor expression recruits the Akt signalling survival pathway. (diva-portal.org)
  • In the present study, we have investigated the association between CB1 receptor expression and the Akt pathway in a well-characterised prostate cancer tissue microarray. (diva-portal.org)
  • The present study provides data that is consistent with the hypothesis that at a high CB1 receptor expression, the Akt signalling pathway becomes operative. (diva-portal.org)
  • TRPV1
  • Binding has been demonstrated by 2-arachidonoylglycerol (2-AG) on the TRPV1 receptor suggesting that this receptor may be a candidate for the established response. (wikipedia.org)