• The most common complication of renal osteodystrophy is fracture, which may be insufficiency fractures through osteomalacic bone or pathologic fractures through brown tumors or amyloid deposits. (medscape.com)
  • Anteroposterior radiograph of the hip in a dialysis patient reveals erosion of a large portion of the medial femoral neck and trochanteric region from amyloid deposition (arrowheads) with a pathologic fracture in the basocervical portion of the femoral neck (arrow). (medscape.com)
  • As many as 30% of myeloma patients may present with a pathologic fracture, and up to two-thirds with bone pain alone as the initial symptom of disease [7]. (crimsonpublishers.com)
  • Risk of a fat embolism is greatest in the first 48 hours after the fracture of a long bone. (rnpedia.com)
  • The bone fracture probabilities were obtained from a cohort study of 3614 women from USA with PMO treated with RIS-GR (1807) or ALN (1807) (Thomasius, 2022). (bvsalud.org)
  • This expert opinion discussed the current level I evidence on the experimental pharmacological agents used to favor bone fracture healing. (bvsalud.org)
  • All the randomized clinical trials investigating pharmacological agents for bone fracture healing were accessed. (bvsalud.org)
  • EXPERT OPINION: Calcitonin could favor bone fracture healing. (bvsalud.org)
  • The case of a patient with Paget's disease of the pelvis ( acetabulum ) who had an intraoperative posterior wall fracture during the insertion of a noncemented acetabular component into an under-reamed acetabular bed of sclerotic Pagetoid bone is reported. (lookfordiagnosis.com)
  • Pathologic fractures due to weight bearing may develop. (wikipedia.org)
  • Skeletal deformity can occur in the vertebral bodies and skull (basilar invagination), and fractures can occur in the vertebrae and long bones. (medscape.com)
  • patients with sclerotic bone, like those with osteoporotic bone, may also be at risk for periprosthetic acetabular fractures when an under-reaming technique is used. (lookfordiagnosis.com)
  • Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. (wikipedia.org)
  • This marked increase in urine calcium is the direct result of an imbalance between bone formation and bone resorption. (medscape.com)
  • In addition, the increased bone resorption precedes the increase in osteoblastic activity. (medscape.com)
  • However, while bone is continuously remodeling by resorption/neoformation during life, tooth's hard tissues are not. (bvsalud.org)
  • On conventional skeletal survey, 10% had minimal subperiosteal bone resorption limited to the phalanges. (rsna.org)
  • By absorptometric analysis and fine-detail radiography, a majority were found to have demineralization and excessive bone resorption. (rsna.org)
  • citation needed] There are two main causes of osteomalacia: insufficient calcium absorption from the intestine because of lack of dietary calcium or a deficiency of, or resistance to, the action of vitamin D, or due to undiagnosed celiac disease. (wikipedia.org)
  • Absorption of calcium from the gastrointestinal (GI) tract has been found to decrease in the acute period following injury. (medscape.com)
  • Osteosarcoma, Ewing sarcoma and chondrosarcoma represent 70% of primary bone tumor diagnoses, and malignant primary bone tumors represent around 3,300 new cases annually in the United States [5,6]. (crimsonpublishers.com)
  • Clinical features, incidence, and survivorship of malignant primary bone tumors [5-7]. (crimsonpublishers.com)
  • The impairment of bone metabolism causes inadequate bone mineralization. (wikipedia.org)
  • Osteoporosis in persons with spinal cord injury was first studied in relation to calcium metabolism and the associated hypercalcemia and renal calculi that followed. (medscape.com)
  • In addition to low systemic levels of circulating mineral ions (for example, caused by vitamin D deficiency or renal phosphate wasting) that result in decreased bone and tooth mineralization, accumulation of mineralization-inhibiting proteins and peptides (such as osteopontin and ASARM peptides), and small inhibitory molecules (such as pyrophosphate), can occur in the extracellular matrix of bones and teeth, contributing locally to cause matrix hypomineralization (osteomalacia/odontomalacia). (wikipedia.org)
  • Vitamin D and calcium supplements are measures that can be used to prevent and treat osteomalacia. (wikipedia.org)
  • Osteomalacia is a generalized bone condition in which there is inadequate mineralization of the bone. (wikipedia.org)
  • Symptoms: Diffuse joint and bone pain (especially of spine, pelvis, and legs) Muscle weakness Difficulty walking, often with a waddling gait Hypocalcemia (positive Chvostek sign) Compressed vertebrae and diminished stature Pelvic flattening Weak, soft bones Easy fracturing Bending of bones Osteomalacia in adults starts insidiously as aches and pains in the lumbar (lower back) region and thighs before spreading to the arms and ribs. (wikipedia.org)
  • Rickets and osteomalacia are different manifestations of the same underlying pathologic process, depending on whether the patient is a child or an adult, respectively. (medscape.com)
  • The histopathologic findings of renal osteodystrophy are commonly used to further classify the condition into high bone turnover states, such as osteitis fibrosa and hyperparathyroidism, and low bone turnover states, such as adynamic bone disease or heavy metal-induced osteomalacia. (medscape.com)
