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  • STIM1
  • The mechanisms through which ICRAC occurs are currently still under investigation, although two candidate molecules, Orai1 and STIM1, have been linked by several studies, and a model of store-operated calcium influx, involving these molecules, has been proposed. (wikipedia.org)
  • STIMATE can physically associate with STIM1 to promote conformational switch of STIM1 from inactive toward an activated state, thereby coupling to and gating the ORAI calcium channels on the plasma membrane. (wikipedia.org)
  • Depletion of TMEM110 with RNAi knockdown or Cas9-mediated gene disruption substantially reduces the puncta formation of STIM1 at ER-PM junctions and remarkably inhibits the calcium/calcineurin/NFAT signaling axis. (wikipedia.org)
  • STIM1-mediated calcium entry is required for thrombin-induced disassembly of VE-cadherin adherens junctions. (wikipedia.org)
  • stimuli
  • He established the concept of multiple calcium mobilising messengers which link cell surface stimuli to release of internal calcium stores, and identified their target two-pore channels (TPCs) and organelles. (wikipedia.org)
  • ubiquitous
  • Calcium (as Ca2+) is a ubiquitous second messenger with wide-ranging physiological roles. (wikipedia.org)
  • He established that cyclic ADP-ribose regulates calcium-induced calcium release and globalisation of calcium signals, and that Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous trigger for initiating and co-ordinating calcium signals, often involving communication between organelles at contact sites. (wikipedia.org)
  • enzymes
  • Mitochondrial matrix calcium levels can reach the tens of micromolar levels, which is necessary for the activation of isocitrate dehydrogenase, one of the key regulatory enzymes of the Krebs cycle. (wikipedia.org)
  • channels
  • An inward Ca2+ current through T-type calcium channels is the last phase, and the main current responsible for the large transient depolarization. (wikipedia.org)
  • LTS are often triggered after an inhibitory postsynaptic potential (IPSP) due to the fast recovery of T-type calcium channels during the IPSP and their opening, as there is a return to resting membrane potential. (wikipedia.org)
  • The time constant of SK channel activation is approximately 5 ms. When calcium levels are depleted, the time constant for channel deactivation ranges from 15-60 ms. All SK channels can be pharmacologically blocked by quaternary ammonium salts of a plant-derived neurotoxin bicuculline. (wikipedia.org)
  • release
  • This inflowing calcium current that results after stored calcium reserves have been released is referred to as Ca2+-release-activated Ca2+ current (ICRAC). (wikipedia.org)
  • research
  • Galione was educated at Felsted School in Essex and Trinity College, Cambridge where he was awarded a Bachelor of Arts degree in Natural Sciences (Pharmacology) in 1985 followed by a PhD in 1989 for research on calcium signalling in the blowfly salivary gland supervised by Michael Berridge. (wikipedia.org)
  • Galione's research investigates calcium signalling. (wikipedia.org)
  • He studied medicine from 1978 to 1984 at Heidelberg University (MD in 1984) and carried out his MD Thesis at the Max Planck Institute for Medical Research, Heidelberg, with Wilhelm Hasselbach (de) on the calcium transport ATPase in skeletal muscle. (wikipedia.org)
  • importance
  • His work highlighted the spatial aspects of calcium signals and in particular the importance of nuclear calcium in governing activity-dependent gene expression and adaptations in the nervous system that include memory formation and acquired neuroprotection. (wikipedia.org)