• kidney
  • SCN is funding a total of 31 goal-directed projects from across Canada that are moving research from lab bench to bedside in areas such as brain injury, kidney disease and breast cancer. (medindia.net)
  • The American Association of Kidney Patients is a voluntary patient organization, which has been dedicated to improving the lives of fellow kidney patients and their families by helping them deal with the physical, emotional and social impact of kidney disease for more than 40 years. (healthfinder.gov)
  • AAKP is a national organization that reaches one million people yearly affected by kidney disease, including patients, family members, renal professionals and friends. (healthfinder.gov)
  • It is the only national kidney patient organization directed by kidney patients for kidney patients. (healthfinder.gov)
  • Ochroconis gallopava was thought to cause epidemic fatal encephalitis only in fowls, turkeys, and poults at first, however recently it has been increasingly recognized as a pathogen for human following solid organ transplantation, such as kidney, liver, heart, and lung. (wikipedia.org)
  • Brain abscess (or cerebral abscess) is an abscess caused by inflammation and collection of infected material, coming from local (ear infection, dental abscess, infection of paranasal sinuses, infection of the mastoid air cells of the temporal bone, epidural abscess) or remote (lung, heart, kidney etc.) infectious sources, within the brain tissue. (wikipedia.org)
  • dopamine
  • it is clear, however, that dopamine production by brain cells in the substantia nigra is diminished in the disease. (thefreedictionary.com)
  • Controlled release of dopamine from a polymeric brain implant In vivo characterization. (docme.ru)
  • During MJ, Freese A, Sabel BA, Saltzrnan WM, Deutch A, Roth RH, Langer R.Controiled release of dopamine from a polymeric brain implant: in vivo characterization. (docme.ru)
  • Studies using continuous intravenous infusion have demonstrated a reduction in these fluctuations, as have manipulations of oral dose and diet, suggesting that steady deiivery of L-dopa or dopamine to the brain is desirable for optimai and perhaps long-term clinical response [13-2 11. (docme.ru)
  • We have developed an alternative potentiai therapeutic modaiity based on the locaiized delivery of dopamine to the corpus striatum from a polymeric brain implant. (docme.ru)
  • Neurotransmitters like dopamine are chemicals which jump the synaptic gaps between brain cells, and are the way the brain communicates with itself. (disabilityattorneychicago.com)
  • In many instances, their function is poorly understood, but dopamine is an important neurotransmitter that has been extensively studied and is clearly very important in many other aspects of brain function besides its role in the basal ganglia. (disabilityattorneychicago.com)
  • Parkinson s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. (medindia.net)
  • acute
  • Like other melanized fungi, the clinical presentation of O. gallopava is phaeohyphomycosis characterized by darkly colored lesions in affected tissues, acute or chronic inflammation, microabscesses, fibrosis, granulomas, and necrosis. (wikipedia.org)
  • Beaumont Hospital's acute stroke service offers acute interventional neuroradiology (e.g. thrombectomy) and neurosurgical (e.g. hemi-craniectomy) services for acute stroke patients referred from other hospitals in the Greater Dublin Area. (wikipedia.org)
  • clinical
  • Molecular imaging and nuclear medicine are useful tools that allow the visualization of different kinds of neuronal functions to evaluate cell transplantation therapy in both experimental and clinical situations, said Kuroda. (innovations-report.com)
  • For the first 1 to 3 days, patients will be admitted to the NIH Clinical Center to undergo a levodopa 'dose-finding' procedure. (clinicaltrials.gov)
  • In adults, many ventricular assist devices (VADs) have been developed to clinical maturity that can function as an effective bridge to transplantation. (ahajournals.org)
  • Beginning with the PROWESS clinical trial of 2001, it was recognised that many of the symptoms of sepsis may be ameliorated by infusion of APC, and mortality rates of septic patients may be significantly decreased. (wikipedia.org)
  • In contrast to the earlier attempts at hand transplantation, the Louisville group had performed extensive basic science research and feasibility studies for many years prior to their first clinical procedure (for example, Shirbacheh et al. (wikipedia.org)
  • symptoms
  • Implementing the collaborative care model for patients with dementia and depression, which often occur together, reduces patients' behavioral and psychological symptoms, diminishes the burden on patients' informal caregivers and enhances the quality of care delivered to the patient. (medindia.net)
  • The onset of symptoms in immunosuppressed individuals after transplantation is very slow, almost several months to years after organ transplantation surgery, but the infection can severely damage the host once it appears. (wikipedia.org)
  • When medications are not enough to control symptoms, surgical techniques such as deep brain stimulation can relieve the associated movement disorders. (wikipedia.org)
