Cancer gene expression profiling. Medical search. Frequent questions

Techniques include DNA microarray technology or sequenced-based techniques such as serial analysis of gene expression (SAGE). (wikipedia.org)
This paper analyzes gene expression datasets from cervical cancer microarray data. (peerj.com)
In this study, we examine gene expression changes through microarray analysis in spheroid versus monolayer ovarian cancer cells treated with TGFβ to induce EMT. (usf.edu)
Prediction of outcome of advanced cervical cancer to thermoradiotherapy according to expression profiles of 35 genes selected by cDNA microarray analysis. (uchicago.edu)
Among these, microarray-based assays have the advantage of simultaneously evaluating the gene expression pattern of thousands of genes. (biomedcentral.com)
The Pathwork ® Tissue of Origin Test (Pathwork Diagnostics, Redwood City, CA, USA) for frozen specimens uses microarray technology to measure the gene expression pattern, comprising 1550 genes, of a tumor with an uncertain origin and compares it to expression patterns of a panel of 15 known tumor types. (biomedcentral.com)
Predicting continuous values of prognostic markers in breast cancer from microarray gene expression profiles. (lu.se)
Bovine mammary gene expression profiling using a cDNA microarray enhanced for mammary-specific transcripts. (sutterhealth.org)
In the present study, we use mRNA microarray to acquire differential expression profiles in human TAD tissues and non-TAD tissues. (hindawi.com)
Then we downloaded another microarray dataset GSE52093 [ 9 ] and screened out the coexpression of differentially expressed genes (DEGs) between TAD patients and non-TAD patients. (hindawi.com)
Microarray technology and next-generation sequencing methods have enabled us to see all of the genes expressed by a given cell type at any particular time, or under a particular circumstance. (genengnews.com)

Hypergeometric analysis was used to identify canonical pathways and curated networks having statistically significant enrichment of differentially expressed genes. (urotoday.com)
The two expression profile datasets were integrated and we found out coexpression of differentially expressed genes (DEGs) using bioinformatics methods. (hindawi.com)
With the development of the gene expression profile, comparisons of differentially expressed genes that participate in the regulation of pathophysiological conditions in pathological tissue and normal tissue were available and convenient, and mRNAs gene expression profiles have been carried out in many diseases including TAD [ 6 ]. (hindawi.com)
Based on differentially expressed genes, possible mechanisms of SWCNT-associated apoptosis resistance and oncogenesis were identified, which included activation of pAkt/p53/Bcl-2 signaling axis, increased gene expression of Ras family for cell cycle control, Dsh-mediated Notch 1, and downregulation of apoptotic genes BAX and Noxa. (cdc.gov)

We observed a different trend of regulation in terms of BCL2 family gene expression and global gene expression profile including genes reported to be expressed in cancer stem cells. (lu.se)

In the context of cancer, gene expression profiling has been used to more accurately classify tumors. (wikipedia.org)
Presented below are ways that gene expression profiling has been used to more precisely classify tumors into subgroups, often with clinical effect. (wikipedia.org)
To further explore the role of HSF1 in ovarian cancer EMT, we cultured multicellular spheroids in a non-adherent environment to simulate early avascular tumors. (usf.edu)
No staging system exists for cancers of unknown primary origin-more precisely, histologically proven metastatic malignant tumors for which the primary site cannot be identified during pretreatment evaluation. (medscape.com)
The Pathwork ® Tissue of Origin Test (Pathwork Diagnostics, Redwood City, CA, USA) is a gene expression test to aid in the diagnosis of metastatic, poorly differentiated and undifferentiated tumors. (biomedcentral.com)
It measures the expression pattern of 1,550 genes in these tumors and compares it to the expression pattern of a panel of 15 known tumor types. (biomedcentral.com)
Metastatic tumors to the brain are the most common central nervous system (CNS) neoplasm and occur in about 15% of all cancer patients. (biomedcentral.com)
The incidence of adrenocortical tumors in children is extremely low (only 0.2% of pediatric cancers). (oncolink.org)
In the non-Brazilian cases, relatives of children with adrenocortical tumors often, although not invariably, have a high incidence of nonadrenal cancers (Li-Fraumeni syndrome). (oncolink.org)
The test will be used to help doctors locate primary tumors in cancer patients. (genomeweb.com)
As tumors are not conceivable as a single disease, breast cancer with different diagnostic features should differ in the hallmarks controlling their clinical differences. (jcancer.org)
SAN ANTONIO - Should breast cancer patients with low but not negative tumor expression of HER2 be considered a distinct patient group that can be treated differently from patients with tumors that are HER2 negative or HER2 positive? (medscape.com)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

