Cancer cells hepatic cells apoptosis of human hepatic stellate hepatic stellate cells. Medical search. Frequent questions

miR-15a/16-1 deletion has been shown to accelerate the proliferation of both human and mouse B-cells through modulation of the expression of genes controlling cell cycle progression. (wikipedia.org)
Inhibition of cell proliferation by the miR-15a/16-1 cluster occurs in both lymphoid and non-lymphoid tissue. (wikipedia.org)
This has been linked to premature cell cycle arrest, through impaired proliferation of heart muscle fibres and through repressed mitotic gene expression. (wikipedia.org)
Effects of taspine on proliferation and apoptosis by regulating caspase-3 expression and the ratio of Bax/Bcl-2 in A431 cells. (rain-tree.com)
Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI90. (rain-tree.com)
Importantly, we demonstrate that the overexpression of miR-148a significantly inhibits HCC cell proliferation and cell cycle progression. (spandidos-publications.com)
Since their discovery in 1993, miRNAs have been described in all multicellular organisms and are associated with a vast breadth of biological functions, including cellular proliferation, cellular differentiation and immunity, as well as tissue remodeling and various human diseases, including cancer ( 4 ). (spandidos-publications.com)
Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
Among cancer of LDL and inhibit SMC and EC proliferation, poten- patients, there was a delayed cancer onset for those who tially reducing the risk of arteriosclerosis. (gotomydoctor.com)
miR-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN. (geneticsmr.com)
Effect of 1,25(OHD on the proliferation of human mesangial cells and their expression of Ki67. (geneticsmr.com)
Targeting effect of microRNA on CD133 and its impact analysis on proliferation and invasion of glioma cells. (geneticsmr.com)
Paracrine effect of bone marrow mesenchymal stem cells on proliferation, apoptosis, and alpha-actin-2 expression in hepatic stellate cells. (geneticsmr.com)
et al, CD155 Cooperates with PD-1/PD-L1 to Promote Proliferation of Esophageal Squamous Cancer Cells via PI3K/Akt and MAPK Signaling Pathways. (sabbiotech.cn)
LIN28B suppresses microRNA let-7b expression to promote CD44+/LIN28B+ human pancreatic cancer stem cell proliferation and invasion. (ajcr.us)
MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A. (ajcr.us)
In the current study, we investigated the role of different extracellular matrix proteins in stellate cell proliferation, activation (alpha smooth muscle actin expression and retinoic acid uptake) and cytoglobin expression. (biomedcentral.com)
This active form of vitamin D can inhibit immune cell proliferation, promote an anti-inflammatory cytokine profile, expand regulatory T cells, enhance glucocorticoid actions, increase glutathione production, and inhibit hepatic stellate cells. (springer.com)
Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats. (springer.com)

Sangre de grado ( Croton palanostigma ) induces apoptosis in human gastrointestinal cancer cells. (rain-tree.com)
et al, The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/ Akt/mTOR, JAK2/STAT3, and MAPK Pathways. (sabbiotech.cn)

Liver fibrosis is a necessary stage for chronic liver diseases, and serious threat to human health. (oncotarget.com)
Hepatic fibrosis is a necessary stage for chronic liver diseases. (oncotarget.com)
Hepatic stellate cells (HSCs) are the primary cell type responsible for fibrosis. (oncotarget.com)
Extracellular vesicles derived from mesenchymal stem/stromal cells (MSCs) have shown therapeutic effects on liver fibrosis. (biomedcentral.com)
Human transformation growth factor- beta 1 (TGF-β1) was used to induce fibrosis at optimal concentration. (biomedcentral.com)
Cohort and case-control studies reported an inverse association between coffee consumption and the degree of liver fibrosis as well as the development of liver cancer. (mdpi.com)
Our findings reveal a critical role for Lyn kinase in modulating inflammatory signals, regulating microvascular permeability and neutrophil recruitment, and in promoting hepatic fibrosis. (nature.com)
Fibrosis is a physiological response to cellular injury in the liver and is mediated by the activation of hepatic stellate cells resulting in the replacement of hepatocytes with extracellular matrix comprised principally of collagen 1 to form a hepatic scar. (biomedcentral.com)
Although the novel hexaco-ordinated globin cytoglobin was identified in activated hepatic stellate cells more than 10 years ago, its role in stellate cell biology and liver fibrosis remains enigmatic. (biomedcentral.com)
Vitamin D deficiency has been commonly present in patients with immune-mediated liver and non-liver diseases, and it has been associated with histological severity, advanced hepatic fibrosis, and non-response to conventional glucocorticoid therapy in autoimmune hepatitis. (springer.com)

