DeletionsBalanced chromosome rearrangementsAbnormalitiesShort arm of chromosomeFluorescenceTranslocationsDistalRearrangementsGenomic breakpointsTranslocationBacterialBovine chromosomeInversionDeletion of chromosomeAcrocentricBreakageAbnormal chromosomeCancerMicroarrayCytogenetic12q13MicrodissectionProbesAberrationsHumanSequencesGeneticRecurrentMolecularInstabilitySegmentsPhiladelphiaMetaphasesBone marroNovoCrypticResearchersPhenotypicGenomicsHeterochromatinSitu hybridizationDiseasesIdentificationLymphocytesSegmentSyndromeGene expressionRare chromosomalChronic myelogenYeastDuplicationNonrandomInfantsFusionPartial
Deletions14
- citation needed] Most deletions in chromosome 1p36 are de novo mutations. (wikipedia.org)
- The purpose of this study was to test the hypothesis that deletions of varying sizes in de novo apparently balanced chromosome rearrangements are a significant cause of phenotypic abnormalities. (nih.gov)
- Our study suggests that the use of molecular cytogenetic techniques is a highly effective way of systematically delineating chromosomal breakpoints, and that the presence of deletions of varying size is an important cause of phenotypic abnormalities in patients with "balanced" de novo rearrangements. (nih.gov)
- Chromosome banding and fluorescence in situ hybridization (FISH) showed recurrent breakpoints in 12q13, clustering near the NAB2 and STAT6 genes, and single nucleotide polymorphism array analysis disclosed frequent deletions affecting STAT6. (scilifelab.se)
- 2. 9p24 deletions A chromosome 9p deletion means that part of one of the body's chromosomes has been lost or deleted. (safehubcollective.org)
- Deletions of chromosome 7 are often detected in myelodysplastic syndrome. (biomedcentral.com)
- The primary focus of our report is to compare our case with the few others in the literature describing interstitial deletions at the long arm of chromosome 7. (hindawi.com)
- Terminal deletions at the long arm of chromosome 7 have been described more frequently in the medical literature [ 1 , 2 ] compared to interstitial deletions at the distal 7q region. (hindawi.com)
- A specific distal 7q interstitial deletion syndrome has not been proposed because of the rarity of these deletions and the various breakpoints described in prior studies. (hindawi.com)
- The aim of this case report is to further understand the phenotypic features associated with interstitial deletions at the long arm of chromosome 7 and offer a basis for the development of a possible syndromic profile for these deletions in the future. (hindawi.com)
- Terminal 6q deletions are a variable group of chromosome disorders, with the largest deletions extending from 6q25.2 to 6qter (up to 16 Mb in size) and the smallest deletions restricted to the most distal band 6q27 (as small as 390 kb in size) [ 1 ]. (biomedcentral.com)
- In addition to revealing breaks, which lead to translocation of parts or all of the gene or its fusion to other genes, the probe set can also be used to identify other CCND1 aberrations such as deletions, amplifications or chromosome 11 hyperdiploidy. (diagnostictechnology.com.au)
- Chromosome analyses showed numeral abnormalities such as 5n ploidies and various kinds of structural abnormalities, such as deletions, translocations, derivatives and isodicentric chromosomes. (biomedcentral.com)
- The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). (cancerindex.org)
Balanced chromosome rearrangements4
- Possible approaches for cytogenomic assessment of couples with balanced chromosome rearrangements and problems like reproductive failures were considered and suggested as useful part of effective genetic counseling. (metasystems-probes.com)
- 3- 6 Phenotypic abnormalities seen in cases with apparently balanced chromosome rearrangements have usually been explained by the disruption of a gene at the breakpoint causing the loss of gene function. (bmj.com)
- Single additional alterations to del(5q) by balanced chromosome rearrangements were rarely found in myelodysplasia. (biomedcentral.com)
- Conversely, balanced chromosome rearrangements were rarely found as a single additional alteration to del (5q). (biomedcentral.com)
Abnormalities5
- Detection and precise genomic mapping of balanced chromosomal abnormalities in patients with impaired fertility or a clinical phenotype represent a challenge for current cytogenomics owing to difficulties with precise breakpoint localization in the regions enriched for DNA repeats and high genomic variation in such regions. (metasystems-probes.com)
