Broad and potent hiv antibodies. Medical search. Frequent questions

Several bNAbs have been tested to date in HIV-1-infected individuals, including the CD4-binding, site-specific antibodies VRC01, 3BNC117, VRC07-523LS and N6-LS, the V3-glycan-specific antibody 10-1074 and the V2-apex-specific antibodies PGDM1400 and CAP256-VRC26.25 (refs. (nature.com)
In these studies, bNAb resistance emerged in nearly all treated participants who received monotherapy, but in two notable cases 4 the repeated administration of a combination of two bNAbs in the setting of viremia maintained viral suppression for 3 months without development of resistance to either antibody. (nature.com)
These glycans are the target of BNabs (broadly neutralizing HIV-1 antibodies), and Moores is studying how these antibodies evolve in vivo. (wikipedia.org)
A potent class of HIV-1 broadly neutralizing antibodies (bnAbs) targets the envelope glycoprotein's membrane proximal exposed region (MPER) through a proposed mechanism where hypervariable loops embed into lipid bilayers and engage headgroup moieties alongside the epitope. (elifesciences.org)
All-atom simulations of 4E10, PGZL1, 10E8 and LN01 docked onto HIV-like membranes consistently form phospholipid complexes at key complementarity-determining region loop sites, solidifying that stable and specific lipid interactions anchor bnAbs to membrane surfaces. (elifesciences.org)
We sought to address this phenomenon for broadly neutralizing antibodies (bnAbs) 4E10, PGZL1, 10E8, and LN01 of unique lineages which all target the semi-concealed membrane-proximal epitope region (MPER) 13 - 16 of the HIV-1 envelope glycoprotein (Env). (elifesciences.org)
Broadly neutralizing HIV-1 antibodies (bNAbs) isolated from infected subjects display protective potential in animal models. (plos.org)
The HIV-1 envelope glycoprotein (Env) is the sole viral target of bnAbs, but is also targeted by binding, non-neutralizing antibodies. (plos.org)
Env-based immunogens tested so far in various animal species and humans have elicited binding and autologous neutralizing antibodies but not bNAbs (with a few notable exceptions). (plos.org)
Broadly neutralizing HIV-1 antibodies (bNAbs) display protective potentials against experimental animal infection and thus are believed to be a key component of an effective HIV vaccine. (plos.org)
Our findings shed new light into how HIV-1 evades detection from B cells that can produce bNAbs and also provides information that is relevant for the design of optimal immunization strategies. (plos.org)
It is believed that the isolation and characterization of such broadly neutralizing antibodies (bnAbs) from different HIV-1-infected donors are critical for understanding human B cell-mediated immune response to HIV-1 infection and for designing immunogens that can elicit bnAbs by vaccination. (oncotarget.com)
The candidate vaccine products are designed to be administered in multiple stages to induce immune system proteins called broadly neutralizing antibodies (bnAbs). (diwou.com)
In multiple animal studies, bnAbs have been shown to provide long-lasting protection against exposure to multiple HIV strains. (diwou.com)
This raised the possibility of engineering vaccines that could induce a person's immune system to generate such bnAbs, thus providing broad protection against multiple HIV strains. (diwou.com)
Using that knowledge, they developed immunogens (molecules that spur an immune reaction in the body) that in animal studies demonstrated the ability to elicit production of anti-HIV bnAbs or their early precursors that target those envelope regions and neutralize the virus. (diwou.com)
We have an active program in understanding the humoral responses to HIV-1 envelope, especially antibodies that can neutralize multiple different strains of HIV, i.e., broadly neutralizing antibodies (bNAbs). (gvn.org)
During the past decade we have been characterizing the antibodies in the serum of rare HIV-infected persons who have bNAbs. (gvn.org)
To inform the development of a long-acting prevention strategy, we evaluated the protective efficacy of broadly neutralizing antibodies (bNAbs) against intravenous SHIV infection in macaques. (cdc.gov)
We are particularly interested in the co-evolution of HIV-1 and broadly-neutralizing IgG antibodies (bNAbs), which may hold the key to the development of an effective HIV-1 vaccine. (stanford.edu)
Although the vaccine Env AE.A244 gp120 is antigenic for the unmutated common ancestor of V1V2 broadly neutralizing antibody (bnAbs), no plasma bnAb activity was induced. (cornell.edu)

PGT121 is a monoclonal antibody isolated in 2011 from an African donor infected with HIV-1 subtype A, whose sera had demonstrated superior neutralization breadth and potency in an observational cohort, and so was considered an 'elite neutralizer' 9 . (nature.com)
mostly by employing serologic methodologies and monoclonal antibody isolation and characterization. (plos.org)
A derivative of the D5 monoclonal antibody that targets the gp41 N-heptad repeat of HIV-1 with broad tier-2 neutralizing activity. (stanford.edu)
2021) Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody. (scripps.edu)
Dexamethasone and monoclonal antibody-based agents have been shown to be effective in reducing the severity of illness. (radiopaedia.org)

