• antibody
  • Formalin-fixed paraffin-embedded human cancer tissue (breast carcinoma) with ab38590 anti-calmodulin, peroxidase-conjugated to the secondary antibody, followed by AEC staining. (abcam.com)
  • Regulation
  • Data suggest that Cys3602 in RyR2 (ryanodine receptor 2 (show RYR2 Antibodies )) plays important role in activation/termination of Ca2 (show CA2 Antibodies )+ release, but it is not essential for calmodulin regulation of RyR2 (show RYR2 Antibodies ). (antibodies-online.com)
  • Target
  • Rief and Junker used mechanical force - actually pulling on complexes of calmodulin and the target peptides at rates of 1 nanometer per second or less - to slow down the processes to observable time scales and to clearly separate the individual unbinding steps. (innovations-report.com)
  • Original paper: "Single-molecule force spectroscopy distinguishes target binding modes of calmodulin," by Jan Philipp Junker and Matthias Rief, published in the online Early Edition of PNAS, Proceedings of the National Academy of Sciences for the week of August 10, 2009. (innovations-report.com)