and (iv) as inhibitors of the transformation of stellate hepatocytes into myofibroblasts, the process responsible for the deposition of collagen fibres leading to cirrhosis. (springer.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Another line of research development centers on the establishment of novel chemical libraries aiming at mechanism-based or lead compound-based drug discovery for cancer/inflammation, particularly by targeting Bcl-2 family proteins and apoptosis pathways, transcription factors as well as epigenetic therapy with the aid of molecular docking and chemical synthesis. (utmb.edu)
In humans, these biologically active compounds have been shown to increase cellular defenses, up-regulate liver detoxification pathways and protect your DNA. (healthheroshop.com)
T cells must substantially increase nutrient uptake to mount a proper immune response and failure to obtain sufficient nutrients or engage the appropriate metabolic pathways can alter or prevent effector T cell differentiation and function. (elifesciences.org)
Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
Phosphatase and tensin homologue (PTEN) triggers a battery of intracellular signaling pathways, especially PI3K/Akt, playing important roles in the pathogenesis of multiple diseases, such as cancer, neurodevelopmental disorders, cardiovascular dysfunction and so on. (biomedcentral.com)

Recently, T β 4 has have been shown to promote the differentiation of progenitor cell lines to cardiomyocytes [ 8 ]. (oncotarget.com)
CCN1 also induced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells to promote their differentiation into cholangiocytes. (jci.org)
This review will discuss the metabolic adaptations necessary for T cells to meet changing biochemical needs throughout different stages of differentiation. (elifesciences.org)
All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)

As the third leading cause of cancer death, HCC accounts for 85-90% of all primary liver cancers and ranks as the fifth most prevalent malignancy worldwide ( 1 ). (spandidos-publications.com)
Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine with beneficial effects in a broad number of tumors, including the primary liver cancers hepatocarcinoma (HCC) and cholangiocarcinoma (CCA). (encyclopedia.pub)
Liver cancer is the third leading cause of cancer-associated mortality, of which hepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. (wjgnet.com)

A novel angiogenesis inhibitor impairs LoVo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation. (rain-tree.com)
There was also no translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus in apoptotic keratinocytes, indicating Tan IIA-induced apoptosis occurs mainly through the caspase pathway. (hindawi.com)
YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway. (utmb.edu)
Induction of autophagy and apoptosis by miR-148a through the sonic hedgehog signaling pathway in hepatic stellate cells. (ajcr.us)

Dysregulation of miRNAs is a common feature in human cancers, but this phenomenon has not been studied extensively in hepatocellular carcinoma (HCC). (spandidos-publications.com)
Primary liver cancer mainly refers to hepatocellular carcinoma (HCC), cholangiocarcinoma and hepatic angiosarcoma. (spandidos-publications.com)
The most frequent types of primary liver cancer in adults are hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), constituting HCC the 70-85% of cases and CCA the 30-15%, depending on the country [ 2 ] . (encyclopedia.pub)

Oxidative phosphorylation dysregulation (OXPHOS) has been demonstrated to be essential for the development of cancer. (scientificarchives.com)
Oxidative stress measured by thioredoxin reductase level as potential biomarker for prostate cancer. (ajcr.us)
Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. (frontiersin.org)
Although excess iron induces oxidative stress in the liver, it is unclear whether it directly activates the hepatic stellate cells (HSC). (westminster.ac.uk)
Excessive Iron Induces Oxidative Stress Promoting Cellular Perturbations and Insulin Secretory Dysfunction in MIN6 Beta Cells. (westminster.ac.uk)

Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer. (geneticsmr.com)
Muc1 promotes migration and lung metastasis of melanoma cells. (ajcr.us)
Lewis Y antigen modified CD47 is an independent risk factor for poor prognosis and promotes early ovarian cancer metastasis. (ajcr.us)
Bone metastasis is observed in up to 70% of breast cancer patients. (cancerindex.org)

