AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
GenomicsEarly Detection of CancerGene Expression ProfilingProstatic NeoplasmsOvarian NeoplasmsBreast NeoplasmsLung NeoplasmsStomach NeoplasmsColonic NeoplasmsNeoplasmsComputational BiologyDatabases, GeneticNeoplasm MetastasisOligonucleotide Array Sequence AnalysisNeoplasm InvasivenessGene Expression Regulation, NeoplasticPancreatic NeoplasmsSequence Analysis, DNAGenetic Predisposition to DiseaseMice, NudeGenome, BacterialCancer VaccinesNeoplasm ProteinsGenomeMutationMolecular Sequence DataUterine Cervical NeoplasmsPhylogenySurvival AnalysisReverse Transcriptase Polymerase Chain ReactionEvolution, MolecularPrognosisAntineoplastic AgentsSurvival RateSoftwareRNA, MessengerCell Line, TumorInternetDisease ProgressionDrug Resistance, NeoplasmAntineoplastic Combined Chemotherapy ProtocolsGenome, PlantCarcinomaUrinary Bladder NeoplasmsCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellGenome, HumanNational Cancer Institute (U.S.)United StatesRiskTumor Markers, BiologicalColorectal NeoplasmsBase SequenceFollow-Up StudiesRetrospective StudiesRisk AssessmentReceptors, EstrogenProteomicsRegistriesXenograft Model Antitumor AssaysIndividualized MedicineGenotypeProspective StudiesAlgorithmsPhenotypeRNA, Small InterferingNeoplasm StagingExpressed Sequence TagsSurvivorsReceptor, erbB-2Chromosome MappingRectal NeoplasmsUser-Computer InterfaceNeoplasm Recurrence, LocalCell Transformation, NeoplasticBlotting, WesternDNA, NeoplasmDNA MethylationPolymorphism, GeneticRNA InterferenceGenetic VariationNeoplasm TransplantationDisease-Free SurvivalCombined Modality TherapyProstate-Specific AntigenSensitivity and SpecificityReproducibility of ResultsEndometrial NeoplasmsOdds RatioAge FactorsMedical OncologyCell SurvivalModels, BiologicalPolymerase Chain ReactionTumor Suppressor Protein p53Cluster AnalysisSmokingMolecular Sequence AnnotationChemotherapy, AdjuvantPromoter Regions, Genetic
2019Public Health GGeneticsGeneGenomicMutationsTranslational GenomicsClinical2020GenomesColorectalGenesPathwaysAimsLaboratoryBioinformaticsMutationAnalysesLund UniversityTranscriptomicsTumorsMolecularOvarian and breastAdvances2002ResearchTumorCommon cancersLiver cancersPatientsOutcomesDetectionLung CancerTherapeuticsCentre2022MethodsPancreaticMutationalProgressionDiagnosticsMelanomaProstateDataLethalPreventionHeterogeneityMorbidityHereditaryMRNABiopsyBreast
20193
Public Health G1
Genetics4
  • In contrast to genetics, which refers to the study of individual genes and their roles in inheritance, genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. (wikipedia.org)
  • Colorectal cancer disparities reflect a complex interplay of biology, genetics, behaviors, and social determinants of health ( 1 ). (aacrjournals.org)
  • Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. (genomeweb.com)
  • Over the past 20 years, the scientific understanding of cancer related genetics has greatly improved. (biomedcentral.com)
Gene35
  • The resulting comprehensive gene expression surveys lead to the identification of new genes and pathways with importance in cancer development and progression, or as targets for new therapies. (karger.com)
  • The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. (nih.gov)
  • Background: Breast cancer is a heterogeneous disease that can be subdivided on the basis of histopathological features, genetic alterations, and gene-expression profiles. (cancerindex.org)
  • PTEN gene is considered an established tumor suppressor gene in different types of cancer including breast cancer. (cancerindex.org)
  • Although gene changes may increase some people's risk of developing breast cancer, environment and lifestyle are also important factors. (medicalnewstoday.com)
  • Men with these gene changes also have a 7% lifetime risk of developing breast cancer and a higher risk of developing prostate cancer . (medicalnewstoday.com)
  • People with a faulty PALB2 gene have a 33-58% lifetime risk of developing breast cancer. (medicalnewstoday.com)
  • Researchers have also linked changes in this gene to an increase in the risk of ovarian cancer. (medicalnewstoday.com)
  • If the gene changes, it increases the likelihood of developing breast cancer. (medicalnewstoday.com)
  • If a person inherits just one faulty copy of this gene, their risk of developing breast cancer increases. (medicalnewstoday.com)
  • Researchers have linked changes in this gene to many types of cancer, including breast cancer. (medicalnewstoday.com)
  • A change in this gene causes hereditary gastric cancer and increases the risk of breast cancer. (medicalnewstoday.com)
  • People with a change in the NF1 gene will likely develop breast cancer at some point in their lives. (medicalnewstoday.com)
  • The researchers noted that changes in the RAD51D gene increased the risk of ER-negative cancer, while changes in CHEK2 , ATM , ERCC3 , and FANCC carry a moderate risk of ER-positive cancer. (medicalnewstoday.com)
  • If there is a fault in the RECQL gene, there is a moderate risk of all types of breast cancer. (medicalnewstoday.com)
  • A genetic counselor can organize a blood test to analyze the person's DNA for gene changes that could increase their risk of breast cancer. (medicalnewstoday.com)
  • Transient receptor potential (TRP) channels contribute to the regulation of intracellular calcium, which can promote cancer hallmarks in cases of dysregulation of gene transcription and calcium-dependent pro-proliferative or anti-apoptotic mechanisms. (dovepress.com)
