Cancer cells hela cells. Medical search. Frequent questions

In the fall the HCC/ALC students had been reading The Immortal Life of Henrietta Lacks and the team of Smith students included a little about cancer when talking about animal cells to connect the science to the visitors' reading assignment. (smith.edu)
Allison Sirois, OGR and working in Sarah Moore's lab, had a lot of interest in doing that and through the Moore lab was able to obtain and work through the safety protocols to get cloned cells from Henrietta Lacks for the HCC/ALC students to study. (smith.edu)
Her name was Henrietta Lacks, but scientists know her as HeLa. (worldcat.org)
They are called 'HeLa' cells from their initial host's name, Henrietta Lacks. (philosophynow.org)
Henrietta Lacks doesn't know it, but she is a leading contributor to the sciences of aging and cancer. (damninteresting.com)
In 1975, after the death of George Gey, the family of Henrietta Lacks learned that her cells still lived, and were all over the world. (damninteresting.com)
When Henrietta Lacks, a 31-year-old African American woman with advanced cervical cancer began to receive treatment for her disease at John Hopkins Hospital in 1951-1 of the only hospitals at the time that was willing to provide treatment to African American patients-a tissue biopsy was taken from her tumor. (onclive.com)
In 1951, a black woman named Henrietta Lacks was diagnosed with cervical cancer and her unusually rapidly proliferating malignant cells, ideal for biomedical research, were taken, used and disseminated around the world without her permission or knowledge. (nbcnews.com)
Henrietta Lacks was a real person-and her cancer cells have led to many medical discoveries. (smithsonianmag.com)
Henrietta Lacks is known as "immortal" for a reason-though she died of cervical cancer in 1951, scientists have used her extraordinary cells countless times since. (smithsonianmag.com)
Her cells "went up in the first space missions to see what would happen to human cells in zero gravity [and] helped with some of the most important advances in medicine: the polio vaccine, chemotherapy, cloning, gene mapping, in vitro fertilization," writes Rebecca Skloot in her best-selling book The Immortal Life of Henrietta Lacks . (smithsonianmag.com)

Apoptosis profile shows (shown that) many cells undergoing apoptosis after treatment. (chemoprev.org)
Thus, EBMD potentially inhibits activation of NF-κB pathway and triggers apoptosis on HeLa cells. (chemoprev.org)
In the present study we investigated the efficacy of Organic extracts of Nigella sativa seed powder for its clonogenic inhibition and induction of apoptosis in HeLa cancer cell. (biomedcentral.com)
All three extracts induced apoptosis in HeLa cells. (biomedcentral.com)
Apoptosis an active physiological process resulting in cellular self-destruction of unwanted cells is absent in cancer cells. (biomedcentral.com)
Khz inhibited cell division and induced apoptosis in A549 cells. (springer.com)
Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. (springer.com)
Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. (springer.com)
Yang M, Zhai X, Ge T, Yang C and Lou G: MiR-181a-5p promotes proliferation and invasion, and inhibits apoptosis of cervical cancer cells via regulating inositol polyphosphate-5-phosphatase A (INPP5A). (spandidos-publications.com)
Wang C, Zhou B, Liu M, Liu Y and Gao R: miR-126-5p restoration promotes cell apoptosis in cervical cancer by targeting Bcl2l2. (spandidos-publications.com)
Zhu K, He Y, Xia C, Yan J, Hou J, Kong D, Yang Y and Zheng G: MicroRNA-15a inhibits proliferation and induces apoptosis in CNE1 nasopharyngeal carcinoma cells. (spandidos-publications.com)
Sounds like the plot to a Star Trek episode, but researchers report that they've developed a biocomputer that can figure out if a cell is cancerous and destroy it by triggering apoptosis -all by detecting miRNA levels, potentially leading to much more targeted cancer therapies than what's available now. (epigenie.com)
And once a cell is categorized as "HeLa," the cellular MacBooks are programmed to produce human Bcl-2-associated X protein-aka, hBax- which triggers apoptosis and kills the cell. (epigenie.com)
The complex's cytotoxicity stems from its inducement of cells to accumulate misfolded proteins, resulting in apoptosis from the unfolded protein response (UPR). (rsc.org)
Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways. (lu.se)
Furthermore the changes in cell growth, cell cycle duration, and extent of apoptosis were analyzed. (bvsalud.org)
In the cell death assay, the cell populations were similar in each cell type after treatment with FA, indicating that growth inhibition by FA was not related to the induction of apoptosis. (bvsalud.org)

