• Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
  • Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. (lookformedical.com)
  • Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
  • Antidonor-HLA antibodies and soluble HLA antigens after kidney transplant. (cnr.it)
  • Monitoring after transplantation in liver and kidney transplant recipients with anti-donor HLA antibodies. (cnr.it)
  • Public epitope specificity of HLA class I antibodies induced by a failed kidney transplant: alloantibody characterization by flow citometric techniques. (cnr.it)
  • Incidence and epitope specificity of HLA DQA1 and DQB1 antibodies in renal transplant recipients. (cnr.it)
  • Clinical Significance of de novo production of HLA of donor-specific antibodies in kidney transplantation. (cnr.it)
  • The mechanism involved in a true allergy usually results in 'tissue injury' by virtue of a number of interactions between antibodies (or lymphoid cells) and 'antigens' (or the invading agents). (alternativescentral.com)
  • Data showed that vaccination with AMP-CpG combined with EBV gp350 and EBVpoly proteins delivered directly to the lymph nodes rapidly induced potent gp350-specific antibodies (IgG), EBV neutralizing antibody responses and EBV-specific T cell responses in HLA transgenic mice. (elicio.com)
  • In this case, an antigen-antibody is formed which, if toxic, can then injure bodily tissue. (alternativescentral.com)
  • For example, during the first reaction, the initial contact between antigen (or allergen) and antibody may alter the body's sensitivity by producing additional histamine. (alternativescentral.com)
  • In various other interactions between antigen and antibody, the cells to which the antigen is affixed are destroyed or else the resulting complexes usually become toxic in nature. (alternativescentral.com)
  • Vaccination with AMP-CpG combined with EBV gp350 and EBVpoly proteins rapidly induced potent gp350-specific IgG and EBV neutralizing antibody responses in HLA transgenic mice. (elicio.com)
  • This technique requires that whole proteins or selected peptide antigens are added to blood cells, allowing the simultaneous analysis of both major histocompatibility complex class I and II restricted T-cell responses ( 7 ). (cdc.gov)
  • The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. (cuanschutz.edu)
  • The company is developing small molecule modulators of ERAP1 and ERAP2, two key proteins in the antigen presentation pathway, to change the antigen repertoire of tumors and thereby increase the number and range of cancer-related antigens, including neoantigens, presented on tumor cells available to engage an immune response. (greywolftherapeutics.com)
  • The human leukocyte antigen ( HLA ) is a gene complex that encodes the major histocompatibility complex ( MHC ) proteins . (amboss.com)
  • The findings revealed that vaccination with Amphiphile-CpG adjuvant induces significantly higher viral antigen-specific cytokine-producing CD8+ T cells compared to vaccination with soluble CpG. (news-medical.net)
  • A dramatic expansion of viral antigen-specific CD8+ T cells with robust polyfunctional effector phenotype was observed in splenocytes of mice immunized with Amphiphile-CpG vaccine. (news-medical.net)
  • The broad coverage against multiple viral determinants and the AMP-CpG adjuvant are likely to provide better protection against primary EBV infection while the strong T cell responses will be critical in controlling the spread of latently infected B cells and the development of EBV-associated diseases, such as malignancies and multiple sclerosis. (elicio.com)
  • The immunogenicity of the vaccine was tested using HLA-expressing transgenic mice. (news-medical.net)
  • The selection of this first mKRAS (mutant KRAS) lead TCR further validates our capabilities to generate 3S TCRs across both neoantigens and cancer-testis antigens. (nwahomepage.com)
  • Neoantigens are tumor-specific antigens, which play a critical role in the growth and maintenance of tumors. (nwahomepage.com)
  • Studies have suggested that the persistence of HER-2/neu-specific CD8 T cells could be improved by incorporating human leukocyte antigen (HLA) class II epitopes in the vaccine. (elsevierpure.com)
  • Our goal in this study was to identify broad coverage HLA-DR epitopes of HER-2/neu, an antigen that is highly expressed in a variety of carcinomas. (elsevierpure.com)
  • Experimental Design: A combination of algorithms and HLA-DR-binding assays was used to identify HLA-DR epitopes of HER-2/neu antigen. (elsevierpure.com)
  • Results: Eighty-four HLA-DR epitopes of HER-2/neu were predicted, 15 of which had high binding affinity for ≥11 common HLA-DR molecules. (elsevierpure.com)
