Loading...



  • stroke
  • Elderly people, especially hypertensive patients, with silent brain infarction have an increased risk of stroke and cognitive decline. (clinicaltrials.gov)
  • It occurs after a variety of brain injury including subarachnoid hemorrhage, stroke, and traumatic brain injury and involves metabolic cascades. (wikipedia.org)
  • 2018
  • Pune, India -- ( SBWIRE ) -- 02/01/2018 -- MarketResearchFuture.com adds "Brain Ischemia Market -2018 Global Analysis, Growth, Trends and Opportunities Research Report Forecasting to 2023" reports to its database. (sbwire.com)
  • pathway
  • Using in vivo and neuronal OGD models, it was recently established that mTORC1 (mammalian Target of Rapamycin Complex-1), a protein complex downstream of PI3K-Akt pathway, is one of the players deregulated after ischemia and OGD. (frontiersin.org)
  • carotid
  • Eklöf B, Siesjö BK: Cerebral blood flow in ischemia caused by carotid artery ligation in the rat. (springer.com)
  • Ischemia within the arteries branching from the internal carotid artery may result in symptoms such as blindness in one eye, weakness in one arm or leg, or weakness in one entire side of the body. (wikipedia.org)
  • Regional brain tissue prostaglandin (PG) levels have been measured during ischaemia produced by bilateral carotid occlusion for 1 hour and following restoration of flow. (ahajournals.org)
  • glutamate
  • Citicoline lowers increased glutamate concentrations and raises decreased ATP concentrations induced by ischemia. (wikipedia.org)
  • During brain ischemia, glutamate is released in excess from the presynaptic terminal, leading to the uncontrollable opening of the glutamate receptors, including the NMDA and AMPA receptors, which allows for an excessive influx of Ca2+ into the intracellular environment. (wikipedia.org)
  • Citicoline
  • Citicoline is a naturally occurring chemical found in the human brain. (empr.com)
  • Once these cross the blood-brain barrier it is reformed into citicoline by the rate-limiting enzyme in phosphatidylcholine synthesis, CTP-phosphocholine cytidylyltransferase. (wikipedia.org)
  • pathways
  • Rather than the conventional cell replacement mechanism, we advance alternative pathways of graft-mediated brain repair involving neurotrophic effects resulting from release of various growth factors that afford cell survival, angiogenesis, and anti-inflammation. (ingentaconnect.com)
  • Optimal blood glucose concentrations in respective group were 10.3 and 6.3 mmol/L, as determined by receiver operator characteristic (ROC) curves.Cerebral ischemia triggers different signaling pathways including mitogen-activated protein kinases (MAPK) which regulate fundamental cell functions. (openthesis.org)
  • strokes
  • Treatments for brain ischemia include alteplase to minimize the effects of ischemic strokes and anticonvulsants for the prevention of seizures, states the Columbia University Medical Center. (reference.com)
  • reactive
  • TLR3 displays a protective role in mouse models of atherosclerosis, and activation of TLR3 signaling is associated with ischemic preconditioning-induced protection against brain ischemia and attenuation of reactive astrogliosis. (wikipedia.org)
  • mice
  • Recombinant human thioredoxin-1 promotes neurogenesis and facilitates cognitive recovery following cerebral ischemia in mice. (curehunter.com)
  • Lapin followed up this research by demonstrating that quinolinic acid could induce convulsions when injected into mice brain ventricles. (wikipedia.org)
  • NMDA
  • Quinolinic acid's neuroactive and excitatory properties are a result of NMDA receptor agonism in the brain. (wikipedia.org)
  • conclude
  • It has also reported that the presence of a Cushing reflex due to an ICP increase could allow one to conclude that ischemia has occurred in the posterior cranial fossa. (wikipedia.org)
  • Disorders
  • Cerebral palsy is a term used for disorders that consist of difficulty controlling movement due to damage to the developing brain, according to WebMD. (reference.com)
  • Studies have demonstrated that quinolinic acid may be involved in many psychiatric disorders, neurodegenerative processes in the brain, as well as other disorders. (wikipedia.org)
  • blood
  • Although the severity of brain damage depends mainly on the degree and duration of the decrease of cerebral blood flow /CBF/, and hence the depletion of macroerg phosphates, mitochondria seem quite resistant to ischemia /Ikrényi et al. (springer.com)
  • Vagotomy almost abolished the decrease in gastric mucosal blood flow during cerebral ischemia. (springer.com)
