Irinotecan HCl is a semisynthetic derivative of camptothecin, an alkaloid extract from plants such as Camptotheca acuminata. (rxmed.com)
Camptothecin (Camptotheca acuminata), (GoldBio Catalog # C-705) has also been produced by endosymbiotic fungi present in Camptotheca acuminata, which is a tree predominantly found in southern China. (goldbio.com)
For example the drugs teniposide and etoposide are derived from podophyllotoxin, which is a non-alkaloid toxin from roots and rhizome of Podophyllum species and topotecan and irinotecan are hydrophilic analogs of the anticancer drug camptothecin obtained from the bark of Camptotheca acuminata. (longdom.org)
Camptothecin was discovered and isolated from the bark of the Chinese happy tree ( Camptotheca acuminata Decne) [ 13 ]. (ajgreenchem.com)
Two topoisomerase I inhibitors, irinotecan and topotecan, are semi-synthetically derived from camptothecin, which is obtained from the Chinese ornamental tree Camptotheca acuminata. (infutureweb.com)
Camptothecin is an alkaloid compound used as an anti-cancer agent. (goldbio.com)
The tree contains the alkaloid camptothecin, of which chemical derivatives are used pharmaceutically in cancer treatment. (thailex.info)
The leaves, bark and stem contain an alkaloid, camptothecin, which is found to inhibit topoisomerase I, an enzyme needed for DNA replication. (healthyhabitsliving.com)
10-Hydroxycamptothecin (10-HCPT), an indole alkaloid isolated from a Chinese tree, Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity in vitro and in vivo. (medkoo.com)
Irinotecan1
Irinotecan is a chemotherapy drug derived from natural compound camptothecin that inhibits topoisomerase 1. (ajgreenchem.com)
Enzyme2
Camptothecins interact specifically with the enzyme topoisomerase I, which relieves torsional strain in DNA by inducing reversible single-strand breaks. (rxmed.com)
Camptothecin has been shown to bind and stabilize a topoisomerase I-DNA complex in vitro , preventing the enzyme from reannealing DNA strands. (goldbio.com)
Foetida2
Camptothecin is found in Mappia foetida ( Nothapodytes foetida ), a plant native to eastern India. (goldbio.com)
We found that pruning, particularly decapitation pruning (T-pruning) can effectively induce contents and derivatization of CPTs in Camptotheca, and the leveled CPTs caused induced endogenous autotoxicity (abnormal morphogenesis) in the plants. (benthamopen.com)
Derivatives2
More than a dozen derivatives and conjugates of Camptothecin are under various stages of clinical trials for anti-cancer applications. (expresspharma.in)
Currently, two semi-synthetic derivatives of camptothecin, topotecan and irinotecan, which retain anti-cancer activity but with less severe side effects, are used to treat a variety of cancers. (buyextracts.com)
Topoisomerase2
Preliminary data are also reviewed on other camptothecin analogues (GG-211 and DX-8951f), on oral formulations, and on non-camptothecin topoisomerase I inhibitors. (nih.gov)
It contains pentacyclic quinolines camptothecin and 10-hydroxycamptothecin which inhibits DNA topoisomerase I and is very effective against cancer cells. (gardenofcures.com)
Acuminate2
Camptotheca acuminate (Happy Tree) was first used traditional medicine (ancient Chinese) as a treatment for common colds, psoriasis, liver problems and digestive problems. (gardenofcures.com)
Scientific research has found the cancer-fighting properties in Camptotheca acuminate thus it is called a cancer-tree. (gardenofcures.com)
Semisynthetic1
This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. (bvsalud.org)
Callus1
Evaluation of biomass and camptothecin production showed that the PGRs influenced biomass and CPT yield of the callus cultures. (notulaebiologicae.ro)
Elaborating on the technical aspects of the research, Khwajah Mohinudeen, an IIT Madras PhD Research Scholar who worked on this study, said, "Researchers from the Plant Cell Bioprocessing laboratory at IIT Madras have been able to successfully isolate the highest-yielding strain of Camptothecin reported to date with sustainable production up to reactor level. (expresspharma.in)
Somatic embryogenesis, plant regeneration, and evaluation of camptothecin content in Nothapodytes foetida. (notulaebiologicae.ro)
Production5
IIT Madras Researchers have now developed an alternative method of Camptothecin production to meet the demand and conserve the natural sources. (expresspharma.in)
The plan now is to use the isolated novel strain for the development of a microbial fermentation based sustainable bioprocess for large scale in vitro production of Camptothecin, preferably in collaboration with interested Industrial partner(s). (expresspharma.in)
In addition to isolating a novel microbial source for bioprocess development for the large scale production of Camptothecin, we have also come up with a rapid screening technique for isolation of high Camptothecin yielding microbial strains from plants. (expresspharma.in)
Hence, this research aims to establish a sustainable and high Camptothecin yielding endophyte, as an alternative source for commercial production of Camptothecin. (expresspharma.in)
Optimization of camptothecin production and biomass yield from endophytic fungus Fusarium solani strain ATLOY-8. (notulaebiologicae.ro)
Anti-cancer1
Researchers from the Indian Institute of Technology Madras (IIT Madras) have identified an alternative source for the anti-cancer drug Camptothecin. (expresspharma.in)
More recently, a number of water-soluble camptothecin analogues have undergone extensive evaluation and have demonstrated significant clinical activity. (nih.gov)
In addition, individuals in the low-risk group were more susceptible to axitinib and camptothecin, whereas lapatinib might be preferred for patients in the high-risk group. (hindawi.com)