  • Aminobisphosphonates (N-BPs) that include pamidronate, zoledronate, or alendronate, are the first-line treatment of bone-related diseases including osteoporosis and bone malignancies. (bvsalud.org)
  • A condition marked by softening of the bones (due to impaired mineralization, with excess accumulation of osteoid), with pain, tenderness, muscular weakness, anorexia, and loss of weight, resulting from deficiency of vitamin D and calcium. (uams.edu)
  • It is concluded that hypoparathyroid patients being treated with vitamin d and calcium should be carefully monitored in the case of an intercurrent illness or a change in medication. (lookfordiagnosis.com)
  • Clinical manifestations, radiographic findings, and bone mineral measurements of 65 patients with primary hyperparathyroidism are reviewed. (rsna.org)
  • Vitamin D should always be administered in conjunction with calcium supplementation (as the pair work together in the body) since most of the consequences of vitamin D deficiency are a result of impaired mineral ion homeostasis. (wikipedia.org)
  • Renal osteodystrophy may also present with nonspecific signs and symptoms, including weakness, bone pain, and skeletal deformity. (medscape.com)
  • This model at the skeletal level following spinal cord injury resembles the high bone turnover rate seen in postmenopausal osteoporosis. (medscape.com)
  • Technically considered a plasma cell dyscrasia, multiple myeloma is the most common primary malignancy of bone [7,8]. (crimsonpublishers.com)
  • Shortly after mitral valve replacement she developed a severe hypercalcemia ( serum calcium 5.95 mmol/l) during a febrile illness. (lookfordiagnosis.com)
  • A relationship describing local, physiologic double-negative (inhibiting inhibitors) regulation of mineralization has been termed the Stenciling Principle of mineralization, whereby enzyme-substrate pairs imprint mineralization patterns into the extracellular matrix (most notably described for bone) by degrading mineralization inhibitors (e.g. (wikipedia.org)
  • Diseases that affect the METABOLIC PROCESSES of BONE TISSUE . (nih.gov)
  • Primary bone lesions are more commonly identified in patients under the age of 40, and can be subdivided into benign and malignant lesions. (crimsonpublishers.com)
  • The presence of multiple osteolytic bone lesions is a defining trademark of the disease. (crimsonpublishers.com)
  • Much less common are soft tissue lesions adjoining the pagetic bone that clinically and radiologically simulate sarcoma but histologically represent exaggerated periosteal bone formation as a manifestation of the basic pathologic process. (lookfordiagnosis.com)
  • Extramedullary hematopoiesis usually occurs in hematological diseases but may also be found as an uncommon complication of Paget's disease , probably due to bone effraction mechanism. (lookfordiagnosis.com)
  • Even so, in the past, dietary calcium reduction was commonly recommended as a way to decrease calcium excretion and prevent the complications of hypercalciuria. (medscape.com)
  • Stored samples from a prior clinical trial aimed at analyzing the effect of alendronate on bone mineral density, provided further evidence of alendronate-mediated latency reversal and activation of immune effector cells. (bvsalud.org)
  • The differences between osteoporosis induced by spinal cord injury and other causes of bone loss (disuse), such as prolonged bed rest, space travel, and lower motor neuron disorders, have since become clearer. (medscape.com)
  • [ 9 ] These other factors further separate spinal cord injury-induced osteoporosis from other causes of disuse demineralization. (medscape.com)
  • The result is an increase in bone reabsorption or osteoporosis related to parathyroid dysfunction in the chronic stages of spinal cord injury. (medscape.com)
  • Most of the time, the only alleged symptom is chronic fatigue, while bone aches are not spontaneous but only revealed by pressure or shocks. (wikipedia.org)
  • Mildly affected patients may present with nonspecific bone pain and tenderness and possibly hypotonia. (medscape.com)
  • The appearance of a sarcoma of bone is a well-recognized complication of Paget's disease . (lookfordiagnosis.com)
  • RESULTS: Computed tomographic scans disclosed osseous changes of the temporal and frontal bones, with areas of high density consistent with Paget disease . (lookfordiagnosis.com)
  • Alveolar bone response to light-force tipping and bodily movement in maxillary incisor advancement: A prospective randomized clinical trial. (vcu.edu)
  • The pain is symmetrical, non-radiating and accompanied by sensitivity in the involved bones. (wikipedia.org)
  • Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones. (wikipedia.org)
  • The loss of bone also may be enhanced by lack of muscle traction on bone or by other neural factors associated with spinal cord injury. (medscape.com)
  • The possible mechanisms for this severe elevation of the calcium level are discussed. (lookfordiagnosis.com)
  • INTRODUCTION: Pharmacological strategies might influence bone healing in terms of time to union or quality of mature bone. (bvsalud.org)
  • However, these physical signs may derive from a previous osteomalacial state, since bones do not regain their original shape after they become deformed. (wikipedia.org)