Calcium muscle skeletal. Medical search. Frequent questions

Small Ankyrins (sAnk1) are muscle-specific isoforms generated by the Ank1 gene that participate in the organization of the sarcoplasmic reticulum (SR) of striated muscles. (mdpi.com)
Objective -To determine whether an alteration in calcium regulation by skeletal muscle sarcoplasmic reticulum, similar to known defects that cause malignant hyperthermia (MH), could be identified in membrane vesicles isolated from the muscles of Thoroughbreds with recurrent exertional rhabdomyolysis (RER). (avma.org)
Skeletal muscle membrane vesicles, prepared by differential centrifugation of muscle tissue homogenates obtained from the horses, were characterized for sarcoplasmic reticulum (SR) activities, including the Ca 2+ release rate for the ryanodine receptor-Ca 2+ release channel, [ 3 H]ryanodine binding activities, and rate of SR Ca 2+ -ATPase activity and its activation by Ca 2+ . (avma.org)
In analogy, the overall Ca 2+ -binding capacity of sarcoplasmic reticulum vesicles from diabetic skeletal muscle was drastically increased. (uaeu.ac.ae)
Exercise promotes the formation of intracellular junctions in skeletal muscle between stacks of sarcoplasmic reticulum (SR) cisternae and extensions of transverse-tubules (TT) that increase co-localization of proteins required for store-operated Ca 2+ entry (SOCE). (elifesciences.org)
Uncontrolled sarcoplasmic reticulum calcium release involving the ryanodine receptor (RYR1) results in sustained muscle contraction, elevated temperature, and metabolic acidosis, and may be fatal if not treated. (bmj.com)
This influx of calcium causes calcium-induced calcium release from the sarcoplasmic reticulum , and free Ca 2+ causes muscle contraction . (wikipedia.org)
These aerobic and non-aerobic muscles obtain Ca2+ from the sarcoplasmic reticulum (SR). The, intrinsic system, ANS, hormone regulated, voluntary, aerobic muscle of the heart get their Ca2+ from SR and Extra Cellular Fluid(ECF). (bartleby.com)
It prevents calcium release from sarcoplasmic reticulum. (medscape.com)
Sequencing of genes involved in the movement of calcium across human skeletal muscle sarcoplasmic reticulum: continuing the search for genes associated with malignant hyperthermia. (cdc.gov)

Accordingly, the volume of SR tubules localized around the myofibrils is strongly reduced in skeletal muscle fibers of 4- and 10-month-old sAnk1 knockout (KO) mice, while additional structural alterations only develop with aging. (mdpi.com)
To verify whether the lack of sAnk1 also alters intracellular Ca 2+ handling, cytosolic Ca 2+ levels were analyzed in stimulated skeletal muscle fibers from 4- and 10-month-old sAnk1 KO mice. (mdpi.com)
Calcium currents in skeletal muscle fibers of an insect, Carausius morosus, inactivate under depolarization. (ox.ac.uk)
Comparison of simulated and measured calcium sparks in intact skeletal muscle fibers of the frog, S.M. Baylor, S. Hollingworth and W.K. Chandler, 2002, Journal of General Physiology , 120, 349-368. (physiomeproject.org)
The reaction involves a high fever (hyperthermia), a rapid heart rate, muscle rigidity, breakdown of muscle fibers (rhabdomyolysis), and increased acid levels in the blood and other tissues (acidosis). (medlineplus.gov)
The muscle fibers are electrically inexcitable during the attacks. (medscape.com)

