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  • interactions
  • At the mossy fiber terminals of hippocampus, nectin-1 and nectin-3 localize at the presynaptic and postsynaptic sides of synaptic junctions, respectively, and their trans-interactions play a role in formation of synapses in cooperation with N-cadherin. (uniprot.org)
  • PMID
  • CDH16 colocalises with CDH1/E-cadherin on the basolateral plasma membrane of thyrocytes, and might play a role during thyroid development [ PMID: 22028439 ]. (ebi.ac.uk)
  • CDH1
  • CDH1 is sometimes used as an abbreviation for 'CDC20 homolog 1' which is an alternate name for the FZR1 gene and thus can be confused with the official symbol for cadherin 1 (CDH1). (nih.gov)
  • Besides genetic mutations in CDH1 gene to induce hereditary diffuse gastric cancer (HDGC), epigenetic factors such as DNA hypermethylation also contribute to the reduction of E-cadherin in gastric carcinogenesis. (hindawi.com)
  • Specificity
  • One current model proposes that cells distinguish cadherin subtypes based on kinetic specificity rather than thermodynamic specificity, as different types of cadherin homotypic bonds have different lifetimes. (wikipedia.org)
  • synapses
  • Furthermore, N-cadherin is preferentially recruited to activated synapses. (rupress.org)
  • B) Synaptic activity promotes the localization of N-cadherin to activated synapses. (rupress.org)
  • During embryonic development, cadherins are initially widely distributed, but they become gradually more localized to pre- and post-synaptic sites while synapses are being formed. (wikipedia.org)
  • expression
  • Loss of E-cadherin expression. (springer.com)
  • Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. (ebi.ac.uk)
  • The expression of VE-cadherin in breast cancer cells modulates cell dynamics as a function of tumor differentiation and promotes tumor-endothelial cell interactions. (nih.gov)
  • Expression of E-cadherin in lung carcinoma, other than those with small cells (NSCLC). (nih.gov)
  • Therefore, the expression of E Cadherin might be an important parameter for the determination of the invasive potential of epithelial neoplasms, and for the transition of a benign to a malignant neoplasm. (abcam.com)
  • The authors further demonstrate that the expression of EGFP-N-cadherin is restricted to some spines and that this expression correlates with the stability of spines. (rupress.org)
  • The expression of the dominant-negative construct of N-cadherin prevents this activity-dependent enlargement of the spine head. (rupress.org)
  • Interestingly, this effect is also prevented by the expression of the full-length N-cadherin, suggesting that a physiological level of N-cadherin is critical for its ability to regulate the spine head width. (rupress.org)
  • Regulation of cadherin expression can occur through promoter methylation among other epigenetic mechanisms. (wikipedia.org)
  • T-cadherin expression results in LDL-induced migration of T-cadherin expressing cells compared to control. (wikipedia.org)
  • Expression of T-cadherin is upregulated in atherosclerotic lesions and post-angioplasty restenosis -conditions associated with pathological angiogenesis. (wikipedia.org)
  • T-cadherin expression is upregulated in ECs, pericytes and VSMC of atherosclerotic lesions. (wikipedia.org)
  • T-cadherin expression in arterial wall after balloon angioplasty correlates with late stages of neointima formation and coincidentally with the peak in proliferation and differentiation of vascular cells. (wikipedia.org)
  • NMDAR activity reduces phosphorylation of β-catenin at tyr-654, thereby inhibiting N-cadherin endocytosis and facilitating surface retention and expression. (wikipedia.org)
  • Cadherin expression is also regulated by activity-induced internalization, which occurs much later than surface stabilization (an average of 4 hours after the stimulus). (wikipedia.org)
  • N-cadherin is widely expressed in the embryo post-implantation, showing high levels in the mesoderm with sustained expression through adulthood. (wikipedia.org)
  • Expression of a mutant form of N-cadherin harboring a large deletion in the extracellular domain inhibited the function of endogenous N-cadherin in adult ventricular cardiomyocytes, and neighboring cardiomyocytes lost cell-cell contact and gap junction plaques as well. (wikipedia.org)
  • Mice with altered expression of N-cadherin and/or E-cadherin showed a dilated cardiomyopathy phenotype, likely due to malfunction of intercalated discs. (wikipedia.org)
  • catenins
  • Even genomes of ancestral metazoan species such as cnidarians and placozoans encode a limited number of distinct cadherins and catenins, emphasizing the conservation and functional importance of these gene families. (ovid.com)
  • α-catenins, when in monomeric form, will associate with the cadherin-catenin complex via β-catenins. (wikipedia.org)
  • N-cadherin complexed to catenins has been described as a master regulator of intercalated disc function. (wikipedia.org)
  • N-cadherins interact with catenins to play an important role in learning and memory (For full article see Cadherin-catenin complex in learning and memory). (wikipedia.org)