Immunohistochemistry confirmed expression of urokinase plasminogen activator (PLAU), urokinase plasminogen activator receptor (PLAUR), and thrombospondin (THBS1) by alveolar macrophages and airway epithelial cells. (nih.gov)
Osteopontin (OPN) expression was validated by immunohistochemistry. (urotoday.com)
Moreover, zebrafish is very well-suited for systematic analysis of gene expression patterns at transcript level by whole-mount in situ hybridization (WISH), and at protein level by immunohistochemistry/immunofluorescence (IHC/IF). (frontiersin.org)
3. Translational research - to identify predictive biomarkers for treatment decision - by immunohistochemistry, gene expression or sequencing. (lu.se)

Title : Impact of gene expression profiling tests on breast cancer outcomes Personal Author(s) : Marchionni, Luigi, M.D Corporate Authors(s) : Johns Hopkins University, Evidence-based Practice Center. (cdc.gov)
Recommendations from the EGAPP Working Group: Can tumor gene expression profiling improve outcomes in patients with breast cancer? (elsevierpure.com)
Summary of Recommendations: The EGAPP Working Group (EWG) found insufficient evidence to make a recommendation for or against the use of tumor gene expression profiles to improve outcomes in defined populations of women with breast cancer. (elsevierpure.com)
Rationale: The measurement of gene expression in breast tumor tissue is proposed as a way to estimate the risk of distant disease recurrence in order to provide additional information beyond current clinicopathological risk stratification and to influence decisions about treatment in order to improve health outcomes. (elsevierpure.com)
Based on their review of the EGAPP-commissioned evidence report, Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes 1 and other data summaries, the EWG found no direct evidence linking tumor gene expression profiling of women with breast cancer to improved outcomes, and inadequate evidence to construct an evidence chain. (elsevierpure.com)
Dive into the research topics of 'Recommendations from the EGAPP Working Group: Can tumor gene expression profiling improve outcomes in patients with breast cancer? (elsevierpure.com)
Clopidogrel pharmacogenomics: next steps: a clinical algorithm, gene-gene interactions, and an elusive outcomes trial. (sutterhealth.org)
Can tumor gene expression profiling improve outcomes in patients with breast cancer? (cdc.gov)
Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. (cdc.gov)
The gene expression biomarker improved discrimination of outcomes compared to all other systems tested (N? (cdc.gov)

While almost all cells in an organism contain the entire genome of the organism, only a small subset of those genes is expressed as messenger RNA (mRNA) at any given time, and their relative expression can be evaluated. (wikipedia.org)
mRNA from the specimens was profiled using Agilent's Functional ID v2.0 array (Agilent, Santa Clara, CA) containing 23,720 sequences. (nih.gov)
It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). (cancerindex.org)
The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. (cancerindex.org)
Herein we examine the temporal and spatial expression patterns of RPRM gene-products (mRNA and protein) during neural development. (frontiersin.org)
These profiles measure mRNA, not protein, so further studies are needed to corroborate that any detected changes in gene expression actually have meaning in the life of the cell. (genengnews.com)
Using mRNA from total blood leukocytes, they found that a full one-quarter of the human genome exhibits changes in expression levels during the early stages of post-trauma (40-80 hours post-trauma). (genengnews.com)
A potential role for untranslated p53 mRNA in cancer biology. (otago.ac.nz)

Gene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotube s. (cdc.gov)

It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. (cancerindex.org)
The SEPTIN9 gene provides instructions for making a protein called septin-9, which is part of a group of proteins called septins. (medlineplus.gov)
Lysosomal function is critical for organismal homeostasis-mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome. (stanford.edu)
In this study, we observed that the expression of anti-apoptotic BCL2 family genes, such as BCL2, BCL2L1, and MCL1, is highly varied in T-ALL patients, and inhibitors targeting proteins coded by these genes display differential. (lu.se)

Meanwhile, Absolute Assignment of Breast Cancer Intrinsic Molecular Subtypes (AIMS) computational method was trained to predict PAM50-based IBCMS. (aacrjournals.org)
By reviewing biomarkers and breast cancer molecular subtypes, we propose that the divergent outcome observed from patients stratified by hormone status are driven by different cancer hallmarks. (jcancer.org)
Thus, stratification of breast cancer by clinically relevant subtypes is urgently required. (jcancer.org)
Back to 1970s, breast cancer was divided into two subtypes according to the status of estrogen receptor (ER). (jcancer.org)
This review aims at identifying these dominant hallmarks driving breast cancer heterogeneity by focusing on identified biomarkers and the associated subtypes. (jcancer.org)
A pilot study to characterize the transcriptomic phenotype of 11 dogs with multicentric BCL yielded two molecular subtypes distinguished on the basis of genes important in oxidative phosphorylation . (bvsalud.org)