  • Scientists analyzed known human CD8+ T cell epitopes from EBV antigens to design a polyepitope vaccine immunogen that incorporates 20 CD8+ T cell epitopes into an engineered protein immunogen. (news-medical.net)
  • EBVpoly is a polyepitope protein developed at QIMR Berghofer Medical Research Institute that includes 20 CD8+ T cell epitopes from EBV latent and lytic antigens with broad coverage against multiple HLA types. (elicio.com)
  • The mRNA vaccines can encode multiple antigens, strengthening the immune response against pathogens and enabling the targeting of multiple microbial variants [19] . (researchgate.net)
  • Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)
  • When the high similarity between the orthopoxviruses is considered, this rapid assay that uses vaccinia antigens could identify recently exposures. (cdc.gov)
  • Memory response becomes more potent and faster after subsequent exposures to an antigen . (amboss.com)
  • that modulation of ERAP2 drives an altogether different change to the antigen repertoire, when compared with ERAP1 modulation, due to ERAP2's clearly differentiated peptide substrate specificities. (greywolftherapeutics.com)
  • This adjuvant was designed to increase lymph node delivery and accumulation of vaccine antigen and adjuvant. (news-medical.net)
  • Figure B. PE conjugated Mouse anti Human CD11c ( MCA2087PE ) and Amethyst Orange conjugated Mouse anti Human HLA DP DQ DR ( MCA477AMO ). (bio-rad-antibodies.com)
  • In this study, scientists have developed a lymph node-targeting multi-epitope subunit vaccine against EVB and tested its efficacy in Human Leukocyte Antigen (HLA)-expressing mice. (news-medical.net)
  • In addition, some of the disorders associated with human leukocyte antigen (HLA) include ankylosing spondylitis, gluten-sensitive enteropathy, insulin-dependent diabetes, systemic lupus erythematosis and certain forms of multiple sclerosis. (alternativescentral.com)
  • However, in the absence of human leukocyte antigen (HLA)-compatible donors, no other curative treatment options are available, and therefore, new treatment strategies, such as gene therapy, should be explored. (biomedcentral.com)
  • Although overt inflammatory responses play a major role in malignant transformation of host cells following an infection, it is a disbalanced immune responses, which contribute to drive malignant transformation. (frontiersin.org)
  • It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. (lookformedical.com)
  • The EBV vaccine is based on the research of Dr. Rajiv Khanna, Professor, Senior Scientist and Coordinator of QIMR Berghofer's Centre for Immunotherapy and Vaccine Development. (elicio.com)
  • Conclusion: The broad coverage and natural immunity to this epitope pool suggests potential usefulness in HER-2/neu-targeting, immune-based therapies such as vaccines. (elsevierpure.com)
  • The innate immune system develops in utero and, unlike the adaptive (acquired) immune system , does not require imprinting or adaptation to specific antigens nor does it provide permanent pathogen -specific immunity . (amboss.com)
  • This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups. (wikipedia.org)
  • HLA class I antigens HLA-A, -C and -E are recognized by CD8+ T cells to mediate cell killing. (hohoweiya.xyz)
  • Using a rapid flow cytometric test, we previously showed that monitoring interferon (IFN)-γ production by antigen-pulsed T cells provides a quantitative and functional assessment of HIV- or cytomegalovirus (CMV)-specific CD8(+) and CD4(+) T cells ( 4 - 6 ). (cdc.gov)
  • Several of these critical changes, such as the reduction of surface HLA-DR on myeloid cells, were reversed in young but not aged patients over time. (medrxiv.org)
  • CD81 has a very broad cellular distribution, being expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. (bdbiosciences.com)
  • Thus, the local immunological milieu in tissue compartments forms the nature and magnitude of the host responses, i.e., frequencies of regulatory T cells (Tregs) vs. T-helper 17 (Th17) cells, amount of pro-inflammatory cytokines vs. anti-inflammatory cytokines, extent of neutrophilia and antigen-presenting-cell (APC) activation, among others. (frontiersin.org)
  • The focus of Dr. Baker's research is to understand how islet-reactive CD4 T cells are activated in the context of T1D. (cuanschutz.edu)
  • The discovery and characterization of new antigens implicated in the pathogenesis of T1D is a high priority as it can lead to new diagnostic tools and anticipate that studies proposed by Dr. Baker will provide critical information to target autoreactive T cells though antigen-specific therapies. (cuanschutz.edu)
  • It operates based on inherited cellular receptors that respond to broad pathogen -related patterns and common threat signals. (amboss.com)
