Caenorhabditis elegans. Medical search. Frequent questions

The nematode Caenorhabditis elegans has a compact nervous system with only 302 neurons. (nature.com)
In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. (cshlpress.com)
The soil nematode Caenorhabditis elegans has served as a useful model to study the mechanism of action of avermectins. (nih.gov)
Defining a behavior that requires the function of specific neurons in the free-living nematode Caenorhabditis elegans can allow one to screen for mutations that disrupt the specification or function of those neurons. (jneurosci.org)
The nematode Caenorhabditis elegans lives in the soil, where it encounters and feeds on a wide variety of bacteria and fungi. (biomedcentral.com)
The nematode Caenorhabditis elegans is a widely used model organism for studying the biology of ageing and neurodegeneration. (researchsquare.com)
We developed two composite systems for monitoring mitophagy in vivo and identified conditions that either induce or suppress mitophagy in the nematode Caenorhabditis elegans . (researchsquare.com)
We have exploited the nematode Caenorhabditis elegans as a novel tool, because its pharynx is evolutionarily related to the vertebrate heart. (unipv.it)
CROLL, N. A. Components and patterns in the behaviour of the nematode Caenorhabditis elegans. (bvsalud.org)

Brenner, S. The genetics of Caenorhabditis elegans . (nature.com)
Since then, with the help of a growing number of investigators, knowledge about the biology of "the worm" has accumulated at a steadily accelerating pace to the extent that C. elegans is now probably the most completely understood metazoan in terms of anatomy, genetics, development, and behavior. (cshlpress.com)
The roundworm Caenorhabditis elegans is an outstanding model organism for studying molecular genetics, developmental biology, neuroscience, and cell biology. (molcells.org)
Despite the classic strengths of C. elegans for cell biology and genetics, very few chemical biology approaches are effective in this system. (unr.edu)
Attribution: This strain was provided by the C. elegans Reverse Genetics Core Facility at the University of British Columbia, which is part of the international C. elegans Gene Knockout Consortium, which should be acknowledged in any publications resulting from its use. (umn.edu)

In 1974, he began research into the molecular and developmental biology of C. elegans, which has since been extensively used as a model organism. (wikipedia.org)
Caenorhabditis elegans - Taxon details on Index to Organism Names (ION). (wikimedia.org)
Caenorhabditis elegans is an ideal model organism for studying the xenobiotic detoxification pathways of various natural and synthetic toxins. (nih.gov)
Laboratory uses == ''C. elegans'' is studied as a [[model organism]] for a variety of reasons. (wikidoc.org)
Caenorhabditis elegans is an important model organism with many useful features, including rapid development and aging, easy cultivation, and genetic tractability. (molcells.org)

C. elegans muscle age is a data set of fluorescence 20X microscopy images of C. elegans nematodes stained with phalloidin to visualize actin in muscles at different ages (1,2,4, and 8). (cellimagelibrary.org)
Home / Teams / Evolutionary Cell Biology in Nematodes - M. Delattre / Publications / Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner. (ens-lyon.fr)
We have used the C. elegans animal pathogenesis model to examine the ability of B. bacteriovorus to protect nematodes from four bacterial pathogens. (bsu.edu)
In Caenorhabditis elegans nematodes, selfing syndrome affects many traits involved in mating, rendering cross- fertilization highly inefficient. (bvsalud.org)

Individuals of ''C. elegans'' are almost all [[hermaphrodite]], with males comprising just 0.05% of the total population on average. (wikidoc.org)
C. elegans'' eggs are laid by the hermaphrodite. (wikidoc.org)
Longitudinal section through the hermaphrodite ''C. elegans. (wikidoc.org)
One noticeable advantage of C. elegans for such assays is that synchronized isogenic populations are simple to prepare because the worm usually exists as a self-fertilizing hermaphrodite that produces hundreds of isogenic progeny. (molcells.org)

In 1900, Maupas initially named it Rhabditides elegans. (wikipedia.org)
Cartographie génique du Nématode libre Caenorhabditis elegans , Maupas 1900, variété Bergerac . (wikimedia.org)