  • Transcription factors (TFs) drive gene expression programs that shape specific phenotypes [ 3 ], and are frequently dysregulated in cancer [ 4 ]. (aging-us.com)
  • Correspondingly, most cancer signaling pathways seem to converge on one or more TFs, termed "master regulators" (MRs) [ 4 ], which direct tumor development, progression, and metastasis through hierarchical control of gene expression patterns. (aging-us.com)
  • Gene Ontology (GO), KEGG, and cancer genomics analyses were performed to identify significant functions, pathways, and the associations of differentially expressed mRNAs. (jcancer.org)
  • Projects focused on early detection of Lung Cancer through gene network analysis. (unibo.it)
  • This study aimed to investigate the role of DNA damage repair gene polymorphisms in the risk of lung cancer. (jcancer.org)
  • Moreover, excision repair cross-complementing group 1 gene ( ERCC1 ) rs3212986 GG homozygosity and rs11615 T allele were associated with a higher risk of developing non-small cell lung cancer (NSCLC) in the Polish population [ 10 ]. (jcancer.org)
  • ERCC2 rs13181 and ERCC1 rs3212986 SNPs have an elevated association with lung cancer risk [ 2 , 11 ], while the O6-methylguanine-DNA methyltransferase gene SNP rs12917 is associated with an increased risk of lung cancer [ 12 ]. (jcancer.org)
  • Within several European countries and the US, patients diagnosed with a potentially hereditary cancer or with a strong family history can receive genetic counselling and testing to establish whether they have an inherited cancer gene mutation. (biomedcentral.com)
  • MED-C took on renewed importance when MOLDX issued a revised lung cancer gene panel LCD in September 2016. (discoveriesinhealthpolicy.com)
  • We recently discovered new ways the BRCA1 gene functions which could help expand our understanding of the development of ovarian and breast cancers. (birmingham.ac.uk)
  • Ovarian cancer G protein-coupled receptor1 inhibits A549 cells migration through casein kinase 2α intronless gene and neutral endopeptidase BMC Cancer. (manipuruniv.ac.in)
  • Pan-cancer analysis of copy number changes in programmed death-ligand 1 (PD-L1, CD274) - associations with gene expression, mutational load, and survival. (uni-heidelberg.de)
  • I address these questions in two steps: firstly, I discuss epistemological implications of the development of Genomics, understood as a data-intensive science, by delving into the theoretical commitments of the concept of gene and the notion of circular causality. (bvsalud.org)
  • The Database of Chromosome Aberrations and Gene Fusions in Cancer, established in 1980, is an attempt to register systematically all published cytogenetic aberrations reported in cancer, including patient and tumor characteristics, gene fusions identified by cytogenetics or massively parallel sequencing, and studies pertaining to the clinical relevance of cytogenetic aberrations and/or gene rearrangements. (lu.se)
  • The database represents a unique international resource that enables clinicians to quickly find relevant information on cytogenetic aberrations and gene fusions in cancer and relate the findings to clinical data, in particular the diagnostic and prognostic significance of specific cytogenetic/genomic changes. (lu.se)
  • Mitelman F, Johansson B, Mertens F, Schyman T, Mandahl N. Cancer chromosome breakpoints cluster in gene-rich genomic regions. (lu.se)
  • Mitelman F. Cancer gene fusions detected by massive parallel sequencing. (lu.se)
  • Mertens F, Johansson B, Fioretos T, Mitelman F. The emerging complexity of gene fusions in cancer. (lu.se)
Genomic15
  • The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group † recommends that persons with newly diagnosed colorectal cancer be offered genetic testing for Lynch syndrome to reduce morbidity and mortality in their close relatives ( 10 ). (cdc.gov)
  • In their article, Myer and colleagues ( 2 ) extend our understanding of biological features contributing to colorectal cancer disparities by presenting genomic profiling results of colorectal adenocarcinomas from 5,301 individuals of African ancestry and 33,770 individuals with ≥50% African and European admixture. (aacrjournals.org)
  • Somatic mutations in cancer cells affect various genomic elements disrupting important cell functions. (biomedcentral.com)
  • Dr. Bild's research program focuses on cancer, and uses large-scale translational genomic and pharmacological studies to interrogate and treat tumor heterogeneity and evolution to refractory states. (cityofhope.org)
  • With clinician collaborators, Dr. Bild's team has initiated and carried out multiple clinical trials that use systems biology and genomic characterization of patient tumors to prevent cancer resistance and progression. (cityofhope.org)
  • Bild's research program focuses on cancer and rare diseases, and uses large-scale translational genomic, systems biology and pharmacological studies to interrogate and treat human disease. (cityofhope.org)
  • With the rise of personalized medicine, and rapid advances in genomic sequencing technology and diagnostic testing, healthcare providers and consumers have an increased need for accurate information about genetic testing, genomics, and heritable conditions. (csms.org)
  • June 27, 2023, Irvine, California - Helio Genomics, a leading developer of genomic AI early cancer detection tests, is proud to announce that its sister company, Laboratory for Advanced Medicine & Health Group (LAMH) ( https://www.lamoncogroup.cn/en/ ), has received approval from the National Medical Products Administration (NMPA) in China for its groundbreaking cfDNA liver cancer detection test. (imanetwork.org)