A deconvolved wide-field fluorescence microscope image of human HeLa cancer cells in metaphase of mitosis. (mitosispictures.com)
Some oncogenic viruses that code for fusogens and are capable of hybridizing cells are: Epstein-Barr virus HPV Hepatitis B and Hepatitis C Human T-cell lymphotropic virus type 1 (HTLV-1) The virus used in laboratories for controlled cell hybridization is inactivated Sendai virus. (wikipedia.org)
Human-mouse hybrid cells, i.e. (wikipedia.org)
These are created as a byproduct of fertility testing, when human sperm potency is measured by how well it can penetrate a hamster egg cell (hamster eggs tend to have similar penetrability to human sperm as do human eggs). (wikipedia.org)
Human cervical cancer and Human rectum cancer tissues. (abcam.com)
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)
Human-derived hepatic cell lines are a valuable alternative to primary hepatocytes for drug metabolism, transport and toxicity studies. (cancerindex.org)
IHC-P: human brain tissue, human bladder cancer tissue. (abcam.com)
The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
The first 'immortal' human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. (worldcat.org)
Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
HeLa cells are an immortal line of human cervical cancer cells used in medical research. (philosophynow.org)
The remarkably resilient cells became the first human cells to be cultured continuously for experiments. (philosophynow.org)
Most cells in the human body can only multiply a certain number of times, then they inevitably die. (damninteresting.com)
So if there were human cells that didn't degrade with multiplication⁠-that showed no limit in the number of times they could divide, and remain alive forever, so long as the environment were suitable and nutrients were available⁠-to what lengths would scientists go to study them? (damninteresting.com)
The aim of this paper is to analyse sunitinib malate in vitro ability to enhance cisplatin cytotoxicity in T24, 5637, and HT1376 human urinary bladder-cancer cell lines. (hindawi.com)
This investigation aims to analyse the in vitro effects of cisplatin and sunitinib malate in isolation and in combination, on one human nonmuscle invasive urinary bladder-cancer cell line (5637) and on two human muscle-invasive urinary bladder-cancer cell lines (T24 and HT1376). (hindawi.com)
This cell line, dubbed the HeLa cell line after Lacks' name, has since become one of the most widely used human cell lines in biologic research over the past half century, with the cell lines having been used in over 100,000 scientific publications on PubMed alone. (onclive.com)
Human papillomaviruses (HPVs) have important roles in the development and progression of cervical cancer, but the underlying mechanisms are yet to be fully elucidated. (spandidos-publications.com)
[vii] In a cell study of reishi mushroom extract, the treatment offered high antitumor and liver protection with low toxicity on human liver cancer cells. (greenmedinfo.com)
Reviewing in vivo and in vitro studies on mice and human cell lines using lion's mane (Hericium erinaceus) and tiger tail (Trametes versicolor) mushrooms, treatments showed immunomodulatory, anticancer, anti-inflammatory and neuroregenerative effects. (greenmedinfo.com)
She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells--taken without her knowledge--became one of the most important tools in medicine: The first immortal human cells grown in culture, which are still alive today, though she has been dead for more than sixty years. (booksamillion.com)
And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. (booksamillion.com)
Rather like HeLa cells , except in the wild without human help. (pandasthumb.org)
Granulysin is an antimicrobial peptide (AMP) expressed by human T-lymphocytes and natural killer cells. (uni-ulm.de)
The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)
To do this, they had to produce an army of never-tiring taste testers - that is, flavor receptors engineered from human embryonic kidney cells (HEK-293, a fetal kidney cell line popular in pharmaceutical research). (hli.org)
In a 2012 letter to Children of God for Life, PepsiCo stated that "Senomyx does not use HEK cells or any other tissues or cell lines derived from human embryos or babies for research performed on behalf of PepsiCo. (hli.org)
OBJECTIVE: We investigated the effects of fusidic acid (FA) on human cervical, thyroid, and breast carcinoma cell lines to determine the potential usefulness of FA in cancer treatment. (bvsalud.org)
CONCLUSION: FA treatment can interfere with cell proliferation by inducing cell cycle arrest in human cervical, thyroid, and breast carcinoma cell lines. (bvsalud.org)
Cadmium , to which large numbers of people are occupationally and otherwise exposed, has been categorized as a human carcinogen by the International Agency for Research on Cancer (IARC). (cdc.gov)
Four different human cell lines: HCT-15 (colorectal adenocarcinoma), PLC/PRF/5 (hepatocellular carcinoma), HeLa (adenocarcinoma) and Chang (likely derived from HeLa cells) cells, were exposed to 30 uM cadmium chloride for time intervals up to 24-hours and the expression level of eIF4E was determined by Western blot analysis using an antibody against human eIF4E. (cdc.gov)
Dr Heidi Mattock and use genetic data to identify the etiology of human canceRs. (who.int)
Intratumoral heterogeneity is an inherent feature of most human cancers and has profound implications for cancer therapy. (lu.se)
The presence of a subclonal population of tumor cells characterized by PDGFRβ expression was further validated in a cohort of human PanNET. (lu.se)