- She got a grant to study chromosomes and, when she returned to Chicago, even though she had "no special interest in chromosome abnormalities in hematological diseases," the course of her research was set by her ready response to clinical colleagues who frequently asked her to study their patients. (laskerfoundation.org)
- Characterisation of breakpoints in patients with apparently balanced constitutional chromosome rearrangements and phenotypic abnormalities has proved an invaluable strategy for identifying disease causing genes, especially those on the X chromosome. (bmj.com)
- As noted above, Chromosome 9, Partial Monosomy 9p is also associated with characteristic abnormalities of the skull and facial (craniofacial) region. (mentalhealthhelpcenter.com)
- Although JTs have been reported in neoplasms and constitutional chromosome abnormalities, they are rare chromosome rearrangements in neoplastic diseases. (biomedcentral.com)
Short arm of chromosome2
- 1p36 deletion syndrome is caused by the deletion of the most distal light band of the short arm of chromosome 1. (wikipedia.org)
- For example, the short arm of chromosome 9 includes bands 9p11 to 9p24, and the long arm includes bands 9q11 to 9q34. (safehubcollective.org)
Fluorescence6
- We characterized the breakpoints in these fifteen cases (two of which were ascertained prenatally), using a combination of high-resolution GTG-banding, fluorescence in situ hybridization (FISH) with bacterial artificial chromosomes (BACs), and data from the Human Genome Project. (nih.gov)
- To investigate the possibility that a novel candidate gene for XLMR was disrupted at the X chromosome translocation breakpoint, we mapped the breakpoint using fluorescence in situ hybridisation (FISH). (bmj.com)
- The next step to discover much more in regards to the rearrangement is fluorescence in situ hybridization (FISH), utilizing probes which span the chromosomal breakpoints, to ensure that it might locate the breakpoints380 Current Genomics, 2017, Vol. 18, No.Wa. (calcimimeticagent.com)
- Pinkel D., Detection of aneuploidy and aneuploidy-inducing agents in human lymphocytes using fluorescence in situ hybridization with chromosome specific DNA probes, Mutat. (gse-journal.org)
- Eastmond D.A., Rupa D.S., Hasegawa L.S., Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in situ hybridization with DNA probes, Mutat. (gse-journal.org)
- Lemieux N., Dutrillaux B., Viegas-Pequignot E., A simple method for simultaneous R- or G-banding and fluorescence in situ hybridization of small single-copy genes, Cytogenet. (gse-journal.org)
Translocations10
- two (cases 31 and 33) were de novo translocations involving the 22q13 band and the short arm of an unidentified acrocentric, with the karyotype 46,XX,der(22)t(22;acro)(q13;p11). (bmj.com)
- Rowley and her colleagues subsequently identified several other signal chromosome translocations, including one characteristic of acute myeloblastic leukemia. (laskerfoundation.org)
- Quickly picking up on her lead that translocations contribute to malignancy, scientists around the world joined the search for chromosomes that either switched genetic material or, in some cases, lost it altogether in a process known as "deletion. (laskerfoundation.org)
- Translocations trigger the switch of genetic components amongst distinctive chromosomes. (calcimimeticagent.com)
- In agreement with ESMO clinical practice recommendations, this case report proves the role of those molecular approaches in detecting cryptic fusion gene in some forms of variant translocations with masked Ph and der(9) chromosomes. (translateinthetownships.com)
- Jumping translocations (JTs) are rare chromosome rearrangements characterized by re-localization of one donor chromosome to multiple recipient chromosomes. (biomedcentral.com)
- Jumping translocations (JTs) are chromosomal rearrangements comprising one donor chromosome and multiple recipient chromosomes [ 1 ]. (biomedcentral.com)
- JTs are characterized by translocations of one donor chromosome to various recipient chromosomes, resulting in several gains of this chromosomal segment and possible loss of segments of the recipient chromosomes [ 1 , 2 ]. (biomedcentral.com)
- Fusion of the break-off donor chromosome segment to telomeric or interstitial regions of recipient chromosomes can form different chromosomal patterns of jumping translocations. (biomedcentral.com)
- Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. (atlasgeneticsoncology.org)
Distal2
- It revealed an 8.6 megabase deletion with the proximal breakpoint in the chromosome band 2q32.2 and the distal breakpoint in 2q33.1. (um.si)
