• bocavirus
  • Human bocavirus (HBoV) is a parvovirus that has been suggested to cause human disease. (wikipedia.org)
  • The term human bocavirus can refer to any bocaparvovirus strain in the Primate bocaparvovirus 1 and Primate bocaparvovirus 2 species that infects humans. (wikipedia.org)
  • nasal
  • The findings also that indicate PIV5-RSV-F may be administered subcutaneously, which is the preferred route for vaccinating infants who may develop nasal congestion as a result of intranasal vaccination.IMPORTANCE Despite decades of research, human respiratory syncytial virus (RSV) is still a major health concern for which there is no vaccine. (physiciansweekly.com)
  • Some signs of severe disease include: poor feeding (less than half of usual fluid intake in preceding 24 hours) significantly decreased activity history of stopping breathing respiratory rate >70/min presence of nasal flaring and/or grunting severe chest wall recession (Hoover's sign) bluish skin The term usually refers to acute viral bronchiolitis, a common disease in infancy. (wikipedia.org)
  • clinical
  • Demographic characteristics and clinical severity of the disease may depend on the number of viruses or on the specific virus detected. (bmj.com)
  • Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR Method down-pointing small open triangle. (wikipedia.org)
  • attachment
  • During cold and peak flu season, infants and small children have the option to receive monthly injections of small medication doses at a weak strength to help prevent virus/ host attachment. (wikipedia.org)
  • Entry into the host cell is achieved by virus attachment to host cell. (wikipedia.org)
  • Pneumoviruses replicate entirely in the cytoplasm, and this process begins with adsorption of the virus to the cellular receptor on the host cell, directed by the viral attachment protein, variously called G, H (hemagglutinin) or HN (hemagglutinin-neuraminidase). (wikipedia.org)
  • Viral replication is initiated only after successful entry into a cell by attachment and fusion between the virus and the host cell lipid membrane. (wikipedia.org)
  • epithelial cells
  • IL-22 is produced by activated NK and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. (wikipedia.org)
  • Gene
  • In humans, histidine decarboxylase is encoded by the HDC gene. (wikipedia.org)
  • Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene. (wikipedia.org)
  • Cadherin related family member 3 (CDHR3), also known as CDH28 or its abbreviation CDHR3, is a protein that in humans is encoded by the CDHR3 gene. (wikipedia.org)
  • Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene. (wikipedia.org)
  • Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene. (wikipedia.org)
  • The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. (wikipedia.org)
  • Human CCL8 genome location and CCL8 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • OC43
  • HCoV-229E is one of the four human coronaviruses which include HC0V-NL63, HCoV-OC43, and HCoV-HKU1 and are globally distributed. (wikipedia.org)
  • genetic
  • A virus consists of genetic material, which may be either DNA or RNA, and is surrounded by a protein coat and, in some viruses, by a membranous envelope. (thefreedictionary.com)
  • Within the host cell the genetic material of a DNA virus is replicated and transcribed into messenger RNA by host cell enzymes, and proteins coded for by viral genes are synthesized by host cell ribosomes. (thefreedictionary.com)
  • Because host cells do not have the ability to replicate "viral RNA" but are able to transcribe messenger RNA, RNA viruses must contain enzymes to produce genetic material for new virions. (thefreedictionary.com)
  • In other viruses a reverse transcriptase contained in the virion transcribes the genetic message on the viral RNA into DNA, which is then replicated by the host cell. (thefreedictionary.com)
  • The taxonomic division is broadly based on antigenic and genetic characteristics, forming four major serotypes or clades, which today are considered distinct viruses. (wikipedia.org)
  • disease
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • Children born prematurely (less than 35 weeks), with a low birth weight or who have from congenital heart disease may have higher rates of bronchiolitis and are more likely to require hospital admission. (wikipedia.org)
  • Building on discoveries that Prince made as a doctoral student, VSI pioneered the prevention of respiratory syncytial virus (RSV) disease in high-risk infants through the use of monoclonal antibody. (wikipedia.org)
  • These viruses are closely associated with both human and veterinary disease. (wikipedia.org)
  • proteins
  • Its name comes from the fact that F proteins on the surface of the virus cause the cell membranes on nearby cells to merge, forming syncytia. (wikipedia.org)
  • In viruses that have membranes, membrane-bound viral proteins are synthesized by the host cell and move, like host cell membrane proteins, to the cell surface. (thefreedictionary.com)
  • Some viruses have only a few genes coding for capsid proteins. (thefreedictionary.com)
  • Although in general viruses "steal" their lipid envelope from the host cell, virtually all of them produce "envelope proteins" that penetrate the envelope and serve as receptors. (thefreedictionary.com)
  • Matrix proteins inside the envelope stabilise virus structure. (wikipedia.org)
  • The pathogenicity of HPIVs is mutually dependent on the viruses having the correct accessory proteins which are able to elicit anti-interferon properties. (wikipedia.org)
  • Parvoviruses (Latin: small viruses) have a 5 kilobase long single-stranded DNA, and they use some of their host's replication proteins to copy their DNA. (wikipedia.org)
  • cytokine
  • IL-26, a human TH17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. (wikipedia.org)
  • protein
  • For example, nucleocapsid protein, N, is needed in greater amounts than RNA polymerase, L. Viruses in the Paramyxoviridae family are also antigenically stable, meaning that the glycoproteins on the viruses are consistent between different strains of the same type. (wikipedia.org)
  • Interferon alpha-1/13, also known as IFN-alpha-1/13, is a protein that in humans is encoded by the IFNA1 and IFNA13 genes. (wikipedia.org)
  • Subsequently, genomic transcription occurs using the viruses own 'viral RNA-dependant RNA polymerase' (L protein). (wikipedia.org)
  • immune
  • Interleukin 26 (IL-26), is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. (wikipedia.org)
  • The vaccination efficacy in these children may also be hampered by the presence of maternally derived antibodies, which may provide partial protection to wild-type virus infections but also suppress the primary immune response on immunization. (wikipedia.org)