Wild-type (WT) AAV serotypes exhibit different tissue tropism due to different capsid protein sequences or variable regions interacting with disparate cell surface receptors, and thus can be utilized for different target tissues 3 . (nature.com)
Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. (wikipedia.org)
After the cells of interest have been isolated from living tissue , they can subsequently be maintained under carefully controlled conditions. (wikipedia.org)
Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. (wikipedia.org)
In practice, the term "cell culture" now refers to the culturing of cells derived from multicellular eukaryotes , especially animal cells, in contrast with other types of culture that also grow cells, such as plant tissue culture , fungal culture, and microbiological culture (of microbes ). (wikipedia.org)
The historical development and methods of cell culture are closely interrelated to those of tissue culture and organ culture . (wikipedia.org)
The laboratory technique of maintaining live cell lines (a population of cells descended from a single cell and containing the same genetic makeup) separated from their original tissue source became more robust in the middle 20th century. (wikipedia.org)
[12] He suggested that the potentialities of individual cells via tissue culture as well as that the reciprocal influences of tissues on one another could be determined by this method. (wikipedia.org)
Since Haberlandt's original assertions, methods for tissue and cell culture have been realized, leading to significant discoveries in biology and medicine. (wikipedia.org)

In 1951, shortly after the birth of her fifth child, Lacks fell seriously ill with cervical cancer. (philosophynow.org)
When Lacks was treated for cancer in 1951, some of her cells were taken for research without her permission. (moreheadplanetarium.org)

Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
Here, making use of a newly generated Pdgfd knockout mouse, we reveal a functionally important malignant cell heterogeneity modulated by PDGF-DD signaling in pancreatic neuroendocrine tumors (PanNET). (lu.se)

instead, we found that PDGF-DD stimulated bulk tumor cell proliferation by induction of paracrine mitogenic signaling between heterogeneous malignant cell clones, some of which expressed PDGFRβ. (lu.se)

Methanolic, n-Hexane and chloroform extracts of Nigella sativa seedz effectively killed HeLa cells. (biomedcentral.com)
Western Blot and TUNEL results suggested that Nigella sativa seed extracts regulated the expression of pro- and anti- apoptotic genes, indicating its possible development as a potential therapeutic agent for cervical cancer upon further investigation. (biomedcentral.com)
These medicinal systems have identified more than 700 individual herbal extracts as well as several drug preparations which claim to treat and/or prevent several diseases including cancer [ 11 ]. (biomedcentral.com)
Cytotoxicity of extracts and compounds isolated from Croton echioides in animal tumor cell (HTC). (scielo.br)
We could verify 4000 proteins by MS1t analysis from HeLA extracts. (lu.se)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
This is due to acute alterations in the tissues surrounding the tumor and in the environment as a result of treatment with anticancer therapeutics, which facilitate the drug resistance of tumor cells. (oncotarget.com)
It was observed that miR‑130a was significantly upregulated in cervical cancer tissues compared with that in adjacent non‑tumorous tissues. (spandidos-publications.com)
The Notch signaling pathway is an evolutionary conserved signal transduction cascade present in almost all tissues and is required for embryonic and postnatal development, as well as for stem cell maintenance, but it is also implicated in tumorigenesis including pancreatic cancer and leukemia. (uni-ulm.de)

Khz cytotoxicity was measured using an MTT assay and the mitochondrial membrane potential (MMP)-related, calcium-induced generation of reactive oxygen species (ROS) in A549 cells was measured by flow cytometry. (springer.com)
Miyajima, A, Nakashima J, Yoshioka K. Role of reactive oxygen species in cis-dichlorodiammineplatium-induced cytotoxicity on bladder cancer cells. (springer.com)
The absorbances averages results obtained showed that the crude extract did not present cytotoxicity for the HTC cells in all the concentrations and evaluated times. (scielo.br)
In this investigation, the cytotoxicity of 23 α-methylene-γ-lactones towards normal breast epithelial MCF-10A cells as well as breast cancer JIMT-1 cells is compared. (lu.se)
Exposure to 30 uM cadmium chloride resulted in significant cytotoxicity and cell death in all four cell lines tested. (cdc.gov)
Our results thus suggest that eIF4E is a cellular target for cadmium toxicity and that the cadmium -induced cytotoxicity and cell death may be due to the inhibition of eIF4E. (cdc.gov)

Furthermore, the expression of miR‑130a was also higher in HPV(+) cervical cancer cell lines compared with that in HPV(‑) cells. (spandidos-publications.com)

To protect her identity, Henrietta's name was first concealed, instead labeled as having come from "Helen Lane", hence the name HeLa Cells. (damninteresting.com)

WB: A431 cell lysate. (abcam.com)
WB: HeLa cell lysate. (abcam.com)

The injectable polio vaccine developed by Jonas Salk was one of the first products mass-produced using cell culture techniques. (wikipedia.org)
The discovery of the immortal, ever-replicating HeLa cell line in 1952 has led to several breakthroughs in biomedical research for countless diseases including cancer, AIDs, and polio. (onclive.com)
Decades later, her family learned that the HeLa cell line made polio vaccinations and many other medical advances possible. (moreheadplanetarium.org)

We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
Knockdown of HPV18 E6 significantly inhibited the expression of miR‑130a in HeLa cervical cancer cells. (spandidos-publications.com)
Furthermore, knockdown of miR‑130a reduced the migration and invasion of HeLa cells. (spandidos-publications.com)
Furthermore, knockdown of TIMP2 rescued the suppressive effects of miR‑130a downregulation on the migration and invasion of HeLa cells. (spandidos-publications.com)

