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Potassium ChannelsPotassiumPotassium Channels, Inwardly RectifyingPotassium Channel BlockersPotassium Channels, Voltage-GatedKv1.3 Potassium ChannelKv1.2 Potassium ChannelIon ChannelsKv1.1 Potassium ChannelCalcium ChannelsShaker Superfamily of Potassium ChannelsKv1.5 Potassium ChannelIon Channel GatingShaw Potassium ChannelsProtein Structure, QuaternaryPotassium Channels, Calcium-ActivatedMolecular Sequence DataAmino Acid SequenceEther-A-Go-Go Potassium ChannelsShab Potassium ChannelsKCNQ1 Potassium ChannelKCNQ Potassium ChannelsShal Potassium ChannelsKineticsCalcium SignalingLarge-Conductance Calcium-Activated Potassium ChannelsKv1.4 Potassium ChannelKCNQ2 Potassium ChannelMembrane PotentialsKATP ChannelsProtein ConformationKCNQ3 Potassium ChannelPotassium Channels, Tandem Pore DomainModels, MolecularPatch-Clamp TechniquesElectrophysiologyDelayed Rectifier Potassium ChannelsRecombinant ProteinsCalcium Channels, L-TypeCalcium Channel BlockersProtein BindingG Protein-Coupled Inwardly-Rectifying Potassium ChannelsSmall-Conductance Calcium-Activated Potassium ChannelsChloride ChannelsElectric ConductivityTetraethylammoniumOocytesGlyburideXenopus laevisCalcium, DietaryCalcium Channels, N-Type4-AminopyridineIntermediate-Conductance Calcium-Activated Potassium ChannelsXenopusKv Channel-Interacting ProteinsScorpion VenomsSodiumLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsCharybdotoxinCalcium Channel AgonistsSodium Channel BlockersCromakalimAdenosine TriphosphatePotassium, DietaryPinacidilNeuronsAction PotentialsSulfonylurea ReceptorsCells, CulturedDose-Response Relationship, DrugRats, Sprague-DawleyBariumTetraethylammonium CompoundsBarium CompoundsCalciumPotassium DeficiencyTRPC Cation ChannelsKv1.6 Potassium ChannelIon TransportCalcium CarbonatePotassium CompoundsPotassium ChlorideApaminCyclic Nucleotide-Gated Cation ChannelsCell LineProtein SubunitsCalcium Channels, T-TypeBenzopyransElapid VenomsLarge-Conductance Calcium-Activated Potassium Channel beta SubunitsCell MembraneReceptors, DrugMutationProtein Structure, TertiaryTime FactorsTRPV Cation ChannelsNicorandilCesiumCalcium ChlorideDiazoxide
IonsSubunitsProtein
Ions7
  • The flow of potassium ions is interrupted by interaction of an inactivating particle, an auxiliary protein in humans but an intrinsic part of the channel in other species. (wikipedia.org)
  • Central to this surveillance system is the movement of calcium ions into and out of cells. (elifesciences.org)
  • Calcium ions are normally kept at very low levels inside of cells and subtle changes in these levels relay information about the external environment. (elifesciences.org)
  • In the case of plant roots, changes in the concentration of calcium ions herald essential information about soil conditions and the presence of microorganisms, and in turn trigger appropriate responses. (elifesciences.org)
  • These proteins act as channels and allow ions to move across cell membranes. (elifesciences.org)
  • Further experiments found that the channel formed by the mutated CNGC protein is leaky and allows calcium ions to enter the cell in the absence of any cue from the environment. (elifesciences.org)
  • The leaky entry of calcium ions likely confuses the plant's surveillance system, which disturbs the normal development of the root. (elifesciences.org)
Subunits3
  • These subunits regulate channel inactivation as well as its expression. (wikipedia.org)
  • brush resides in a cluster of redundant CNGCs encoding subunits which resemble metazoan voltage-gated potassium (Kv1-Kv4) channels in assembly and gating properties. (elifesciences.org)
  • The results reveal a mechanism by which quantitative competition between channel subunits for tetramer assembly can impact the phenotype of the mutation carrier. (elifesciences.org)
Protein5
  • The recommended name for this protein is potassium voltage-gated channel subfamily A member 1 but a number of alternatives have been used in the literature including HuK1 (human K+ channel I), RBK1 (rubidium potassium channel 1), MBK (mouse brain K+ channel), voltage gated potassium channel HBK1, voltage gated potassium channel subunit Kv1.1, voltage-gated K+ channel HuKI and AEMK (associated with myokymia with periodic ataxia). (wikipedia.org)
  • The protein is believed to have six domains (S1-S6) with the loop between S5 and S6 forming the channel pore. (wikipedia.org)
  • The C-terminus is associated with a PDZ domain protein involved in channel targeting. (wikipedia.org)
  • The protein functions as a potassium selective channel through which the potassium ion may pass in consensus with the electrochemical gradient. (wikipedia.org)
  • These findings provide important insights into the function of CNGCs and reveal how a small change in a channel protein can have far reaching effects on an organism. (elifesciences.org)