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  • sensitivity
  • In the mid 1990s, immunoassays for C-reactive protein (CRP), with greater sensitivity than those previously in routine use, revealed that increased CRP values, even within the range previously considered normal, strongly predict future coronary events. (jci.org)
  • acute
  • Abernethy and Avery ( 1941 ) showed that serum taken from humans and monkeys contained protein that has the ability to precipitate with C polysaccharide during the acute stage of various infectious diseases, but in the presence of Ca 2+ . (springer.com)
  • The occurrence during acute infections of a protein normally present in the blood: I. Distribution of the reactive protein in patients' sera and the effect of calcium on the flocculation reaction with C polysaccharide of pneumococcus. (springer.com)
  • Address correspondence to: Mark B. Pepys, Department of Medicine, Centre for Amyloidosis and Acute Phase Proteins, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom. (jci.org)
  • This article provides information about CRP as a protein and an acute-phase reactant, and a knowledge-based framework for interpretation and analysis of clinical observations of CRP in relation to cardiovascular and other diseases. (jci.org)
  • C-reactive protein colocalizes with complement in human hearts during acute myocardial infarction," Circulation , vol. 95, no. 1, pp. 97-103, 1997. (hindawi.com)
  • Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction," Journal of Clinical Pathology , vol. 59, no. 2, pp. 196-201, 2006. (hindawi.com)
  • It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. (wikipedia.org)
  • They are known as classical acute phase proteins (APP), known for over a century. (wikipedia.org)
  • The concentration of this plasma protein is altered by sex steroids and stimuli that elicit an acute phase response. (wikipedia.org)
  • 2001
  • In addition to her contributions to the study of protein folding, Carol has conducted important work on ribosomes, molecular chaperones and most recently membrane proteins.In 2001, she returned to Cambridge to take up a professorship in the Department of Chemistry, becoming this department's first female professor. (wikipedia.org)
  • inflammatory
  • BACKGROUND The study aim was to determine the kinetics of serum pro- and anti-inflammatory cytokines and C-reactive protein (CRP) in hip-fracture patients over a month postfracture, and their relationship to postoperative (postop) complications and cognitive level. (mendeley.com)
  • antibodies
  • C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion," Surgery , vol. 142, no. 5, pp. 722-733, 2007. (hindawi.com)
  • Saliva is a useful biological fluid for assaying steroid hormones such as cortisol, genetic material like RNA, proteins such as enzymes and antibodies, and a variety of other substances, including natural metabolites, including saliva nitrite, a biomarker for nitric oxide status (see below for Cardiovascular Disease, Nitric Oxide: a salivary biomarker for cardio-protection). (wikipedia.org)
  • They are a superfamily of multifunctional conserved proteins, some of which are components of the humoral arm of innate immunity and behave as functional ancestors of antibodies (Abs). (wikipedia.org)
  • nuclear
  • snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. (wikipedia.org)
  • somatic
  • Tillett WS, Francis T. Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. (springer.com)
  • synthesis
  • In particular, the synthesis of a number of proteins is rapidly upregulated, principally in hepatocytes, under the control of cytokines originating at the site of pathology. (jci.org)
  • The later discovery of hepatic synthesis demonstrated that it is a native protein. (wikipedia.org)
  • Genetic
  • While there is an association between increased levels of C-reactive protein and risk of developing cancer, there is no association between genetic polymorphisms influencing circulating levels of CRP and cancer risk. (wikipedia.org)
  • Recent applications emphasize the development of increasingly sophisticated techniques to detect additional proteins, genetic material, and markers of nutritional status. (wikipedia.org)
  • Role
  • It is suggested that both proteins mediate the uptake of synaptic macromolecules and play a role in synaptic plasticity. (wikipedia.org)
  • structure
  • After a postdoctoral training fellowship at the University of Bristol, she took up a junior position in the mass spectrometry unit at the University of Oxford, where she began analysing protein folding.Her research on the three-dimensional structure of proteins in particular has demonstrated the power of such techniques in studying large molecular compounds. (wikipedia.org)
  • necessary
  • The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection," Journal of Biological Chemistry , vol. 287, no. 51, pp. 43116-43125, 2012. (hindawi.com)
  • kinase
  • D. Li, B. Yang, and J. L. Mehta, "Tumor necrosis factor- α enhances hypoxia-reoxygenation-mediated apoptosis in cultured human coronary artery endothelial cells: critical role of protein kinase C," Cardiovascular Research , vol. 42, no. 3, pp. 805-813, 1999. (hindawi.com)
  • Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms including, the polyol pathway, advanced glycation end-products formation, activation of protein kinase C isoforms, and the hexosamine pathways. (ijmcmed.org)
  • After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (JNK) pathway. (wikipedia.org)
  • residues
  • These carbons are electrophiles that readily form covalent bonds by acting as acceptors in Michael reactions to form covalent bonds with exposed nucleophile sites, particularly thiol residues, in diverse proteins. (wikipedia.org)
  • atherosclerosis
  • 12 Evidence from murine atherosclerosis models suggests that initial leukocyte adhesion to the endothelium is mediated via KC, the murine equivalent of IL-8, whereas subsequent interaction between monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR1 is essential for transendothelial diapedesis and recruitment into the subendothelial space. (ahajournals.org)
  • interaction
  • These displaying phages can then be screened against other proteins, peptides or DNA sequences, in order to detect interaction between the displayed protein and those other molecules. (wikipedia.org)