  • complexes
  • In turn, these forces elicit mechanosensory signals from cadherin complexes that ultimately impact on cell phenotype and function in multiple cell types ( 29 , 30 ), including pancreatic islets ( 31 ). (diabetesjournals.org)
  • High-molecular weight (HMW) complexes of adiponectin were suggested to be a specific ligand for T-cadherin. (wikipedia.org)
  • Cell
  • In addition to an extracellular (outside the cell) component, cadherins also have a piece that penetrates through the membrane and a piece that is inside the cell. (news-medical.net)
  • The interior portions of the cadherins form a complex within the cell. (news-medical.net)
  • Cadherins are also important in other aspects of cell organization, like the formation of boundaries, coordinated cell movements, and maintenance of structural and functional cell and tissue polarity. (news-medical.net)
  • Chlamydia pneumoniae infection promotes monocyte transendothelial migration by increasing vascular endothelial cell permeability via the tyrosine phosphorylation of VE-cadherin. (nih.gov)
  • Abcam's E-Cadherin Mouse ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Mouse E-Cadherin in serum, plasma and cell culture supernatants. (abcam.com)
  • Interestingly, cadherins can also function as mechanosensors that affect cell phenotype and function in a dose-dependent manner ( 25 , 26 ). (diabetesjournals.org)
  • 32 ) uncover direct involvement of E- and N-cadherin in the control of β-cell secretory function in response to glucose. (diabetesjournals.org)
  • This approach allowed them to emulate cadherin-mediated adhesions in single β-cells adherent to a substrate that presented high concentrations of recombinant E-cad/Fc, N-cad/Fc, or P-cad/Fc as if presented by another cell ( Fig. 1 ). (diabetesjournals.org)
  • cadherins may thus contribute to the sorting of heterogeneous cell types. (abcam.com)
  • As E-cadherin is vitally involved in signaling pathways modulating cell proliferation, survival, invasion, and migration, dysregulation of E-cadherin leads to dysfunction of gastric epithelial cells and contributes to gastric cancer development. (hindawi.com)
  • It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development. (wikipedia.org)
  • Many cadherins are specified for specific functions in the cell, and they are differentially expressed in a developing embryo. (wikipedia.org)
  • After development, cadherins play a role in maintaining cell and tissue structure, and in cellular movement. (wikipedia.org)
  • In vivo T-cadherin was detected on the apical cell surface of the chick interstinal epithelium. (wikipedia.org)
  • In cultures of transfected MDCS cells, T-cadherin was also expressed apically, whereas N-cadherin located basolaterally corresponded to the zone of cell contacts. (wikipedia.org)
  • The apical cell surface distribution of T-cadherin was proposed to possibly endow T-cadherin with recognition functions. (wikipedia.org)
  • At basal levels of synaptic activity, N-cadherins are largely monomers and are thus weakly adhesive to cadherins located in the cell on the opposite side of the synapse. (wikipedia.org)
  • Many cell types express combinations of cadherin types. (wikipedia.org)
  • N-cadherin, as well as other cadherins, interact with N-cadherin on an adjacent cell in an anti-parallel conformation, thus creating a linear, adhesive "zipper" between cells. (wikipedia.org)
  • N-cadherin plays a role in the development of the vertebrate heart at the transition of epithelial cells to trabecular and compact myocardial cell layer formation. (wikipedia.org)
  • In cardiac muscle, N-cadherin is found at intercalated disc structures which provide end-on cell-cell connections that facilitate mechanical and electrical coupling between adjacent cardiomyocytes. (wikipedia.org)
  • molecule
  • Furthermore, E Cadherin plays a crucial role in the maintenance of the epithelial junctional complex and is as such an important molecule in maintaining epithelial integrity. (abcam.com)
  • There are multiple classes of cadherin molecule, each designated with a prefix (in general, noting the type of tissue with which it is associated). (wikipedia.org)
  • embryonic
  • VE-cadherin is indispensable for proper vascular development - there have been two transgenic mouse models of VE-cadherin deficiency, both embryonic lethal due to vascular defects. (wikipedia.org)
  • receptors
  • The properties of T-cadherin as an LDL receptor were markedly different from the presently known types of LDL receptors. (wikipedia.org)
  • Evidence suggest that N-Cadherins stabilize the connection between the presynaptic terminal and postsynaptic spine and that this stabilization increases the likelihood that released glutamate will bind receptors on the postsynaptic neuron. (wikipedia.org)
  • tissue
  • Cadherins are expressed in a tissue specific manner and and are required for assembly of cells into solid tissue. (abcam.com)
  • adhesive
  • Inhibition of N-cadherin binding via blocking antibodies prevents the induction of late phase L-long term potentiation, suggesting that the adhesive property of dimeric N-cadherin is necessary for late phase L-LTP. (wikipedia.org)