Results -Time course of SR Ca 2+ -induced Ca 2+ release and [ 3 H]ryanodine binding to the ryanodine receptor after incubation with varying concentrations of ryanodine, caffeine, and ionized calcium did not differ between muscle membranes obtained from control and RER horses. (avma.org)
Conclusions and Clinical Relevance -Despite clinical and physiologic similarities between RER and MH, we concluded that RER in Thoroughbreds does not resemble the SR ryanodine receptor defect responsible for MH and may represent a novel defect in muscle excitation-contraction coupling, calcium regulation, or contractility. (avma.org)
Under the assumption that the single channel Ca(2+) current of a ryanodine receptor (RYR) is 0.5-2 pA, the results suggest that 1-5 active RYRs generate an average Ca(2+) spark in a frog intact muscle fiber. (physiomeproject.org)
The channels interact with another type of calcium channel called ryanodine receptor 1 (RYR1) channels (produced from the RYR1 gene). (medlineplus.gov)
In many cases of CCD, mutations in RYR1 have been detected, resulting in defective calcium handling of the skeletal muscle ryanodine receptor. (bmj.com)
Chloroform extract of hog barn dust modulates skeletal muscle ryanodine receptor calcium-release channel (RyR1). (cdc.gov)
Dulhunty and her colleagues were studying how the ryanodine receptor, a type of protein receptor, functions in muscle cells. (the-scientist.com)
Within a few months, Dulhunty and her colleagues published their first paper on the role of the omega class glutathione S-transferase, GSTO1-1, in inhibiting the ryanodine receptor in cardiac muscle and in increasing the activity of the skeletal muscle ryanodine receptor. (the-scientist.com)
Phenotype and genotype of muscle ryanodine receptor rhabdomyolysis-myalgia syndrome. (cdc.gov)

Affected patients may present with congenital muscle hypotonia, pronounced proximal weakness, delayed motor development, and slightly elevated creatine kinase (CK) levels. (bmj.com)
Measurements of creatine kinase are used in the diagnosis and treatment of myocardial infarction, skeletal muscle diseases, and diseases of the central nervous system. (cdc.gov)

Calsequestrin, a high-capacity Ca 2+ -binding protein, is involved in the regulation of the excitation-contraction-relaxation cycle of both skeletal and cardiac muscle fibres. (uaeu.ac.ae)
These skeletal muscle calcium channels play a key role in a process called excitation-contraction coupling, by which electrical signals (excitation) trigger muscle tensing (contraction). (medlineplus.gov)
A TROPONIN complex subunit that binds calcium and help regulate calcium-dependent muscle contraction. (nih.gov)
Overview of Disorders of Calcium Concentration Calcium (Ca) is required for the proper functioning of muscle contraction, nerve conduction, hormone release, and blood coagulation. (msdmanuals.com)

Histologically, using oxidative enzyme stains, it is identified by the abundance of central cores, characterised by localised areas of mitochondrial depletion and sarcomere disorganization exclusively in type 1 skeletal muscle fibres, and extending throughout their length. (bmj.com)

The mitochondrial calcium uniporter (MCU) mediates mitochondrial calcium uptake, a process of utmost physiological importance, especially in tissues with high energy demands such as skeletal muscle. (tum.de)
In the present work, a novel function of MCU as a mitochondrial redox modulator with downstream effects on energy metabolism and muscle performance was discovered. (tum.de)
Previous studies have indicated impaired muscle strength in people with vitamin D deficiency may be linked to impaired muscle mitochondrial function. (pharmacytimes.com)
The researchers in this study used a mouse model to determine the effects of diet-induced vitamin D deficiency on skeletal muscle mitochondrial function. (pharmacytimes.com)
Tissue and blood samples were collected monthly to quantify vitamin D and calcium concentrations and to assess markers of muscle mitochondrial function and number. (pharmacytimes.com)
After 3 months of diet-induced vitamin D deficiency, skeletal muscle mitochondrial function was found to be impaired by up to 37%, which was not due to a reduced number of mitochondria or a reduction in muscle mass, according to the researchers. (pharmacytimes.com)
The findings suggest vitamin D deficiency could impair mitochondrial function and reduce the amount of energy produced in the muscles, leading to poor muscle function, according to the study authors. (pharmacytimes.com)
They suggest that vitamin D deficiency decreases mitochondrial function, as opposed to reducing the number of mitochondria in skeletal muscle. (pharmacytimes.com)
We are particularly interested to examine whether this reduction in mitochondrial function may be a cause of age-related loss in skeletal muscle mass and function. (pharmacytimes.com)
Although the study indicates vitamin D deficiency has influence over mitochondrial function in skeletal muscle, the research team was unable to determine precisely how this process occurred. (pharmacytimes.com)
Philp and his team plan to conduct future research aiming to establish how vitamin D deficiency alters mitochondrial control and function in skeletal muscle. (pharmacytimes.com)