My research interests are broadly based on the interface of synthetic organic chemistry and medicinal chemistry, and in particular on the drug discovery of bioactive molecules to probe biological systems or act as potential therapeutic agents in neuroscience, cancer/inflammation, infectious diseases, and other human conditions. (utmb.edu)
A role of Src family kinase members in causing sterile inflammation and human disease is only recently recognized. (nature.com)
Patients with severe alcoholic hepatitis may benefit over the short term from specific therapies directed toward reducing liver injury, enhancing hepatic regeneration, and suppressing inflammation. (medscape.com)

Furthermore, Tan IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single-cell gel electrophoresis assay (SCGE), and flow cytometry methods. (hindawi.com)
Flow Cytometry: HuH-7 cell and HuH-7 shHMGB1 cell stained with ARG65863 anti-HMGB1 antibody [SQab1711] at 1 µg/ml dilution. (arigobio.cn)

Activated hepatic stellate cells (HSCs) have been shown to play a function in angiogenesis and vasculogenesis. (oncotarget.com)
The activation of resident HSCs into fibroblast-like cells is a hallmark of hepatic fibrogenesis [ 3 ]. (oncotarget.com)
In this study, our data show that Tβ4 was significantly decreased in human HSC cell line LX-2 and CCl4-treated mouse liver, and Tβ4 significantly suppressed cell viability and migration of HSCs. (oncotarget.com)
HSCs undergo phenotypic changes from quiescent vitamin A storing cells, involved in maintenance of the normal basement matrix, into proliferative myofibroblast-like cells, expressing myogenic markers such as alpha smooth muscle actin (αSMA). (biomedcentral.com)
This could be considered to be part of a feedback loop as changes in ECM composition results in changes in HSC cell surface receptors, particularly integrins indicating that the ECM should not be regarded simply as an inert physical scaffold but a dynamic structure that is able to influence the phenotype of HSCs [ 2 , 8 , 9 ]. (biomedcentral.com)
HSCs express numerous cell surface receptors including both discoidin domain receptors (DDRs)-which are receptors for collagen I and many of the integrin subunits, which are a major family of cell surface receptors for extracellular molecules and play a critical role in many biological functions [ 7 , 10 ]. (biomedcentral.com)

In Cancers (Basel) on 2022 Nov 15 by Xiyang Tan, Jie Yang, et al. (sabbiotech.cn)

We also present a thorough analysis of the role of succinate in the initiation of metabolic and epigenetic changes that contribute to the development of cancer, as well as its effects on angiogenesis, cell invasion, and migration. (scientificarchives.com)
The progression of hepatocellular carcinogenesis is thought to involve the deregulation of genes that are critical to cellular processes, such as cell cycle control, cell growth, apoptosis, cell migration and spreading. (spandidos-publications.com)
Selective inhibition of EGFR downstream signaling reverses the irradiation-enhanced migration of HNSCC cells. (ajcr.us)
Functional studies revealed increased expression of ICAM-1 on induced patient-derived endothelial cells (iECs) and of β2-integrins on patient neutrophils that increase neutrophil adhesion and vascular transendothelial migration (TEM). (nature.com)

Down-regulation of calreticulin promotes apoptosis in hepatic stellate cells. (arigobio.cn)
Up-regulated CKS2 promotes tumor progression and predicts a poor prognosis in human colorectal cancer. (ajcr.us)
Up regulation of the long non-coding RNA NEAT1 promotes esophageal squamous cell carcinomacell progression and correlates with poor prognosis. (ajcr.us)

Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools. (nih.gov)

The involvement of autophagy in the development of diabetes is corroborated by affecting the physiology and role of pancreatic β cells and the homeostasis of glucose. (frontiersin.org)
Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. (nih.gov)

Tas13D inhibits growth of SMMC-7721 cell via suppression VEGF and EGF expression. (rain-tree.com)
Suppression of the biological activity of neuroglioma cells by down-regulation of miR-1. (geneticsmr.com)
Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and miR-21/β-catenin Axis with HJC0152. (utmb.edu)
Importantly, therapeutic delivery of antagomiR-182 with cationized mannan-modified extracellular vesicles effectively targets macrophages, leading to miR-182 inhibition, macrophage reprogramming, and tumor suppression in multiple breast cancer models of mice. (bvsalud.org)
Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)

