Cancer cell cell sarcoma yoshida. Medical search. Frequent questions

BMC Cancer 2023 Jul 8;23(1):639. (nih.gov)
J Cancer Res Clin Oncol 2023 May;149(5):1717-1731. (nih.gov)
Cancer Sci , 2023 Jun 26. (google.com)

2004). Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. (nature.com)
Colorectal cancer (CRC) is one of most prevalent malignant neoplasms of the digestive system [1]. (researchsquare.com)
Indeed, the identification of histotype-specific (pathognomonic) gene alterations is of paramount importance in the differential diagnosis among sarcoma variants, between malignant and benign mimics, as well as between sarcoma and other tumor types ( 1 - 3 ). (frontiersin.org)
Both epithelial and mesenchymal components of carcinosarcoma show high-grade malignant cells. (medscape.com)
Synovial sarcoma and malignant peripheral nerve sheath tumor pose a significant diagnostic challenge given similar histomorphology. (eurekamag.com)
Although the presence of a t(X;18) rearrangement or expression of TLE1 can help confirm the diagnosis of synovial sarcoma, negative results for these tests are not diagnostic of malignant peripheral nerve sheath tumor. (eurekamag.com)
The goal of the present study was to determine the diagnostic utility of SOX10 to discriminate between synovial sarcoma and malignant peripheral nerve sheath tumor. (eurekamag.com)
Forty-eight cases of malignant peripheral nerve sheath tumor, all from patients with documented neurofibromatosis, and 97 cases of genetically confirmed synovial sarcoma, including 4 intraneural synovial sarcomas, were immunohistochemically stained for SOX10. (eurekamag.com)
Therefore, SOX10 is a specific (93%), albeit not very sensitive (67%), diagnostic marker to support a diagnosis of malignant peripheral nerve sheath tumor over synovial sarcoma. (eurekamag.com)
We study the highly malignant bone tumour osteosarcoma, which has one of the most rearranged genomes of all cancers and a high cell-to-cell variability. (lu.se)

His findings opened the way of cancer research in terms of cells, and developed biomedical research on chemotherapy. (wikipedia.org)
Poor Treatment Outcomes with Second-Line Chemotherapy in Advanced Synovial Sarcoma. (nih.gov)
In most cases, due to the lack of tumor-specific symptoms, HCC is diagnosed at an advanced stage (Barcelona Clinic Liver Cancer classification C), and the mainstay of treatment is chemotherapy ( 4 ). (spandidos-publications.com)
Park H, Imoto S , Miyano S. Comprehensive information-based differential gene regulatory networks analysis (CIdrgn): Application to gastric cancer and chemotherapy-responsive gene network identification. (google.com)
Phase II trial of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for untreated non-squamous non-small-cell lung cancer. (shengsci.com)
abstract： PURPOSE:We conducted a phase II trial to evaluate the efficacy and safety of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for advanced non-squamous non-small-cell lung cancer (NSCLC). (shengsci.com)

Usefulness of NKX2.2 Immunohistochemistry for Distinguishing Ewing Sarcoma from Other Sinonasal Small Round Blue Cell Tumors. (nih.gov)
Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma. (nih.gov)
What is Ewing's Sarcoma Family of Tumors? (sarcomahelp.org)
While the origin of these tumors is still not definitively known, the two theories with the most support suggest that these tumors arise from a primitive cell derived either from an embryologic tissue called the neural crest, or from resident cells in the body (called mesenchymal stem cells) that have a capability to become one of a variety of tissue types. (sarcomahelp.org)
Subsequently, these two tumors have been grouped into a class of cancers entitled Ewing's Sarcoma Family of Tumor (ESFT), all of which demonstrate this translocation. (sarcomahelp.org)
Tumors in the Ewing's family of sarcomas are made of primitive cells, which are cells that haven't yet decided what type of cell they are. (sarcomahelp.org)
The term "sarcoma" identifies a heterogeneous group of rare tumors comprising over 60 different histologic variants ( 1 ). (frontiersin.org)
Detection of Human Lung Epithelia Cell Growth Factors Produced by a Lung Carcinoma Cell Line: Use in Culture of Primary Solid Lung Tumors. (epa.gov)
The 2020 World Health Organization tumor classification system acknowledges four categories within the endometrial stromal tumors: endometrial stromal nodule, low-grade ESS (LGESS), high-grade ESS (HGESS), and undifferentiated uterus sarcoma (UUS), among which LGESS and HGESS are histologically, genetically and clinically distinct from UUS [ 3 ]. (e-crt.org)
Approximately 1%-2% of solid tumors are soft-tissue sarcomas, and leiomyosarcomas comprise roughly 2%-9% of these sarcomas. (medscape.com)
The tumors generally are made up of spindle-shaped cells and have a high cellularity. (medscape.com)
The distinction is further complicated by similar immunophenotype and especially by occasional synovial sarcomas that present as intraneural tumors. (eurekamag.com)
Several recent experiments have suggested that the growth of some types of tumors is not only dependent on angiogenesis (i.e., mature endothelial-cell dependent generation of new blood vessels) but also is associated with vasculogenesis, which means endothelial progenitor cell (EPC) dependent generation of new blood vessels [2]. (alk-inhibitors.com)
It is possible to cure gallbladder cancer when tumors are treated surgically at an early stage. (medscape.com)