Human immunodeficiency virus (HIV)-1-specific broadly neutralizing monoclonal antibodies are currently under development to treat and prevent HIV-1 infection. (nature.com)
By neutralising sites such as these (the high-mannose patch), Doores hoped to protect against HIV infection. (wikipedia.org)
Nonetheless, in cases of chronic inflammation and infection as in HIV, rare antibodies with lipid affinity can emerge 5 - 8 . (elifesciences.org)
Following HIV-1 infection, serum neutralizing antibody responses against the evolving autologous viral swarm are generated by the vast majority of infected subjects, usually within the first few months of infection [ 1 - 6 ]. (plos.org)
In 10-30% of infected subjects, antibodies capable of neutralizing not only the autologous virus but also heterologous viruses are generated, usually following several years of infection [ 2 , 5 , 7 - 13 ]. (plos.org)
The identification of human monoclonal antibodies (mAbs) able to neutralize a broad spectrum of primary HIV-1 isolates is highly important for understanding the immune response of HIV-1 infection and developing vaccines and therapeutics. (oncotarget.com)
Therefore, Y498 is a novel neutralizing human mAb targeting a conformation-dependent CD4bs-based epitope, and its isolation and characterization could provide helpful information for elucidating human immune response to HIV-1 infection and designing effective vaccines and immunotherapeutics. (oncotarget.com)
In the absence of a vaccine that can elicit broadly protective immunity and prevent infection, and given the lack of major breakthroughs on the horizon to provide one, the idea of conferring potent, sustained vaccine-like protection against HIV infection through gene therapy is certainly worth strong consideration," Nancy Haigwood from the Oregon Health & Science University in the US, who wasn't involved in the study, told the BBC . (sciencealert.com)
Natural anti-CCR5 antibodies can be decisive in preventing HIV infection in mucosal tissues and offer prompt and effective protection just at major sites of virus entry. (biomedcentral.com)
Current advances in isolating antibodies from HIV-infected individuals have allowed for the discovery of a large number of new, broadly neutralizing anti-HIV antibodies directed against the host receptor (CD4) binding site-a functional site on the surface of the virus that allows for cell entry and infection. (drugdiscoverytrends.com)
We propose that additional investigation into the role of ADCP in protective viral responses, the specific virus epitopes targeted by ADCP antibodies, and the types of phagocytes and Fc receptors involved in ADCP at sites of virus infection will provide insight into strategies to successfully leverage this important immune response for improved antiviral immunity through rational vaccine design. (frontiersin.org)
and monoclonal recombinant antibodies are also currently being pursued for prevention of HIV-1 infection in large Phase IIb clinical trials (NTC02716675 and NCT02568215). (frontiersin.org)
My main area of research prior to the Covid-19 pandemic including studying humoral immune responses to infection, especially HIV-1. (gvn.org)
We are currently involved in engineering and preclinical development of these monoclonal antibodies with the hope that they can be used to treat and/or prevent HIV-1 infection. (gvn.org)
A novel vaccine for the AIDS virus may become possible through a new compound proving highly effective in preventing HIV infection. (newatlas.com)
The HIV virus spreads infection by using spikes that coat its surface to latch onto healthy cells. (newatlas.com)
Here we show that focusing the immune response to exposed N-terminal residues of the fusion peptide, a critical component of the viral entry machinery and the epitope of antibodies elicited by HIV-1 infection, through immunization with fusion peptide-coupled carriers and prefusion-stabilized envelope trimers, induces cross-clade neutralizing responses. (scitok.com)
HIV-1 infection is initiated by the viral glycoprotein Env, which, after interaction with cellular coreceptors, adopts a transient conformation known as the pre-hairpin intermediate (PHI). (stanford.edu)
this immunoglobulin receptor is expressed on macrophages and dendritic cells, which are implicated in the early stages of HIV-1 infection of mucosal surfaces. (stanford.edu)
As FcgammaRI is expressed on macrophages and dendritic cells, which are present at mucosal surfaces and are implicated in the early establishment of HIV-1 infection following sexual transmission, these results may be important in the development of a prophylactic HIV-1 vaccine. (stanford.edu)
2021) Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates. (scripps.edu)
The new study builds on previous discoveries by the Farzan laboratory, which show that a co-receptor called CCR5 contains unusual modifications in its critical HIV-binding region, and that proteins based on this region can be used to prevent infection. (ebola.com)
OBJECTIVE: Sexually transmitted infections (STIs) increase mucosal HIV infection risk and have the potential to reduce preexposure prophylaxis efficacy. (cdc.gov)
OBJECTIVE: The opioid epidemic has increased parentally acquired HIV infection. (cdc.gov)
Over the course of the COVID-19 pandemic, he has made significant contributions to our understanding of antibody-spike interactions through in-depth structural analysis that detail the specificities and mechanisms of how monoclonal neutralizing antibodies bind spike to prevent infection. (stanford.edu)
HIV infection is efficiently controlled but not cured by Anti-Retroviral Therapy (ART) (Deeks et al. (europa.eu)
These guidelines were developed by the Panel on Clinical Practices for Treatment of HIV Infection, convened by the Department of Health and Human Services (DHHS) and the Henry J. Kaiser Family Foundation. (cdc.gov)
Guidance for the use of antiretroviral treatment in pediatric HIV infection is not contained in this report. (cdc.gov)
Although the pathogenesis of HIV infection and the general virologic and immunologic principles underlying the use of antiretroviral therapy are similar for all HIV-infected persons, unique therapeutic and management considerations apply to HIV-infected children. (cdc.gov)
The recommendations contained herein are presented in the context of and with reference to the first section of this report, Principles of Therapy for HIV Infection, formulated by the National Institutes of Health (NIH) Panel to Define Principles of Therapy of HIV Infection. (cdc.gov)
Cognitive disorder in the setting of human immunodeficiency virus (HIV) infection has long been recognized as an important and disabling aspect of the disease. (medscape.com)
[ 1 ] In addition to its effects on the cellular immune system, HIV enters the central nervous system (CNS) early in the course of the infection and causes several important CNS conditions over the course of the disease, such as HIV encephalopathy and HAND. (medscape.com)
In addition, patients are at risk for many other neurologic complications of HIV infection, including vacuolar myelopathy, peripheral neuropathies, and polymyositis, which can contribute to further disability. (medscape.com)
For other discussions of HIV infection, see HIV Disease , Pediatric HIV Infection , and Antiretroviral Therapy for HIV Infection . (medscape.com)
HIV infection in the CNS can be detected and monitored by cerebrospinal fluid (CSF) viral load measurements. (medscape.com)
Higher rates of infection with HIV are exhibited among injection drug users mainly because of unsafe injecting behavior. (benthamscience.com)
Some practitioners supply FS patients with a broad-spectrum oral antibiotic that is to be taken at the first signs of a bacterial infection. (medscape.com)
Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
Інфекція вірусом імунодефіциту людини (ВІЛ) Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
Психосоціальний підхід до дітей із ВІЛ-інфекцією Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
In the United States, since HIV infection was first recognized, more than 10,000 cases have been reported in children and young adolescents, but this number represents only 1% of total cases. (msdmanuals.com)

We report that the variable domains of recombinant HIV-1 Env immunogens activate a large number of B cell clones that give rise to many non-neutralizing antibodies, and that removing the variable domains from the immunogen reduces the number of activated B cell lineages and leads to the development of autologous neutralizing antibodies, a step towards bNAb-production. (plos.org)
Doria-Rose 2014 Nature 509, 55-62) suggesting that - for select antibodies - a common set of immunogens might spur the induction and maturation of similar antibodies in the general population. (nih.gov)
A third line involves the structure-based engineering of the trimeric spike ectodomain into immunogens with the ability to stimulate the induction of broadly neutralizing antibodies. (nih.gov)
2011. Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures. . (cornell.edu)
Thus, deletion of V1 in HIV envelope immunogens may improve antibody responses to V2 virus vulnerability sites and increase the efficacy of HIV vaccine candidates. (bvsalud.org)
In mice, these immunogens elicited monoclonal antibodies capable of neutralizing up to 31% of a cross-clade panel of 208 HIV-1 strains. (scitok.com)
Conti S, Kaczorowski KJ, Song G, Porter K, Andrabi R, Burton DR, Chakraborty AK, Karplus M. (2021) Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site. (scripps.edu)
2021) Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. (scripps.edu)
2021) Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization. (scripps.edu)
The long-term goal of this work will be structure-based design of potent and stable immunogens for vaccination against emerging and re-emerging zoonotic viruses. (stanford.edu)