  • LAMH's unique product offers immense promise for early diagnosis of hepatocellular carcinoma, the most common form of liver cancer, leveraging state-of-the-art genomic technology. (imanetwork.org)
  • LAMH is a sister company of Helio Genomics, specializing in the development of innovative genomic solutions. (imanetwork.org)
  • With a focus on early cancer detection, Helio Genomics aims to leverage genomic insights to enhance patient outcomes across diverse populations. (imanetwork.org)
  • 2 - 4 Expression profiling on a genomic scale led to the classification of the intrinsic subtypes of breast cancer, thus allowing for the prediction of disease progression and patient stratification. (dovepress.com)
  • As part of the COBRE project, she will direct new efforts to uncover population-specific genomic signatures of cancer risk. (brown.edu)
  • At The Institute for Genomic Research (TIGR) I was part of the team that launched the field of parasite genomics, with the publication of the genome of several Plasmodium and trypanosomatid species, Theileria parva and Trichomonas vaginalis . (umaryland.edu)
  • The Genome Structure Function section of the Institute of Cancer and Genomic Sciences investigates the fundamentals of the active information database that is our genome, in normal and disease states. (birmingham.ac.uk)
Mutations16
  • Although many efforts in cancer prevention and control have routinely focused on behavioral risk factors, such as tobacco use, or on the early detection of cancer, such as colorectal cancer screening, advances in genetic testing have created new opportunities for cancer prevention through evaluation of family history and identification of cancer-causing inherited mutations. (cdc.gov)
  • Mutations in these genes are associated with increased risk for breast, ovarian, prostate, and pancreatic cancers ( 2 ). (cdc.gov)
  • Each year, BRCA1 and BRCA2 mutations account for 3% of all breast cancers and 10% of all ovarian cancers ( 3 ). (cdc.gov)
  • Mutations in these genes are associated with increased risk for certain cancers, including colorectal cancer, and cancers of the endometrium and ovary ( 7 ). (cdc.gov)
  • A number of promoter mutations have been linked with an increased risk of cancer. (biomedcentral.com)
  • Cancer somatic mutations in binding sites of selected transcription factors have been found under positive selection. (biomedcentral.com)
  • For many transcription factors, including multiple members of FOX, HOX, and NR families, we show that human cancers accumulate fewer mutations than expected by chance that increase or decrease affinity of predicted binding sites. (biomedcentral.com)
  • Frequencies of synonymous and non-synonymous substitutions allow studying selection of cancer somatic mutations in protein-coding regions [ 11 ]. (biomedcentral.com)
  • Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer. (nih.gov)
  • Mutations/polymorphisms in the 55 kDa subunit of DNA polymerase epsilon in human colorectal cancer. (nih.gov)
  • Effects of cancer mutations Cancer is a mutational disease o. (thermofisher.com)
  • The genetic mutations that increase the likelihood of breast cancer are the same for all women . (medicalnewstoday.com)
  • At the BC Cancer Centre, the Personalized Onco-Genomics (POG) clinical trial is looking for genetic markers in a wide range of cancers, trying to match those mutations with particular therapies. (cbc.ca)
  • The absence of whole-genome maps of somatic mutations has meant that searches for new cancer-related lncRNAs have relied on conventional transcriptomic approaches that reveal changes in their expression levels that accompany cancer. (nature.com)
  • Somatic mutations are genetic alterations in cells that increase cancer risk. (fda.gov)
  • During the past decade, advancement within the field of genomics has led to the identification of melanoma-specific mutations, namely, v-Raf murine sarcoma viral oncogene homolog B and neuroblastoma RAS viral oncogene homolog, as well as to the development of agents that target these driver mutations. (medscape.com)
Translational Genomics1
  • The authors would like to acknowledge Clinical Genomics Lund, SciLifeLab and Center for Translational Genomics (CTG), Lund University, for providing expertise and service with sequencing and analysis. (lu.se)
Clinical6
  • NEW YORK (GenomeWeb) - Cancer diagnostics company Empire Genomics announced today that it has received approval from New York State to offer molecular and cellular tumor marker testing through the state's Clinical Laboratory Evaluation Program (CLEP). (genomeweb.com)
  • Polymorphisms in DNA damage repair genes are important determinants for cancer susceptibility, clinical phenotype diversity, and therapy. (jcancer.org)
  • Agendia, a genomics cancer diagnostics company, opened a new clinical genomics laboratory on 5 August 2010. (pharmaceutical-technology.com)
  • MeLuDI" (short for "melanoma/lung cancer diagnostics") was the name of a project at the Department of Oncology, Clinical Sciences, Lund University. (lu.se)
  • The MeLuDI project produced clinical genomics data from samples from patients having specific types of cancer, but also aimed to support cancer research. (lu.se)
  • Clinical Cancer Research. (lu.se)
20201
  • One 2020 study included 5,054 Black women who had received a breast cancer diagnosis and 4,993 Black women who had not received a breast cancer diagnosis. (medicalnewstoday.com)
Genomes6
  • Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. (wikipedia.org)
  • Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. (wikipedia.org)
  • The proper copying and repair of DNA to maintain the correct sequence and structure of genomes is critical to the proper function of cells, and repair and replication is frequently disrupted in cancers and targeted by cancer treatments. (birmingham.ac.uk)
  • We use ExInAtor to predict drivers from the GENCODE annotation across 1112 entire genomes from 23 cancer types. (nature.com)
  • By sequencing pairs of normal and tumour genomes from large patient cohorts, projects such as the ICGC (International Cancer Genome Consortium) and TCGA (The Cancer Genome Atlas) aim to create definitive driver mutation catalogues for all common cancers 1 , 2 . (nature.com)
  • 1 ) for sequence similarity with 51 mimivirus genomes available in the public domain since March 2016, the date on which the article by Zhang et al. (cdc.gov)
Colorectal13
  • Each year, Lynch syndrome accounts for 1%-3% of all colorectal cancer cases ( 8 ). (cdc.gov)
  • The risk for colorectal cancer among persons with Lynch syndrome is substantially higher than that of the general population (Table 1) ( 9 ). (cdc.gov)
  • Persons are more likely to have Lynch syndrome if they or their close relatives have had colorectal, endometrial, or ovarian cancers, especially at younger ages ( 7 ). (cdc.gov)
  • Persons with Lynch syndrome can talk to their health care provider about starting screening for colorectal cancer with colonoscopy at a younger age and screening more frequently than persons who are at average risk ( 10 ). (cdc.gov)
  • Understanding molecular features of colorectal cancer across diverse populations is an indispensable step toward reducing the pronounced disparities in this disease burden. (aacrjournals.org)
  • Parallel to striking disparities by race/ethnicity, sex, and geographic region in colorectal cancer burden, recent epidemiologic evidence suggests that community health behaviors and the built environment-such as air/water pollution, access to health care services, violence, and food environment-can influence behaviors that contribute to disparities in colorectal cancer risk and outcomes. (aacrjournals.org)
  • It is also important to recognize that institutional racism may contribute to inequities and health disparities in colorectal cancer outcomes via chronic stress from health care mistrust and implicit bias. (aacrjournals.org)
  • Moreover, distinct genetic and biological features may interact with individual behaviors (e.g., diet) and lead to a disproportionate burden of colorectal cancer across population subgroups. (aacrjournals.org)
  • Yet across these key factors, the biology of colorectal cancer disparities is the least understood. (aacrjournals.org)
  • The African ancestry cohort had a higher proportion of females diagnosed with colorectal cancer compared with cases with European ancestry (49% vs. 44%, respectively). (aacrjournals.org)
  • In a concise format, the booklet provides information and resources for healthcare providers, patients, and patient family members about Hereditary Breast and Ovarian Cancer (HBOC) Syndrome and Lynch Syndrome (LS, formerly called Hereditary Non-Polyposis Colorectal Cancer Syndrome). (csms.org)
  • The incidence and mortality of colorectal cancer is persistently highest in Black/African-Americans in the United States. (scirp.org)
  • Colorectal Cancer (CRC) is the fourth most common cancer in the United States (US) and second most lethal [1]. (scirp.org)
Genes18
  • What genes cause breast cancer? (medicalnewstoday.com)
  • Researchers have linked a number of genes, including BRCA1 and BRCA2, to the development of breast cancer. (medicalnewstoday.com)
  • Other genes that could increase the likelihood of a person developing breast cancer include ATM , TP53 , CHEK2 , and PTEN . (medicalnewstoday.com)
  • Read on to learn more about breast cancer-related genes and how they increase the risk of breast cancer. (medicalnewstoday.com)
  • According to the American Cancer Society, if a woman inherits just one faulty copy of either of these genes, there is a 70% chance that they will develop cancer by the age of 80 years. (medicalnewstoday.com)
  • Researchers have also linked the BRCA genes to the development of ovarian cancer . (medicalnewstoday.com)
  • There are a number of genes that could increase a person's risk of developing breast cancer. (medicalnewstoday.com)
  • Genetic testing can determine whether or not a person has breast cancer genes. (medicalnewstoday.com)
  • Cancer genomics analysis revealed that 36 of the most differentially expressed mRNAs were involved in a pancreatic cancer network and were associated with many critical mutated genes such as TP53, KRAS, SMAD4, and CDKN2A. (jcancer.org)
  • The matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy-based genotyping system was used to genotype 601 individuals (200 lung cancer patients and 401 age- and sex-matched healthy controls) for polymorphisms in excision repair cross-complementing group 1 ( ERCC1 ) and ERCC5 genes. (jcancer.org)
  • ERCC5 rs4771436 and rs1047768 genotypes were associated with an increased risk of lung cancer, suggesting that polymorphisms in DNA repair genes are significantly related to the risk of lung cancer, and play an important role in the occurrence of lung cancer. (jcancer.org)
  • An important connection linking the DNA damage repair pathway to cancer development is variations in DNA damage repair genes. (jcancer.org)