NKX2.2 immunohistochemistry in the distinction of Ewing sarcoma from cytomorphologic mimics: Diagnostic utility and pitfalls. (nih.gov)
NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma. (nih.gov)
The tumor which bears his name is generally referred to as Ewing's sarcoma when spoken and either Ewing's sarcoma or Ewing sarcoma when written. (sarcomahelp.org)
Pathologists have long known that Ewing sarcoma looks very similar to an even rarer soft tissue tumor called primitive neuroectodermal tumor ( PNET ). (sarcomahelp.org)

Past award winners include the following: 1992 Takashi Sugimura, National Cancer Center (Japan) 1999 Mitsuaki Yoshida, BANYU Pharmaceutical Co. 2002 Yusuke Nakamura, University of Tokyo 2008 Tadatsugu Taniguchi, University of Tokyo 2012 Shigekazu Nagata, Kyoto University After his death, Japanese cancer researchers established the Yamagiwa-Yoshida Memorial international study grants in honor of Katsusaburō Yamagiwa and Tomizo Yoshida. (wikipedia.org)

Liver cancer is the third leading cause of cancer-related death worldwide and has a poor prognosis, and thus the development of more effective treatments is strongly desired ( 1 ). (spandidos-publications.com)
Uterine sarcoma accounts for 3-7% of all primary uterine malignancies which carry a poor prognosis (Barral et al. (biomedcentral.com)
Uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS) are among the most frequent uterine sarcomas, which, in adults, lead to fatal lung metastases and patients have an extremely poor prognosis (Tsuyoshi and Yoshida 2018 ). (biomedcentral.com)
This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. (cancer-genetics.org)
Patient-derived cell lines are essential tools for elucidating disease mechanisms associated with poor prognosis and for developing therapies. (cancer-genetics.org)
The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)

田中伸哉、鈴鹿淳、王磊、津田真寿美、龔剣萍、高阪真路、間野博行、「ハープ現象の発見：DNゲルでがん幹細胞を創り出す（Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogel）」、実験医学、Nature Biomedical (hokudai.ac.jp)

The unique chromosomal rearrangements of endometrial stromal sarcoma (ESS) make it possible to distinguish high-grade ESS (HGESS) and low-grade ESS (LGESS) from the molecular perspective. (e-crt.org)
Endometrial stromal sarcomas (ESSs), originating from endometrial mesenchymal cells, are rare uterine malignancies that account for approximately 0.2% of uterine malignancies [ 1 , 2 ]. (e-crt.org)
Dr. Shahzad's clinical interests are in the surgical management of advanced gynecologic malignancies, including cytoreductive surgery for ovarian cancer, complex minimally invasive laparoscopic and robotic surgery for endometrial and cervical cancers as well as fertility sparing surgical techniques. (moffitt.org)
Morphologic distinction between uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS) alone is not straightforward and has been shown to be challenging especially with poor differentiation, so immunohistochemistry (IHC) is often employed as an adjunct to morphology in uterine sarcoma. (biomedcentral.com)
Can- endometrial cancer risk in women in the European cer Epidemiol Biomarkers Prev 17(11):3062-3068. (who.int)