An accumulation of cardiac muscle fibres sees a consequent block in the transition between the pre-mitotic/G2 phase and mitotic phase of the cell cycle, with postnatal inhibition of the miR-15 family inducing cardiac muscle fibres to enter mitosis. (wikipedia.org)
Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines. (rain-tree.com)

The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)

Mesenchymal stem and stromal cells (MSCs), defined as fibroblast-like non-hematopoietic cells, have been discovered in various organs and named after their site of origin. (biomedcentral.com)
Three-dimensional assessment of bystander effects of mesenchymal stem cells carrying a cytosine deaminase gene on glioma cells. (ajcr.us)

The miR-15a/16-1 cluster has further been found to be highly expressed in CD5+ cells, therefore hinting at an important role of miR-15/16 in normal CD5+ B-cell homeostasis. (wikipedia.org)

Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU. (geneticsmr.com)

Among these unconventional activities, an iron-dependent form of non-apoptotic cell death, termed ferroptosis, attracts great interest. (nature.com)
A number of ferroptosis inducers have been proposed as potential drugs for cancer therapy. (nature.com)
Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis. (nih.gov)

NAR can be encapsulated by chitosan nanoparticles-TPP conjugates, thereby improving NAR cellular absorption and cytotoxicity against cancer cells. (scientificarchives.com)
The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models. (duke.edu)
Hanahan and Weinberg's seminal paper 'The Hallmarks of Cancer' was revised in 2011 to include deregulating cellular energetics and evasion of immune destruction ( Hanahan and Weinberg, 2011 ). (elifesciences.org)

It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)

Beclin-1-independent autophagy mediates programmed cancer cell death through interplays with endoplasmic reticulum and/or mitochondria in colbat chloride-induced hypoxia. (ajcr.us)

The kit is suitable for high throughput screening of apoptosis inducers and inhibitors. (eurogentec.com)
Efficacy and mechanism of action of the tyrosine kinase inhibitors gefitinib, lapatinib and neratinib in the treatment of HER2-positive breast cancer: preclinical and clinical evidence. (ajcr.us)

Western blot analysis of extracts from 293 cells, treatedwith EGF or calf intestinal phosphatase (CIP), using Akt(Phospho-Ser473) Antibody #11054. (sabbiotech.cn)

Additionally, a viable therapeutic strategy may involve triggering the cell death mechanism in cancer cells by blocking mitochondrial metabolism with a natural substance. (scientificarchives.com)
Consequently, we proposed naringenin nanoparticles as a novel therapeutic target for SDH regulators in cancer. (scientificarchives.com)
Dr. Devi's research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer. (duke.edu)
Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)
Furthermore, H 2 S donors and some H 2 S hybrids have been evaluated in many experimental models of human disease and have shown promising therapeutic results. (hindawi.com)
Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
CCR5 blockage by maraviroc: a potential therapeutic option for metastatic breast cancer. (cancerindex.org)

Knock-in mice expressing a CCN1 mutant that is unable to bind α v β 5 /α v β 3 were impaired in ductular reaction, leading to massive hepatic necrosis and mortality after bile duct ligation (BDL), whereas treatment of these mice with soluble JAG1 rescued ductular reaction and reduced hepatic necrosis and mortality. (jci.org)

The TME, however, can be metabolically hostile due to insufficient vascular exchange and cancer cell metabolism that leads to hypoxia, depletion of nutrients, and accumulation of waste products. (elifesciences.org)
Further, inhibitory receptors present in the TME can inhibit T cell metabolism and alter T cell signaling both directly and through release of extracellular vesicles such as exosomes. (elifesciences.org)
This review will discuss the metabolic changes that drive T cells into different stages of their development and how the TME imposes barriers to the metabolism and activity of tumor infiltrating lymphocytes. (elifesciences.org)
As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)
Finally, we will provide an overview of how utilizing an understanding of T cell metabolism may inform strategies to alter the TME or enhance T cell metabolism to strengthen the immunotherapy arsenal. (elifesciences.org)
The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)

