• PMID
  • Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). (nih.gov)
  • Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. (nih.gov)
  • interaction
  • Title: Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit. (nih.gov)
  • peptide
  • Synthetic peptide conjugated to KLH derived from within residues 100 to the C-terminus of Human Calmodulin. (abcam.com)
  • Professor Matthias Rief and colleagues at the Technische Universitaet Muenchen had previously shown that they could fix a single calmodulin molecule between a surface and the cantilever tip of a specially built atomic-force microscope, expose it to calcium ions in solution, induce peptide binding and unbinding, and measure changes in the molecule's mechanical properties as it did its work. (innovations-report.com)
  • By applying mechanical force," Junker says, "we are able to dismantle the calmodulin-target peptide complex with surgical precision. (innovations-report.com)
  • Synthetic peptide corresponding to Human Calmodulin 1/2/3 aa 10-30 (C terminal) conjugated to keyhole limpet haemocyanin. (abcam.com)
  • Synthetic peptide corresponding to Human Calmodulin. (abcam.com)
  • RYR2
  • Hydrogen peroxide reduces calmodulin binding to RYR2 in rat cardiomyocytes. (nih.gov)
  • Data suggest that Cys3602 in RyR2 (ryanodine receptor 2 (show RYR2 Antibodies )) plays important role in activation/termination of Ca2 (show CA2 Antibodies )+ release, but it is not essential for calmodulin regulation of RyR2 (show RYR2 Antibodies ). (antibodies-online.com)
  • genes
  • There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. (nih.gov)
  • target
  • Though Calmodulin's flexibility is more evident when it is bound to a target protein, NMR studies have shown that the linker region of Calmodulin is flexible, even when it is not bound to a target protein. (wikipedia.org)
  • Rief and Junker used mechanical force - actually pulling on complexes of calmodulin and the target peptides at rates of 1 nanometer per second or less - to slow down the processes to observable time scales and to clearly separate the individual unbinding steps. (innovations-report.com)
  • Original paper: "Single-molecule force spectroscopy distinguishes target binding modes of calmodulin," by Jan Philipp Junker and Matthias Rief, published in the online Early Edition of PNAS, Proceedings of the National Academy of Sciences for the week of August 10, 2009. (innovations-report.com)