Rarely, mucinous differentiation or squamous cell carcinoma is seen. (medscape.com)
risk of esophageal squamous cell carcinoma. (who.int)
A prospective of five cervical cancer screening tests assessed the risk of esophageal squamous cell carcinoma. (who.int)

Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
Pre-operative radiotherapy is associated with superior local relapse-free survival in advanced synovial sarcoma. (nih.gov)
STMN1 expression was associated with shorter progression-free survival and overall survival for all analyzed uterine cancer cases (Davidson and Micci 2017 ). (biomedcentral.com)
This is the anatomic basis for the improved survival in patients undergoing liver resection for T1b gallbladder cancer. (medscape.com)

As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)

Drs. Gabriela Mercado and Frederic Barr of the University of Pennsylvania present an excellent discussion of chromosomal translocations in sarcomas elsewhere on this site. (sarcomahelp.org)
Extraskeletal myxoid chondrosarcoma (EMC), a soft-tissue sarcoma with unique clinicopathologic features and characteristic chromosomal translocations, is extremely rare in the pediatric population. (cancer-genetics.org)

Among other things, Dr. Ewing 'laid the foundations of what is now known as the Memorial Sloan-Kettering Cancer Centre, building up a strong team of physicians who later distinguished themselves in the various specialties of oncology. (sarcomahelp.org)
Dr. Shahzad was recruited to Moffitt Cancer Center in 2013 as a gynecologic oncologist in The Center for Women's Oncology. (moffitt.org)
He completed his Gynecology Oncology fellowship training at the prestigious University of Wisconsin-Madison, School of Medicine and Public Health, alongside with PhD in endocrinology-reproductive physiology with special focus in cancer biology. (moffitt.org)
In: Journal of Cancer Research and Clinical Oncology Jg. (uni-due.de)

After returning to his homeland, Yoshida served as a professor of pathology at Nagasaki University from 1938 to 1944, Tohoku University from 1944 to 1952, before being appointed as a professor of pathology at the Faculty of Medicine, University of Tokyo in 1952, where he became a dean in 1958. (wikipedia.org)
In 1994, the WHO adopted the International Association for the Study of Lung Cancer (IASLC) pathology panel to comprise the core membership of the WHO committee, to develop a new revised classification of lung and pleural tumours. (ersjournals.com)

Aberrant activation of the Wnt/β-catenin signaling pathway is one of the most frequent abnormalities in human cancer, including colorectal cancer (CRC). (researchsquare.com)
Previous studies revealed pivotal functions of WNT family members in colorectal cancer, as well as their prognostic values. (researchsquare.com)
Nevertheless, the prognostic role and mechanisms underlying WNT7b in colorectal cancer development remains unclear. (researchsquare.com)
We used the colorectal cancer cell-line HCT116 and normal colorectal cell-line CCD-18co for immunofluorescence staining and nuclear/cytoplasmic separated western blotting. (researchsquare.com)

2008). Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. (nature.com)

This study aimed to screen the hub genes and the immune cell infiltration pattern in ULMS by bioinformatics methods. (biomedcentral.com)
Finally, we used western blot to preliminarily detect the hub genes in cell lines. (biomedcentral.com)
Finally, the correlation analysis results indicate that NK cells activated and mast cells activated positively correlated with the hub genes. (biomedcentral.com)
A series of evidence confirm that the five hub genes and the infiltration of seven types of immune cells are related to USML occurrence. (biomedcentral.com)
Chromosomes are the cellular storage units for genes contained within the nucleus (which is the genetic center) of the cell and are analogous to a spool with the DNA or genetic message being the thread on the spool. (sarcomahelp.org)
Humans have a duplicate set of 23 chromosomes (or a total of 46 chromosomes) in any given cell that carries all of the human genes. (sarcomahelp.org)
In particular, about one third of all sarcomas presents pathognomonic chromosome rearrangements (translocations, deletions, insertions) that result in fusion genes and corresponding expression of fusion transcripts ( 4 ). (frontiersin.org)
Possible mechanisms for developing acquired resistance to anti-cancer drugs include mutations of genes encoding proteins that are the targets of drugs or are present in downstream pathways of proteins inhibited by drugs as well as the activation of collateral pathways ( 19 , 20 ). (spandidos-publications.com)
To this end, we screen primary tumour material for pathogenetic aberrations using next-generation sequencing technology and we manipulate genes of interest in cancer model systems using the CRISPR/Cas9 gene editing system. (lu.se)
Genes, Chromosomes and Cancer. (lu.se)