PGT121 reduced plasma HIV RNA levels by a median of 1.77 log in viremic participants, with a viral load nadir at a median of 8.5 days. (nature.com)
Two individuals with low baseline viral loads experienced ART-free viral suppression for ≥168 days following antibody infusion, and rebound viruses in these individuals demonstrated full or partial PGT121 sensitivity. (nature.com)
These data suggest that further investigation of the potential of antibody-based therapeutic strategies for long-term suppression of HIV is warranted, including in individuals off ART and with low viral load. (nature.com)
This valuable study reports multi-scale molecular dynamics simulations to investigate a class of highly potent antibodies that simultaneously engage with the HIV-1 Envelope trimer and the viral membrane. (elifesciences.org)
These immune assays will be advanced by the development of standardized viral stocks, such as HIV-1 infectious molecular clones (IMC), that i) express a reporter gene, ii) are representative of globally diverse subtypes and iii) are engineered to easily exchange envelope (env) genes for expression of sequences of interest. (plos.org)
When antibodies try to mimic the receptor, they touch a lot of other parts of the viral envelope that HIV can change with ease," said one of the team, Matthew Gardner , from the Scripps Institute. (sciencealert.com)
Many viral infections, including HIV, exhibit sex-based pathogenic differences. (bvsalud.org)
In 2008, IAVI established the Vaccine Design and Development Laboratory (DDL) to further research on novel replicating viral vector technology for delivering candidate HIV vaccines. (iavi.org)
Since its founding, the DDL has become one of the world's leading vaccine research and development labs, evolving their design of viral vectors based on the vesicular stomatitis virus (VSV) to develop HIV vaccine candidates. (iavi.org)
We propose that the V2 and C2 regions of AE-Env gp120 contain the major determinants of viral resistance to CD4bs antibodies. (biomedcentral.com)
The envelope glycoproteins (Env), gp120 and gp41, of human immunodeficiency virus type 1 (HIV-1) play a central role in viral transmission and mediate attachment and incorporation of the virus into target cells through specific interactions with the CD4 receptor and chemokine co-receptors [ 1 ]. (biomedcentral.com)
HIV and AIDS are top priorities at the IHV as our scientists seek to better understand how to treat and prevent viral diseases. (gvn.org)
The newest discoveries in the fight against chronic viral diseases associated with AIDS, HIV and cancers are available at the IHV's Clinical Center. (gvn.org)
The HIV-1 gp41 N-heptad repeat (NHR) region of the prehairpin intermediate, which is transiently exposed during HIV-1 viral membrane fusion, is a validated clinical target in humans and is inhibited by the Food and Drug Administration (FDA)-approved drug enfuvirtide. (stanford.edu)
When antibodies try to mimic the receptor, they touch a lot of other parts of the viral envelope that HIV can change with ease. (ebola.com)
Now, the Barnes laboratory investigates viral-host interactions and translates knowledge of the structural correlates of antibody-mediated neutralization of viruses into the rational development of highly protective antibodies. (stanford.edu)
The persistence of HIV in treated patients results from the establishment of a viral reservoir insensitive to ART and poorly visible to the immune system. (europa.eu)
Thus, understanding HIV persistence and developing drugs able to flush out HIV, in order to achieve viral eradication or "sterilizing cure" remain outstanding challenges. (europa.eu)
Plasma viral load is considered as the strongest determinant of sexual transmission of HIV. (benthamscience.com)

However, studies have suggested a more complex role of the gp41 endodomain [ 11 , 12 ], showing neutralization of HIV-1 by Abs directed to an epitope in CT of gp41 [ 13 - 15 ]. (plos.org)
We have previously described R1a-B6, an alpaca-derived single domain antibody (nanobody), that is capable of potent cross-subtype neutralization in vitro of H1N1, H5N1, H2N2, and H9N2 influenza viruses, through binding to a highly conserved epitope in the influenza hemagglutinin stem region. (frontiersin.org)
Structural definition of a conserved neutralization epitope on HIV-1 gp120. (openwetware.org)
We have developed an efficient in-vivo antibody discovery platform using our hyperimmune mice by streamlining Beacon-based single B cell screening, hybridoma screening, and downstream hit expansion workflow for deep repertoire mining and epitope diversity. (hub-xchange.com)

A new drug candidate is so potent against all strains of HIV , researchers think it could work as a new kind of vaccine. (sciencealert.com)
Unlike antibodies , which fail to neutralise a large fraction of HIV-1 strains, our protein has been effective against all strains tested, raising the possibility it could offer an effective HIV vaccine alternative. (sciencealert.com)
The Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), an international collaboration led by Scripps Research, has received a $129 million grant from the National Institutes of Health to advance next-generation vaccines designed to coax the immune system into producing antibodies capable of disarming numerous strains of HIV. (diwou.com)
Burton and his colleagues opened a new front in HIV vaccine design in 2009 when they discovered two potent antibodies in the blood cells of a woman living with HIV that were capable of neutralizing 70 percent of 162 HIV reference strains representative of the global epidemic. (diwou.com)
This includes protections against the strains HIV-2 and simian immunodeficiency virus (SIV). (newatlas.com)
However, to date these mAbs have only been weakly effective against tier-1 HIV-1 strains, which are most sensitive to neutralizing antibodies. (stanford.edu)
Here, we engineered D5_AR, a more potent variant of the anti-NHR antibody D5, and established its ability to inhibit HIV-1 strains that are more difficult to neutralize and are more representative of circulating strains (tier-2 strains). (stanford.edu)
Although late boosting of RV144 vaccinees expanded a novel pool of neutralizing B cell clonal lineages, we hypothesize that boosts with stably closed trimers would be necessary to elicit antibodies with greater breadth of tier 2 HIV-1 strains. (cornell.edu)