  • When this occurs, PD patients change rapidly from stages with good response to medication and few symptoms ("on" state) to phases with no response to medication and important motor symptoms ("off" state). (wikipedia.org)
  • These symptoms are caused by a combination of increased intracranial pressure due to a space-occupying lesion (headache, vomiting, confusion, coma), infection (fever, fatigue etc.) and focal neurologic brain tissue damage (hemiparesis, aphasia etc. (wikipedia.org)
  • Other symptoms and findings depend largely on the specific location of the abscess in the brain. (wikipedia.org)
  • Organisms that are most frequently associated with brain abscess in patients with AIDS are poliovirus, Toxoplasma gondii, and Cryptococcus neoformans, though in infection with the latter organism, symptoms of meningitis generally predominate. (wikipedia.org)
  • The resulting symptoms differ based on the affected area of the brain. (wikipedia.org)
  • After the initial stroke, other symptoms depend on the area of the brain affected. (wikipedia.org)
  • cardiac
  • Though the treatment of children with acquired and congenital heart disease has advanced significantly in recent years, a subset of patients will experience refractory myocardial failure, necessitating cardiac transplantation. (ahajournals.org)
  • In the initial stages, perfusing the tissue with a solution that does not contain calcium is useful particularly when isolating cardiac myocytes, as the absence of calcium causes separation of the intercalated disks. (wikipedia.org)
  • occur
  • When it does occur in humans, a wide range of sites may become involved, including the lung, heart, brain, the superficial cutaneous or subcutaneous areas, and other parts of the body. (wikipedia.org)
  • Another school of thought focuses on hypothermia's ability to prevent the injuries that occur after circulation returns to the brain, or what is termed reperfusion injuries. (wikipedia.org)
  • stroke
  • Overcoming damage to the brain - and getting drugs to the brain - are challenges following a stroke. (washington.edu)
  • There are several conditions that can predispose someone to watershed stroke by increasing the likelihood that insufficient blood supply will be able to reach the brain. (wikipedia.org)
  • Early diagnosis and timely medical intervention can drastically reduce the severity of a stroke, limit damage to the brain, improve the chances of a full recovery and reduce recovery times massively. (wikipedia.org)
  • Reperfusion injury plays a part in the brain's ischemic cascade, which is involved in stroke and brain trauma. (wikipedia.org)
  • trials
  • This program supports phase I/II trials with the potential to be economically viable for health care systems and show a benefit to patients. (medindia.net)
  • This procedure is called therapeutic hypothermia, and it has been shown by a number of large, high-quality randomised trials to significantly improve survival and reduce brain damage after birth asphyxia in newborn infants, almost doubling the chance of normal survival. (wikipedia.org)
  • neurons
  • Neurons are generated in large numbers by NSCs during a specific period of embryonic development through the process of neurogenesis, and continue to be generated in adult life in restricted regions of the adult brain. (wikipedia.org)
  • The human brain is an extremely complex system of heterogeneous tissues and consists of an extremely diverse array of neurons. (wikipedia.org)
  • assessment
  • Patients receiving Healthy Aging Brain Center care are given an initial cognitive assessment including neuro-psychological testing, a brain imaging test, medication review and structured neurological and physical evaluations. (medindia.net)
  • This paper describes the long-term follow up over a 3-10-year postoperative period of the patients, grafted and non-grafted, recruited to this cohort using the 'Core assessment program for intracerebral transplantations-HD' assessment protocol. (bmj.com)
  • Ethical
  • To fulfill this mission, the AATB publishes Standards to ensure that the conduct of tissue banking meets acceptable norms of technical and ethical performance. (healthfinder.gov)
  • human tissue
  • Surplus human tissue can sometimes be obtained at the time of planned surgery, for example specimens of right atrial appendage are often excised and discarded during coronary artery bypass surgery. (wikipedia.org)
  • involve
  • This may be performed by simply submerging the tissue in the solution, or may involve more complex arrangements such as Langendorff perfusion. (wikipedia.org)
  • surplus
  • Sometimes this is done with surplus tissue, tissue that can regenerate, or tissues more desperately needed elsewhere (examples include skin grafts, vein extraction for CABG, etc. (wikipedia.org)
  • bone
  • HSB oversees the nation's organ, bone marrow and cord blood donation and transplantation systems, poison control and vaccine injury compensation programs, and a drug discount program for certain safety-net health care providers. (healthfinder.gov)