The question has been addressed whether the highly structured spatial organization of sites of Ca2+ release, uptake and action in skeletal muscle substantially impacts the dynamics of cytosolic Ca2+ handling and thereby the physiology of the cell. (tue.nl)
Titin is a giant scaffold protein with multiple functions in striated muscle physiology. (frontiersin.org)
Having pioneered the study of muscle physiology in mammals, she uncovered how ion channels enable muscle movement. (the-scientist.com)
Dulhunty was attracted to learning how muscle works as an undergraduate student studying physiology and biochemistry at the University of Sydney. (the-scientist.com)
Throughout her career, Dulhunty has been driven by her curiosity to know how the underlying physiology of the body works, and, as a result, has made important discoveries about how skeletal and heart muscle contractions are generated and regulated. (the-scientist.com)

Advise patients to promptly report to their physician unexplained and/or persistent muscle pain, tenderness, or weakness. (nih.gov)
At least 11 mutations in the CACNA1S gene have been identified in people with hypokalemic periodic paralysis, a condition that causes episodes of extreme muscle weakness, usually in the arms and legs. (medlineplus.gov)
It is unclear precisely how these changes lead to episodes of muscle weakness in people with hypokalemic periodic paralysis. (medlineplus.gov)
Later in life muscle strength may improve, but in rare cases progressive muscle weakness is observed. (bmj.com)
The heterogeneous group of muscle diseases known as periodic paralyses (PP) is characterized by episodes of flaccid muscle weakness occurring at irregular intervals. (medscape.com)
The physiologic basis of flaccid weakness is inexcitability of the muscle membrane (ie, sarcolemma). (medscape.com)
Muscle strength is normal between attacks but, after a few years, some degree of fixed weakness develops in certain types of PP (especially primary PP). All forms of primary PP (except Becker myotonia congenita [MC]) are either autosomal dominant inherited or sporadic (most likely arising from point mutations). (medscape.com)
Discussion in this article primarily addresses the sodium, calcium, and potassium channelopathies as well as secondary forms of PP. Chloride channelopathies are not associated with episodic weakness and are discussed in more detail in the articles on myotonic disorders. (medscape.com)
The muscular dystrophies (MD) are a group of genetic diseases characterized by progressive weakness and degeneration in the voluntary muscles that control movement. (drweil.com)
There are over thirty variations of this disease, each one differing in terms of symptoms, distribution and extent of muscle weakness, age of onset, rate of progression, and how it is passed on. (drweil.com)
In mild cases, MD may progress slowly, and lifespan may be normal, whereas in more severe cases, muscle weakness can progress quickly (to the point of respiratory failure in some individuals) with functional disability, loss of movement and premature death. (drweil.com)
In general, symptoms include some form of progressive muscle weakness, lack of coordination and a progressive crippling due to contractures of muscles around joints. (drweil.com)
Signs and symptoms may include frequent falls, enlarged calf muscles, a waddling gait with weakness in the lower leg muscles, and difficulty getting up from a seated or lying position. (drweil.com)
Muscle weakness can also be a facet of the disease, along with cataracts, cardiac abnormalities, and endocrine disturbances (such as diabetes). (drweil.com)
Severity of symptoms can vary greatly and include weakness in the facial muscles giving rise to a thin face, drooping eyelids, and a swan-like neck with potential difficulties speaking and swallowing. (drweil.com)
Weakness in the arms and legs usually starts slowly with the limb muscles farthest from the torso - feet and lower legs, hands and forearms. (drweil.com)
Weakness in respiratory muscles can cause difficulties with breathing, and heart rhythm abnormalities can lead to repeated bouts of fatigue, dizziness, and fainting.Rarely, infants can have this form of MD, known as congenital myotonic dystrophy. (drweil.com)
Although they often do not exhibit myotonia (the inability to relax muscles after voluntarily contracting them), the infant form seems to be more severe with muscle weakness, respiratory abnormalities, difficulties with sucking and swallowing along with cognitive impairment. (drweil.com)
Facioscapulohumeral MD usually begins in the teenage years, causing progressive weakness in muscles of the face, arms, legs, and around the shoulders and chest. (drweil.com)
Inclusion Body Myositis ,or IBM, is one of many muscle diseases known as inflammatory myopathies, which causes slowly progressing muscular atrophy and weakness(NINDS IBM ,2014,para 1). (bartleby.com)
Signs and symptoms are characterized as: muscles weakness, muscle atrophy, twitching and reduced muscle reflexes. (bartleby.com)
Clinical features include muscle weakness. (msdmanuals.com)