We conducted a study to determine prevalence of HPV types in oropharyngeal cancers in the United States and establish a prevaccine baseline for monitoring the impact of vaccination. (cdc.gov)
Results indicate that vaccines could prevent most oropharyngeal cancers in the United States, but their effect may vary by demographic variables. (cdc.gov)
Oropharyngeal cancers include malignancies that occur where the oral cavity and pharynx merge, including in the palatine and lingual tonsils, the posterior 1/3 (base) of the tongue, the soft palate, and the posterior pharyngeal wall. (cdc.gov)
Supported by evidence that existing vaccines effectively reduce oral HPV infections, these formulations may also reduce incidence of oropharyngeal cancers ( 7 ). (cdc.gov)

The unique pattern of gene expression for a given cell or tissue is referred to as its molecular signature. (wikipedia.org)
The results provide evidence that genes involved in tissue remodeling and repair are differentially regulated in the lungs of obstructed smokers and suggest that they are potential therapeutic targets. (nih.gov)
Hierarchical clustering defined signatures, which differentiated between cancer and healthy tissue, muscle-invasive or non-muscle invasive cancer and healthy tissue, grade 1 and grade 3. (urotoday.com)
Osteopontin was markedly overexpressed in invasive cancer compared to healthy tissue. (urotoday.com)
Can testing of tumor tissue for mutations in EGFR pathway downstream effector genes. (cdc.gov)
The purpose of this study was to evaluate the performance of the Tissue of Origin Test in the diagnosis of primary sites for metastatic brain cancer patients. (biomedcentral.com)
Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis. (nature.com)
According to Agendia, CupPrint uses a gene-expression database of 32 different tissue types and 78 tumor types, and can rapidly determine whether the primary tumor belongs to one of the major categories. (genomeweb.com)
HPV DNA was extracted from tumor tissue samples from patients in whom cancer was diagnosed during 1995-2005. (cdc.gov)
The samples were obtained from cancer registries and Residual Tissue Repository Program sites in the United States. (cdc.gov)

Current cancer research makes use primarily of DNA microarrays in which an arrayed series of microscopic spots of pre-defined DNA oligonucleotides known as probes are covalently attached to a solid surface such as glass, forming what is known as a gene chip. (wikipedia.org)
Here, we further examined the gene expression profile by using genome microarrays to profile molecular mechanisms of SWCNT oncogenesis. (cdc.gov)

Does PCA3 Testing for the Diagnosis and Management of Prostate Cancer. (cdc.gov)
PCA3 testing in the diagnosis and management of prostate cancer based on an evidence review, conducted through the AHRQ Effective Health Care Program (EHC), is being finalized and prepared for peer review. (cdc.gov)

We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
On the right of each survival plot, there are heat maps of the corresponding datasets, and the numbers represent the number of patients in each 20-gene score group. (biomedcentral.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
This study aims at integrating two gene expression profile datasets and verifying hub genes and pathways involved in TAD as well as exploring potential molecular mechanisms. (hindawi.com)

0.05), and these candidate genes could be used as potential diagnostic biomarkers and therapeutic targets of TAD. (hindawi.com)
But even so, gene-expression profiling can be enormously valuable in finding biomarkers, highlighting druggable targets, revealing the metabolic pathways important in a biological process, and identifying subsets of a population that might respond to a certain therapy or be more susceptible to a certain clinical outcome. (genengnews.com)
Besides estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, novel biomarkers have shown their prognostic and predictive values, complicating our understanding towards to the heterogeneity of such cancers. (jcancer.org)

DNA labeled with fluorophores (target) is prepared from a sample such as a tumor biopsy and is hybridized to the complementary DNA (cDNA) sequences on the gene chip. (wikipedia.org)
The level of fluorescence at a particular spot provides quantitative information about the expression of the particular gene corresponding to the spotted cDNA sequence. (wikipedia.org)

Survival curves for good prognosis (orange line) and poor prognosis (grey line) breast cancer patients according to 70-gene and 76-gene prognosis profiles are showed ( a and b , respectively). (biomedcentral.com)
However, for patients with a KMT2A rearrangement (KMT2A-r), the prognosis appears to depend on the fusion partner gene rather than the karyotype structure. (cancerindex.org)
1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)
Based on this, genes associated with better or worse prognosis can thus be chalked out as predictors of treatment response and potential resistance. (news-medical.net)