  • SNPs in genes encoding proteins involved in DNA damage repair pathways are associated with the risk and prognosis of various cancers, including lung cancer. (jcancer.org)
  • Using a stratified approach, we identify 15 high-confidence candidates: 9 novel and 6 known cancer-related genes, including MALAT1, NEAT1 and SAMMSON . (nature.com)
  • We have presented a first catalogue of mutated lncRNA genes driving cancer, which will grow and improve with the application of ExInAtor to future tumour genome projects. (nature.com)
  • This vast population of uncharacterized genes likely includes many with novel roles in cancer. (nature.com)
  • Proto-oncogene lncRNAs include HOTAIR, upregulated in multiple cancers, which recruits the repressive PRC2 chromatin regulatory complex to hundreds of genes 11 . (nature.com)
  • Genes Chromosomes Cancer 55:291-310, 2016. (lu.se)
Pathways4
  • Further analysis of transcription factors with conserved binding motifs can reveal cell regulatory pathways crucial for the survivability of various human cancers. (biomedcentral.com)
  • Alterations in the DNA damage repair pathway are hallmarks of cancer [ 7 ], and the relationships between such pathways and cancer are varied and complex. (jcancer.org)
  • Kaempferol Due to the wide presence of cAMP signaling pathways in cancer we predict that further investigation of both sAC and other cAMP microdomains will lead to additional cancer biomarkers. (bioinf.org)
  • Exposure to MWCNT tended to favor those pathways involved in immune responses, specifically T-cell responses, whereas exposure to asbestos tended to favor pathways involved in oxygen species production, electron transport, and cancer. (cdc.gov)
Aims3
  • By tailoring the product to the regional population, LAMH aims to revolutionize liver cancer surveillance and enhance patient care in China. (imanetwork.org)
  • By fostering strong partnerships with major hospital systems and leveraging patient education groups, LAMH aims to further drive improvements in liver cancer outcomes and make a lasting difference in the lives of patients. (imanetwork.org)
  • This review aims to identify and detail awareness, knowledge, perceptions, and attitudes towards genetic counselling/testing for cancer risk prediction in ethnic minority groups. (biomedcentral.com)
Laboratory3
  • While the word genome (from the German Genom, attributed to Hans Winkler) was in use in English as early as 1926, the term genomics was coined by Tom Roderick, a geneticist at the Jackson Laboratory (Bar Harbor, Maine), over beers with Jim Womack, Tom Shows and Stephen O'Brien at a meeting held in Maryland on the mapping of the human genome in 1986. (wikipedia.org)
  • 2. Department of Radiation Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, and Key Laboratory of Tumor Radiosensitization and Normal Tissue Radioprotection of Liaoning Province, Shenyang, Liaoning 110042, China. (jcancer.org)
  • It was initiated in 2014, went into "production" phase in 2015-01-01, and ended 2016-06-23 after it had been announced 2016-01-21 that another laboratory should perform the analyses in question. (lu.se)
Bioinformatics1
Mutation5
  • Mutation carriers face a substantially higher risk for developing breast and ovarian cancers by age 70 years than do women in the general population ( Table 1 ) ( 4 , 5 ). (cdc.gov)
  • Persons are more likely to have a BRCA1 or BRCA2 mutation if they or their close relatives on either their mother's or father's side of the family have had breast cancer before age 50 years, triple negative breast cancer,* ovarian cancer, cancer in both breasts, breast cancer in a male relative, or multiple relatives with breast, pancreatic, or high grade prostate cancer ( 2 ). (cdc.gov)
  • To avoid statistical bias we account for mutation signatures of different cancer types. (biomedcentral.com)
  • thus, mutation signatures of different cancer types should be properly taken into account to avoid statistical bias. (biomedcentral.com)
  • The idea is that there might be a drug out there that can target the particular cancer mutation. (cbc.ca)
Analyses2
  • Next-generation sequencing analyses revealed the expression of TRPV1 in several native breast cancer tissues, which was subsequently validated via reverse transcriptase-polymerase chain reaction. (dovepress.com)
  • Our HCC signature covered well-established liver cancer hallmarks, and network analyses revealed coordinated interaction between several MRs. One novel MR, SEC14L2 , exerted an anti-proliferative effect in HCC cells and strongly suppressed tumor growth in a mouse model. (aging-us.com)
Lund University1
  • During fall 2016, a number of research projects at Lund University involved lab work using a workflow very close to the one used for the original MeLuDI project, so it was decided that a modified version of the MeLuDI software was to be used to track samples. (lu.se)
Transcriptomics1
  • Fan, T. W. M., Bandura, L. L., Higashi, R. M. & Lane, A. N. Metabolomics-edited transcriptomics analysis of Se anticancer action in human lung cancer cells. (nature.com)
Tumors5
  • Having this syndrome increases the risk of breast cancer, leukemia , brain tumors, and connective tissue cancer. (medicalnewstoday.com)
  • Speaking about detecting cancer predisposition alterations, Pfister said, "More than 90 percent of patients and families want to be informed about patient-relevant germline findings that we might detect in the tumors. (aacr.org)
  • Lung cancer is one of the common malignant tumors in the world, and it remains the leading cause of cancer mortality because of its high malignant and metastatic potential [ 1 ]. (jcancer.org)