Altered mechanisms of Ca 2+ transport may underlie the contractile dysfunctions that have been frequently reported to occur in diabetic cardiac and skeletal muscle tissues. (uaeu.ac.ae)
Increased curiosity about CAPN3 was highly stimulated when it had been reported that mutations in its gene bring about limb-girdle muscular dystrophy (LGMD) type 2A, seen as a the continuous atrophy of hip and make muscle tissues (LGMD2A, or calpainopathy) (21). (exposed-skin-care.net)
Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)

This inactivation depends on the current being carried across the membrane by calcium ions, rather than strontium or barium ions. (ox.ac.uk)
When parathyroid hormone (PTH) binds to receptors on these cells, the osteocytic membrane pumps calcium ions from the bone fluid into the extracellular fluid. (medscape.com)
Calcium channels made with the CACNA1S subunit are located in the outer membrane of muscle cells, so they can transmit electrical signals from the cell surface to inside the cell. (medlineplus.gov)
RYR1 channels are located in the membrane of a structure inside the cell that stores calcium ions. (medlineplus.gov)
The resting muscle fiber membrane is polarized primarily by the movement of chloride through chloride channels and is repolarized by movement of potassium. (medscape.com)
Ion channel dysfunction is usually well compensated with normal excitation, and additional triggers are often necessary to produce muscle inexcitability owing to sustained membrane depolarization. (medscape.com)
Ryanodine is an ion channel, embedded in an internal membrane within the muscle cell, that surrounds a pocket of calcium ions. (the-scientist.com)

Calcium is required for muscle contractions and also for many cells (like neurons) to properly secrete signals and hormones. (brainmass.com)
Muscles of hollow organs like the digestive tract and uterus can also become progressively weak, causing problems with digestion and insufficient uterine contractions during childbirth. (drweil.com)
Dantrolene stimulates muscle relaxation by modulating skeletal muscle contractions at sites beyond the myoneural junction and acting directly on muscle itself. (medscape.com)

More than 99% of the total body calcium is stored in bone in the form of phosphate and hydroxide salts, predominantly as hydroxyapatite. (medscape.com)
Parathyroid hormone (PTH) promotes absorption of calcium from the bone in 2 ways. (medscape.com)
The process of bone remodelling ensures that there is a near constant amount of calcium in the blood. (brainmass.com)
As a female goes through puberty, her weight and height increases, skeletal growth is completed, bone mass increases and the body begins to change in composition. (ennonline.net)
Historically, vitamin D had been linked to skeletal disease including calcium, phosphorus, and bone metabolism, 1 2 osteoporosis, 3 fractures, 4 5 muscle strength, 6 and falls. (bmj.com)
Calcium measurements are used in the diagnosis and treatment of parathyroid disease, bone diseases, chronic renal disease and tetany. (cdc.gov)
Treatment to increase calcium excretion and reduce bone resorption of calcium involves saline, sodium diuresis, and medications such as those used for treatment of seizure disorders. (msdmanuals.com)
It should be emphasized that these patients frequently have bone lesions, which leads to release of calcium from the damaged bone tissue. (medscape.com)
The main effects of parathyroid hormone are to increase the concentration of plasma calcium by increasing the release of calcium and phosphate from bone matrix, increasing calcium reabsorption by the kidney, and increasing renal production of 1,25-dihydroxyvitamin D-3 (calcitriol), which increases intestinal absorption of calcium. (medscape.com)
Skeletal manifestations include a selective cortical bone loss. (medscape.com)