Monitoring changes in the immune profile in blood samples can help identifying changes in tumor biology and therapy responsiveness over time. (eur.nl)
Immune-related gene expression profiles offer a highly reproducible method to monitor changes of the immune system. (eur.nl)
The aim of this study was to determine the differences in immune-related gene expression between RNA isolated from stabilized whole blood and RNA isolated from PBMCs. (eur.nl)
Subsequently, immune-related gene expression was profiled using the PanCancer Immune Profiling Panel of NanoString technology. (eur.nl)
Furthermore, reverse causality remains a concern since pulmonary symptoms may be early manifestations of lung cancer or acquired lung diseases in patients whose immune system has already been compromised by undiagnosed cancer. (nature.com)
However, the relation between SEPTIN9 gene mutations and immune function is unclear. (medlineplus.gov)
Activating invasion and metastasis' and 'evading immune destruction' drive the differentiation of triple negative breast cancers. (jcancer.org)
2) Stromal and immune interactions in colorectal cancer. (qub.ac.uk)

The reviewer also asked question about gene set enrichment analysis, which I believe is written slightly confusing way. (peerj.com)
Gene set enrichment analysis (GSEA) showed enrichment of cytokine signaling in all three cell lines which was supported by the phospho-kinase array where STAT5 phosphorylation was found to be elevated in resistant cells. (lu.se)

Does the diagnosis of breast or ovarian cancer trigger referral to genetic counseling? (sutterhealth.org)
He is also working in the DECAMP consortium (Detection of Early Cancer Among Military Personnel) which aims to improve the early diagnosis of lung cancer in veterans via biomarker validation and development. (bu.edu)

Overall, our analyses provide novel opportunities for the normalisation of genome-wide expression profiling data. (biorxiv.org)

In spite of a number of epidemiological and intervention studies, little or no correlation between VE intake and incidence of cancer has been found. (nature.com)
Gene-environment correlation: difficulties and a natural experiment-based strategy. (sutterhealth.org)
We examine the genetic correlation between pulmonary function phenotypes and lung cancer, followed by Mendelian randomization (MR) using novel genetic instruments to formally test the causal relevance of impaired pulmonary function, using the largest available dataset of 29,266 lung cancer cases and 56,450 controls from the OncoArray lung cancer collaboration 16 . (nature.com)

Gene expression profiling is a technique used in molecular biology to query the expression of thousands of genes simultaneously. (wikipedia.org)

abstract = "The association between Human Papillomavirus (HPV) DNA and oropharyngeal squamous cell carcinoma (SCC) has been supported by numerous studies strongly implicating HPV infection as a factor in the development of this cancer. (elsevierpure.com)
From the abstract: 'Using a discovery cohort of 173 meningiomas, we developed a 34-gene expression risk score and performed clinical and analytical validation of this biomarker on independent meningiomas from 12 institutions across 3 continents (N? (cdc.gov)
From the abstract: ' In 2021, the American College of Medical Genetics and Genomics (ACMG) recommended reporting actionable genotypes in 73 genes associated with diseases for which preventive or therapeutic measures are available. (cdc.gov)

It took me a long time to appreciate just how extensively population heterogeneity and other unmeasured sources of variation introduce unwanted and systematic biases into the statistical analysis of gene-expression studies," Dr. Storey noted. (genengnews.com)
This review novels in its global view on breast cancer heterogeneity, which clarifies many confusions in this field and contributes to precision medicine. (jcancer.org)
This, on one hand, helps us in more accurate disease management, but, on the other hand, complicates our understanding towards breast cancer heterogeneity. (jcancer.org)
Gene expression profiling has revealed molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) in both humans and dogs . (bvsalud.org)

Conclusions: Transcriptomic profiling identifies patients with an excellent outcome without any systemic adjuvant therapy in clinically low-risk patients of the SweBCG91-RT and METABRIC cohorts. (lu.se)

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

Of note, similar gene expression patterns associated with metastatic behaviour of breast cancer tumor cells have also been found in breast cancer of dog, the most common tumor of the female dog. (wikipedia.org)
Metastatic adenocarcinoma presenting as isolated axillary lymphadenopathy in women is usually a manifestation of an occult breast primary cancer . (medscape.com)
Metastatic brain cancers are the most common intracranial tumor and occur in about 15% of all cancer patients. (biomedcentral.com)
This test could be a very useful tool for pathologists as they classify metastatic brain cancers. (biomedcentral.com)

The cells forming this mass undergo natural selection: as cells acquire mutations that enhance their survivability or reproductive capacity, they dominate the growing tumor as other cells are out-competed (see: somatic evolution in cancer). (wikipedia.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Hara Levy, professor of physiology at the Human and Molecular Genetics Center of the Medical College of Wisconsin, studies cystic fibrosis (CF). Although CF is caused by mutations in the CF transmembrane conductance regulator gene, patients with identical genetic mutations in this gene can suffer variable levels of lung disease severity. (genengnews.com)
A few SEPTIN9 gene mutations have been identified in individuals with hereditary neuralgic amyotrophy, a disorder characterized by episodes of severe pain and muscle wasting (amyotrophy) in the shoulders and arms. (medlineplus.gov)