- We studied 5 consecutive cases of GCT involving the distal radius operated by en-bloc resection of tumor followed by reconstruction with ipsilateral non-vascularized fibular graft with a minimum 1 year follow-up. (jbstjournal.com)
Rearrangements4
- The terminal regions of human chromosomes are known to contain specialised DNA sequences and may be vulnerable to rearrangements causing human genetic diseases and particularly idiopathic mental impairment. (bmj.com)
- Our study involved 33 patients with a "pure" partial 22q13 monosomy, with exclusion of all rearrangements involving loss or gain of euchromatic material from any other chromosome than number 22. (bmj.com)
- Background: Rearrangements involving chromosome 5p often result in two syndromes, Cri-du-chat (CdC) and Trisomy 5p, caused by a deletion and duplication, respectively. (um.si)
- The CCND1 FISH probe set is designed to detect rearrangements involving regions of the human CCND1 gene located on chromosome band 11q13. (diagnostictechnology.com.au)
Genomic breakpoints2
- This was in line with WGS and Cap-seq results, revealing variable breakpoints in chromosomes 1 and 10 and genomic breakpoints that should not yield functional fusion transcripts. (mendeley.com)
- Circles indicate genomic breakpoints. (calcimimeticagent.com)
Translocation5
- Rowley had identified the first "translocation" in cancer, providing clear evidence that the cause of CML could be related to the fact that by moving from one chromosome to another, the aberrant segment of chromosome 22 was no longer sitting next to genes that controlled its behavior. (laskerfoundation.org)
- A female patient with non-syndromic mental retardation was shown by high resolution GTL banding to have inherited an apparently balanced translocation, 46,X,t(X;8)(q28;q12)mat. (bmj.com)
- Intriguingly, we found that the X chromosome breakpoint in the daughter could not be defined by a single breakpoint spanning genomic clone and further analysis showed a 650 kb submicroscopic duplication between DXS7067 and DXS7060 on either side of the X chromosome translocation breakpoint. (bmj.com)
- However, other mechanisms of disease causation have also been described where (1) a breakpoint disrupts or alters gene expression via a position effect 7 or (2) a cryptic deletion or duplication is identified at the translocation breakpoint. (bmj.com)
- The cryptic interstitial deletion on chromosome band 4q12 leading to FIP1L1-PDGFRA fusion is quite unique as it is generated by a cryptic chromosomal deletion, rather than a translocation (Gotlib and Cools, 2008). (atlasgeneticsoncology.org)
Bacterial1
- Cai L., Taylor J. F., Wing R.A., Gallagher D.S., Woo S.S., Davis S.K., Construction and characterization of a bovine bacterial artifical chromosome library, Genomics 29 (1995) 413-425. (gse-journal.org)
Bovine chromosome2
- Eggen A., Solinas T.S., Fries R.A., Cosmid specific for sequences encoding a microtubule associated protein, MAPIB, contains a polymorphic microsatellite and maps to bovine chromosome 20q14, J. Hered. (gse-journal.org)
- A comparative radiation hybrid map of bovine chromosome 18 and homologous chromosomes in human and mice. (fbn-dummerstorf.de)
Inversion5
- The Precise Breakpoint Mapping in Paracentric Inversion 10q22.2q23.3 by Comprehensive Cytogenomic Analysis, Multicolor Banding, and Single-Copy Chromosome Sequencing. (metasystems-probes.com)
- Here, we present a comprehensive cytogenomic approach to breakpoint mapping in a rare paracentric inversion on 10q (in a patient with oligoasthenoteratozoospermia and necrozoospermia) that does not affect other phenotype traits. (metasystems-probes.com)
- The breakpoints of the 1R inversion were between (1) the 5S rDNA site and the NOR-region on the satellite of the short arm, and (2) between two AAC(5) sites close to the centromere on the long arm. (unboundmedicine.com)
- (g) Schematic representation of the double inversion leading to the formation of the der(3) chromosome. (biomedcentral.com)
- The CBFB-MYH11 fusions are formed by inversion on chromosome 16, that are presented within the M4E0 subtype of AML [10]. (calcimimeticagent.com)
Deletion of chromosome2
- By way of example, in prostate cancer, the TMPRSS2-ERG fusion genes are generated from interstitial deletion of chromosome 21q22 [8]. (calcimimeticagent.com)
- Intermediate deletion of chromosome 7 between bands 21 and 22 was observed (arrow indicates the deleted segment). (ogscience.org)
Acrocentric2
- Karyotype was abnormal, with unbalanced 1q JTs to the short arms of acrocentric chromosomes 14 and 21, leading to gain of 1q. (biomedcentral.com)