But intrigued by the "lipid effect," scientists checked for it in two cancer-cell lines, the famous HeLa cells, and a lung cancer cell line called H460. (carbomer.com)
This study aimed to investigate the anti-proliferative effects of Khz on A549 lung cancer cells. (springer.com)
In a lung cancer-induced study of mice, treatment with reishi mushrooms inhibited cell viability and mobility of lung cancer cells in vitro. (greenmedinfo.com)

Laetrile has been used for cancer treatment both as a single agent and in combination with a metabolic therapy program that consists of a specialized diet, high-dose vitamin supplements, and pancreatic enzymes . (cancer.gov)
RBPJL is specifically expressed in the exocrine pancreas, whereas it is mostly undetectable in pancreatic tumour cell lines. (uni-ulm.de)
Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD. (lu.se)

A clinical study to evaluate of the combination of AHCC plus PLD in the treatment of ovarian cancer is being pursued. (researchgate.net)
Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
Zhao S, Ye G, Fu G, Cheng JX, Yang BB, Peng C. Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. (springer.com)

Today, one of the main purposes of generating hybrid cell lines is to fuse cells that secrete a useful product with an immortal cell line to maximize the secretions. (wikipedia.org)
Hybrid cell lines are also used to study cancer and map genes The three most common methods of fusing cells to make a hybrid line are via oncogenic viruses, polyethylene glycol, or electrofusion. (wikipedia.org)
When exposed to an alternating electric field, cells in suspension will line up like a chain along the electrical field lines. (wikipedia.org)
Authenticating Hybrid Cell Lines. (wikipedia.org)
In vitro cellular uptake studies of the nanoparticles into prostate cancer cell lines were performed using light scattering microscopy to provide three-dimensional (3D) imaging. (mdpi.com)
These cell lines responded less strongly but similarly to lipid concentrations. (carbomer.com)
To test this possibility, the scientists tried dosing their cell lines with 2DG, a glucose molecule with a hydrogen atom substituted for a hydroxyl (OH-) group that gets stuck in the pathway that breaks down glucose. (carbomer.com)
When they did this, all three cells lines were slower to grow and divide. (carbomer.com)
Cancer cell lines were selected from lung and cervical cancer cell line that are commonly used for stereotactic body radiotherapy and effective with methotrexate. (frontiersin.org)
The study was performed on the 5637, T24, and HT1376 urinary bladder-cancer cell lines. (hindawi.com)
5637 and HT1376 cell lines were kindly provided by Dr. Paula Videira of the Universidade Nova de Lisboa, Lisboa, Portugal. (hindawi.com)
Transcript of Catholic Culture Podcast Episode 106, in which Michael Pakaluk and Jay Richards join host Thomas V. Mirus for a discussion of the moral issues involved with the production and testing of vaccines using illicitly-obtained fetal cell lines. (catholicculture.org)
First, let me be absolutely clear that the Church has said multiple times over the years that vaccines produced or tested using aborted fetal cell lines may be used for serious health reasons, and has made the specific judgment that it is licit to take COVID-19 vaccines under the present circumstances. (catholicculture.org)
The two cell lines were treated with various concentrations of the compounds in dose response assays, and the 50 % inhibitory concentration (IC50) was determined from dose response curves. (lu.se)
The Vaccine Chart of the Sound Choice Pharmaceutical Institute (SCPI) lists dozens of vaccines and medical products that contain aborted fetal cell lines. (hli.org)
Furthermore, exposure to cadmium chloride resulted in significant inhibition of eIF4E in all cell lines, and the highest inhibition was noticed following the 24-hours exposure to cadmium chloride. (cdc.gov)

Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
The HeLa cells are remarkably persistant, fast-growing, and invasive. (damninteresting.com)
If confirmed in vivo , this conjugation may provide a means of new perspectives in muscle-invasive urinary bladder cancer treatment. (hindawi.com)
The standard approach for muscle-invasive urinary bladder cancer treatment is based on a radical cystectomy with bilateral pelvic lymph node dissection. (hindawi.com)
It is conceivable that this change may be related to that which enables the cells of a compact tumor to become invasive. (onclive.com)
During their lifetime, approximately 12% of women in the USA will develop invasive breast cancer, the second leading cause of cancer death of women in the USA [1]. (amrita.edu)
Current treatment methods for breast cancer include invasive surgical procedures, radiotherapy, hormone therapy and chemotherapy. (amrita.edu)

Certain oncogenic viruses encode for fusogens, which are proteins that encourage two cell membranes to fuse. (wikipedia.org)
Modified versions of AAVs range from genetic alterations of the viral cap gene to conjugation of proteins such as streptavidin or antibodies to promote interaction with specific cells. (nature.com)
A 40-kd major outer membrane protein (MOMP) and 10- and 60-kd chlamydial heat-shock proteins (cHSPs) have been implicated in the immunopathologic response, but further studies are needed to provide a better understanding of these cell-mediated immune responses. (medscape.com)
The RB synthesizes its own DNA, RNA, and proteins but requires energy in the form of adenosine triphosphate (ATP) from the host cell. (medscape.com)
We also identified low-abundant proteins with functions related to (i) cell signaling, (ii) immune system regulators, and (iii) proteins regulating folding, sorting, and degradation, as well as (iv) vesicular transport proteins. (lu.se)
These approaches promise to enable researchers to assess, on a large scale, both expression level and functional state of the proteins that carry out most functions in a cell. (lu.se)

