• feces
  • Panleukopenia is primarily spread through contact with an infected animal's bodily fluids, feces, or other fomites, as well as by fleas. (wikipedia.org)
  • Usually, feces from diarrheic dogs are screened using ELISA or hemagglutination (HA) assays, but these techniques have very low sensitivity. (zoologix.com)
  • Positive detection of parvovirus in the feces, using in-clinic fecal swab tests (Enzyme-Linked-Immunosorbant-Assay, or ELISA) is accurate and diagnostic. (borzoiclubofamerica.org)
  • single-stranded
  • Inside the capsid is a linear single-stranded DNA genome in the size range 4-6 kb so the small genome of parvovirus can encode only a few proteins. (wikipedia.org)
  • Parvovirus particles (virions) have a durable non-enveloped protein capsid ~20-30 nm in diameter that contains a single copy of the linear single-stranded ~ 5kb DNA genome, which terminates in small imperfect palindromes that fold into dynamic hairpin telomeres. (wikipedia.org)
  • veterinarian
  • The Chicago Veterinary Medical Association urges any new dog or cat owner to visit the veterinarian as soon as possible and start a comprehensive health care plan. (chicagovma.org)
  • Because some problems can be life threatening, vaccination of cats should be done only by a veterinarian or under the supervision of a veterinarian. (maxshouse.com)
  • Because these factors may change over time, many professional organizations recommend routine annual examinations, where a vaccination plan for each individual feline can be decided during a discussion between the veterinarian and cat owner. (wikipedia.org)
  • encode
  • All parvoviruses encode two major gene complexes: the non-structural (or rep) gene that encodes the replication initiator protein (called NS1 or Rep), and the VP (or cap) gene, which encodes a nested set of ~2-6 size variants derived from the C-terminus of the single VP protein sequence. (wikipedia.org)
  • hepatitis
  • Cossart and her group were focused on hepatitis B and were processing blood samples when they discovered a number of "false positives" later identified as parvovirus B19. (wikipedia.org)
  • fatal
  • When asked to explain their decisions to the media and community members, spokespeople for many of these shelters use words like "forced," "had no choice," "fatal," and "deadly," creating the impression that the disease is not treatable and all affected dogs, perhaps even all exposed ones, will inevitably succumb. (maddiesfund.org)
  • However, a full blown case of parvovirus untreated can easily be fatal. (zoologix.com)
  • This genus includes canine parvovirus, which causes gastrointestinal tract damage in puppies that is about 80% fatal. (wikipedia.org)
  • necrosis
  • Parvovirus, however, is more serious and the presence of bloody diarrhea, a low white blood cell count, and necrosis of the intestinal lining also point more towards parvovirus, especially in an unvaccinated dog. (wikipedia.org)
  • kidney
  • Morphological studies of CPV-infected Norden laboratory feline kidney (NLFK) cells and canine fibroma cells (A72) displayed characteristic apoptotic events. (pubmedcentralcanada.ca)
  • For instance, a young energetic dog that is vomiting is more likely to have eaten something it shouldn't have, while a senior cat with weight loss, increased drinking, and vomiting is more likely to have a medical problem such as kidney disease or thyroid disease. (vetstreet.com)
  • gastrointestinal
  • The gastrointestinal tract and lymphatic system can be affected at any age, leading to vomiting, diarrhea and immunosuppression but cerebellar hypoplasia is only seen in cats that were infected in the womb or at less than two weeks of age, and disease of the myocardium is seen in puppies infected between the ages of three and eight weeks. (wikipedia.org)
  • disease
  • This does not mean that all the dogs without protective titer levels were susceptible to disease. (maddiesfund.org)
  • Dogs that develop the disease show signs of the illness within 3 to 7 days. (wikipedia.org)
  • Additionally, some dogs who had been exposed to or recovered from the disease itself had developed natural immunity. (maddiesfund.org)
  • If you've got a dog and a cat, though, it's difficult to know if one can catch a disease from the other. (thenest.com)
  • Therefore, a small percentage of cats vaccinated against a particular disease will not be immunized against that disease. (maxshouse.com)
  • The incidence of the disease is highest in young dogs and tends to start some time after the pup has lost its maternal antibody. (zoologix.com)
  • If the changes had been put into place earlier, many of the dogs that developed disease, including those that died, would have likely been saved. (maddiesfund.org)
  • In 1978, a devastating new disease of nearly endemic proportions emerged and swept through the dog world. (borzoiclubofamerica.org)
  • The disease does not get better or worse with age, but the cat or dog can usually learn to somewhat compensate for it and should have a normal lifespan. (wikipedia.org)
  • tend
  • This distinction is important because the medical conditions that tend to cause regurgitation are different from those associated with Click here to learn one way your vet may manage vomiting in dogs '}">vomiting . (vetstreet.com)
  • veterinary
  • Research published in Veterinary Microbiology 2 found that at two shelters in the Midwest, between 68.6% and 84.3% of the dogs showed protective titer levels for CPV, while only between 37.3% and 41.2% showed protective levels of antibodies for CDV. (maddiesfund.org)
  • Dog owners should realize CPV is probably present in the environment nearly anywhere dogs frequent parks, dog show venues, feed stores, the veterinary clinic dog-walking area. (borzoiclubofamerica.org)
  • known
  • It is caused by a signal from the brain to the stomach that originates in a part of the brain known as the Click here to learn how vomiting signals work in your dog. '}">vomiting center . (vetstreet.com)
  • The viral capsid of a parvovirus is made up of two to four proteins, known as VP1-4 that form an icosahedral symmetry that is resistant to acids, bases, solvents and temperature up to 50 °C (122 degrees Fahrenheit). (wikipedia.org)
  • dehydration
  • Diarrhea and vomiting result in dehydration that upsets the electrolyte balance and this may affect the dog critically. (wikipedia.org)
  • Dehydration from prolonged or severe Click here to learn one way your vet may manage vomiting in dogs '}">vomiting is of immediate concern, and it may be necessary to admit your pet to the hospital for fluid replacement while a diagnosis is being pursued. (vetstreet.com)
  • protein
  • 1. A nucleic acid molecule encoding a parvovirus structural protein or fragment thereof, wherein at least about 50-100% of the nucleic acid molecule's codons are optimized for expression in a nonpermissive mammalian cell. (patentsencyclopedia.com)
  • 4. The nucleic acid molecule of claim 1, wherein the parvovirus structural protein or fragment thereof is a parvovirus B19 (B19V) structural protein or fragment thereof, and wherein the nonpermissive mammalian cell is a mammalian non-erythroid lineage cell. (patentsencyclopedia.com)
  • 43. The immunogenic composition of claim 42, further comprising a nucleic acid molecule encoding a parvovirus B19 (B19V) structural protein or fragment thereof, wherein the codons of the nucleic acid molecule are optimized for expression in a mammalian non-erythroid lineage cell. (patentsencyclopedia.com)