Due to their rarity and heterogeneity, the accuracy of sarcoma diagnosis remains challenging. (frontiersin.org)
In the diagnosis of sarcomas, tumor cell morphology (shape, pattern of growth, microenvironment contexture) and the expression of differentiation markers represent the most important factors, but molecular investigations are increasingly employed to complement these pathological assessments. (frontiersin.org)
In 1924, Blalock suggested avoiding surgery on patients with gallbladder cancer if the diagnosis could be made preoperatively. (medscape.com)

Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma. (go.jp)
Either partial knockdown of WNT7b or blockade of the Wnt/β-catenin signaling pathway reversed EMT process and inhibited the migration of HCT116 cells. (researchsquare.com)

Primary gastrointestinal (GI) sarcomas in general are a very rare entity, accounting for 1%-2% of GI malignancies. (medscape.com)
ULMS accounts for 60-70% of all uterine sarcoma and 1% of all uterine malignancies, but it is most dangerous due to their characteristic chemo-resistance and metastatic potential (Juhasz-Böss et al. (biomedcentral.com)

Antiangiogenic approaches for the treatment of advanced synovial sarcomas. (nih.gov)
By contrast, only 7/97 (7%) synovial sarcomas were SOX10-positive. (eurekamag.com)
Only three synovial sarcomas showed ≥2+ staining but, importantly, two of these were intraneural synovial sarcoma. (eurekamag.com)

Epigenetic Downregulation of Hsa-miR-193b-3p Increases Cyclin D1 Expression Level and Cell Proliferation in Human Meningiomas. (cdc.gov)
The compound does not inhibit the proliferation of normal fibroblasts nor that of hemopoietic progenitor cells. (tripod.com)

Synovial sarcoma is a high-grade soft tissue malignancy, for which current cytotoxic chemotherapies provide limited benefit. (nature.com)
This is in contrast to other soft tissue sarcomas in which the lung is the most common site of metastasis. (medscape.com)

Immunohistochemistry (IHC) is often employed as an adjunct to morphology in uterine sarcoma as morphologic distinction alone is not straightforward and has been shown to be challenging especially with poor differentiation or in cases with equivocal features (Hwang et al. (biomedcentral.com)
We show that AFAP1L1 can transform cells, promote migration and co-expression with active Lyn profoundly influences cell morphology and movement. (nature.com)

Epithelial-mesenchymal transition (EMT) is a developmental process by which epithelial cells are converted to mesenchymal cells during embryogenesis, tissue remodeling, wound healing, and tumor metastasis [4, 5]. (researchsquare.com)

Molecular characterization of canine SHP2 mutants and anti-tumour effect of SHP2 inhibitor, SHP099 , in a xenograft mouse model of canine histiocytic sarcoma. (go.jp)
Stevenson JD, Jaiswal A, Gregory JJ, Mangham DC, Cribb G, Cool P. Diffuse pigmented villonodular synovitis (diffuse-type giant cell tumour) of the foot and ankle. (boneandjoint.org.uk)
Poincloux R, Lizarraga F, Chavrier P . Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia. (nature.com)
Genetic heterogeneity within a single tumour is the breeding ground for cancer progression and treatment failure. (lu.se)
Extracts of Aloe vera Linne have been found to exhibit cytotoxicity against human tumour cell lines. (tripod.com)
This study examines the anti-tumour effects of di(2-ethylhexyl)phthalate (DEHP) isolated from Aloe vera Linne, in human and animal cell lines. (tripod.com)
abstract： PURPOSE:M30 and M65 ELISAs are proposed as surrogate biomarkers of tumour cell death in patients and are being applied increasingly in the pharmacodynamic (PD) evaluation of anticancer drugs during clinical trials. (shengsci.com)