Calcium is the main regulator of skeletal muscle metabolic activity. (tue.nl)
7 In the 2000s, growing scientific attention turned to non-skeletal chronic diseases as vitamin D deficiency was linked to cancer, 8 cardiovascular diseases, 9 10 metabolic disorders, 11 infectious diseases, 12 and autoimmune diseases, 13 14 15 as well as mortality. (bmj.com)

Although the agrin/MuSK signaling pathway remains largely unknown, changes in intracellular calcium levels are required for agrin-induced AChR aggregation (Megeath and Fallon [1998]: J Neurosci 18: 672-678). (nih.gov)
Our results establish a novel role for L-CaChs as important sources of the intracellular calcium necessary for the aggregation of AChRs. (nih.gov)

Noxiustoxin (NTX) is a toxin from the venom of the Mexican scorpion Centruroides noxius Hoffmann which block voltage-dependent potassium channels and calcium-activated potassium channels. (wikipedia.org)
Furthermore, it affects calcium-activated potassium channels of skeletal muscles. (wikipedia.org)

Vitamin D deficiency may impair muscle function through a reduction in energy production in the muscles, according to a new study published in the Journal of Endocrinology . (pharmacytimes.com)
Further research investigating the direct effect of vitamin D deficiency on muscle function and strength will be required to confirm this finding, they added. (pharmacytimes.com)
Our results show there is a clear link between vitamin D deficiency and oxidative capacity in skeletal muscle," said Andrew Philp, PhD, BSc, in a press release. (pharmacytimes.com)
Vitamin D deficiency may impair muscle function [news release]. (pharmacytimes.com)

The model showed that subtle changes in sarcomere microstructure influenced the local calcium concentration. (tue.nl)
Furthermore, local calcium concentration sensed by mitochondria was higher than average calcium concentration and also above the activation constant of the mitochondria, whereas the local concentration was not. (tue.nl)
The resulting increase in calcium ion concentration within muscle cells stimulates muscles to contract, allowing the body to move. (medlineplus.gov)
An increase in calcium ion concentration also causes skeletal muscles to contract abnormally, which leads to muscle rigidity. (medlineplus.gov)
The channel regulates the changes in calcium ion concentration that control the muscle contractile apparatus and, in turn, muscle movement. (the-scientist.com)
In addition, proper calcium concentration is required for. (msdmanuals.com)
Calcium concentration, both total and free, is characterized by a high physiological variation, depending on age, sex, physiological state (eg, pregnancy), and even season (owing to the seasonal variation of vitamin D, which is directly involved in the regulation of calcium concentration). (medscape.com)
Unless serum proteins contain abnormalities, total serum calcium concentration is normally between 8.5 and 10.2 mg/dL of serum. (medscape.com)
Because ionized calcium is the only component of the total serum calcium level that is regulated by calciotropic hormones, decisions on the total serum calcium concentration should not be made unless changes in concentrations of plasma proteins, particularly albumin , are considered. (medscape.com)
In patients multiple myeloma, the globulin concentration is often increased, leading to excessive binding of calcium to the monoclonal paraprotein and occasional elevation of the total serum calcium concentration, yet the ionized calcium level may be normal in these individuals. (medscape.com)
The secretion of parathyroid hormone is regulated directly by the plasma concentration of ionized calcium. (medscape.com)

CAPN3 is normally a component from the skeletal muscles triad, in charge of calcium release. (exposed-skin-care.net)

Pregnancy is characterized by physiologic changes in mineral metabolism, to allow calcium accretion in the fetal skeleton [ 1-3] . (who.int)