We established conditions for RNA interference (RNAi) in C. elegans to target multiple genes simultaneously in a high-throughput setting. (biomedcentral.com)
We established a high throughput method for examining genetic interactions using combinatorial RNAi in C. elegans . (biomedcentral.com)
C. elegans is also amenable to sophisticated, yet convenient, genetic techniques, such as feeding RNAi, transgenesis via microinjection, mutagenesis screening, and CRISPR/Cas9 genome editing. (molcells.org)

Now I'd got this culture, C. elegans , it had been isolated in Bristol and a strain had also been isolated in France where a man called Nigon had worked on it, that was called the Bergerac strain. (webofstories.com)
C]], the laboratory strain of ''C. elegans'' has an average life span of approximately 2-3 weeks and a generation time of approximately 4 days. (wikidoc.org)
This novel strain serves as a useful model to study the mechanism of Alzheimer's disease cognitive decline as C. elegans have a relatively short lifespan that allows for extensive therapeutic and genetic screening. (msu.edu)

We used this assay to examine the redundancy of duplicated genes in the genome of C. elegans that correspond to single orthologs in S. cerevisiae or D. melanogaster and identified 16 pairs of duplicated genes that have redundant functions. (biomedcentral.com)
Agar-based solid culture systems are the most common C. elegans lifespan assay approach. (molcells.org)
We adapted this versatile fluorescent microscopy assay and examined C. elegans animals carrying mtRosella, under normal and mitophagy-inducing conditions such as oxidative stress, mitochondrial stress and heat stress. (researchsquare.com)

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. (nih.gov)
We have identified a large number of proteins/genes that are differentially expressed in C. elegans when exposed to Shigella using both proteomic and transcriptomic approaches. (edu.au)
Furthermore, the data gained from experiments using these methods have contributed new insights into our understanding of the glycosylation of proteins with mitochondrial function.The first such method is a chemical biology approach for the discovery of glycoproteins in Caenorhabditis elegans (C. elegans). (unr.edu)
mutants will be broadly useful as a method for identifying multiple types of post-translationally modified proteins and analyzing their synthesis pathways with the power of C. elegans genetic analysis.The second method that I developed is an experimental strategy for identifying proteins that contain different post-translational modifications between samples (Chapter 5). (unr.edu)

In 1963, Sydney Brenner proposed research into C. elegans, primarily in the area of neuronal development. (wikipedia.org)

de Bono, M. & Maricq, A.V. Neuronal substrates of complex behaviors in C. elegans . (nature.com)
Chronis, N., Zimmer, M. & Bargmann, C.I. Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans . (nature.com)
B ) Venn diagram depicting TFs with significant age-associated differential expression alongside hpk-1 within 3 or more of the 36 neuronal and/or 11 non-neuronal cell clusters (yellow and blue, respectively), and the intersection with TFs that have previously been implicated in C. elegans longevity (red). (elifesciences.org)

Caenorhabditis elegans - Taxon details on National Center for Biotechnology Information (NCBI). (wikimedia.org)

We investigated whether CNVs constitute a common mechanism of genetic change during adaptation in experimental Caenorhabditis elegans populations. (biomedcentral.com)
C. elegans survival assays have played key roles in identifying novel genetic factors that regulate many aspects of animal physiology, such as aging and lifespan, stress response, and immunity against pathogens. (molcells.org)
Because many genetic factors discovered using C. elegans are evolutionarily conserved, survival assays can provide insights into mechanisms underlying physiological processes in mammals, including humans. (molcells.org)
C. elegans is a popular model for studying aging because of short lifespan and genetic tractability. (molcells.org)

Osche placed it in the subgenus Caenorhabditis in 1952, and in 1955, Dougherty raised Caenorhabditis to the status of genus. (wikipedia.org)

Systematic analyses of loss-of-function phenotypes have been carried out for most genes in Saccharomyces cerevisiae , Caenorhabditis elegans , and Drosophila melanogaster . (biomedcentral.com)
Experiments in human cell lines, mice, Drosophila, and Caenorhabditis elegans have shown that endonuclease G (ENDOG) plays a protective role against the development of TSC. (medscape.com)