  • In cases of trauma, for example in compound skull fractures where fragments of bone are pushed into the substance of the brain, the cause of the abscess is obvious. (wikipedia.org)
  • hospitals
  • An average 60 patients per day are admitted for trauma or elective treatment, making it one of the busiest general Hospitals in the country. (wikipedia.org)
  • Beaumont Hospital is one of two hospitals (the other being Cork University Hospital) which offers neuro-oncology treatment to patients throughout the Republic of Ireland. (wikipedia.org)
  • diseases
  • SNM members have introduced-and continue to explore-biological and technological innovations in medicine that noninvasively investigate the molecular basis of diseases, benefiting countless generations of patients. (innovations-report.com)
  • This complexity has made studying the brain and understanding how it works a difficult task in neuroscience, especially when it comes to neurodegenerative diseases. (wikipedia.org)
  • proliferation
  • In previous studies, cultured neurospheres have been transplanted into the brains of immunodeficient neonatal mice and have shown engraftment, proliferation, and neural differentiation. (wikipedia.org)
  • complications
  • Two phases are usually distinguished: an initial phase in which the individual with PD has already developed some disability for which he or she needs pharmacological treatment, and a second stage in which the patient develops motor complications related to levodopa usage. (wikipedia.org)
  • A former strategy to reduce motor complications was to withdraw patients from L-DOPA for some time. (wikipedia.org)
  • infection
  • One patient had a driveline infection requiring treatment. (ahajournals.org)
  • Infection accompanies brain involvement, respiratory tract involvement, pulmonary infections, and skin infections and many others. (wikipedia.org)
  • When the fungal infection only concerns with systemic involvement except the brain, the probability of cure is higher. (wikipedia.org)
  • A significant age acceleration effect could be detected in brain (7.4 years) and blood (5.2 years) tissue due to HIV-1 infection with the help of a biomarker of aging, which is known as epigenetic clock. (wikipedia.org)
  • treatments
  • Ultimately the goal is to strengthen these mechanisms anddevelop new treatments that can repair the diseased brain. (medindia.net)
  • study
  • Study shows that a new patient and caregiver centered model of innovative, coordinated brain care for older adults improves health outcomes and quality of care for those with cognitive impairment. (medindia.net)
  • A new study from the Regenstrief Institute, Eskenazi Health and Indiana University Center for Aging Research implementation scientists who developed the Healthy Aging Brain Center care model shows that such care also produces impressive cost savings. (medindia.net)
  • Three-quarters of the non-Healthy Aging Brain Center study participants were female. (medindia.net)
  • Patients enrolled in the study will, if possible, stop taking all antiparkinson medications except levodopa (Sinemet) for one month before the study begins and through its duration. (clinicaltrials.gov)
  • For this study, patients will stop taking their usual oral levodopa medicine and instead will have levodopa infused through a vein for up to 12 hours. (clinicaltrials.gov)
  • All participants will receive placebo at some time during the study, and some patients will receive only placebo throughout the entire 4 weeks. (clinicaltrials.gov)
  • At the end of each week, patients will be readmitted to the hospital and receive the previous week's dose of riluzole or placebo in combination with a levodopa infusion at the rate determined in the dose-finding phase of the study. (clinicaltrials.gov)
  • medications
  • The staff then helps both the patient and family caregivers develop a personal treatment plan that typically includes recognizing potentially harmful medications, prescribing new medications, initiating brain and physical exercise regimens, training in problem solving, and working on reducing stress to improve daily life. (medindia.net)
  • and encourages use of medications that are not harmful to older brains. (medindia.net)
  • If patients have periods of immobility alternating with periods of severely impaired mobility, they may need changes in their medication schedule or new, additional medications. (thefreedictionary.com)
  • mammalian
  • The first evidence that neurogenesis occurs in certain regions of the adult mammalian brain came from [3H]-thymidine labeling studies conducted by Altman and Das in 1965 which showed postnatal hippocampal neurogensis in young rats. (wikipedia.org)
  • function
  • Historically, major breakthroughs in how the brain works have resulted from injury or disorder in human brain function, leading to understanding of how regions of the brain work. (wikipedia.org)
  • Once blood flow is reestablished, oxygen species contained in the blood will damage the ischemic tissue because the function of the scavengers is decreased. (wikipedia.org)
  • onset
  • Most patients report gradual onset of fatigue, or malaise, followed by evidence of a tremor in one or more extremities, typically a hand when it is at rest. (thefreedictionary.com)