• actin
  • This conclusion is based on studies with HtTA-1 HeLa cells that were induced by overexpression of constitutively active Cdc42Hs to form typical adherens-type intercellular junctions enriched in cadherins (N-cadherin), beta-catenin, filamentous actin and myr 3. (biologists.org)
  • Overexpression of constitutively active Rac1 induced a distinct type of adherens junction in HeLa cells that was characterized by elaborate intercellular interdigitations enriched in N-cadherin, beta-catenin and F-actin. (biologists.org)
  • integrates
  • The proposed research is significant because it focuses on creating a robust, quantitative experimental platform to study the formation of the cadherin complex in vitro and integrates a quantitative understanding of cell mechanics. (gatech.edu)
  • Using conformation specific antibodies I show that Trp2 integrates into the domain fold of its own cadherin molecule in physiological conditions, but that this integration is not stable owing to structural constraints imposed by calcium binding to the cadherin. (bl.uk)
  • Assembly
  • We have engineered two different types of surfaces, based on self-assembly monolayers of alkanethiols on gold surfaces as well as micro-fabricated post-array detectors that present isolated and purified vascular endothelial cadherin ligands. (gatech.edu)
  • model
  • This raises the possibility that Trp2 could participate in intermolecular interactions during adhesion by inserting into opposing cadherins in what is referred to as the strand exchange model of cadherin adhesion. (bl.uk)
  • This model is tested directly by introducing cysteine substitutions into opposing cadherins such that disulphide bonds can form between them during adhesion only if they engage in strand exchange. (bl.uk)
  • directly
  • We show that the basolateral membrane aquaporin (AQP)-3, but not the equivalent apical membrane AQP5, is delivered in post-Golgi structures directly to forming cell-cell contacts where it co-accumulates precisely with E-cadherin. (rupress.org)
  • dynamic
  • Our results thus define the mechanism of cadherin adhesion as a dynamic balance between the conflicting tendencies of Trp2 to engage in intramolecular and intermolecular interactions. (bl.uk)
  • manner
  • Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. (wikipedia.org)