  • An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells. (lu.se)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
Molecular4
  • A better understanding of the molecular mechanisms of cancer development and progression is the basis for the development of new diagnostic and therapeutic strategies. (karger.com)
  • In his presentation, titled "A comprehensive European approach to precision pediatric cancer medicine," Pfister elaborated on the efforts by the European precision pediatric oncology program called INFORM (short for Individualized Therapy For Relapsed Malignancies in Childhood), a multi-national registry spanning nine European countries, which offers comprehensive real-time molecular profiling for pediatric patients who have no standard treatment options. (aacr.org)
  • The company plans to offer genetic testing and molecular diagnostics to help physicians make treatment decisions for cancer patients. (genomeweb.com)
  • Translational research on prostate cancer: Identification of molecular targets for development of new therapies in chemo- and hormone resistant prostate cancer. (lu.se)
Ovarian and breast1
  • Seven interconnected themes integral to surgical decision making were identified: fertility/menopause/cancer risk reduction/surgical choices/surgical complications/sequence of ovarian-and-breast prophylactic surgeries/support/satisfaction. (bmj.com)
Advances1
  • Advances in genomics have triggered a revolution in discovery-based research and systems biology to facilitate understanding of even the most complex biological systems such as the brain. (wikipedia.org)
20021
Research14
  • Despite continuous research efforts in the past decades, there are still cancers where no effective treatment is available, such as advanced kidney cancer or hormone-refractory prostate cancer. (karger.com)
  • Current developments in genomics have a dramatic impact on the whole field of research. (karger.com)
  • Thermo Fisher Scientific will be there to present the latest sequencing innovations in reproductive genomics research. (thermofisher.com)
  • Helio Genomics is a leading developer of liquid biopsy early cancer detection tests, committed to revolutionizing healthcare through cutting-edge research and development. (imanetwork.org)
  • 1 A series of high-throughput methods have changed cancer research and therapy. (dovepress.com)
  • Research Scientist at Cancer Research UK, Cambridge University (UK). (unibo.it)
  • Research Fellow at Institute of Applied Genomics, Udine (Italy). (unibo.it)
  • PROVIDENCE, R.I. [Brown University] -With a new five-year, $11.5 million grant from the National Institutes of Health, Brown University will expand its research in computational biology and launch a new Center of Biomedical Research Excellence (COBRE), which will support five early career faculty members as they tackle the genomics underlying diseases such as cancer, preeclampsia and severe lung infections. (brown.edu)
  • The unusual offer has raised eyebrows among some in the cancer research community. (cbc.ca)
  • Contextual Genomics is making it clear this is not a research project. (cbc.ca)
  • Chinese Australian groups were less studied, but of interest was a finding from qualitative research indicating that different views of who close family members are could impact on reported family history of cancer, which could in turn impact a risk assessment. (biomedcentral.com)
  • More detailed research is needed in countries other than the US and across a broader spectrum of ethnic minority groups to develop effective culturally sensitive approaches for cancer prevention. (biomedcentral.com)
  • Our research is defining the normal mechanisms of DNA replication and repair, with the aim of understanding how it is deregulated in cancer cells. (birmingham.ac.uk)
  • The information is freely available ( https://mitelmandatabase.isb-cgc.org) as an integrated component of the Cancer Genomics Cloud (CGC) - a flexible and powerful platform for cancer genomics research initiated and sponsored by the US National Cancer Institute (NCI). (lu.se)
Tumor3
  • Your health care provider might see a tumor, such as skin or oral cancer. (medlineplus.gov)
  • Unlike adult cancers, pediatric cancers have low tumor mutational burden, making it challenging to find druggable targets and new treatment approaches. (aacr.org)
  • The STAT3 Inhibitor Galiellalactone Effectively Reduces Tumor Growth and Metastatic Spread in an Orthotopic Xenograft Mouse Model of Prostate Cancer. (lu.se)
Common cancers2
  • Breast cancer is one of the most common cancers affecting women worldwide. (dovepress.com)
  • Renal cell carcinoma is one of the most common cancers in the urinary system, causing over 140,000 deaths worldwide each year[ 1 ]. (medsci.org)
Liver cancers1
  • We believe this approval will have a profound impact on patient outcomes by enabling the detection of liver cancers at an earlier stage, when curative treatment is more likely. (imanetwork.org)
Patients9
  • Through the collection and evaluation of a family cancer history by a trained health care provider, patients and families at increased risk for a hereditary cancer syndrome can be identified, referred for genetic counseling and testing, and make informed decisions about options for cancer risk reduction ( 1 ). (cdc.gov)
  • There are many resources for cancer patients . (medlineplus.gov)
  • Today, you will hear about pioneering countrywide efforts that knock down barriers to collaboration and networking for the benefit of all children with cancer, enabling data-, software-, and results-sharing with the goal to extend improvements in diagnosis, care, and outcome to all pediatric patients," Mardis said. (aacr.org)