Thus, a precise characterization of KMT2A-r and the fusion partner genes, especially in CKs, is of interest for managing AML. (cancerindex.org)

1) Molecular subtyping in colorectal cancer. (qub.ac.uk)
Genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives. (cdc.gov)

Cancer is a category of disease characterized by uncontrolled cell growth and proliferation. (wikipedia.org)
Pathways associated with cell cycle and proliferation were markedly upregulated in muscle-invasive and grade 3 cancers. (urotoday.com)
The proteotoxic stress-responsive transcription factor HSF1 is frequently overexpressed in a variety of cancers and is vital to cellular proliferation and invasion in some cancers. (usf.edu)
The altered gene expression may enhance several cancer-related events such as cell division (proliferation), cell movement, and the development of new blood vessels (angiogenesis) that nourish a growing tumor. (medlineplus.gov)
Lymphoma, a type of blood cancer, results from the uncontrolled proliferation of lymphocytes. (news-medical.net)

Classification of cancers has been dominated by the fields of histology and histopathology which aim to leverage morphological markers for accurate identification of a tumor type. (wikipedia.org)
Resisting cell death', 'genome instability and mutation' and 'deregulating cellular energetics' refine breast cancer classification with their predictive values. (jcancer.org)
Evading growth suppressors', 'enabling replicative immortality', 'inducing angiogenesis' and 'tumor-promoting inflammation' have not been involved in breast cancer classification which need more focus in the future biomarker-related research. (jcancer.org)

2004. Pesticides and lung cancer risk in the agricultural health study cohort. (cdc.gov)
The current results indicated that B[a]P seems to induce EMT in lung cancer cells, and it also may drive disease progression in patients with lung cancer. (nih.gov)
Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. (nature.com)
Mendelian randomization analyses demonstrate that reduced FEV 1 increases squamous cell carcinoma risk (odds ratio (OR) = 1.51, 95% confidence intervals: 1.21-1.88), while reduced FEV 1 /FVC increases the risk of adenocarcinoma (OR = 1.17, 1.01-1.35) and lung cancer in never smokers (OR = 1.56, 1.05-2.30). (nature.com)
These findings support a causal role of pulmonary impairment in lung cancer etiology. (nature.com)
Lung cancer is the most commonly diagnosed cancer worldwide and the leading cause of cancer mortality 1 . (nature.com)
Lung cancer and obstructive pulmonary disease share multiple etiological factors, such as cigarette smoking, occupational inhalation hazards, and air pollution, and 50-70% of lung cancer patients present with co-existing COPD or airflow obstruction 6 . (nature.com)
Disentangling the role of pulmonary impairment in lung cancer development is important from an etiological perspective, for refining disease susceptibility mechanisms, and for informing precision prevention and risk stratification strategies. (nature.com)
In this study we comprehensively assess the shared genetic basis of impaired lung function and lung cancer risk by conducting genome-wide association analyses in the UK Biobank cohort to identify genetic determinants of three pulmonary phenotypes, forced expiratory volume in 1s (FEV 1 ), forced vital capacity (FVC), and FEV 1 /FVC. (nature.com)
Many melanoma and lung cancer patients frequently show dramatic responses when treated with targeted therapies (kinase inhibitors). (otago.ac.nz)
The impact of KRAS expression levels on the emergence of drug tolerance in lung cancer. (otago.ac.nz)

The generality of induction of Two major issues faced when city in humans is clear, but in other and response to radiation damage studying radiation carcinogenesis is cases the data are few or non-exist- is discussed for all types of ionizing that radiation-induced cancers are ent. (who.int)

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer of lymphocytes, and a large proportion of patients are either unresponsive or develop resistance towards R-CHOP-the standard treatment regimen. (news-medical.net)
Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation. (bvsalud.org)

