• voltage-gated ca
  • They make their entrance into the cytoplasm either from outside the cell through the cell membrane via calcium channels (such as calcium-binding proteins or voltage-gated calcium channels), or from some internal calcium storages such as the endoplasmic reticulum and mitochondria. (wikipedia.org)
  • sodium
  • Aza-cage compounds were also obtained by reductive amination, but by using sodium cyanoborohydride as reducing agent instead. (nwu.ac.za)
  • For example, the sodium-calcium exchanger uses energy from the electrochemical gradient of sodium by coupling the influx of sodium into cell (and down its concentration gradient) with the transport of calcium out of the cell. (wikipedia.org)
  • neuronal
  • This study confirms the potential of the polycyclic structures as lead compounds in the search for molecules that prevent neuronal death due to apoptosis. (nwu.ac.za)
  • aluminium
  • While calcium is a poorer conductor of electricity than copper or aluminium by volume, it is a better conductor than both of them by mass due to its very low density. (wikipedia.org)
  • Findings
  • In view of previous findings on the NMDAR and calcium channel blocking activity of several pentacycloundecyl amines, it was thus envisaged that the triquinylamines would present similar results. (nwu.ac.za)
  • extent
  • Both compounds reduced in a great extent the contractions of rabbit's aorta rings, and they inhibited with less potency the papillary contractions of rat's right ventricle. (worldwidescience.org)
  • The ratiometric dye, Fura-2/AM, in combination with a microplate reader with undifferentiated PC-12 rat phaeochromocytoma cells proved to be more effective and adequate in measuring the extent of calcium flux into the cells after KCI-stimulated depolarisation. (nwu.ac.za)
  • increases
  • These results suggest that the lactol / hemiacetal might have the ability to antagonise ovreceptors and / or stimulate o2-receptors, as both these effects could lead to calcium level increases. (nwu.ac.za)
  • Within a typical cell, the intracellular concentration of ionized calcium is roughly 100 nM, but is subject to increases of 10- to 100-fold during various cellular functions. (wikipedia.org)
  • Effects
  • The effects of calcium on human cells are specific, meaning that different types of cells respond in different ways. (wikipedia.org)
  • industrial
  • A broad range of CHEMICALS: CALCIUM & CALCIUM COMPOUNDS manufacturers has been compiled in this industrial directory designed to provide information on leading, quality oriented manufacturers serving Alabama AL. (macraesbluebook.com)
  • Polyethylene glycol (PEG) is a polyether compound with many applications from industrial manufacturing to medicine. (wikipedia.org)
  • high
  • Abstract 】 Objective To establish a calcium compound card iris car bamazepine capsule by high performance liquid chromatography. (docsford.com)
  • If beryllium did form compounds with an ionization state of +2, it would polarize electron clouds that are near it very strongly and would cause extensive orbital overlap, since beryllium has a high charge density. (wikipedia.org)
  • addition
  • In addition to these characteristics that might define them as NMDAR antagonists, the triquinylamines also share structural similarities to the pentacycloundecane cage compounds. (nwu.ac.za)
  • In addition, the plasma membrane Ca2+ ATPase (PMCA) obtains energy to pump calcium out of the cell by hydrolysing adenosine triphosphate (ATP). (wikipedia.org)
  • properties
  • Estos resultados permiten concluir que las 1,4- dihidropiridinas I y II poseen acciones antagonistas del calcio vasoselectivas marcadas y este mecanismo está dado por el bloqueo de la corriente de calcio tipo L de manera dependiente del potencial Resumen en inglés The calcium antagonist properties of 2 new 1,4 synthetic dihydropyridines (I and II) were studied. (worldwidescience.org)
  • Calcium chloride's freezing-point depression properties are used to slow the freezing of the caramel in caramel-filled chocolate bars. (wikipedia.org)
  • channel
  • Under the terms of the agreement, Neuromed grants Merck an exclusive worldwide license to research, develop and commercialize NMED-160 and other compounds that selectively target the N-type calcium channel. (bionity.com)
  • The main aim of this investigation was thus to perform structure-activity analyses between the pentacycloundecylamines and triquinane derivatives with regard to their respective NMDAR and calcium channel blocking activities. (nwu.ac.za)
  • form
  • Like the other elements placed in group 2 of the periodic table, calcium has two valence electrons in the outermost s-orbital, which are very easily lost in chemical reactions to form a dipositive ion with the stable electron configuration of a noble gas, in this case argon. (wikipedia.org)
  • It also reacts with the oxygen and nitrogen in the air to form a mixture of calcium oxide and calcium nitride. (wikipedia.org)
  • action
  • They also shortened the duration of the heart action potential to 0 mV, and decreased the L calcium current in ventricular cardiomyocites isolated from rats. (worldwidescience.org)
  • In order to determine a more specific site of action for these compounds, a competition radioligand binding study was performed. (nwu.ac.za)
  • The way to overcome this is through the process of bone resorption, in which calcium is liberated into the bloodstream through the action of bone osteoclasts. (wikipedia.org)
  • lead
  • Neuromed Pharmaceuticals Ltd. and Merck & Co., Inc. announced that they have signed a research collaboration and license agreement to research, develop and commercialize novel compounds for the treatment of pain and other neurological disorders, including Neuromed's lead compound, NMED-160, which is currently in Phase II development for the treatment of pain. (bionity.com)
  • Since this may eventually lead to excitotoxicity, the block of calcium flux through the ion channels with the highest calcium ion permeability may thus serve as a major step towards the prevention of neurodegeneration. (nwu.ac.za)
  • Calcium can be cut with a knife with effort, although it is still harder than lead. (wikipedia.org)
  • production
  • La combinación más efectiva fue el empleo de partículas de E. grandis, combinadas indistintamente con los cementos CPC40 o ARI50, adicionados con 3% de cloruro de calcio Resumen en inglés The most part of residues generated during wood mechanic processing remains unexplored for construction material non-structural compounds production. (worldwidescience.org)
  • important
  • Thermodynamic quantities for the dissociation equilibria of biologically important compounds. (biochemj.org)
  • Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation. (wikipedia.org)
  • Additional
  • Neuromed would also receive royalties on worldwide sales of NMED-160 and any additional compounds developed under this agreement. (bionity.com)
  • Additional milestone payments would be payable should further compounds be developed. (bionity.com)
  • An additional compound, the lactol derivative of the triquinanes, was synthesised by reducing the triquinane dione with sodiumborohydride. (nwu.ac.za)
  • known
  • Alizarin or 1,2-dihydroxyanthraquinone (also known as Mordant Red 11 and Turkey Red) is an organic compound with formula C 14H 8O 4 that has been used throughout history as a prominent red dye, principally for dyeing textile fabrics. (wikipedia.org)
  • Its compounds were known to the ancients, though their chemistry was unknown until the seventeenth century. (wikipedia.org)
  • common
  • By Le Chatelier's principle and the common ion effect, increasing the concentration of calcium in the water will reduce the dissolution of calcium compounds essential to the structure of concrete. (wikipedia.org)
  • activity
  • This dualistic feature of these compounds can be attributed to activity on both the sigma receptors and calcium channels, as the PC-12 cells distinctly express both these pharmacological entities. (nwu.ac.za)
  • found
  • There were also calcium traces found in the gut, but this may have been fragments of shell attached to its food rather than the animal`s organs. (wikipedia.org)
  • example
  • Calcium compounds on the other hand are very widely used in many industries: for example, they are used in foods and pharmaceuticals for calcium supplementation, in the paper industry as bleaches, in cement, in the manufacture of soaps, and as electrical insulators. (wikipedia.org)