The work provides insights into how broadly neutralizing antibodies associate with lipids proximal to membrane-associated epitopes to drive neutralization. (elifesciences.org)
Engineered mutations to the 10E8 paratope at light-chain solvent-exposed residues that add positive charge or hydrophobic sidechains proved to increase antibody association to anionic phospholipid vesicles in vitro and also boosted neutralization potency 27 . (elifesciences.org)
Determination of the structure of the HIV-1 gp120 envelope glycoprotein (Kwong 1998 Nature 393, 648-659), provided a physical map of the primary target of neutralizing antibodies against HIV-1 and showed how gp120 conformational diversity can prevent antibody-mediated neutralization (Kwong 2002 Nature 420, 678-682) and how N-linked carbohydrates can form an "evolving glycan shield" (Wei 2003 Nature 422, 307-312). (nih.gov)
18 constructs expressing various subtypes C and CRF01_AE Envs, mostly acute, in subtype-matched and -unmatched HIV backbones were tested for functionality and neutralization sensitivity. (plos.org)
Our results suggest a possible effect of non- env HIV-1 genes on the interaction of Env and neutralizing antibodies and highlight the need to generate a library of IMCs representative of the HIV-1 subtype spectrum to be used as standardized neutralization assay reagents for assessing HIV-1 vaccine efficacy. (plos.org)
Oligomeric HIV-1 envelope proteins delivered with a potent adjuvant are expected to elicit strong antibody responses with broad neutralization specificity. (bvsalud.org)
It's also plausible that understanding effective neutralization by powerful antibodies may be useful in vaccine development. (drugdiscoverytrends.com)
however, many CRF01_AE viruses are resistant to neutralization mediated by these antibodies. (biomedcentral.com)
Our data may provide important information to understand the molecular mechanism regulating the neutralization susceptibility of CRF01_AE viruses to CD4bs antibodies. (biomedcentral.com)
Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody-antigen immune complexes and immunoproteins or Fc receptor expressing immune effector cells. (frontiersin.org)
Crystal and cryo-electron microscopy structures of these antibodies revealed fusion peptide-conformational diversity as a molecular explanation for the cross-clade neutralization. (scitok.com)
The high-affinity immunoglobulin receptor FcgammaRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat. (stanford.edu)
this inhibition has been largely restricted to tier-1 viruses, which are most sensitive to neutralization by sera from HIV-1-infected individuals. (stanford.edu)
Here, we show that the neutralization activity of the well-characterized NHR-targeting antibody D5 is potentiated >5,000-fold in TZM-bl cells expressing FcgammaRI compared with those without, resulting in neutralization of many tier-2 viruses (which are less susceptible to neutralization by sera from HIV-1-infected individuals and are the target of current antibody-based vaccine efforts). (stanford.edu)
bNAb concentrations were determined longitudinally in plasma samples via TZM-bl neutralization assays using virions pseudotyped with 10-1074-sensitive (X2088_c9) or 3BNC117-sensitive (Q769.d22) HIV envelope proteins. (cdc.gov)
Research in our lab is aimed at defining the structural correlates of broad and potent antibody-mediated neutralization of viruses. (stanford.edu)

The envelope glycoprotein GP120 of HIV-1 is covered in N-linked-glycans. (wikipedia.org)
The HIV-1 envelope (Env) glycoproteins are produced as a 160 kDa polyprotein that is subsequently processed to yield virion-associated, trimeric complexes of non-covalently associated gp120-gp41 heterodimers [ 1 , 2 ]. (plos.org)
Strong antibody responses were detected against the V1 and V2 domains of gp120. (bvsalud.org)
The increased potency of a new HIV antibody (green and blue), is explained by an insertion (pink) that contacts the inner domain of the HIV gp120 spike protein (yellow). (drugdiscoverytrends.com)
By conducting structural studies, the researchers were able to identify how NIH45-46 interacted with gp120-a protein on the surface of the virus that's required for the successful entry of HIV into cells-to neutralize the virus. (drugdiscoverytrends.com)
Using this information, they were able to create a new antibody (dubbed NIH45-46 G54W ) that is better able to grab onto and interfere with gp120. (drugdiscoverytrends.com)
The CD4 binding site (CD4bs) of envelope glycoprotein (Env) gp120 is a functionally conserved, important target of anti-human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies. (biomedcentral.com)
The canary pox vector and gp120 vaccine (ALVAC-HIV and AIDSVAX B/E gp120) in the RV144 HIV-1 vaccine trial conferred an estimated 31% vaccine efficacy. (cornell.edu)
HIV-1-uninfected RV144 vaccine recipients were reimmunized 6-8 years later with AIDSVAX B/E gp120 alone, ALVAC-HIV alone, or a combination of ALVAC-HIV and AIDSVAX B/E gp120 in the RV305 trial. (cornell.edu)
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. (openwetware.org)
The antigenic structure of the HIV gp120 envelope glycoprotein. (openwetware.org)
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. (openwetware.org)
Structure of a V3-containing HIV-1 gp120 core. (openwetware.org)
Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates. (openwetware.org)
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. (openwetware.org)
Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120. (openwetware.org)
Energetics of the HIV gp120-CD4 binding reaction. (openwetware.org)
CD4-binding obstacles in conformational transitions and allosteric communications of HIV gp120. (openwetware.org)
Interaction Analysis between HIV gp120 and the Antibodies by Fragment Molecular Orbital Method. (openwetware.org)
The Molecular Basis of pH-Modulated HIV gp120 Binding Revealed. (openwetware.org)
Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1. (openwetware.org)
Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. (openwetware.org)

By improving the efficacy of antibodies that can neutralize HIV, the researchers point to the possibility of clinical testing for NIH45-46 G54W and other antibodies as therapeutic agents. (drugdiscoverytrends.com)
There is clearly an urgent need for additional approaches and antibodies present new opportunities for both therapeutic and prophylactic intervention. (frontiersin.org)
The emergence of highly transmissible SARS-CoV-2 variants of concern (VOC) that are resistant to therapeutic antibodies highlights the need for continuing discovery of broadly reactive antibodies. (scitok.com)
This discovery will likely have a tremendous impact on the research conducted in the field of HIV cure both at basic and therapeutic approaches. (europa.eu)
NEW YORK and VIENNA, Austria, Nov. 20, 2023 (GLOBE NEWSWIRE) -- HOOKIPA Pharma Inc. (NASDAQ: HOOK, 'HOOKIPA'), a company developing a new class of immunotherapeutics based on its proprietary arenavirus platform, today announced that the Company has received clearance from the U.S. Food and Drug Administration (FDA) for its Investigational New Drug (IND) application for HB-500, a novel arenaviral therapeutic vaccine for the treatment of HIV. (khon2.com)
Our novel arenaviral therapeutic vaccine offers promise in helping to address the unmet need for a functional HIV cure. (khon2.com)
HB-500 is an alternating, 2-vector arenaviral therapeutic vaccine for the treatment of HIV. (khon2.com)
Intracellular delivery of multiple functional peptides forms a basis for potent, non-invasive mode of delivery, providing distinctive therapeutic advantages. (aacrjournals.org)
Discovery of functional therapeutic monoclonal antibodies against GPCR and ion channels has been a challenge. (hub-xchange.com)
A case study featuring a therapeutic antibody discovery campaign targeting a cell surface receptor using a single B cell workflow with broad epitopic diversity will be presented. (hub-xchange.com)