Most telling perhaps is that 70-80% of breast cancer patients receiving chemotherapy based on traditional predictors would have survived without it. (wikipedia.org)
Background Intrinsic breast cancer molecular subtyping (IBCMS) provides significant prognostic information for patients (pts) with breast cancer (BC) treated with chemotherapy, human epidermal growth factor receptor 2 (HER2) targeted therapies, and endocrine therapies (ETs). (aacrjournals.org)
Some patients with breast cancer develop local recurrence after breast-conservation surgery despite postoperative radiotherapy, while others remain free of local recurrence even in the absence of radiotherapy. (lu.se)
A highly distinct gene-expression profile for patients developing local recurrence after breast-conservation surgery despite radiotherapy has been identified. (lu.se)
Using DNA microarrrays containing ∼8,000 genes, we profiled breast cancer samples from 81 patients, including 37 with IBC and 44 with noninflammatory breast cancer (NIBC). (figshare.com)
For one test, the EWG found preliminary evidence of potential benefit of testing results to some women who face decisions about treatment options (reduced adverse events due to low risk women avoiding chemotherapy), but could not rule out the potential for harm for others (breast cancer recurrence that might have been prevented). (elsevierpure.com)
Adiposity, inflammation, genetic variants and risk of post-menopausal breast cancer findings from a prospective-specimen-collection, retrospective-blinded-evaluation (PRoBE) design approach. (sutterhealth.org)
Early diffusion of gene expression profiling in breast cancer patients associated with areas of high income inequality. (sutterhealth.org)
Higher absolute lymphocyte counts predict lower mortality from early-stage triple-negative breast cancer. (sutterhealth.org)
Agendia currently markets a similar product called MammaPrint in Europe and the US that is used in diagnosing breast cancer recurrence. (genomeweb.com)
Increased production of particular isoforms of the septin-9 protein has been associated with breast and prostate cancers. (medlineplus.gov)
High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes. (medlineplus.gov)
Breast cancer is a complex disease encompassing multiple tumor entities, each characterized by distinct morphology, behavior and clinical implications. (jcancer.org)
Breast cancer is the most common neoplasm among women in the majority of the developed countries, accounting for one-third of newly diagnosed malignancies [ 1 ]. (jcancer.org)
HER2 Low Breast Cancer: New Clinical Entity or Testing Artifact? (medscape.com)
That was the question posed during a session at the recent San Antonio Breast Cancer Symposium (SABCS) 2022. (medscape.com)
He explained that it is not a clearcut question as to whether HER2 expression in breast cancer is either positive or negative, with the former implying some expression and the latter none at all. (medscape.com)
He admitted that, while there have been many studies, the majority have found no overall survival difference between breast cancer patients whose disease could be classified as HER2 low as opposed to HER2 negative or zero. (medscape.com)
This difference was primarily driven by HR-negative breast cancer patients who did not achieve a pathologic complete response (pCR), Curigliano noted. (medscape.com)
There was a 2% difference in 5-year overall survival among patients with advanced triple-negative breast cancer. (medscape.com)
Purpose: There is currently no molecular signature in clinical use for adjuvant endocrine therapy omission in breast cancer. (lu.se)
Experimental Design: We performed a whole-transcriptome analysis of SweBCG91-RT, a randomized phase III trial of ± radiotherapy after breast-conserving surgery for node-negative stage I-IIA breast cancer. (lu.se)
In a clinically low-risk subgroup of the METABRIC cohort not treated with systemic therapy, no breast cancer death occurred among the MET141 low-risk patients. (lu.se)

Each dataset was divided in three groups of patients depending on the 20-gene score, and the survival of each group was represented in Kaplan-Meier curves. (biomedcentral.com)
Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). (oncolink.org)
Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. (oncolink.org)
Together with Dr Cath Drummond, I am investigating the ability of cancer cells to shift to drug-tolerant states, allowing their initial survival - and eventual resistance - following treatment with targeted therapies. (otago.ac.nz)
Mesothelioma is a rare but very aggressive cancer with one of the lowest 5-year survival rates. (otago.ac.nz)
Therapy resistance remains one of the major challenges for cancer treatment that largely limits treatment benefits and patient survival. (lu.se)

Anonymous Reviewer ( 2018 ) Peer Review #2 of 'Integrative machine learning analysis of multiple gene expression profiles in cervical cancer (v0.3)' . (peerj.com)
Wong K ( 2018 ) Peer Review #1 of 'Integrative machine learning analysis of multiple gene expression profiles in cervical cancer (v0.2)' . (peerj.com)
The 2 HPV vaccines approved by the US Food and Drug Administration protect against infection with HPV-16 and HPV-18, which are the high-risk types most frequently associated with cervical cancer. (cdc.gov)

Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. (usf.edu)
In order to determine the role of HSF1 in ovarian cancer, inducible HSF1 knockdown cell lines were created. (usf.edu)
Knockdown of HSF1 in SKOV3 and HEY ovarian cancer cell lines attenuates the epithelial-tomesenchymal transition (EMT) in cells treated with TGFβ, as determined by western blot and quantitative RT-PCR analysis of multiple EMT markers. (usf.edu)
These findings suggest that HSF1 is important in the ovarian cancer TGFβ response and in EMT. (usf.edu)

Interestingly, both TGF-beta1 and SERPINE2 have been identified as candidate genes in COPD genetic linkage and association studies. (nih.gov)