Research shows that calcium signals play a serious role in the control of neuronal (nerve) functions and plasticity (the ability of the brain to change formations during interconnections between neurons). (brainmass.com)
Braughler, J.M., Dyncan, L.A. and Goodman, T. (1985) Calcium enhances in vitro free radical induced damage to brain synaptosomes mitochondria and cultured spinal cord neurons. (scirp.org)
Cardiac muscle has some similarities to neurons and skeletal muscle, as well as important unique properties. (wikipedia.org)
1987. The influence of skeletal muscle on the electrical excitability of dorsal root ganglion neurons in culture. (cdc.gov)

In the kidney, parathyroid hormone (PTH) blocks reabsorption of phosphate in the proximal tubule while promoting calcium reabsorption in the ascending loop of Henle, distal tubule, and collecting tubule. (medscape.com)

Calcium homeostasis is a complex process involving the following 4 key components: serum calcium, serum phosphate, 1,25-dihydroxyvitamin D-3, and parathyroid hormone (PTH). (medscape.com)
A schematic diagram of calcium homeostasis can be seen below. (medscape.com)
Schematic diagram of calcium homeostasis. (medscape.com)
Crises reflect a disturbance of skeletal muscle calcium homeostasis. (bmj.com)

Joan Domingo-Espín J, Lindahl M, Nilsson-Wolanin O, Cushman S W, Stenkula K G, Lagerstedt J O. Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal. (lu.se)

The functional benefits of exercise on SOCE, constitutive Ca 2+ entry and muscle force production were lost in mice with muscle-specific loss of Orai1 function. (elifesciences.org)

Differential splicing of the titin gene results in numerous species- and muscle-specific titin isoforms. (frontiersin.org)

Malignant hyperthermia (MH) is a rare hypermetabolic syndrome of the skeletal muscle and a potentially fatal complication of general anesthesia. (sciencedaily.com)

The disorder is due to abnormally increased levels of cell calcium in the skeletal muscle. (sciencedaily.com)

In the I-band part skeletal muscle titin is composed of a series of proximal Ig-domains, the N2A-domain (including the N2-A unique sequence), the PEVK domain [high abundance of proline (P), glutamic acid (E), valine (V), and lysine (K)] and the distal Ig-domains. (frontiersin.org)

Symptoms include body temperature of up to 107 degrees, muscle rigidity, system-wide organ failure, and possible death. (sciencedaily.com)
Although serum calcium levels above 11.5 mg/dL commonly cause symptoms, patients may be asymptomatic at this level. (medscape.com)

The primary action of 1,25-(OH) 2 D3 is to promote gut absorption of calcium by stimulating formation of calcium-binding protein within the intestinal epithelial cells. (medscape.com)
In most laboratories, autoanalyzers are used to measure the total serum calcium level accurately and reproducibly, although atomic absorption spectrophotometers probably provide even greater accuracy. (medscape.com)
The absorption of zinc may be reduced by calcium salts. (who.int)

Dulhunty had set up electrophysiology experiments on a receptor from mammalian cardiac muscle fiber to measure its activity, and her initial measurements on the receptor's activity were going nicely. (the-scientist.com)
I could see immediately that the glutathione transferase began to inhibit the cardiac muscle receptor's activity," she recalls. (the-scientist.com)

Troponin C1 is skeletal and cardiac type whereas troponin C2 is skeletal type. (nih.gov)
The voluntary Skeletal Muscles are long, slender, multinucleate disks with obvious striations have T-tubules utilizing actin and troponin. (bartleby.com)

All forms of familial PP show the final mechanistic pathway involving aberrant depolarization, inactivating sodium channels, and muscle fiber inexcitability. (medscape.com)
Like skeletal muscle, depolarization causes the opening of voltage-gated calcium channels and release of Ca 2+ from the t-tubules . (wikipedia.org)