Recurrences of cancer in the liver, lung or peritoneal are major outcomes of CRC treatment failure. (researchsquare.com)
Diagnostic value of exfoliated tumor cells combined with DNA methylation in bronchoalveolar lavage fluid for lung cancer. (cdc.gov)
Lung cancer is currently the most frequently diagnosed major cancer and the most common cause of cancer mortality in males worldwide. (ersjournals.com)
It has been 17 years since the World Health Organization (WHO) classification was updated in 1981 1 , and since this time considerable progress has been made in understanding the epidemiological histogenetic and molecular biology of lung cancer. (ersjournals.com)

Kure S, Yoshie O: A syngeneic monoclonal antibody to murine Meth-A sarcoma (HepSS-1) recognizes heparan sulfate glycosaminoglycan (HS-GAG): cell density and transformation dependent alteration in cell surface HS-GAG defined by HepSS-1. (exbio.cz)

Impact of natural killer cells on outcomes after allogeneic hematopoietic stem cell transplantation: A systematic review and meta-analysis. (moffitt.org)

EMT programming allows tumor cells to adapt to the constant changes of the tumor microenvironment, in so doing to successfully metastasize. (researchsquare.com)
In the specimens selected for CGH analysis, the proportion of tumor cells were estimated after hematoxylin-eosin staining of tissue sections preceding to DNA extraction. (biomedcentral.com)
In all cases the tumor cells comprised at least 85% of the total tissue areas. (biomedcentral.com)
EPA also inhibited growth of the MAC16 tumor in a dose-dependent manner, and this correlated with suppression of the expression of the 20S proteasome α-subunits in tumor cells, suggesting that this may be the mechanism of tumor growth inhibition. (aacrjournals.org)
The cytotoxicity mechanism consists of the induction of apoptosis, whereas the selectivity against neuroectodermal tumor cells is founded on a specific energy-dependent pathway of drug incorporation. (tripod.com)

In addition, the differential immune cell infiltration between UL and ULMS tissues was investigated using the CIBERSORT algorithm. (biomedcentral.com)
We found a higher infiltration of five types of cells (memory B cells, M0-type macrophages, mast cells activated, M1-type macrophages, and T cells follicular helper) in ULMS tissues than NL tissues, while the infiltration of two types of cells (NK cells activated and mast cells resting) was lower than in NL tissues. (biomedcentral.com)
ULMS is the most common histological subtype of uterine sarcoma originating in the smooth muscles of the myometrium. (biomedcentral.com)
Because ULMS is not sensitive, treatment options are available, and it accounts for a considerable proportion of uterine cancer deaths [ 2 ]. (biomedcentral.com)
We aimed to assess the diagnostic utility of Transgelin, Stathmin, BCOR and Cyclin-D1 separately and in-combinations in distinguishing ULMS from ESS, and to evaluate their prognostic value in patients with such sarcoma subtypes. (biomedcentral.com)
Combination of Stathmin, Transgelin, BCOR and Cycline-D1 raised the accuracy of differentiation between ULMS and ESS to 100% and has prognostic roles in such sarcomas. (biomedcentral.com)

The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. (nature.com)

Actionable mutations enriched in homologous recombination repair, cell cycle, and phosphoinositide 3-kinase/AKT/mammalian target of rapamycin pathways were detected in 60% of HGESS patients. (e-crt.org)

Clinical outcomes of patients with advanced synovial sarcoma or myxoid/round cell liposarcoma treated at major cancer centers in the United States. (nih.gov)
BACKGROUND:The correlation of the oncological outcomes of docetaxel and cabazitaxel in Japanese metastatic castration-resistant prostate cancer (mCRPC) patients has not been unclear. (shengsci.com)

Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)

Federally funded cancer research : coordination and innovation : hearing before the Committee on Oversight and Government Reform, House of Representatives, One Hundred Fifteenth Congress, first session, March 29, 2017. (epa.gov)

Is an Exercise Program for Pediatric Cancer Patients in Palliative Care Feasible and Supportive? (uni-due.de)

In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
Thus EPA antagonizes loss of skeletal muscle proteins in cancer cachexia by down-regulation of proteasome expression, and this may also be the mechanism for inhibition of tumor growth. (aacrjournals.org)
Stathmin1 ( STMN1) is a cytoplasmic phosphoprotein known as oncoprotein 18 involved in the regulation of the cell cycle as the protein that destabilizes microtubules. (biomedcentral.com)