  • Through INFORM, the investigators have been successful in identifying potential drug targets, previously unidentified cancer predisposition markers, and potential biomarkers for many pediatric patients recruited to the program. (aacr.org)
  • however, patients diagnosed with pancreatic cancer remain extremely vulnerable to relapse and death. (jcancer.org)
  • Projects focused on the analysis of regulatory network activation in cancer patients. (unibo.it)
  • Many melanoma and lung cancer patients frequently show dramatic responses when treated with targeted therapies (kinase inhibitors). (otago.ac.nz)
  • Genetic testing for risk of hereditary cancer can help patients to make important decisions about prevention or early detection. (biomedcentral.com)
  • In addition, in some patients with a personal or family history of breast and ovarian cancer, the protective role of BRCA1 in DNA-copying is disabled - while its break repair function is still active. (birmingham.ac.uk)
Outcomes1
  • The initiative includes a major component on cancer precision treatment, and a large scale cohort study program to generate knowledge applicable to all areas of health and disease, including cancer risk factors and outcomes. (cdc.gov)
Detection2
  • What can a TED talker, an early Cancer detection test, and "23 and Me" all learn from autonomous cars? (rechargebiomedical.com)
  • This achievement marks a significant milestone for blood-based cancer detection and is the first liver cancer liquid biopsy test approved by the NMPA. (imanetwork.org)
Lung Cancer7
  • Lan X, Li Y, Wu Y, Li X, Xu L. The Association of ERCC1 and ERCC5 Polymorphisms with Lung Cancer Risk in Han Chinese. (jcancer.org)
  • However, their relationship with lung cancer remains unclear. (jcancer.org)
  • The ERCC5 rs4771436 GG genotype, recessive model (GG vs. GT+TT), and the ERCC5 rs1047768 recessive model (CC vs. CT+TT) were associated with significantly increased risks of lung cancer ( P =0.029, P =0.014, and P =0.044, respectively), especially in men and individuals aged 60 years or younger. (jcancer.org)
  • In recent years, in addition to environmental factors, genetic factors have become a hot spot in the etiology of lung cancer. (jcancer.org)
  • The impact of KRAS expression levels on the emergence of drug tolerance in lung cancer. (otago.ac.nz)
  • MeLuDI is an extension package to BASE with registration wizards for melanoma-lung cancer projects, in analogy with the package "Reggie" for the SCAN-B breast cancer project. (lu.se)
  • Originally, the focus was on melanoma and lung cancer, but later on, more cancer types were supported. (lu.se)
Therapeutics1
  • Mardis went on to describe how large-scale efforts to study pediatric cancers provide evidence for the utility of therapeutics used in the treatment of adult cancers, such as small molecule inhibitors and antibody-based treatments, for pediatric cancers. (aacr.org)
Centre1
  • The AGORA cancer centre is being built at the Lausanne University Hospital site next to Lake Geneva, Switzerland. (pharmaceutical-technology.com)
20221
Methods1
  • CCMB researchers have developed innovative methods to analyze complex genomics data sets. (brown.edu)
Pancreatic8
  • Others, such as esophageal or pancreatic cancer, MAY NOT cause symptoms until the disease has reached an advanced stage. (medlineplus.gov)
  • 10 TRPV1 agonist, capsaicin, is capable of inducing apoptosis 11 , 12 and inhibiting cancer cell growth by cell cycle arrest in many different types of cancer, for example, osteosarcoma, colon, and pancreatic cancer cells, while normal cells remained unharmed. (dovepress.com)
  • Chen J, Wang S, Jia S, Ding G, Jiang G, Cao L. Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis. (jcancer.org)
  • Pancreatic cancer is a devastating disease with a low five-year survival rate. (jcancer.org)
  • However, few studies have investigated the role of pancreatic cancer-derived exosomes (PEXs) in DC-meditated immune escape. (jcancer.org)
  • Pancreatic cancer is a devastating disease that is difficult to diagnose, which helps to explain the 10% five-year survival rate [ 1 ]. (jcancer.org)
  • Moreover, approximately 53,070 Americans were predicted to have been diagnosed with pancreatic cancer, and approximately 41,780 Americans were predicted to have died of pancreatic cancer in 2016. (jcancer.org)
  • New strategies to prevent and cure pancreatic cancer are therefore urgently required. (jcancer.org)
Mutational1
  • Heterogeneity in mutational signatures between cancer types and individuals is accounted for using a simple local trinucleotide background model, which yields high precision and low computational demands. (nature.com)
Progression2
  • Complement component 1 Q subcomponent binding protein (C1QBP) plays a vital role in the progression and metabolism of cancer. (medsci.org)
  • In recent years a small but growing number of lncRNA have been implicated in cancer progression through various mechanisms 9 . (nature.com)
Diagnostics2
  • Antibodies directed against the soluble adenylyl cyclase (sAC) are highly specific markers for melanoma especially for lentigo maligna melanoma and are being described as "second generation" cancer diagnostics which are diagnostics that Kaempferol determine the 'state' of a cell and not just identify the cell type. (bioinf.org)