We have succeeded in improving the breadth and potency of HIV-1-neutralzing antibodies, so that the best, such as VRC01.23 (Kwon 2021 Mabs 13:1946918) can neutralize ~95% of our 208-strain cross-clade panel with an IC80 of less than 1 µg/ml. (nih.gov)
In doing so, we have isolated a new family of broadly neutralizing antibodies that represent the broadest and most potent mAbs against HIV-1 described to date. (gvn.org)
A much more promising strategy is to use recombinant monoclonal antibodies (mAbs) against influenza and several are currently in clinical development ( 9 - 13 ). (frontiersin.org)
it is the target of the FDA-approved drug enfuvirtide and of neutralizing monoclonal antibodies (mAbs). (stanford.edu)
Taken together, these results provide support for vaccine strategies that target the PHI by eliciting antibodies against the gp41 NHR and support investigation of anti-NHR mAbs in non-human primate passive immunization studies.ImportanceDespite advances in anti-retroviral therapy, HIV remains a global epidemic and has claimed more than 32 million lives. (stanford.edu)

Secondary endpoints included antigen-specific antibody (IgG) and cellular immune responses (cytokine-producing peripheral blood mononuclear cells and T cells). (bvsalud.org)
Both vaccine presentations are safe and well tolerated and elicit robust antigen-specific serum antibody and Th1-type cellular immune responses. (bvsalud.org)
Compared to the non-thermostable presentation, the thermostable vaccine formulation generates greater serum antibody responses (p (bvsalud.org)
The partial success of the RV144 trial underscores the importance of envelope-specific antibody responses for an effective HIV-1 vaccine. (bvsalud.org)
Although performed with a small number of macaques, this study demonstrates the utility of oligomeric envelopes formulated with Advax in eliciting broad antibody responses with the potential to provide protection against SIV transmission. (bvsalud.org)
The Fc receptor-dependent function of antibody-dependent cellular phagocytosis (ADCP) provides mechanisms for clearance of virus and virus-infected cells, as well as for stimulation of downstream adaptive immune responses by facilitating antigen presentation, or by stimulating the secretion of inflammatory mediators. (frontiersin.org)
Fc receptor-dependent antibody functions are also involved in activation of downstream adaptive immune responses by facilitating antigen presentation or by stimulating the secretion of inflammatory mediators ( 12 , 13 ). (frontiersin.org)
Immunization of guinea pigs and rhesus macaques induced similarly broad fusion peptide-directed neutralizing responses suggesting translatability. (scitok.com)
We are excited to collaborate with HOOKIPA in leveraging their arenaviral technology, which has clinically demonstrated the ability to induce potent antigen specific CD8+ T cell responses and represents a promising approach for new cancer immunotherapies ," said James Sabry, Global Head of Pharma Partnering at Roche. (financialcontent.com)
HOOKIPA's novel, replicating arenaviral technology has demonstrated the ability to induce potent antigen-specific T cell responses and promising anti-tumor activity in a Phase 1 clinical trial which treated patients with advanced Human Papillomavirus 16-positive head and neck cancers. (financialcontent.com)
Preclinical studies have also demonstrated the ability of arenaviral immunotherapies to break self-tolerance and induce potent T cell responses to tumor self-antigens and mutated epitopes, or target parts of a mutated, cancer-causing gene. (financialcontent.com)
Following this training, he completed postdoctoral research at the California Institute of Technology, where he combined biophysical methods with in vivo approaches to understand how viruses such as HIV-1 and SARS-CoV-2 infect host cells and elicit specific humoral immune responses (P. Bjorkman). (stanford.edu)
In addition, we are investigating antibody responses to SARS-CoV-2 and related zoonotic coronaviruses (CoV), with the related goal of developing broadly-protective immunotherapies and vaccines against variants of concern and emerging CoV threats. (stanford.edu)
HOOKIPA's replicating and non-replicating technologies are engineered to induce robust and durable antigen-specific CD8+ T cell responses and pathogen-neutralizing antibodies. (wlns.com)

Using highly potent antibodies isolated from HIV-positive people, researchers have recently begun to identify ways to broadly neutralize the many possible subtypes of HIV. (drugdiscoverytrends.com)

The structure of the b12 antibody revealed how the binding site for the CD4 receptor formed a site of vulnerability to neutralizing antibody (Zhou 2007 Nature 329, 811-817). (nih.gov)
The VRC01 antibody, which we helped to identify in 2010 (Wu 2010 Science 329, 856-861), uses mimicry of the CD4 receptor to neutralize over 90 percent of HIV-1 isolates, though the inability of germline versions of VRC01 to bind to HIV-1 Env and its extraordinary level of somatic hypermutation suggest roadblocks to eliciting similar antibodies (Zhou 2010 Science 329, 811-817). (nih.gov)
One functional constraint involves receptor binding - with the site on HIV-1 Env involved in binding the CD4 receptor providing a "supersite of vulnerability. (nih.gov)
These Fc receptor-dependent antibody functions provide a direct link between the innate and adaptive immune systems by combining the potent antiviral activity of innate effector cells with the diversity and specificity of the adaptive humoral response. (frontiersin.org)
Fc receptor-dependent antibody functions are important components of the immune response that provide mechanisms for clearance of infected host cells, immune complexes, or opsonized pathogens. (frontiersin.org)
Whereas conventional antibodies have only been able to block one, the new approach focuses on shutting off both of these receptor sites. (newatlas.com)
Led by Michael Farzan, a professor at The Scripps Research Institute (TSRI), the researchers were building on the knowledge that the CCR5 receptor possesses unusual modifications in the HIV-binding region. (newatlas.com)
We identify four receptor-binding domain targeting antibodies from three early-outbreak convalescent donors with potent neutralizing activity against 12 variants including the B.1.1.7 and B.1.351 VOCs. (scitok.com)

In other words, if the antigen-antibody reaction is compared to a "key-and-lock" model, natural antibodies found in human secretions act as "passe-partout" keys to offer a background protection against most pathogens, food antigens and microbes, before the antigen-specific response can develop [ 4 ]. (biomedcentral.com)

In the process of engaging the antigen, antibodies complementarity-determining regions (CDR) may need to navigate interactions with or concealment by lipid molecules. (elifesciences.org)
Here, we engineered and tested 11 IgG variants of D5, an anti-NHR mAb, by recombining previously described mutations in four of D5's six antibody complementarity-determining regions. (stanford.edu)
While post-boost plasma did not have bnAb activity, the vaccine boosts expanded a pool of envelope CD4 binding site (bs)-reactive memory B cells with long third heavy chain complementarity determining regions (HCDR3) whose germline precursors and affinity matured B cell clonal lineage members neutralized the HIV-1 CRF01 AE tier 2 (difficult to neutralize) primary isolate, CNE8. (cornell.edu)