  • Applications of phage display technology include determination of interaction partners of a protein (which would be used as the immobilised phage "bait" with a DNA library consisting of all coding sequences of a cell, tissue or organism) so that the function or the mechanism of the function of that protein may be determined. (wikipedia.org)
  • Daxx, a Death domain-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. (wikipedia.org)
  • Several additional interacting proteins are known, but not always is there an understanding of the specific function and relevance of this interaction. (wikipedia.org)
  • binds
  • By immobilizing a relevant DNA or protein target(s) to the surface of a microtiter plate well, a phage that displays a protein that binds to one of those targets on its surface will remain while others are removed by washing. (wikipedia.org)
  • In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. (wikipedia.org)
  • genes
  • Conversely, the expression of uncoupling protein-1 and of the same mitochondrial genes was increased in brown adipose tissue. (jci.org)
  • In the cells of extant organisms, the vast majority of the proteins present in the mitochondria (numbering approximately 1500 different types in mammals) are coded for by nuclear DNA, but the genes for some, if not most, of them are thought to have originally been of bacterial origin, having since been transferred to the eukaryotic nucleus during evolution. (wikipedia.org)
  • cells
  • If a "phagemid" vector is used (a simplified display construct vector) phage particles will not be released from the E. coli cells until they are infected with helper phage, which enables packaging of the phage DNA and assembly of the mature virions with the relevant protein fragment as part of their outer coat on either the minor (pIII) or major (pVIII) coat protein. (wikipedia.org)
  • Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter for example, the breaking down of glucose to pyruvate, by cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. (wikipedia.org)
  • Between 2% and 5% of T cells develop auto-reactive receptors. (wikipedia.org)
  • These medullary epithelial cells express an autoimmune regulator (AIRE) which allows these cells to present proteins specific to other parts of the body to T lymphocytes. (wikipedia.org)
  • This helps eliminate autoreactive T cells that recognize a protein from a specific body part. (wikipedia.org)
  • expression
  • We have created transgenic (Tg) rats expressing an antisense GHS-R mRNA under the control of the promoter for tyrosine hydroxylase (TH), thus selectively attenuating GHS-R protein expression in the Arc. (jci.org)
  • Daxx is uniformly expressed throughout the body, except in the testes and thymus, which have especially high expression of the protein. (wikipedia.org)
  • The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. (wikipedia.org)
  • large
  • In this way, large libraries of proteins can be screened and amplified in a process called in vitro selection, which is analogous to natural selection. (wikipedia.org)
  • A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. (wikipedia.org)
  • important
  • Thus, the activation of the HBP by nutrients represents a biochemical link between nutrient availability, mitochondrial proteins, and energy expenditure, and it is likely to play an important role in the regulation of energy balance. (jci.org)
  • initial
  • An initial workup for vasculitis in children includes urinalysis, C-reactive protein (CRP) or sedimentation rate (ESR), imaging, and biopsy. (arupconsult.com)
  • The bacterioruberin radical produced is less reactive than the initial radical, and will likely react with another radical, resulting in termination of the radical chain reaction. (wikipedia.org)
  • host
  • Phage eluted in the final step can be used to infect a suitable bacterial host, from which the phagemids can be collected and the relevant DNA sequence excised and sequenced to identify the relevant, interacting proteins or protein fragments. (wikipedia.org)
  • makes
  • The symmetrical substitution pattern with reactive bromine atoms makes 1,2,4,5-tetrabromobenzene an interesting starting compound for nematic liquid crystals with crossed mesogens and for columnar (diskotic) liquid crystals with an extensive planar, "board-like" tetrabenzoanthracene ring system. (wikipedia.org)
  • complex
  • When a protein containing this amino acid (A) is lightened with ultraviolet light while interacting with another protein (B), the complex formed from these two proteins (AB) remains attached and can be isolated for its study. (wikipedia.org)
  • negative
  • These highly acidic proteins are overwhelmingly negative in charge and are able to remain in solution even at high salt concentrations. (wikipedia.org)
  • energy
  • The three main purposes of metabolism are the conversion of food/fuel to energy to run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes. (wikipedia.org)
  • Center
  • This technology was further developed and improved by groups at the Laboratory of Molecular Biology with Greg Winter and John McCafferty, The Scripps Research Institute with Lerner and Barbas and the German Cancer Research Center with Breitling and Dübel for display of proteins such as antibodies for therapeutic protein engineering. (wikipedia.org)
  • components
  • While at first Daxx was said to be a "death protein", it is suggested that associating with centromeric components leads to another function of Daxx. (wikipedia.org)
  • function
  • The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. (wikipedia.org)
  • methods
  • Competing methods for in vitro protein evolution include yeast display, bacterial display, ribosome display, and mRNA display. (wikipedia.org)
  • changes
  • Upon absorption of a photon, retinal changes conformation, causing a conformational change in the bacterioopsin protein which drives proton transport. (wikipedia.org)
  • Predictive medicine changes the paradigm of medicine from being reactive to being proactive and has the potential to significantly extend the duration of health and to decrease the incidence, prevalence and cost of diseases. (wikipedia.org)
  • test
  • Now given that there is no test to measure Cytokines directly, Dr. Shoemaker tested for the Matrix MetalloProteinase-9 (MMP9) protein instead. (biotoxinjourney.com)