The search of the C. elegans genome database for an AGT protein revealed the presence of a protein (cAGT-2) with some similarity to known AGTs in addition to the easily recognized cAGT-1 protein. (psu.edu)
ABSTRACT INVESTIGATION OF NEURODEGENERATIVE TAUOPATHIES USING CAENORHABDITIS ELEGANSByDerek Vonarx Neurodegenerative tauopathies are a class of neurodegenerative disease characterized by the accumulation of tau protein into neurofibrillary tangles in the human brain. (msu.edu)
From population and comparative genomics, we infer the insertion is derived in N2 and related laboratory lines, likely arising during the domestication of Caenorhabditis elegans, and breaking a conserved protein. (nyu.edu)

Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. (nih.gov)

abstract = "We present an optogenetic illumination system capable of real-time light delivery with high spatial resolution to specified targets in freely moving Caenorhabditis elegans. (princeton.edu)

Evolution of fertilization ability in obligatorily outcrossing populations of Caenorhabditis elegans . (bvsalud.org)

Berezikov, E. / Expression pattern analysis of microRNAs in Caenorhabditis elegans . (knaw.nl)
Isik, M & Berezikov, E 2013, ' Expression pattern analysis of microRNAs in Caenorhabditis elegans ', Methods in Molecular Biology , vol. 936, pp. 129-141. (knaw.nl)

We are examining what specific pathways are activated in C. elegans in response to Shigella infection and how they contribute to the Shigella -induced pathogenesis in the worm. (edu.au)

Knockdown of the C. elegans IMPACT homolog impt-1 activated the ISR pathway and increased lifespan and stress resistance of worms in a gcn-2 -dependent manner. (biomedcentral.com)
In C. elegans , different protocols of DR elicit different degrees of lifespan extension and stress resistance by often distinct and complementary mechanisms [ 7 ]. (biomedcentral.com)
for example, C. elegans stress resistance and lifespan assays usually take several days and weeks, respectively. (molcells.org)
Here, we briefly discuss the methods, requirements, advantages, and disadvantages of different survival assays using C. elegans , such as lifespan assays crucial for aging research, various abiotic stress resistance assays, and pathogen resistance assays important for studying immunity. (molcells.org)
To circumvent these issues, a nematode, C. elegans, model was developed because C. elegans have a short lifespan of three weeks, can be genetically modified to express human tau, and are inexpensive to maintain. (msu.edu)

Here, we report that Caenorhabditis elegans CED-3 caspase regulates asymmetric cell division. (ucl.ac.uk)

A comparison with a similar experiment in which C. elegans was infected with the gram-negative Aeromonas hydrophila reveals that merely 9% of the identified spots, some of which even exhibiting an opposite regulation, are present in both studies. (biomedcentral.com)

In relation to lipid metabolism, C. elegans does not have any specialized adipose tissues, a pancreas, a liver, or even blood to deliver nutrients compared to mammals. (wikipedia.org)

We have previously established that the spontaneous, genome-wide rate of gene duplication in C. elegans is two orders of magnitude higher than the point mutation rate [ 8 ]. (biomedcentral.com)

C. elegans is unsegmented, vermiform, and bilaterally symmetrical. (wikipedia.org)

C. elegans neurons contain dendrites which extend from the cell to receive neurotransmitters, and a process that extends to the nerve ring (the "brain") for a synaptic connection between neurons. (wikipedia.org)
C. elegans has motor excitatory and inhibitory neurons, known as cholinergic and gabaergic neurons, which simply act as further regulation for the tiny creature. (wikipedia.org)
Our results demonstrate that we can excite specific neurons expressing ChR2 while simultaneously monitoring G-CaMP fluorescence in several other neurons, making it possible to rapidly decipher functional connections in C. elegans neural circuits. (nature.com)
Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans . (nature.com)
We identified serotonin-immunoreactive neurons required for tail curling or "turning" behavior exhibited by C. elegans males during mating. (jneurosci.org)

Caenorhabditis elegans (/ˌsiːnoʊræbˈdaɪtəs ˈɛləɡæns/) is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. (wikipedia.org)
In recent years, C. elegans (a soil-dwelling nematode) has become an attractive animal model to study host-pathogen interactions. (edu.au)