This understanding will allow the develop of new vaccines that encourage the generation of antibodies that can protect against pathogenic bacteria. (wikipedia.org)
The Structural Biology Section (SBS) seeks to apply structural biology to the development of effective vaccines - especially a vaccine against HIV-1. (nih.gov)
Standardized assays to assess vaccine and antiviral drug efficacy are critical for the development of protective HIV-1 vaccines and drugs. (plos.org)
The efficacy of ALVAC-based HIV and SIV vaccines in humans and macaques correlates with antibodies to envelope variable region 2 (V2). (bvsalud.org)
Human serum usually contains natural IgG, IgM and IgA antibodies, generated independently of any exposure to foreign antigens or vaccines or elicited in the course of infectious or autoimmune diseases. (biomedcentral.com)
An international collaboration has received a $129 million award from the National Institutes of Health (NIH) to advance next-generation Human Immunodeficiency Virus (HIV) vaccines. (precisionvaccinations.com)
There are no preventive vaccines for HIV, but there are HIV prevention medicines, such as pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP). (precisionvaccinations.com)

CRF01_AE is a major circulating recombinant form of HIV-1 prevalent in Southeast Asia. (biomedcentral.com)
2021) Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen. (scripps.edu)
In fact, when new combinations between different HIV-1 subtypes occurs, it results in different Unique Recombinant Forms (URFs), some developed into Circulating Recombinant Forms (CRFs) as propagated in three or more epidemiologically unlinked individuals. (benthamscience.com)

The modeling platform developed here uncovers insights into lipid participation in antibodies' recognition of membrane proteins and highlights antibody features to prioritize in vaccine design. (elifesciences.org)

But what Farzan's team has discovered is that a particular type of protein found on the surface of white blood cells can actually bind to the surface of the HIV virus in two different places simultaneously, which means that not only does the virus no longer have a chance to change the position of its receptors to escape, it's also being blocked from entering the T lymphocyte cells. (sciencealert.com)
In this review, we discuss the properties of Fc receptors, antibodies, and effector cells that influence ADCP. (frontiersin.org)
The team produced a new drug candidate capable of binding to both receptors at once and blocking entry of HIV into the healthy cell as a consequence. (newatlas.com)

Today, daily medication called antiretroviral therapy can suppress HIV to undetectable levels in the blood and prevent sexual transmission of the virus. (diwou.com)
This report includes the guidelines developed by the Panel regarding the use of laboratory testing in initiating and managing antiretroviral therapy, considerations for initiating therapy, whom to treat, what regimen of antiretroviral agents to use, when to change the antiretroviral regimen, treatment of the acutely HIV-infected person, special considerations in adolescents, and special considerations in pregnant women. (cdc.gov)
All patients who have advanced or symptomatic HIV disease should receive aggressive antiretroviral therapy. (cdc.gov)
The guidelines contain recommendations for the clinical use of antiretroviral agents in the treatment of adults and adolescents (defined in Considerations for Antiretroviral Therapy in the HIV-Infected Adolescent) who are infected with the human immunodeficiency virus (HIV). (cdc.gov)
These guidelines are intended for use by physicians and other health-care providers who use antiretroviral therapy to treat HIV-infected adults and adolescents. (cdc.gov)
Prior to the advent of highly active antiretroviral therapy (HAART), dementia was a common source of morbidity and mortality in HIV-infected patients. (medscape.com)

This discovery will certainly open new research avenues towards the characterization, control and eradication of the latent HIV reservoir. (europa.eu)

A better understanding of how antibodies develop membrane affinity and target membrane-proximal epitopes would be impactful for antibody therapeutics, auto-immunity, and vaccine development 10 - 12 . (elifesciences.org)
Oligomers showed high-affinity interaction with CD4 and were highly immunogenic in rabbits, inducing Tier 2 SIV-neutralizing antibodies. (bvsalud.org)
Increased serum antibody affinity to SIVmac251 gp140 and generation of Env-specific memory B cells were observed in the immunized macaques. (bvsalud.org)
Antibody affinity? (hub-xchange.com)

Excitingly, by combining both second and third lines of investigation, we succeeded in inducing cross-clade neutralizing antibodies in mice, guinea pigs, and rhesus macaques (Xu 2018 Nat Med. (nih.gov)
Developed by researchers from more than a dozen research institutions and led by a team at the Scripps Research Institute in the US, the drug is effective against doses of HIV-1, HIV-2 and SIV (simian immunodeficiency virus ) that have been extracted from humans or rhesus macaques - including what researchers consider to be the 'hardest-to-stop' variants. (sciencealert.com)
The study shows that the new drug candidate blocks every strain of HIV-1, HIV-2 and SIV (simian immunodeficiency virus) that has been isolated from humans or rhesus macaques, including the hardest-to-stop variants. (ebola.com)

We show here that vaccine-induced antibodies to SIV variable region 1 (V1) inhibit anti-V2 antibody-mediated cytotoxicity and reverse their ability to block V2 peptide interaction with the α4ß7 integrin. (bvsalud.org)
Our findings demonstrate that a single intramuscular injection in mice of AAV encoding R1a-B6 fused to Fc fragments of different isotypes equipped either, with or without antibody dependent cellular cytotoxicity (ADCC) activity, was able to drive sustained high-level expression (0.5-1.1 mg/mL) in sera with no evidence of reduction for up to 6 months. (frontiersin.org)

Passive transfer of serum antibodies from convalescent patients has been used in the past ( 7 , 8 ), however, this approach is of limited use in a global pandemic emergency. (frontiersin.org)
Additionally, we demonstrate that a single dose of the αCD40.RBD vaccine, injected without adjuvant, is sufficient to boost a rapid increase in neutralizing antibodies in convalescent non-human primates (NHPs) exposed six months previously to SARS-CoV-2. (nature.com)
One Sentence SummaryUltrapotent antibodies from convalescent donors neutralize and mitigate resistance of SARS-CoV-2 variants of concern. (scitok.com)

The analyses published were conducted with a simian immunodeficiency virus (SIV) model, commonly used in a preclinical setting as a surrogate to HIV. (khon2.com)
Gadi has over twenty years of experience in oncology R&D with an emphasis in preclinical antibody discovery. (hub-xchange.com)

D5_AR exhibited weak cross-clade neutralizing activity against a diverse set of tier-2 HIV-1 viruses, which are less sensitive to neutralizing antibodies than tier-1 viruses and are the target of current antibody-based vaccine efforts. (stanford.edu)