Genes in this pathway have been shown to be involved in the activation of transforming growth factor (TGF)-beta1 and matrix metalloproteinases and are subject to inhibition by SERPINE2. (nih.gov)
Genes associated with the classical complement pathway were downregulated in non-muscle invasive cancer. (urotoday.com)
Gene expression profiling in kidney cancer: combining differential expression and chromosomal and pathway analyses. (uchicago.edu)
The gene ontology and pathway enrichment of DEGs were performed by DAVID and Kyoto Encyclopedia of Genes and Genomes online analyses, respectively. (hindawi.com)
Traditional bioinformatics methods including gene ontology (GO) and pathways enrichment analyses of DEGs combined protein-protein interaction (PPI) network and cytohubber calculating software as well as Molecular Complex Detection (MCODE) analysis were used to analyze the key gene and pathway. (hindawi.com)

This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
This gene encodes a protein with protease activity and is expressed in the placenta. (cancerindex.org)
However, measuring gene expression profiles in whole blood samples can be complicated because of the high protein and enzyme abundancy that affect the stability and quality of the RNA. (eur.nl)
Importantly, a precise temporal description of RPRM protein expression during the development of neuronal structures is still missing. (frontiersin.org)
Approximately 15 slightly different versions (isoforms) of the septin-9 protein may be produced from this gene. (medlineplus.gov)
The expression of the anti-apoptotic protein BCL2 has been shown to be deregulated in T-cell acute lymphoblastic leukemia (T-ALL), where different T-ALL cells display a differential response to the BCL2-specific inhibitor venetoclax. (lu.se)

These results show the potential of gene expression profiling to contribute to a better understanding of IBC, and to provide new diagnostic and predictive factors for IBC, as well as for potential therapeutic targets. (figshare.com)
Agendia said that it had used Arcturus' profile to create a gene expression-based diagnostic test called CupPrint. (genomeweb.com)

Despite advances in management, bladder cancer remains a major cause of cancer related complications. (urotoday.com)
Characterisation of gene expression patterns in bladder cancer allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. (urotoday.com)
The present study contributes to a growing body of work on gene expression signatures in bladder cancer. (urotoday.com)
The data support an important role for osteopontin in bladder cancer, and identify several pathways worthy of further investigation. (urotoday.com)
Urodrill - a novel MRI-guided endoscopic biopsy technique to sample and molecularly classify muscle-invasive bladder cancer without fractionating the specimen during transurethral resection. (lu.se)

Alterations in the activity (expression) of the SEPTIN9 gene are associated with certain cancers. (medlineplus.gov)
Dr. Billatos is investigating gene expression alterations in the bronchial airway associated with acute exposure to tobacco cigarettes. (bu.edu)

The expression profile of CIS cells was compared with microdissected gonocytes, oogonia, and cultured embryonic stem cells with and without genomic aberrations. (ku.dk)
Does genomic profiling to assess Type 2 Diabetes risk improve. (cdc.gov)
In this genomic age, one possible answer is that a cell can be defined by a profile of all of the genes it is expressing. (genengnews.com)
We calculated 15 transcriptomic signatures from the literature and combined them into an average genomic risk, which was further used to derive a novel 141-gene signature (MET141). (lu.se)
Single -gene genomic applications, such as cascade testing for Lynch syndrome, have a potential effect in cancer prevention in high-risk families (5). (cdc.gov)

As clinical parameters are insufficient for identifying these two groups of patients, we investigated if gene-expression profiling would add further information. (lu.se)
One third of patients with cancer of unknown primary origin have poorly or undifferentiated carcinoma. (medscape.com)
A similar approach, with leave-one-out cross-validation, identified an 85-gene set that divided IBC patients with significantly different pathological complete response rate (70% in one group and 0% in the other group). (figshare.com)
Whole blood samples from 12 pancreatic cancer patients were collected before and after chemotherapy (n = 24). (eur.nl)
In the Brazilian cases, the patients' families do not exhibit a high incidence of cancer, and a single, unique mutation at codon 337 in exon 10 of the TP53 gene is consistently observed. (oncolink.org)
At the "Critical Assessment of Massive Data Analysis" conference held recently in Vienna, John Storey, from the Lewis-Sigler Institute for Integrative Genomics at Princeton University, gave a talk on dissecting the inflammatory complications in critically injured patients by within-patient gene-expression changes. (genengnews.com)
his statistical challenge in this study was to correlate gene expression over multiple time points, in multiple patients, with multiple and different clinical presentations. (genengnews.com)
While the major signaling pathways that contribute to DLBCL have been uncovered, variations in the genes involved in these pathways can differentially impact treatment response, suggesting that one treatment may not benefit all patients. (news-medical.net)
Given the unique trial design of SweBCG91-RT, where adjuvant endocrine and chemotherapy were largely unadministered, we sought to evaluate the potential of transcriptomic profiling for identifying patients who may be spared adjuvant endocrine therapy. (lu.se)
Results: In SweBCG91-RT, 454 patients were node-negative, postmenopausal, and systemically untreated with ER-positive, HER2-negative cancers, which constitutes a low-risk subgroup and potential candidates for therapy omission. (lu.se)