These drawbacks may be explained, at least in part, by the various phenotypes and histological characteristics of tumor liver cells and its microenvironment [ 5 ] . (encyclopedia.pub)
Macrophages and dendritic cells can produce 1,25-dihydroxyvitamin D within the microenvironment. (springer.com)

In the case of the ⫽ endothelial cells men, there was also a delay, but of only 3 years. (gotomydoctor.com)
We characterize the role of increased Lyn kinase activity in neutrophils, endothelial cells and lesional liver biopsies and utilized an iPSC-derived endothelial cell platform for disease modeling of neutrophilic vasculitis and to screen and evaluate drug efficacy. (nature.com)

The expression of miR-15a is associated with survival in triple negative breast cancer. (wikipedia.org)
The survival rate of treated cells was also examined by MTT assay. (ircmj.com)

Specifically, miR-15a/16-1 downregulates BCL2 expression and is itself deleted or downregulated in tumour cells. (wikipedia.org)
The expression of Tβ4 was significantly decreased in human HSC cell line LX-2 and CCl4-treated mouse liver. (oncotarget.com)
Intriguingly, the expression of DNMT1, which is a target of miR-148a, is inversely correlated with the expression of miR-148a in HCC cells. (spandidos-publications.com)
A recent demonstration of the differential expression of miRNAs and their target mRNAs in cancer and the discovery that some miRNAs can function as oncogenes or tumor suppressors have sparked considerable interest in elucidating their role in tumorigenesis ( 5 , 6 ). (spandidos-publications.com)
A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)
Real-time PCR analysis indicated that in compound-treated cells the gene expression level of Bcl-2 has been downregulated, while Bax was upregulated, compared to untreated control cells. (ircmj.com)
Mechanistically, cancer cells induce miR-182 expression in macrophages by TGFß signaling, and miR-182 directly suppresses TLR4, leading to NFκb inactivation and M2 polarization of TAMs. (bvsalud.org)
PTEN expression alteration is crucial to the pathogenesis of cancer and other diseases. (biomedcentral.com)
Our results demonstrate that cytoglobin expression is correlated with a more quiescent phenotype of stellate cells in culture and that cytoglobin is regulated by the extracellular matrix through integrin signalling dependent on activation of focal adhesion kinase. (biomedcentral.com)
Vitamin D ameliorates stress ligand expression elicited by free fatty acids in the hepatic stellate cell line LX-2. (springer.com)

Mitochondria synthesize ATP using oxygen to produce necessary energy for living cells. (dojindo.com)

Journal of Experimental and Clinical Cancer Research. (ncku.edu.tw)

Mitochondrial regulation of apoptosis further downstream was investigated, showing changes in the mitochondrial membrane potential, cytochrome c release into the cytoplasm, and enhanced activation of cleaved caspase-3 and Poly ADP-ribose polymerase (PARP). (hindawi.com)

Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. (sabbiotech.cn)

SCC group revealed infiltration by sheets of malignant squamous cells with or without keratin pearls and inflammatory cells, in addition to upregulation of TGF-ß, Sirt-1, MALAT-1, and Bax, whereas SCC/iPSCs group showed an improved submandibular histoarchitecture with the maintenance of the secretory function. (bvsalud.org)

Apoptosis was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. (hindawi.com)

With this general idea in mind, and in active collaboration with other biologists and pharmacologists, my group is dedicated to establish a strong and creative research program that applies state-of-the-art chemical approaches to biological problems impacting diagnosis, prevention and treatment of human diseases. (utmb.edu)
We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases. (nature.com)
Lowering of mitochondrial activity and dysfunction are known to be closely related to cancer, aging, and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. (dojindo.com)
In addition, it has also been shown that smooth muscle actin appear in stress fibers of fibroblastic cells during pathological situations involving contractile phenomena such as wound healing and fibrocontractive diseases. (thermofisher.com)

Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)

Thirty Wistar albino rats were equally assigned into three groups: group I (control), group II (Squamous cell carcinoma (SCC)): submandibular glands were injected SCC cells, and group III (SCC/iPSCs): SCC rats were treated by 5 × 106 iPSCs. (bvsalud.org)
A proteogenomic portrait of lung squamous cell carcinoma. (nih.gov)