Antibodies can target epitopes on integral membrane proteins very near to the lipid bilayer surface, even those partially embedded within the headgroup region. (elifesciences.org)

Her research showed that while 60% of COVID-19 patients elicited a strong antibody response, only 17% of them retained this potency three months later. (wikipedia.org)

Importantly, the Antibody Mediated Prevention (AMP) study (HVTN 704/HPTN 085) showed an IC80 of less than 1 µg/ml was required for protection by antibody VRC01. (nih.gov)

Previous NIH support for this international collaboration allowed us to lay the scientific foundation for developing an unprecedented and highly promising approach to HIV vaccination. (diwou.com)
Scripps Research is one of the premier research institutions in the world, and their efforts-along with their international partners-to develop an HIV vaccination could help save millions of lives. (diwou.com)
Neutralizing antibody reactions after natural illness or vaccination comprise a major component of safety from virus illness (1). (researchhunt.com)
Previous NIH support for this international collaboration allowed us to lay the scientific foundation for developing an unprecedented and highly promising approach to HIV vaccination," said Dennis Burton, Ph.D., director of the Scripps CHAVD and co-chair of the Department of Immunology and Microbiology at Scripps Research. (precisionvaccinations.com)

This improves the antibody's breadth-or extent to which it effectively targets many subtypes of HIV-and potency by an order of magnitude, according to Ron Diskin, a postdoctoral scholar in Bjorkman's laboratory at Caltech and the paper's lead author. (drugdiscoverytrends.com)

One area in which we and others have already made an impact is in understanding how HIV-1 is able to evade the humoral immune system. (nih.gov)
These and other studies - including the determination of the crystal structure of the entire spike ectodomain (Pancera 2014 Nature 514, 455-461) and the determination of the crystal structure of fully glycosylated envelope trimers (Stewart-Jones 2016 Cell 165, 813-826) - have led to an understanding of the molecular trickery that protects HIV-1 from the humoral immune response. (nih.gov)
Several functions have been proposed for natural antibodies, including a first-line role in the defense against infections, a scavenger-like activity to apoptosis by-products and a turn-off, regulative role in the maintenance of immune homeostasis [ 7 , 14 ]. (biomedcentral.com)
Antibodies are a key component of the human adaptive immune system, and the elicitation of antibodies has been correlated with vaccine efficacy in many diseases ( 1 ). (frontiersin.org)
HIV is a virus that attacks the immune system, affecting an individual's ability to fight infections and disease. (thepharmacist.co.uk)
Acquired immune deficiency syndrome (AIDS) is the final stage of HIV. (thepharmacist.co.uk)
When HIV infects a cell, it targets the CD4 lymphocyte, an integral part of the body's immune system. (ebola.com)

Alongside developing new medical therapies, Moores is interested in how the body responds to carbohydrate antigens in the form of antibody recognition. (wikipedia.org)
Her work has primarily focussed on the carbohydrate antigens on HIV-1. (wikipedia.org)
Y498 cross-reacted with diverse Env antigens and neutralized 30% of 70 tested HIV-1 isolates. (oncotarget.com)
B-1 cells are found in peritoneal and pleural cavities where they provide first-line defence through antibodies able to bind polysaccharide antigens and repeated motifs that are typically found in microbial cell walls and macromolecules [ 2 , 3 ]. (biomedcentral.com)
Both encode the same HIV antigens. (khon2.com)

A second area in which we and others have made an impact is in understanding how human antibodies can neutralize diverse HIV-1 isolates. (nih.gov)

Here we describe two IMCs derived from subtypes C and CRF01_AE HIV-1 primary isolates expressing LucR (IMC.LucR) that were engineered to express heterologous gp160 Envs. (plos.org)
A central goal of HIV-1-vaccine research is the elicitation of antibodies capable of neutralizing diverse primary isolates of HIV-1. (scitok.com)

Now, a team led by biologists at the California Institute of Technology (Caltech) has built upon one of these naturally occurring antibodies to create a stronger version they believe is a better candidate for clinical applications. (drugdiscoverytrends.com)
This 7-year award from NIH's National Institute of Allergy and Infectious Diseases (NIAID) will support refinement and manufacture of novel HIV vaccine candidates so that they can move into early-stage, human clinical testing. (precisionvaccinations.com)
In partnership with the International AIDS Vaccine Initiative (IAVI), the researchers will launch the first human study of a sequential vaccine in Phase I clinical trial (IAVI W001) to test a novel HIV vaccine candidate, BG505 SOSIP.664 gp140 during 2019. (precisionvaccinations.com)
Clinical trials of a broadly neutralizing antibody (bNAb) provided proof-of-concept that passive immunization against HIV can be efficacious in people. (cdc.gov)
In 1996, the Department of Health and Human Services and the Henry J. Kaiser Family Foundation convened the Panel on Clinical Practices for the Treatment of HIV to develop guidelines for the clinical management of HIV-infected persons. (cdc.gov)
HOOKIPA is responsible for advancing the HIV program through the completion of a Phase 1b clinical trial. (khon2.com)
The RV305 (NCT01435135) HIV-1 clinical trial was a placebo-controlled randomized double-blinded study that assessed the safety and efficacy of vaccine boosting on B cell repertoires. (cornell.edu)
His efforts resulted in three approved drugs - DUPIXENT®, LIBTAYO® and Evkeeza® and 20 clinical drug candidates.He earned his Ph.D. from Drexel University and proposed that the use of biparatopic EGFR antibodies would be a potent biotherapeutic for EGFR overexpressing tumors. (hub-xchange.com)
Clinical dementia is a fairly broad-based decline of brain function, and most definitions center on the patient's intellectual decline and memory dysfunction. (medscape.com)

Electron microscopy of two of these antibodies bound with near-native gp140 trimers showed that they recognized an open conformation of the Env trimer. (cornell.edu)

however, ~20% of HIV-1-infected individuals do develop antibodies that broadly neutralize HIV-1 isolates. (oncotarget.com)