  • Nanovaccines can improve antigen presentation, targeted delivery, stimulation of the body's innate immune system, and a strong T-cell response without putting people at risk. (researchgate.net)
  • Identifying the mechanisms underlying DR in LC patients and possible therapeutic alternatives for more efficient therapy is a central goal of LC research. (preprints.org)
  • Dr. Benninger's research focuses on understanding the mechanisms underlying pancreatic islet function and decline in type1 and type2 diabetes. (cuanschutz.edu)
  • The results are consistent across patients which either have a higher tumor mutational burden, heterozygosity of the Class I HLA locus or greater structural / sequence divergence at the Class I HLA locus. (greywolftherapeutics.com)
  • Therefore, this study selects 225 patients with Acute Myeloid Leukemia (AML) in our hospital from Jan 2013 to Dec 2016 as study objects to explore CD7, CD34, CD56 and HLA-DR expression antigen and its relations with clinical effects and prognosis. (biomedres.info)
  • Drug resistance (DR) is a complex process that occurs due to a variety of genetic and acquired factors. (preprints.org)
  • After the initial exposure to the antigen, an alteration in sensitivity to that antigen usually occurs. (alternativescentral.com)
  • Upon the second or third exposure to this same antigen, a more harmful reaction occurs to the change in sensitivity that results in actual tissue damage. (alternativescentral.com)
  • Moreover, antigen-specific T-cell responses could be detected in exposed, but uninfected persons, as shown in those with HIV infection ( 3 ). (cdc.gov)
  • Flow cytometric analysis of T-cell responses to smallpox antigens after recent smallpox vaccination and in long-term vaccinated or not vaccinated persons. (cdc.gov)
  • HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. (wikipedia.org)
  • Dr. Alonso's primary academic interest is redesigning the system in which care is provided to children and adolescents with type 1 diabetes. (cuanschutz.edu)
  • They can be the result of a genetic disturbance in the immune system, or even derived from a situation whereby the immune system actually tolerates an antigen invader instead of neutralizing it. (alternativescentral.com)
  • This graph shows the total number of publications written about "HLA-DR2 Antigen" by people in this website by year, and whether "HLA-DR2 Antigen" was a major or minor topic of these publications. (musc.edu)
  • Medigene's end-to-end (E2E) platform, has successfully generated not one but three KRAS G12V-HLA-A*11 TCRs, each with distinct, multiple HLA-A*11 subtype recognition patterns that exceed the Company's selection criteria for highly specific, sensitive and potentially safer (3S) TCRs. (nwahomepage.com)
  • To explore correlations between CD7, CD34, CD56 and HLA-DR expressions and its prognosis among patients with acute myeloid leukemia. (biomedres.info)
  • CD7, CD34, CD56 and HLA-DR expressions of bone marrow among patients were detected. (biomedres.info)
  • Complete remission rate of CD7, CD34, CD56 and HLA-DR antigen expression positive among patients with Acute Myeloid Leukemia (AML) is low, mean survival is short and prognosis is poor. (biomedres.info)
  • There are reports showing that CD7, CD34, CD56 and HLA-DR expressions have a certain correlations with prognosis of patients with leukemia [ 7 - 9 ]. (biomedres.info)
  • A goal of Dr. Akturk's lab is to identify risk factors to develop diabetes and develop screening algorithms to prevent morbidity and mortality related to diabetic ketoacidosis and understand PD-1 pathway in possible prevention of the development of childhood onset type 1 diabetes. (cuanschutz.edu)
  • Dr. Aturk's research is focused on immune checkpoint inhibitor-induced type 1 diabetes. (cuanschutz.edu)
  • Dr. Albers develops mathematical models of physiology, machine learning models, and their associated inference methods to support the extraction and creation of new knowledge from data related to diabetes, to support clinician-centric decision support, and to support patient-centric decision support for chronic disease self-management. (cuanschutz.edu)
  • Complimentary to these studies, Dr Benninger's lab is also developing ultrasound-based imaging diagnostics for non-invasively detecting islet decline in pre-symptomatic diabetes and as a platform for image-guided drug delivery. (cuanschutz.edu)
  • The unique approach of our E2E platform to generate and optimize 3S TCRs, has continued to deliver above expectations and we are delighted to have been presented with the positive challenge of having to select a lead from three strong candidates for our MDG2011 program targeting KRAS G12V-A11," said Dr. Selwyn Ho, Chief Executive Officer at Medigene. (nwahomepage.com)
  • HLA-DR2 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)