with Pubmed ID, gene symbol/accession number and viral interacting protein. (polygenicpathways.co.uk)
Expression2
Metabolomics and transcriptomic analysis revealed that BBBP suppressed the arginine biosynthesis by up-regulating NOS3 expression and the PI3K-Akt signaling pathway was also regulated by BBBP, as indicated by 55 DEGs. (bvsalud.org)
ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015 . (polygenicpathways.co.uk)
System1
The heart tissues express all of the essential components of the signal transduction system responsible for the innate immunity in the heart tissue. (highwire.org)
Susceptibility genes1
567 The two breast cancer susceptibility genes BRCA1 and BRCA2 are apparently responsible for about half of all hereditary breast and ovarian cancers. (binaryoptiontradingscam.com)
Pathways5
RESULTS: Coumarins have been reported to downregulate RANKL-RANK signaling and various downstream signaling pathways required for osteoclast development, such as NF-κB, MAPK, Akt, and Ca2+ signaling, as well as pathways downstream of the nuclear factor of activated T-cells (NFATc1), including tartrate-resistant acid phosphatase (TRAP), cathepsin K (CTSK), and matrix metalloproteinase 9 (MMP-9). (bvsalud.org)
We review the genetics of psoriatic arthritis and discuss the role of the innate immune system as important in the pathogenesis of PsA by focusing on key signaling pathways and cellular makeup. (bvsalud.org)
Understanding the candidate genes identified in PsA highlights pathways of critical importance to the pathogenesis of psoriatic disease including the key role of the innate immune response, mediated through IL-23/IL-17 axis, RANK and NFκB signaling pathways. (bvsalud.org)
This regulation occurs through the specificity of recruited immune cells and their differentiation, signaling pathways and gene expression. (biomedcentral.com)
NF-κB is attractive for inflammation studies due to the early activation, and the involvement in the large numbers of signaling pathways and the many genes related to immune functions that it controls [ 4 , 5 ]. (biomedcentral.com)
MAPK1
We found that morphine-activated BV-2 cells, including the upregulation of p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation, pro-inflammatory cytokines, and Toll-like receptor-4 (TLR-4) mRNA expression, which was inhibited by metformin. (biomedcentral.com)
Nuclear3
Several studies showed that morphine induces a proinflammatory response through binding to Toll-like receptor 4 (TLR4), leading to initiation of the TLR4 signaling cascade, as do direct modulators of p38 and nuclear factor-κB (NF-κB), subsequently regulating the expression of multiple inflammation factors [ 7 , 8 ]. (biomedcentral.com)
OBJECTIVE: To summarize the research progress on the calcitonin gene-related peptide (CGRP) and receptor activator of nuclear factor κB (RANK)/receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) system during bone reconstruction to provide theoretical basis for further research on the prevention and treatment of bone-related diseases. (bvsalud.org)
Because expression of this receptor is transcriptionally regulated by nuclear factor-κB (NF-κB), which is activated by enteric pathogens as a part of the host epithelial response to infection, we investigated whether such bacterial pathogens could directly increase Gal1-R expression in the T84-cell model system. (jci.org)
Activation2
We have shown previously that galanin-1 receptors (Gal1-R) are expressed by epithelial cells lining the human GI tract, and upon activation cause Cl - secretion. (jci.org)