Neutralizing anti-drug antibodies were not elicited. (nature.com)
At the Scripps Research Institute as part of her post doctoral work, she worked on the glycobiology on HIV and broadly-neutralizing antibodies. (wikipedia.org)
Thus, our current understanding on how the expansion of particular B cell lineages by Env may be linked to the development of non-neutralizing antibodies is limited. (plos.org)
The two forms were equally immunogenic, but only the latter elicited neutralizing antibodies by stimulating a more restricted expansion of B cells to a narrower set of IGH/IGK/IGL-V genes that represented a small fraction (0.003-0.02%) of total B cells. (plos.org)
One line involves understanding the B cell pathways that produce broadly neutralizing antibodies and seeking to replicate their development. (nih.gov)
We've observed select broadly neutralizing antibodies to develop similarly in multiple donors (e.g. (nih.gov)
We found the N-terminal eight residues of the fusion peptide to be a region targeted by neutralizing antibodies (Kong 2016 Science 352, 828-338. (nih.gov)
In this study, we isolated a novel human mAb termed Y498 from a phage display antibody library constructed with the PBMC samples of a CRF07_BC-infected Chinese donor whose sera exhibited broadly neutralizing activity. (oncotarget.com)
In early 1990s, the first-generation human neutralizing antibodies (b12, 2G12, 2F5 and 4E10) were isolated from clade B-infected individuals by phage display and electrofusion or Epstein-Barr virus (EBV) transformation-based techniques [ 1 - 3 ]. (oncotarget.com)
In recent years, a number of novel neutralizing antibodies with different specificities have been isolated and characterized by using new B cell-based sorting and screening approaches [ 4 , 5 ]. (oncotarget.com)
Neutralizing antibodies (NAbs) can block virus entry by binding Env and inhibiting attachment or conformational changes required for fusion [ 4 - 7 ]. (plos.org)
Our new antibody is now arguably the best of the currently available, broadly neutralizing anti-HIV antibodies. (drugdiscoverytrends.com)
Cross-subtype neutralizing single domain antibodies against influenza present new opportunities for immunoprophylaxis and pandemic preparedness. (frontiersin.org)
The N terminus of the HIV-1-fusion peptide is thus a promising target of vaccine efforts aimed at eliciting broadly neutralizing antibodies. (scitok.com)
Burton DR. (2021) A new lease on life for an HIV-neutralizing antibody class and vaccine target. (scripps.edu)
Data from the new study showed the drug candidate binds to the envelope of HIV-1 more potently than the best broadly neutralizing antibodies against the virus. (ebola.com)
Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies. (openwetware.org)
These antibodies appeared to have a neutralizing effect on G-CSF. (medscape.com)

Welcome to hubXchange's East Coast Antibody Therapeutics Xchange 2022, bringing together executives from pharma and biotech to address and find solutions to the key issues faced in developing antibody therapeutics, through a series of roundtable discussions. (hub-xchange.com)

Cellular factors which play role in host defense mechanisms against HIV were identified and their role in HIV induced inflammation was established. (europa.eu)
HIV persistence may arise from ongoing residual virus replication and/or from latently-infected cells defined as the cellular reservoir in which long-lived resting memory CD4+ T cells harbouring an integrated but transcriptionally silent provirus represent the largest pool in the blood (Chomont et al. (europa.eu)

SeyedAhmad SeyedAlinaghi , " Frontiers in HIV Research ", Bentham Science Publishers (2016). (benthamscience.com)

Thus far, a subtype B IMC backbone expressing Renilla luciferase (LucR), and into which the ectodomain of heterologous env coding sequences can be expressed has been successfully developed but as execution of HIV-1 vaccine efficacy trials shifts increasingly to non-subtype B epidemics (Southern African and Southeast Asia), non-subtype B HIV-1 reagents are needed to support vaccine development. (plos.org)

The primary endpoints were safety and tolerability, pharmacokinetics (PK) and antiviral activity in viremic HIV-infected adults not on ART. (nature.com)

Antibodies can exert their protective functions via a multitude of mechanisms. (frontiersin.org)
Once injected into muscle tissue, like HIV itself, the vehicle turns those cells into "factories" that could produce enough of the new protective protein to last for years, perhaps decades, Farzan said. (ebola.com)

However, the evidence for rules for lipid recognition in antibodies is still incomplete . (elifesciences.org)
Analysis of recognition of the CD4 supersite in 14 donors suggest that steric access to the CD4 supersite is a primary physical constraint limiting antibody recognition (Zhou 2015 Cell 161, 1280-1292). (nih.gov)
Structural basis of coreceptor recognition by HIV-1 envelope spike. (openwetware.org)

HIV has probably originated from multiple zoonotic transmissions of Simian Immunodeficiency Virus (SIV) from non-human primates to humans in West and Central Africa. (benthamscience.com)

PGT121 targets a V3-glycan-dependent site on HIV-1 Env 9 . (nature.com)

To pursue this and other novel concepts in HIV vaccine research, the Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) was formed in 2012 with a $77 million grant from NIAID. (diwou.com)
The award will fund the Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), comprised of 26 investigators: eight principal investigators at Scripps Research and 18 principal investigators at 13 other CHAVD-affiliated scientific organizations, including projects at four foreign sites. (precisionvaccinations.com)
In a remarkable new advance against the virus that causes AIDS, scientists from the Jupiter, Florida campus of The Scripps Research Institute (TSRI) have announced the creation of a novel drug candidate that is so potent and universally effective, it might work as part of an unconventional vaccine. (ebola.com)
Major advances in HIV/AIDS treatment regimens have fundamentally altered the natural history of the disease and sharply reduced HIV-related morbidity and mortality in countries where such treatments are accessible. (europa.eu)
however, the strength of the recommendation to treat should be based on the patient's willingness to accept therapy as well as the prognosis for AIDS-free survival as determined by the HIV RNA copy per mL of plasma and the CD4+ T cell count. (cdc.gov)
again, risk of progression to AIDS, as determined by HIV RNA viremia and CD4+ T cell count, should guide the decision to treat. (cdc.gov)
While effective treatments have significantly extended the lives of people living with HIV and reduced the transmission of the virus, there is no cure for HIV or AIDS. (khon2.com)
Thirty years after the first description of AIDS, an estimated 35.0 million [33.2 million-37.2 million] people were living with HIV at the end of 2013. (benthamscience.com)

Anatomy16

Organisms13

Diseases18

Chemicals and Drugs91

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Psychiatry and Psychology10

Phenomena and Processes44

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science5

Named Groups5

Health Care19

Geographicals4

BNAbs21

Monoclonal antibody5

Infection41

Immunogens10

Viral19

Epitope4

Strains8

Neutralization16

GP12022

Therapeutic10

MAbs5

Responses14

Highly potent antibodies1

Receptor8

Antigen-specific1

Complementarity-determi3

Vaccines7

Recombinant3

Vaccine design1

Receptors3

Antiretroviral therapy6

Characterization1

Affinity4

Rhesus macaques3

Cytotoxicity2

Convalescent3

Preclinical2

Viruses1

Epitopes1

Strong antibody1

VRC011

Vaccination4

Potency1

Immune7

Antigens5

Human antibodies1

Primary isolates2

Clinical9

Gp1401

Isolates1

Neutralizing18

Therapeutics1

Cellular2

20161

Efficacy1

Antiviral activity1

Protective2

Recognition3

Primates1

Targets1

AIDS8