This same study demonstrated a mortality rates from coronary heart disease was ob- decreased relative risk for cancer of 0.54 for men, 0.57 served. (gotomydoctor.com)
Primary liver cancer constitutes the sixth most prevalent type of tumor and is the fourth common cause of cancer-related mortality worldwide [ 1 ] . (encyclopedia.pub)
Moreover, the high mortality associated with liver cancer is related to its lack of sensitivity and development of resistances to a few treatments that lead to the chemotherapy failure. (encyclopedia.pub)

We will then examine how tumor cells create a toxic milieu for T cells that enter the TME. (elifesciences.org)
Furthermore, the high refractoriness of liver cancer to treatments has been associated with the interaction of very complex and diverse mechanisms of chemoresistance, which can act synergistically to protect tumor cells from the chemotherapy agents [ 3 ] . (encyclopedia.pub)

The long non-coding RNA lnc-ZNF180-2 is a prognostic biomarker in patients with clear cell renal cell carcinoma. (ajcr.us)
Journal of Renal and Hepatic Disorders. (westminster.ac.uk)

In this review, we have discussed the status and roles of various immune effector cells ( e.g ., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. (wjgnet.com)
Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)
pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. (nature.com)
Tissue infiltration by activated innate immune cells, including monocytes, macrophages, and neutrophils, if untreated, leads to rapidly progressive organ injury, that can involve many organ systems. (nature.com)
Vitamin D receptors are expressed on the principal cell populations involved in the innate and adaptive immune responses. (springer.com)

Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
Phase II is a crucial step- if molecules from Phase I are not fully metabolized by Phase II conjugation, they may cause free radical damage to proteins, RNA and DNA within the cell. (healthheroshop.com)
Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. (thermofisher.com)

Several anti-diabetic strategies including adiponectin, ezetimibe, liraglutide, taurine, adipose tissue-derived stem cells (ADSCs) and even exercise as well as natural products such GABA tea, geniposide, guava extract, vitamin D have been shown to target autophagy. (frontiersin.org)

Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
Other much rarer genetic disorders can cause hepatic iron overload, but the clinical picture is usually dominated by symptoms and signs due to failure of other organs (eg, anemia in hypotransferrinemia or atransferrinemia, or neurologic defects in aceruloplasminemia). (msdmanuals.com)

A diverse array of infiltrating immunocytes regulates the development and progression of HCC, as is the case in many other cancers. (wjgnet.com)

Mol Cancer Ther, vol 11 no. 7 (2012), pp. 1518-1527 [ 10.1158/1535-7163.MCT-11-0787 ] [ abs ]. (duke.edu)
Cancer Gene Ther, vol 19 no. 1 (2012), pp. 30-37 [ 10.1038/cgt.2011.63 ] [ abs ]. (duke.edu)
Mol Cancer Ther, vol 9 no. 5 (2010), pp. 1432-1442 [ 10.1158/1535-7163.MCT-10-0160 ] [ abs ]. (duke.edu)

Anatomy25

Organisms12

Diseases32

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Proliferation19

Induces apoptosis2

Fibrosis10

Hepatocytes1

Pathways6

Differentiation4

Primary liver cancers3

Pathway4

Hepatocellular carcinoma3

Oxidative5

Metastasis4

Inflammation3

Flow cytometry2

HSCs6

20221

Migration4

Promotes3

Progenitor1

Pancreatic2

Suppression6

Inhibition2

Cycle arrest2

Mesenchymal2

Homeostasis1

Colorectal cancer1

Ferroptosis3

Cellular3

Protein2

Mediates1

Inhibitors2

Intestinal1

Therapeutic7

Necrosis1

Metabolism6

Microenvironment2

Endothelial2

Survival2

Expression10

Mitochondria1

Experimental1

Mitochondrial membrane potential1

Translocation1

Inflammatory1

Inhibitor1

Diseases4

Induction1

Squamous cell2

Mortality3

Tumor cells2

Renal2

Immune5

Proteins3

Stem1

Disorders2

Progression1

Ther3