Homologous elements (composed of cell types normally found in the uterus) are typically undifferentiated spindle cell sarcoma, pleomorphic sarcoma, or fibrosarcoma. (medscape.com)

Significantly, in osteosarcoma cell lines, knockdown of AFAP1L1 inhibits phosphorylated MLC2 recruitment to filamentous-actin structures, disrupts invadopodia formation, cell attachment, migration and invasion. (nature.com)

Emerging therapeutic targets for synovial sarcoma. (nih.gov)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA in peripheral blood cells. (google.com)

Methods Cell culture B16-F10 melanoma cells which can grow in the C57BL/6 strain mouse were purchased from the National Cell bank of Iran (NCBI, Pasteur institute of Iran). (alk-inhibitors.com)

Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients. (ucsd.edu)

By interaction with extracellular matrix components, growth factors, enzymes, and their inhibitors, they regulate and influence tissue distribution of the cells and biological activities of the proteins. (exbio.cz)

Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. (nature.com)

Cancer Metastasis Rev. 2006 Jun;25(2):269-77. (nih.gov)
Cancer Metastasis Rev. 2006. (nih.gov)
Invasion and metastasis are controlled by the invadopodia, which delivers matrix-degrading enzymes to the invasion interface permitting cancer cell penetration and spread into healthy tissue. (nature.com)
Gallbladder cancer generally spreads via the lymphatic channels and venous drainage, and peritoneal metastasis is common. (medscape.com)

Tomizo Yoshida (吉田富三, Yoshida Tomizō, 1903-1973) was a prominent Japanese pathologist, famous for discovering the Yoshida sarcoma. (wikipedia.org)
They look blue to a pathologist because of the staining that is used when identifying the cancer, so the cells are referred to as 'small round blue cells. (sarcomahelp.org)

This work describes the set-up of a shared platform among the laboratories of the Alleanza Contro il Cancro (ACC) Italian Research Network for the identification of fusion transcripts in sarcomas by using Next Generation Sequencing (NGS). (frontiersin.org)

Using a combination of gain- and loss-of-function approaches, we show that EGR1 modulation of PTEN contributes to HDAC inhibitor-induced apoptosis in synovial sarcoma. (nature.com)
The labeling of the 3' ends of DNA fragments provides an easy measure of cells undergoing apoptosis. (rndsystems.com)
Detection of Apoptosis in Staurosporine-treated ML-1 Cells. (rndsystems.com)
Induction of apoptosis in human leukaemic cell lines K562, HL60 and U937 by diethylhexylphthalate isolated from Aloe vera Linne. (tripod.com)
We investigated the effect of diethylhexylphthalate (DEHP) from Aloe vera Linne on the apoptosis of human leukaemic cell lines K562, HL60 and U937 to examine its pharmacological activity. (tripod.com)

Human T-cell leukemia virus type 1 (HTLV-1) establishes chronic infection in humans and induces a T-cell malignancy called adult T-cell leukemia-lymphoma (ATL) and several inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (bvsalud.org)
We believe that this paradox is key in understanding what is required of a cell to allow rapid manifestation as a high-grade malignancy. (lu.se)
Cancer of the gallbladder is uncommon, though it is the fifth most common gastrointestinal (GI) malignancy. (medscape.com)

Osteoblasts (cells that make the organic matrix of bone and then mineralize bone) and osteoclasts (cells that resorb bone) are regulated by parathyroid hormone (PTH), calcitonin , estrogen , vitamin D , various cytokines, and other local factors such as prostaglandins. (msdmanuals.com)

A methylation- and immune-related lncRNA signature to predict ovarian cancer outcome and uncover mechanisms of chemoresistance. (cdc.gov)

Although histone deacetylase (HDAC) inhibitors are known to suppress synovial sarcoma in vitro and in vivo , the exact mechanism is not clear. (nature.com)
Chung JS, Shiue LH, Duvic M, Pandya A, Cruz PD Jr, Ariizumi K: Sézary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface. (exbio.cz)

Oval- to spindle-shaped cells forming a fascicle (hematoxylin and eosin [H&E] stain, high power). (medscape.com)
The stain was scored for intensity and fraction of cells staining. (eurekamag.com)

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)

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