The first instance of intentionally generated hybrid cells was described in 1960 by Barski, Sorieul, and Cornefert in their paper "Production of cells of a 'hybrid' nature in cultures in vitro of 2 cellular strains in combination," originally published in French. (wikipedia.org)
Different strains of HeLa cells, all descended from that original sample, have been invaluable in a wide range of medical research ever since. (philosophynow.org)
They're close to (if not actually) the #1 contaminant in cell culture strains world-wide. (damninteresting.com)

Drop everything and go read Carl Zimmer's post about the recent discovery of a dog cancer cell lineage that has left behind its multicellular ancestry . (pandasthumb.org)

For more than 80 years, the reigning idea has been that cancer cells fuel their explosive growth by soaking up glucose from the blood, using its energy and atoms to crank out duplicate sets of cellular components. (carbomer.com)
Infection with chlamydial organisms invokes a humoral cell response, resulting in secretory immunoglobulin A (IgA) and circulatory immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies and a cellular immune response. (medscape.com)

A hybrid cell line is a fusion of cells from two different cell types. (wikipedia.org)
For example, immunoglobin-producing B lymphocytes can be fused with myeloma to produce an immortal line of cells called hybridoma that secrete immunoglobin. (wikipedia.org)
Should the law have given control of the cell line to Henrietta's family? (philosophynow.org)
After irradiation, gene expression levels of OATP1B1/1B3/1B7 showed changes in each cell line. (frontiersin.org)
Although the research that emerged from the discovery of the HeLa cell line has helped to prevent 4.5 billion global infections and 10.3 million global deaths, the unethical and controversial nature of their discovery has raised issues with regard to privacy and consent in underrepresented patient populations. (onclive.com)
In honor of Black History Month, Markman looks back on the progress that has been made through the HeLa cell line, incidents that have contributed to a lack of trust in the medical community, and efforts that need to be made to ensure that the rights of underserved patient populations are maintained in clinical cancer trials. (onclive.com)
In line with this, RBPJL is able to fully reconstitute transcriptional repression at Notch target genes in cells lacking RBPJ. (uni-ulm.de)
But the initial cells that started the immortal HeLa cell line were taken from Lacks without her consent or the knowledge of her family. (smithsonianmag.com)
The university added: "Johns Hopkins never patented HeLa cells, and therefore does not own the rights to the HeLa cell line. (smithsonianmag.com)
The fetal skin cell line that PSPs are based on was taken from an electively aborted baby whose body was donated to the University. (hli.org)

In addition, TSA-mediated cell death was reduced by the overexpression of HIF-1α but it was rescued by transfection with a HIF-1α mutant (K674R). (oncotarget.com)

So years passed, and the Lacks family remained completely unaware that these cells existed. (philosophynow.org)
When Mrs Lacks was hospitalized for her illness, the cancer cells were harvested and cultured⁠-this is normal for her treatment. (damninteresting.com)
The interest of evolution might be better served by asking why the Lacks family was never consulted about distributing her cells. (damninteresting.com)
3 While most cancer cell samples tended to divide a few times and die before any notable research could be conducted, investigators found that Lacks' cells continued to divide indefinitely, provided they were given the right amount of nutrients. (onclive.com)
3,4 There is, however, one pressing issue with the discovery that has negatively impacted the relationship between the medical community and with patients of color: Lacks' cervical cancer cells were collected without her or her family's consent. (onclive.com)
Although the collection of Lacks' cells is a subject that continues to be surrounded by controversy to this day, it's difficult to deny the progress that has been made in medical research as a byproduct of this discovery, in the field of cancer and beyond. (onclive.com)
Now, reports Andrea K. McDaniels for the Baltimore Sun , Lacks' family is demanding compensation from the university who first took the cells. (smithsonianmag.com)
Skloot helped draw attention to the once-untold story of Lacks and her family, who were not aware that her cells had been used at all until decades after her death. (smithsonianmag.com)
Lacks' family never received compensation for her cells, and many family members didn't understand just how her cells had been used. (smithsonianmag.com)
In a statement, the University says that there were no modern consent laws when they took Lacks' cells. (smithsonianmag.com)
The Lacks family, in turn, tells McDaniels that pharmaceutical corporations and other entities have profited from her cells and that they want the cells to be the property of her estate. (smithsonianmag.com)
Whether or not the Lacks family gets the compensation they think they deserve, the ongoing conversation about her cells is part of a larger debate about ethics, privacy and informed consent. (smithsonianmag.com)
It's been more than 60 years since Lacks' cells changed medicine forever-and her personal story is far from over. (smithsonianmag.com)