Immunoblotting of microsomal membranes from normal and streptozotocin-induced diabetic muscle revealed no significant changes in heart, but an increase in the relative abundance of calsequestrin and calsequestrin-like proteins in skeletal muscle. (uaeu.ac.ae)
The expression of fast muscle marker proteins was not affected, indicating that no relevant fibre transformation occurred in streptozotocin-treated rat muscles. (uaeu.ac.ae)
Protein-interactions e.g., with muscle ankyrin repeat proteins or muscle LIM-protein link titin to hypertrophic signaling and via p62 and Muscle Ring Finger proteins to mechanisms that control protein quality control. (frontiersin.org)
Channels made with the altered CACNA1S proteins likely activate the RYR1 channel improperly in response to certain drugs (particularly some anesthetics and a type of muscle relaxant used during surgery). (medlineplus.gov)
This was the start of Dulhunty's work to discover the significance of these proteins in muscle. (the-scientist.com)

Taurine is significantly involved in functions of the cardiovascular, skeletal muscle, retina, and the central nervous system. (academicjournals.org)

The results suggest that oxidative damage of erythrocyte caused by phenyl hydrazine could be prevented by calcium channel antagonist, diltiazem, which may act as antioxidant also. (scirp.org)

Signals transmitted by CACNA1S-containing channels turn on (activate) RYR1 channels, which then release calcium ions inside the cells. (medlineplus.gov)
As a result, large amounts of calcium ions are released from storage within muscle cells. (medlineplus.gov)
Mutations in the CACNA1S gene change single protein building blocks (amino acids) used to make the CACNA1S protein, which alters the structure and function of calcium channels in skeletal muscle cells. (medlineplus.gov)
The altered channels open more slowly than usual, reducing the flow of calcium ions into these cells. (medlineplus.gov)
Overexpression of Bax induces down-regulation of store-operated calcium entry in prostate cancer cells. (osu.edu)
Nash, G.B., Boghossian, S., Parmar, J., Dormandy, J.A. and Bevan, D. (1989) Alteration of the mechanical properties of sickle cells by repetitive deoxygenation: role of calcium and the effects of calcium blockers. (scirp.org)
Muscle samples were collected and myogenic cells were isolated and cultivated. (nature.com)
Proliferating, BrdU-positive cells in muscle sections were detected with immunohistochemistry indicating different cell types and decreasing proliferation with age. (nature.com)
The conduction system consists of specialized heart muscle cells , situated within the myocardium . (wikipedia.org)
On a whim, she decided to add the enzyme glutathione transferase to the muscle cells' medium, just because the chemical was sitting on the lab bench next to her. (the-scientist.com)

An elevated intact parathyroid hormone level with an elevated ionized serum calcium level is diagnostic of primary hyperparathyroidism. (medscape.com)
Patients with secondary hyperparathyroidism usually have low-normal calcium and elevated parathyroid hormone. (medscape.com)

Through their secretion of parathyroid hormone (PTH), the parathyroid glands are primarily responsible for maintaining extracellular calcium concentrations. (medscape.com)

The major target end organs for parathyroid hormone (PTH) action are the kidneys, skeletal system, and intestine. (medscape.com)
These are considered healthy choices because they contain a considerable amount of Vitamin D. Vitamin D helps your body regulate its calcium levels and is good for your kidneys, parathyroid glands, skin, etc. (lifehack.org)

to its most active form, calcitriol (which increases the percentage of dietary calcium absorbed by the intestine). (msdmanuals.com)

The primary response to parathyroid hormone (PTH) by the kidney is to increase renal calcium resorption and phosphate excretion. (medscape.com)
Feedback inhibition of parathyroid hormone (PTH) release occurs primarily by direct effect of calcium at the level of the parathyroid gland. (medscape.com)
Compared to parathyroid hormone (PTH), vitamin D exerts a much slower regulatory effect on calcium balance. (medscape.com)
Diagnosis is by measuring serum ionized calcium and parathyroid hormone concentrations. (msdmanuals.com)
Thus, overproduction of parathyroid hormone results in elevated levels of plasma calcium. (medscape.com)
The serum level of parathyroid hormone, calcium, phosphorus, and 25-hydroxyvitamin D should be measured. (medscape.com)