This gene-expression profile provides substantially added value to conventional clinical markers, e.g., age, histological grade, and tumor size in predicting local recurrence despite radiotherapy. (lu.se)

10% HER2 expression is deemed negative as long as the result of immunohistochemical staining is weak and incomplete or the result of in situ hybridization (ISH) is negative. (medscape.com)

The information derived from gene expression profiling often helps in predicting the patient's clinical outcome. (wikipedia.org)
Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GA, UK. (urotoday.com)
We describe the clinical and molecular features of a child who presented with a large abdominal mass, AML, and a new CK, involving chromosomes 11, 16, and 19 leading to a KMT2A-MLLT1 fusion and 2 extra copies of the ELL gene, thus resulting in the concurrent overexpression of MLLT1 and ELL. (cancerindex.org)
Researchers around the globe are harnessing gene-expression profiling studies in a variety of clinical settings to prevent and treat a number of diseases. (genengnews.com)
His innovation was to correlate the within-patient change in gene expression with the severity of the clinical outcome, rather than using absolute expression values as has traditionally been done. (genengnews.com)
By measuring the change in expression within each patient, regardless of the patient's baseline values, this method leads more easily to a clinical translation of the results. (genengnews.com)
Two leading clinicians debated whether the differences between the three groups have clinical relevance or whether the degree of HER2 expression is merely a marker for other disease processes. (medscape.com)
Clinical Cancer Research , 26 (1), 171-182. (lu.se)

We also study how these pathways go awry in human diseases such as cancer, neurodegeneration and metabolic syndrome, in order to engineer new therapeutic modalities. (stanford.edu)

Institute of Bioengineering and Swiss Institute for Experimental Cancer Research, School of Life Sciences, ωcole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. (jci.org)

In particular, with some exceptions such as olfactory receptors and genes involved in keratin production, transporter genes are significantly more heterogeneously expressed than are most non-transporter genes. (biorxiv.org)
these often differ significantly from the 'housekeeping' genes commonly used for normalisation in transcriptomics and qPCR studies. (biorxiv.org)
In addition, 192/730 genes showed significantly higher gene counts in Tempus samples, 157/730 genes showed higher gene counts in PBMCs. (eur.nl)

Gene expression was related to forced expiratory flow between 25 and 75% of forced expiratory volume (FEF(25-75%) % predicted) revealing a signature gene set of 203 transcripts. (nih.gov)

Unique expression patterns for these developmentally very related cell types revealed that CIS cells were very similar to gonocytes because only five genes distinguished these two cell types. (ku.dk)
Our results demonstrate that HPV-positive oropharyngeal tumours displayed gene expression patterns indicative of a viral signature and that HPV-negative oropharyngeal tumours do not display similar expression patterns. (elsevierpure.com)
Thus, we provide a reference dataset describing the expression patterns of RPRM gene products during zebrafish and mouse development as a first step to approach the physiological role of the RPRM gene family. (frontiersin.org)

Comprehensive Cancer Control (CCC) is a collaborative community-based approach that uses an "integrated and coordinated approach to reduce cancer incidence, morbidity, and mortality" (1). (cdc.gov)

R-CHOP has even been reported to activate certain oncogenes (genes that can cause cancer) and favor a specific subset of cells also referred to as sub-clonal populations. (news-medical.net)

We apply this knowledge to understand how lysosomal dysfunction leads to human diseases including neurodegeneration, cancer and metabolic syndrome. (stanford.edu)

Anatomy17

Organisms9

Diseases37

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment66

Phenomena and Processes76

Disciplines and Occupations6

Information Science9

Health Care14

Microarray11

Differentially expressed genes4

Regulation1

Tumors13

Immunohistochemistry4

Outcomes10

MRNA8

Epithelial cells1

Proteins4

Subtypes6

Oropharyngeal cancers4

Tissue10

Microarrays2

Prostate Cancer2

Datasets4

Biomarkers3

CDNA2

Prognosis4

Immune8

Enrichment analysis2

Diagnosis2

Genome-wide expression1

Correlation3

Thousands of genes1

Abstract3

Heterogeneity4

Identifies1

Differentiation1

Metastatic4

Mutations4

Characterization1

Colorectal Cancer2

Proliferation5

Classification3

Lung11

Humans1

Lymphoma2

Breast23

Survival6

Cervical3

Ovarian cancer4

Candidate genes1

Pathway5

Protein7

Diagnostic2

Bladder cancer5

Alterations2

Genomic5

Patients10

Recurrence1

Situ Hybridization1

Clinical8

Therapeutic1

Life sciences1

Significantly3

Transcripts1

Patterns3

Morbidity and morta1

Subset1

Diseases1