5: On a lab tour, Allison Sirois explains how she grows HeLa cells in an incubator. (smith.edu)

When cells were transfected with GFP-HIF-1α, treatment with TSA increased the number of green fluorescence protein (GFP)-positive cells. (oncotarget.com)
Super-resolution fluorescence microscopy and scanning electron microscopy indicated that Gran1 interacts with the surface of Mtb , causing lethal distortions of the cell wall. (uni-ulm.de)

This conundrum brings to question whether cancer ST6GAL1 overexpression is beneficial or ultimately detrimental to long-term patient outcomes and highlights the incomplete mechanistic understanding of how ST6GAL1 is involved in cancer progression. (nature.com)
It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
However, the underlying molecular mechanisms by which miR‑130a promotes cervical cancer progression have remained largely elusive. (spandidos-publications.com)
Gao YL, Zhao ZS, Zhang MY, Han LJ, Dong YJ and Xu B: Long noncoding RNA PVT1 facilitates cervical cancer progression via negative regulating of miR-424. (spandidos-publications.com)
As a result, there is an emergent need to explore previously unmapped mechanisms regulating distinct subpopulations of tumor cells and to understand their contribution to tumor progression and treatment response. (lu.se)

4: Allison Sirois explains the use of an inverted microscope to look at live HeLa cells. (smith.edu)

Our approach could provide a promising platform for expanding clinical AAV development to treat bone pathologies such as cancer and osteoporosis. (nature.com)
Its therapeutic effects on urinary bladder cancer have already been assessed in two clinical studies of phase II cancers and showed clinical benefits [ 10 , 11 ]. (hindawi.com)
High expression of miR‑130a was significantly associated with lymph node metastasis and an advanced clinical stage of cervical cancer. (spandidos-publications.com)
In a clinical study of 105 cancer patients undergoing chemotherapy or radiation treatments, a combination of reishi mushroom extract and geraniums improved immunity and fought the cancer and secondary infections that could have compromised treatment and health. (greenmedinfo.com)
In a clinical study of asymptomatic children from 3 to 5 years old, treatment with beta glucans from reishi mushrooms showed increased immune system cells in the peripheral blood -- signaling a strong defense against childhood infections. (greenmedinfo.com)
Aberrant platelet-derived growth factor receptor beta (PDGFRβ) signaling in cancer has motivated the development of several antagonists currently in clinical use, including imatinib, sunitinib, and sorafenib. (lu.se)

A cell cycle arrest in early S-phase and in G 0 /G 1 -phase was also found after exposure to cisplatin and sunitinib malate, in isolation, respectively. (hindawi.com)
Nonetheless, there is a scarce of data available about the combination of sunitinib malate and cisplatin on urinary bladder cancer. (hindawi.com)

There has been little question that minority patient populations and underserved populations have been particularly at risk for gross deficiencies in privacy," Markman, physician and president of Medicine and Science at Cancer Treatment Centers of America, and the editor-in-chief of OncologyLive , said in an interview with OncLive . (onclive.com)
The researchers from Boston and Zurich developed their biocomputer, or "classifier" gene circuit, to specifically identify HeLa cells in populations with other kinds of cells. (epigenie.com)

Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. (springer.com)

Thu, Y.M. and Richmond, A., 2010, NF-κB Inducing Kinase: A Key Regulator in the Immune System and Cancer, Cytokine Growth Factor Rev. , 21 (4), 213-226. (chemoprev.org)

p53, a tumor suppressor gene, helps regulate the cell cycle. (biomedcentral.com)
Photothermal therapy combined with gene therapy that supports hyperthermia is proposed as a novel multimodal treatment method for prostate cancer. (mdpi.com)
This study investigated relationships between accumulation of methotrexate and gene expression levels of solute carrier and ATP-binding cassette transporters in cancer cells after a single and high-dose X-ray irradiation. (frontiersin.org)
In control, gene expression levels of OAT1 in all cells was below the limit of measurement. (frontiersin.org)
Irradiation of cancer cells thus alters gene expression levels of both solute carrier transporters (OATP1B1/1B3/1B7) and ABC transporters (MRP1/2) and decreases accumulation of 3 H-MTX in cancer cells over time due to elevated expression of MRP1/2. (frontiersin.org)
mutations high frequency of IDH1/2 mutations in oligodendrogliomas, astrocytomas and in alteRations in the RB1 pathway in The TET2 gene encodes the -KG- secondary glioblastomas derived thereof low-gRade diffuse gliomas lacking dependent enzyme that catalyses suggests that these tumours share a common genetic alteRations the conversion of 5-methylcytosine to common progenitor cell population. (who.int)

Zhou Y, Yang C, Wang K, Liu X and Liu Q: MicroRNA-33b inhibits the proliferation and migration of osteosarcoma cells via targeting hypoxia-inducible factor-1α. (spandidos-publications.com)

Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
Chlamydiae are small gram-negative obligate intracellular microorganisms that preferentially infect squamocolumnar epithelial cells. (medscape.com)
Chlamydia infects columnar epithelial cells, which places the adolescent female at particular risk because of the presence of the squamocolumnar junction on the ectocervix until early adulthood. (medscape.com)
The initial response of epithelial cells to infection is a neutrophilic infiltration, followed by lymphocytes, macrophages, plasma cells, and eosinophilic invasion. (medscape.com)

These finding are particularly beneficial in the treatment of recurrent cancer when maintaining a good quality of life during chemotherapy is a priority and allows patients to have a natural, nutritional approach to preventing and managing chemotherapy adverse effects. (researchgate.net)
Chemoradiotherapy combines chemotherapy with anticancer drugs and radiotherapy to treat cancer. (frontiersin.org)

A wound healing assay and a Transwell assay were applied to study cell migration and invasion. (spandidos-publications.com)

In 1970s and '80s, scientists working with radioactively tagged glucose showed that practically all the lipids inside tumor cells were made from glucose the cells took up from the extracellular environment, a finding that seemingly corroborated the "glucose hypothesis. (carbomer.com)
When scientists spiked the culture medium with lipids, raising concentrations to those typical of blood, the cells preferred to scavenge lipids from the medium rather than synthesizing them. (carbomer.com)
The effect was discovered in cultures of fibroblasts, which divide until they touch one another and then stop, giving scientists a chance to compare the metabolism of proliferating and quiescent cells. (carbomer.com)
Because of the glucose hypothesis, scientists have devoted a lot of attention to developing cancer therapies that inhibit either glucose metabolism or lipid synthesis. (carbomer.com)
The scientists tested this idea by dosing their cultures with a drug called SSO that irreversibly binds to a lipid transporter in the cell membrane, inhibiting lipid uptake. (carbomer.com)
In a meta-analysis by scientists of 23 trials involving 4,246 cancer patients, reishi mushrooms enhanced longevity and quality of life in cancer patients. (greenmedinfo.com)
Henrietta's family did not learn of her immortality until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. (booksamillion.com)
Bringing together Universities and high school students, UniStem Day is an opportunity to foster learning, discovery and debate in the field of stem cell research - inspiring the scientists of tomorrow. (lu.se)
These and many more questions will be answered by PhD students, postdoctoral fellows, and senior scientists from Lund Stem Cell Center during UniStem Day 2024. (lu.se)
In more than 40 years, the two scientists have developed methods to distinguish patients that need additional treatment after cancer surgery from those for whom an operation is sufficient and extra treatment would only cause unnecessary stress. (lu.se)

Molecular characterization of colorectal cancer patients. (cdc.gov)

Cancer remains one of the most dreaded diseases causing an astonishingly high death rate, second only to cardiac arrest. (biomedcentral.com)
In a scenario where conventional medicine has failed to develop techniques that could reduce the incidence of death due to cancer, complementary and alternative medicine (CAM) is slowly emerging as an option. (biomedcentral.com)
Vincent Lotz asks who should have the decisive power over someone's cells after their death: their family, or the medical community? (philosophynow.org)
After her death, without the knowledge or permission of her family, the hospital's laboratory used it in a routine experiment they had been performing on every cell sample they received. (philosophynow.org)
Programmed cell death and Bcl-2 protection in very low oxygen. (springer.com)
Jacobson MD. Reactive oxygen species and programmed cell death. (springer.com)
There was no discussion about future use for these cells, but after her death, the remarkable quality of the cells was noticed. (damninteresting.com)
A peptide from the shiitake mushroom showed promising results in growth arrest, cell death and cleaning out damaged cells in a breast cancer in vitro study. (greenmedinfo.com)
UPR induced cell death is relatively uncommon and led the researchers to find a method to characterize the speciation of TRIP in vitro. (rsc.org)
This strongly suggests that the Re complex is intact while it induces cell death, adding to the developing mechanistic understanding of their activity. (rsc.org)
Cancer is the leading cause of death worldwide, and there is a constant need for new treatment strategies. (lu.se)
The SiRNA mediated silencing of eIF4E resulted in significant cell death. (cdc.gov)

Recently a team of four Smithies created a unique program that built off of a standard microscopy activity that introduces students to light microscopes with a plant and animal cell investigation. (smith.edu)

Therefore, HPV/miR‑130a/TIMP2 signaling may be a potential target for the prevention of cervical cancer metastasis. (spandidos-publications.com)

It is also responsible for inhibition of vascular endothelial growth factors receptors, plateletderived growth factor receptors, and stem cell factor receptor [ 8 , 9 ]. (hindawi.com)

Their inclusion should not be viewed as an endorsement of the content of the websites, or of any treatment or product, by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board or the National Cancer Institute . (cancer.gov)
13 ] Laetrile supporters viewed this reversal as an attempt by the U.S. government to block access to new and promising cancer therapies , and pressure mounted to make laetrile available to the public. (cancer.gov)
Both local and systemic therapies are available for breast cancer now. (amrita.edu)

Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers. (frontiersin.org)
We examined expression levels of organic anion-transporting polypeptide (OATP)1B1, OATP1B3, OATP1B7, and organic anion transporter (OAT)1 as solute carrier transporters and multidrug resistance-associated protein (MRP)1 and MRP2 as ATP-binding cassette transporters, using real-time polymerase chain reaction and accumulation of 3 H-MTX in cancer cells after 10-Gy irradiation, assuming stereotactic body radiotherapy. (frontiersin.org)

Which Cosmetics Use Fetal Cells? (hli.org)
However, regardless of how strongly you support life, you may unknowingly be cooperating in aborted fetal cell research by purchasing products that use aborted fetuses either in the product itself or in its development. (hli.org)
Your children might enjoy using coffee creamers and eat soup with artificial flavor enhancers (Senomyx and Firmenich) tested on artificial taste buds engineered from aborted fetal cells. (hli.org)
The merge does not seem to have stopped the use of aborted fetal cells in development. (hli.org)

In 1907 the zoologist Ross Granville Harrison demonstrated the growth of frog embryonic cells that would give rise to nerve cells in a medium of clotted lymph . (wikipedia.org)

3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk. (cdc.gov)

This vaccine was made possible by the cell culture research of John Franklin Enders , Thomas Huckle Weller , and Frederick Chapman Robbins , who were awarded a Nobel Prize for their discovery of a method of growing the virus in monkey kidney cell cultures. (wikipedia.org)

Gran1 was selectively internalized by macrophages, the major host cell of Mtb , and restricted the proliferation of the pathogen. (uni-ulm.de)

This cancer information summary provides an overview of the use of laetrile as a treatment for people with cancer. (cancer.gov)
Laetrile was first used as a cancer treatment in Russia in 1845, and in the United States in the 1920s. (cancer.gov)
Inappropriate advertisement of laetrile as a cancer treatment resulted in a U.S. Food and Drug Administration investigation that culminated in charges and conviction of one distributor. (cancer.gov)
The startling result, reported in the journal Cell Chemical Biology, calls into question aspects of cancer research and treatment founded on the glucose hypothesis. (carbomer.com)
It's the basis for how we diagnose cancer and manage its treatment in the clinic. (carbomer.com)
Flow cytometry analysis showed that the percentage of A549 cells in sub-G1 phase of the cell cycle increased in response to Khz treatment. (springer.com)
RESULTS: After FA treatment, the cancer cells showed a decrease in growth rate. (bvsalud.org)

Wang S, Hui Y, Li X and Jia Q: WITHDRAWN: Silencing of lncRNA-CCDC26 restrains the growth and migration of glioma cells in vitro and in vivo via targeting miR-203. (spandidos-publications.com)
[iv] In both in vitro and in vivo studies, results showed that mice with induced testicular cancer treated with the Cordyceps sinensis mushroom had significantly smaller and fewer tumors than the control group. (greenmedinfo.com)

According to the American Cancer Society, on an average, 559,312 people die of the disease each year [ 1 ] despite tremendous efforts to find methods of control and cure. (biomedcentral.com)
One of the older innovations to emerge from the discovery were methods for testing for cancerous cells that proved to be so reliable, they continue to be used by investigators in the modern age. (onclive.com)
5 Two methods of quick and simple plating of single HeLa cells that results in the growth and formation of colonies from individual cells were detailed in a paper that was published in 1956. (onclive.com)
Based on these findings, investigators concluded that these methods would be useful for examining mammalian cell growth, physiology, genetics, and biochemistry in addition to examining how cells respond to drugs, viruses, and high-energy radiation. (onclive.com)

Therapy with white button mushrooms impacted prostate-specific antigen (PSA) levels and inhibited prostate cancer by decreasing immunosuppressive factors. (greenmedinfo.com)

The study aim was to evaluate the cytotoxic activity, using the MTT test [3-(4,5-Dimethilthiazol-2-yl)-2,5-diphenil tetrazolium bromide], from the crude extract of Picrasma crenata (Pau Tenente) and its isolated compounds, quassin and parain, in culture of rat liver tumor cells (HTC). (scielo.br)

Anatomy18

Organisms5

Diseases34

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes60

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science5

Named Groups1

Health Care14

Geographicals1

Henrietta Lacks11

Apoptosis17

Human35

Tissue9

19512

Knockout2

Induction1

Extracts5

Tissues4

Cytotoxicity6

Cervical cancer cell lines1

Helen Lane1

Lysate2

Polio3

Knockdown4

Lung cancer3

Pancreatic3

Ovarian3

Lines16

Invasive7

Proteins6

Strains3

Multicellular1

Cellular2

Line10

Transfection1

Lacks13

Incubator1

Fluorescence2

Progression6

Inverted microscope1

Clinical6

Cisplatin2

Populations2

Protein expression1

Immune System1

Gene6

Proliferation and migration1

Epithelial cells4

Chemotherapy2

Assay1

Scientists10

Colorectal Cancer1

Death12

Microscopy1

Metastasis1

Inhibition1

Therapies3

Radiotherapy2

Fetal4

Embryonic1

Mechanisms1

Vaccine1

Macrophages1

Treatment7

Vitro and in vivo2

Methods4

Prostate1

Liver1