  • Keywords: Soluble adenylyl cyclase cAMP Microdomain Cancer Diagnostics 1 Introduction Cyclic adenosine monophosphate (cAMP) is one of the most ancient CDCL1 signaling molecules present from bacteria to man. (bioinf.org)
Melanoma2
  • Melanoma is the third most common systemic cancer that leads to brain metastases. (medscape.com)
  • Brain metastases, as in other systemic cancers, such as lung or breast, remain a significant complication of melanoma. (medscape.com)
Prostate2
  • Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth. (nih.gov)
  • Galiellalactone Inhibits Stem Cell-Like ALDH-Positive Prostate Cancer Cells. (lu.se)
Data4
  • Our data demonstrate negative selection against binding sites alterations and suggest that such selection pressure protects cancer cells from rewiring of regulatory circuits. (biomedcentral.com)
  • Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
  • Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM. (nature.com)
  • Ongoing projects include the ( i ) the study of species biology and the nature of host-parasite interactions, based on comparative genomics and ( ii ) studies of speciation, drug resistance, vaccine efficacy and vaccine design, informed by population genomics data. (umaryland.edu)
Lethal1
  • This lethal disease is the fourth most common cause of cancer-related deaths among Americans [ 2 ]. (jcancer.org)
Prevention2
  • Possible interventions include starting breast cancer screening earlier with mammography alone, or in combination with breast magnetic resonance imaging, chemo-prevention medications as recommended by the USPSTF, such as tamoxifen or raloxifene, or surgical options, such as risk-reducing mastectomy or oophorectomy ( 1 , 6 ). (cdc.gov)
  • As a member of the National Cancer Institute's Cancer Systems Biology Consortium and principal investigator of multi-institutional grants, her team focuses on the development and application of multi-omic tools in the clinic for cancer prevention and treatment. (cityofhope.org)
Heterogeneity1
  • However, the relationship between methylation patterns and the heterogeneity of breast cancer has not been comprehensively characterized. (lu.se)
Morbidity1
  • Two hereditary cancer syndromes for which public health professionals have worked to reduce the burden of morbidity and mortality are hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome. (cdc.gov)
Hereditary1
  • Although hereditary cancers make up a small proportion of all cancers, the number of affected persons can be large, and the level of risk among affected persons is high. (cdc.gov)
MRNA1
  • A potential role for untranslated p53 mRNA in cancer biology. (otago.ac.nz)
Biopsy2
  • Urodrill - a novel MRI-guided endoscopic biopsy technique to sample and molecularly classify muscle-invasive bladder cancer without fractionating the specimen during transurethral resection. (lu.se)
  • A Four-kallikrein Panel Predicts High-grade Cancer on Biopsy: Independent Validation in a Community Cohort. (lu.se)
Breast15
  • However, the role of PTEN alterations in north Indian breast cancer has not been explored especially in defining a group with distinct histological factors. (cancerindex.org)
  • Methodology: 181 sporadic breast cancer and their adjacent normal tissues were included in the present study. (cancerindex.org)
  • They will also likely develop breast cancer at a younger age and have it in both breasts. (medicalnewstoday.com)
  • This means that cells can continuously divide, which causes breast cancer. (medicalnewstoday.com)
  • Learn more about how breast cancer affects Black women here. (medicalnewstoday.com)
  • If breast cancer runs in a person's family, they may want to undergo genetic testing. (medicalnewstoday.com)
  • If the test reveals that the person has a high risk of developing breast cancer or any other condition, they can ask the genetic counselor for advice on what to do next. (medicalnewstoday.com)
  • SALMON: survival analysis learning with multi-omics neural networks on breast cancer. (nature.com)
  • however, no study has examined the expression profiles of human TRP channels in breast cancer on a large scale. (dovepress.com)
  • In this study, stimulation by the TRPV1 agonist, capsaicin, of SUM149PT cells, a model system for the most aggressive breast cancer subtype, triple-negative breast cancer, led to intracellular calcium signals that were diminished by the specific TRPV1 antagonist, capsazepin. (dovepress.com)
  • In conclusion, the current study revealed the expression profiles of human TRP channels in 60 different breast cancer tissues and cell lines and furthermore validated the antitumor activity of TRPV1 against SUM149PT breast cancer cells, indicating that activation of TRPV1 could be used as a therapeutic target, even in the most aggressive breast cancer types. (dovepress.com)
  • whereas human epidermal growth factor receptor 2 (HER2)-positive breast cancers can be targeted by specific drugs, the triple-negative breast cancer phenotype is defined by chromosomal instability and low expression levels of estrogen receptor (ER) alpha, progesterone receptor (PR), and HER2, rendering treatment rather difficult. (dovepress.com)
  • 5 Triple-negative breast cancer is characterized by limited treatment options and frequent local recurrence. (dovepress.com)
  • Similarly, in the US overall cancer incidence and mortality has been found to be highest in Black men compared to other ethnic groups, and whilst Black women have a lower incidence of breast cancer than White women they have a worse mortality rate [ 12 ]. (biomedcentral.com)
  • Aberrant DNA methylation is frequently observed in breast cancer. (lu.se)