This "Book of the Worm" serves as a reference source for C. elegans investigators as well as an introductory monograph for other biologists. (cshlpress.com)

Caenorhabditis elegans - Taxon details on World Register of Marine Species (WoRMS). (wikimedia.org)

For most C. elegans survival assays, both solid and liquid media systems with bacterial foods are employed. (molcells.org)
In recent years Caenorhabditis elegans has proven to be an attractive animal model of bacterial pathogenesis for a range of pathogens. (bsu.edu)

Our data demonstrate that the pharyngeal pumping of C elegans is significantly and selectively reduced by LCs from AL patients suffering from cardiomyopathy, but not by amyloid LCs with different organ tropism or nonamyloidogenic LCs from multiple myeloma. (unipv.it)

Caenorhabditis elegans has proven to be an appropriate model for transcriptome studies of host-pathogen interactions. (biomedcentral.com)

LB agar was chosen and C. elegans samples were collected 1 h, 4 h, 8 h and 24 h post S. aureus infection or E. coli incubation. (biomedcentral.com)

Some of these microbes are known pathogens, capable of infecting and even killing C. elegans . (biomedcentral.com)

The pharynx is a muscular food pump in the head of C. elegans, which is triangular in cross-section. (wikipedia.org)

Many in vivo experiments using C. elegans can be done in a relatively short time. (molcells.org)

This leads to translation of an alternative and functional open reading frame of the ATF4 gene ( atf-5 in C. elegans ) [ 20 , 21 ]. (biomedcentral.com)

Survival assays using C. elegans are powerful methods for studying physiological processes. (molcells.org)

The past few years have seen the completion of two major long-term projects that provide new insights into C. elegans development and lay important groundwork for future investigation: completion of the cell lineages of both sexes, from zygote to adult, and description of the complete anatomy at the level of electron microscope resolution, providing a complete "wiring diagram" of cell contacts in the animal. (cshlpress.com)

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. (alzforum.org)
This workflow can be used to test C . elegans responses to different toxins and also the response of different mutant strains to a toxin of interest. (nih.gov)
Assays that utilized their naïve attractive response were performed on N2 wild-type C. elegans and the pkc-1 mutant nj1, to determine how long the effects of the associative conditioning to these odors would last. (technologynetworks.com)

The neural circuit for touch sensitivity in Caenorhabditis elegans . (nature.com)

Previously we showed that few males of Caenorhabditis elegans wild type strains are able to successfully produce any cross progeny after experiencing temperature stress. (marquette.edu)
Sepulveda, Nicholas B. and Petrella, Lisa N., "Temperature Stressed Caenorhabditis elegans Males Fail to Mate Successfully and Successful Males Produce Very Few Viable Cross Progeny" (2021). (marquette.edu)

Numerous gut granules are present in the intestine of C. elegans, the functions of which are still not fully known, as are many other aspects of this nematode, despite the many years that it has been studied. (wikipedia.org)

Using laser destruction of the centrosomes during Caenorhabditis elegans mitosis, we show that neither of these mechanisms is necessary to achieve proper chromatid segregation. (ens-lyon.fr)

Bargmann, C.I. & Avery, L. Laser killing of cells in Caenorhabditis elegans . (nature.com)
Many of the 131 cells that are "programmed" to die during C. elegans development are the smaller daughter of a neuroblast that divides asymmetrically by size and fate. (ucl.ac.uk)
We speculate that the new nonapoptotic function of C. elegans CED-3 caspase in asymmetric neuroblast division is relevant to the function(s) of mammalian caspases in stem cells. (ucl.ac.uk)

In fact, C. elegans has been known to exhibit avoidance behaviour towards different types of pathogenic micro-organisms. (biomedcentral.com)

Temporal developmental progression is highly coordinated in Caenorhabditis elegans. (psu.edu)

Anatomy24

Organisms11

Diseases1

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology3

Phenomena and Processes60

Information Science4

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Nematode Caenorhabditis elegans9

Genetics5

Organism5

Nematodes4

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19002

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Cells3

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Developmental1