- The two largest macrochromosome pairs are submetacentric, while all other chromosomes are acrocentric or (for the smallest microchromosomes) probably telocentric. (ariakesuisan.com)
Breakage1
- As previously reported, the breakpoints place of complicated variant t(9;22) is nonrandom using a marked clustering to certain chromosome bands suggesting that some regions are additional prone to breakage. (translateinthetownships.com)
Abnormal chromosome2
- The BM karyotype, in addition to 5q deletion, showed an acquired abnormal chromosome 3 (Figure 1 a). (biomedcentral.com)
- The most common type of chromosomal abnormality is known as aneuploidy, an abnormal chromosome number due to an extra or missing chromosome. (safehubcollective.org)
Cancer4
- At a time when the idea that cancer had a genetic basis was widely disbelieved, Nowell's results provided the first clear evidence that a particular genetic defect in a single chromosome can lead to a population or clone of identical cells that accumulate in numbers to form a deadly malignancy. (laskerfoundation.org)
- The tiny Philadelphia chromosome became a clear and consistent marker of CML, a cancer of the myeloid or bone marrow cells, with broad implications for diagnosis and prognosis of disease. (laskerfoundation.org)
- 14] and in Atlas of chromosome in cancer databases [15], and inside the fragile web-site, FRA12A, which can be caused by an expanded CGG repeat inside the 5-prime untranslated area on the DIP2B gene (OMIM 611379) [16]. (translateinthetownships.com)
- Evaluation of chromosome 6p22 as a breast cancer risk modifier locus in a follow-up study of BRCA2 mutation carriers. (uniklinikum-dresden.de)
Microarray3
- Multicolor banding, chromosomal microarray analysis, chromosome microdissection with reverse painting, and single-copy sequencing of the rearranged chromosome were performed to determine the length and position of the inverted region as well as to rule out a genetic imbalance at the breakpoints. (metasystems-probes.com)
- Most previous case studies involving 7q21.13q22.1 described a broader region or lacked precise breakpoints because they were analyzed before high-resolution microarray became available. (ogscience.org)
- To delineate the precise breakpoint, genome-wide high-resolution microarray (Affymetrix Cytoscan 750K array, Affymetrix Inc., Santa Clara, CA, USA) was performed. (ogscience.org)
Cytogenetic2
- PCR-based markers and cytogenetic analysis with genomic in situ hybridisation were applied to identify alien chromatin in four genetically diverse populations of wheat ( Triticum aestivum ) lines incorporating chromosome segments from Thinopyrum intermedium and Secale cereale (rye). (nature.com)
- Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome-positive chronic myelogenous leukemia: high incidence of early complete and major cytogenetic responses. (medscape.com)
12q131
- The 12q13 chromosome area, involved in our case, was described by Costa et al. (translateinthetownships.com)
Microdissection1
- We have used recombinant clones derived from microdissection of the fragile X region to characterize breakpoints around the fragile site at Xq27.3. (ox.ac.uk)
Probes1
- The two probes are designed to recognize sequences on both sides of an area in the 5' regulatory region of the CCND1 gene where breakpoints have been found frequently. (diagnostictechnology.com.au)
Aberrations2
- Almost every chromosome is affected by numeric or structural aberrations. (neurotransmitter.net)
- The aim of the project is to improve the surveillance of patients with chromosome 6 aberrations and the support for their families by increasing the available information about these rare aberrations. (biomedcentral.com)
Human10
- It was only four years earlier that the precise number of human chromosomes had been fixed at 46 and chromosome studies were, by today's standards, quite primitive. (laskerfoundation.org)
- 18- 21 Xq28 is a highly gene rich region of the human X chromosome and we focused on the X chromosome breakpoint as the identification of a disrupted gene here would be a rapid way to identify a further candidate gene for X linked mental retardation within Xq28. (bmj.com)
- The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. (lookformedical.com)
- The outermost circle displays human chromosomes along with genomic coordinates and G-banding stains (NCBI Build 36.1). (blogspot.com)
- Human chromosome 1 pair after G-banding . (wikidoc.org)
- Chromosome 1 pair in human male karyogram . (wikidoc.org)