Agrin responsiveness was significantly reduced in primary muscle cultures from the muscular dysgenesis mouse, a natural mutant, which does not express the L-CaCh. (nih.gov)
Muscular dystrophy is a general term for a group of inherited diseases involving defects in the genes responsible for normal muscle functioning. (drweil.com)
The most common types of muscular dystrophy, like Duchenne's and Becker's appear to be due to a genetic mutation resulting in the absence or deficiency of dystrophin , a protein involved in maintaining the integrity of muscle. (drweil.com)
Acting as levers is a function of the muscular and skeletal systems, not the integumentary system. (proprofs.com)
Dr Bakker's research focuses on the mechanisms of muscle damage from sport and chronic diseases, including strenuous exercise, eccentric exercise and Duchenne muscular dystrophy. (edu.au)

The CACNA1S gene provides instructions for making the main piece (subunit) of a structure called a calcium channel. (medlineplus.gov)
This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. (wikidoc.org)

Explain how a drug that interferes with the functioning of voltage-gated calcium channels could decrease the transmission of painful signals . (brainmass.com)

Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase when higher doses are used concomitantly with cyclosporine and strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, HIV protease inhibitors). (nih.gov)

Channels containing the CACNA1S protein are found in muscles used for movement (skeletal muscles). (medlineplus.gov)
As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
Protein needs are highest between the ages of 11-14 years due to growth and increase of muscle mass. (ennonline.net)
Total serum calcium is less difficult to measure than the ionized calcium component is, and ionized calcium measurements are rarely needed if serum protein concentrations can be measured. (medscape.com)

Hereto, the spatiotemporal dynamics of the free calcium distribution in a fast-twitch muscle sarcomere was studied using a reaction-diffusion computational model. (tue.nl)
1998 112:297-316), but was adapted to handle local calcium dynamics in mouse EDL fast twitch muscle at 35C. (tue.nl)
These results indicate that TT association with SR-stacks enhances Orai1-dependent SOCE to optimize Ca 2+ dynamics and muscle contractile function during acute exercise. (elifesciences.org)
Understanding the dynamics of calcium signals is achieved. (brainmass.com)
The dynamics of calcium signals which are achieved are given. (brainmass.com)

The up-regulation of the high-capacity Ca 2+ -binding element calsequestrin might represent a compensatory mechanism of diabetic skeletal muscle. (uaeu.ac.ae)
Her laboratory investigates the molecular mechanism of muscle-kidney crosstalk through a muscle-enriched myokine, MG53. (osu.edu)
Our previous studies showed that Gln had the potential to increase muscle fiber size in piglets 16 , but the mechanism was not clear. (nature.com)

Negatively charged phosphate ion may passively flow through the intestinal cell because of flux of the positively charged calcium ion. (medscape.com)

Cranial musculature and respiratory muscles usually are spared. (medscape.com)

An overabundance of calcium ions activates processes that generate heat (leading to increased body temperature) and produce excess acid (leading to acidosis). (medlineplus.gov)

The heart is a functional syncytium as opposed to a skeletal muscle syncytium . (wikipedia.org)

Anatomy55

Organisms17

Diseases19

Chemicals and Drugs89

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes55

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena3

Information Science3

Health Care2

Sarcoplasmic reticulum10

Fibers6

Ryanodine receptor9

Creatine kinase2

Contraction4

Fibres1

Mitochondrial11

Physiology5

Weakness22

Tissues3

Membrane7

Contractions3

Bone10

Metabolic2

Intracellular2

Potassium channels2

Vitamin D deficien4

Concentration11

Triad1

Metabolism1

Neurons4

Promoting calcium reabsorption1

Homeostasis4

Uptake1

Mice1

Isoforms1

Malignant1

Abnormally1

Proximal1

Symptoms2

Absorption3

Cardiac muscle2

Troponin2

Depolarization2

Proteins5

Cardiovascular1

Oxidative1

Cells10

Hyperparathyroidism2

Extracellular1

Kidneys2

Increases1

Parathyroid6

Muscular5

Subunit2

Voltage-gated c1

Rhabdomyolysis1

Protein4

Dynamics5

Mechanism3

Intestinal1

Respiratory muscles1

Increased body temperature1

Functional1