- Chromosome 1 is the designation for the largest human chromosome . (wikidoc.org)
- It was the last completed chromosome, sequenced two decades after the beginning of the Human Genome Project . (wikidoc.org)
- The following are some of the gene count estimates of human chromosome 1. (wikidoc.org)
- The following is a partial list of genes on human chromosome 1. (wikidoc.org)
Sequences1
- Comparative mapping of five coding DNA sequences on cattle chromosomes 7 and 25. (fbn-dummerstorf.de)
Genetic2
- The condition is caused by a genetic deletion (loss of a segment of DNA) on the outermost band on the short arm (p) of chromosome 1. (wikipedia.org)
- The problems of genetic counseling associated with enrichment for repeats and high DNA variability of usual breakpoint regions were discussed. (metasystems-probes.com)
Recurrent1
- The most recurrent numerical alterations were gains in rat chromosome 4 (RNO4) and losses in RNO15. (biomedcentral.com)
Molecular3
- Seven different mildew resistant wheat lines derived from crosses between triticale and bread wheat were examined by molecular cytogenetics and chromosome C-banding in order to determine their chromosomal composition. (unboundmedicine.com)
- Here especially highlighted variations of FISH are molecular combing, chromosome orientation-FISH (CO-FISH), telomere-FISH, parental origin determination FISH (POD-FISH), FISH to resolve the nuclear architecture, multicolor-FISH (mFISH) approaches, among other applied in chromoanagenesis studies, Comet-FISH, and CRISPR-mediated FISH-applications. (frontiersin.org)
- We describe the clinical and molecular features of a child who presented with a large abdominal mass, AML, and a new CK, involving chromosomes 11, 16, and 19 leading to a KMT2A-MLLT1 fusion and 2 extra copies of the ELL gene, thus resulting in the concurrent overexpression of MLLT1 and ELL. (cancerindex.org)
Instability1
Segments1
- The most commonly deleted segments are clustered at band 7q22. (biomedcentral.com)
Philadelphia5
- In 1960, Peter Nowell discovered the "Philadelphia chromosome. (laskerfoundation.org)
- What made Nowell and Hungerford notice the Philadelphia chromosome, named after the city in which they worked, was its size. (laskerfoundation.org)
- Likewise, more than a decade passed before scientists understood exactly why the Philadelphia chromosome was so small. (laskerfoundation.org)
- Using banding technology, she discovered that the tiny Philadelphia chromosome was missing a piece of itself. (laskerfoundation.org)
- Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. (medscape.com)
Metaphases3
- Partial metaphases showing the normal and the rearranged chromosome 3. (biomedcentral.com)
- The complex chromosome 3 rearrangement was found in all the metaphases, strongly suggesting its role as a driver mutation. (biomedcentral.com)
- FISH evaluation on 200 nuclei and metaphases using the subtelomeric 9qter probe was performed to further investigate the involvement of chromosome 9 in the complicated rearrangement: it showed a typical signal pattern.3. (translateinthetownships.com)
Bone marro1
- Here we report on a 79-year woman with an aggressive form of myelodysplastic syndrome with del(5q), no TP53 mutation, and a novel complex rearrangement of chromosome 3 in bone marrow cells. (biomedcentral.com)
Novo2
- Case presentation: Here we present a 5-month-old Slovenian girl, with de novo terminal deletion and inverted duplication of chromosome 5p. (um.si)
- In most cases, Chromosome 9, Partial Monosomy 9p appears to result from spontaneous (de novo) errors very early in embryonic development that occur for unknown reasons (sporadically). (mentalhealthhelpcenter.com)
Cryptic1
- DiscussionWe describe a patient with CML associated using a novel cryptic complicated variant t(9;22), involving chromosome 12 besides chromosomes 9 and 22, which was unmasked and characterized by RT-PCR and FISH analyses. (translateinthetownships.com)
Researchers4
- After photographing chromosomes under a microscope, researchers literally cut them up, like paper dolls, and arranged them according to size, thereby producing a karyotype. (laskerfoundation.org)
- Researchers know that Down syndrome is caused by an extra chromosome, but no one knows for sure why Down syndrome occurs or how many different factors play a role. (safehubcollective.org)
- The Chromosome 6 Project is a collaboration between researchers and clinicians at the University Medical Center Groningen and members of a Chromosome 6 support group on Facebook. (biomedcentral.com)
- Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction ). (wikidoc.org)
Phenotypic1
- Based on the various breakpoints in prior studies, a number of phenotypic variations have been identified that are unique to each of the reports. (hindawi.com)
Genomics1
- Libert F., Lefort A., Okimoto R., Womack J., Georges M., Construction of a bovine genomic library of large yeast artificial chromosome clones, Genomics 18 (1993) 270-276. (gse-journal.org)
Heterochromatin1
- The submetacentric chromosomes and the Z (female) chromosome show rather little constitutive heterochromatin (C bands), while the W chromosomes are at least two thirds heterochromatin. (ariakesuisan.com)
Situ hybridization1
- Assignment of the protein-tyrosine phosphatase beta gene (PTPRB) to cattle chromosome 5q23→q24 by in situ hybridization and somatic cell panel analysis. (fbn-dummerstorf.de)
Diseases1
- Which diseases are caused by an extra chromosome? (safehubcollective.org)
Identification2
- Occasional patients have had a chromosomal rearrangement with a 4q12 breakpoint, such as t(1;4)(q44;q12), which ultimately led to the identification of the fusion gene or t(4;10)(q12;p11) (Cools et al. (atlasgeneticsoncology.org)
- Identification and chromosome assignment of 23 genes expressed in meat and dairy cattle. (fbn-dummerstorf.de)
Lymphocytes1
- Replication studies in the mother and daughter showed a skewed X inactivation pattern in lymphocytes, with the normal X chromosome preferentially inactivated. (bmj.com)
Segment2
- In fact, she showed that in patients with CML, a crucial segment of chromosome 22 broke off and moved to chromosome 9, where it did not belong. (laskerfoundation.org)
- Chromosome 7q deletion is a relatively rare chromosomal syndrome that is classified by the location of the deleted segment, as follows: proximal (7q11→21), intermediate (7q21→32), or terminal (7q32→qter) [ 1 ]. (ogscience.org)
Syndrome3
- The breakpoints for 1p36 deletion syndrome have been variable and are most commonly found from 1p36.13 to 1p36.33. (wikipedia.org)
- For example, an extra copy of chromosome 21 causes Down syndrome (trisomy 21). (safehubcollective.org)
- Does an extra chromosome always mean Down syndrome? (safehubcollective.org)
Gene expression1
- As neither chromosome banding nor FISH analysis identify more than a minor fraction of the fusion-positive cases, and because multiple primer combinations are required to identify all possible fusion transcripts by RT-PCR, alternative diagnostic markers might instead be found among deregulated genes identified at global gene expression analysis. (scilifelab.se)
Rare chromosomal2
- Mosaic trisomy 9 is a rare chromosomal disorder in which the entire 9th chromosome appears three times (trisomy) rather than twice in some cells of the body. (safehubcollective.org)
- Chromosome 9, Partial Monosomy 9p is a rare chromosomal disorder in which there is deletion (monosomy) of a portion of the 9th chromosome. (mentalhealthhelpcenter.com)
Chronic myelogen1
- Nowell collaborated with the late David Hungerford who, he says, "knew more about chromosomes than I did," and together they made the startling observation that individuals suffering from chronic myelogenous leukemia (CML) had an abnormally small chromosome in the tumor cells. (laskerfoundation.org)
Yeast1
- Although hybrids of these two species inherit three chromosomes from each parent, the majority of spores (the yeast equivalent of sperm) that these hybrids produce fail to develop into new yeast cells. (elifesciences.org)
Duplication1
- Are there any symptoms of chromosome 9p duplication? (safehubcollective.org)
Nonrandom1
- At least three distinct meiotic drive alleles, one on each S. kambucha chromosome, independently contribute to hybrid infertility by causing nonrandom spore death. (elifesciences.org)
Infants1
- Most infants with Chromosome 9, Partial Monosomy 9p have a normal birth weight and length. (mentalhealthhelpcenter.com)
Fusion2
- At times a fusion gene is brought on by deletion, which only entails 1 chromosome. (calcimimeticagent.com)
- 2. Research Techniques OF FUSION GENES Historically, the exploration of chimeric genes started with all the observation on chromosomal rearrangement by means of chromosome banding analysis (karyotyping). (calcimimeticagent.com)
Partial2
- Individuals with Chromosome 9, Partial Monosomy 9p may also have various malformations of the hands and feet. (mentalhealthhelpcenter.com)
- In some individuals with the disorder, Chromosome 9, Partial Monosomy 9p may also be characterized by genital defects. (mentalhealthhelpcenter.com)