  • The human brain requires a constant flow of blood to sustain itself. (millerandzois.com)
  • Blood supplies the brain with oxygen and nutrients. (millerandzois.com)
  • When the supply and/or circulation of blood to the brain is interrupted, the brain is deprived of essential oxygen and brain cells began to die. (millerandzois.com)
  • Infant brain ischemia can occur when blood and oxygen flood to the baby are cut off or interrupted during pregnancy or during labor and delivery. (millerandzois.com)
  • Reduced blood flow to the fetus can in turn result in infant brain ischemia. (millerandzois.com)
  • Abnormally fast contractions and a rapid labor can create conditions that temporarily restrict blood flow to the baby's brain. (millerandzois.com)
  • The standard of accepted medical care requires the delivery team to properly monitor for the complications that can interrupt blood flow to the baby's brain during pregnancy or delivery. (millerandzois.com)
  • In this case the blood flow to the baby's brain was apparently interrupted by umbilical cord compression during labor. (millerandzois.com)
  • Focal brain ischemia reduces blood flow to a specific brain region, increasing the risk of cell death to that particular area. (wikipedia.org)
  • Sickle shaped blood cells clot more easily than normal blood cells, impeding blood flow to the brain. (wikipedia.org)
  • Compression of blood vessels may also lead to brain ischemia, by blocking the arteries that carry oxygen to the brain. (wikipedia.org)
  • Ischaemia, which results from reduced blood profusion of tisssues, decreasing nutrient and oxygen supply, induces REST transcription and nuclear accumulation, leading to the epigenetic repression of neuronal genes leading to cell death. (wikipedia.org)
  • Quinolinic acid is unable to pass through the blood-brain barrier (BBB) and must be produced within the brain microglial cells or macrophages that have passed the BBB. (wikipedia.org)
  • diagnosis
  • World Brain ischemia market research report is segmented on the basis of diagnosis which are segmented into MRI, CT, ultrasound, angiography and other. (sbwire.com)
  • disease
  • In addition to these cancers, defects in REST have also been attributed a role in Huntington Disease, neuroblastomas, and the effects of epileptic seizures and ischemia. (wikipedia.org)
  • Research
  • is a direct appreciation by Market Research Future of the market potential of the Brain Ischemia Market. (sbwire.com)
  • Global Brain Ischemia market research report is expected to grow at a CAGR of 6.5% during forecasted period 2017-2023. (sbwire.com)
  • The report of global brain ischemia market research report by Market Research Future comprises of extensive primary research along with detail analysis of qualitative as well as quantitative aspects by various industry experts and key opinion leaders to gain a deeper insight of the market and industry performance. (sbwire.com)
  • Molecular Brain Research. (wikipedia.org)
  • severe
  • Global ischemia is often the result of cardiac arrest, and if left untreated for too long, may result in severe brain damage, explains the Columbia University Medical Center. (reference.com)
  • treatment
  • 4 Thus, brain damage is a major public health problem deserving every effort towards understanding its pathogenesis and treatment. (springer.com)
  • stroke
  • Elderly people, especially hypertensive patients, with silent brain infarction have an increased risk of stroke and cognitive decline. (clinicaltrials.gov)
  • It occurs after a variety of brain injury including subarachnoid hemorrhage, stroke, and traumatic brain injury and involves metabolic cascades. (wikipedia.org)
  • reperfusion injury
  • While reperfusion may be essential to protecting as much brain tissue as possible, it may also lead to reperfusion injury. (wikipedia.org)
  • During a normal embryologic processes, or during cell injury (such as ischemia-reperfusion injury during heart attacks and strokes) or during developments and processes in cancer, an apoptotic cell undergoes structural changes including cell shrinkage, plasma membrane blebbing, nuclear condensation, and fragmentation of the DNA and nucleus. (wikipedia.org)
  • neurogenesis
  • 281. Filipkowski RK, Kaczmarek L. Severely impaired adult brain neurogenesis in cyclin D2 knock-out mice produces very limited phenotypic changes. (gov.pl)
  • Stamenkovic S, Sekeljic V, Radenovic L, Andjus R.P. (2012): Ischemia and neurogenesis - link between pathology and repair? (of.by)
  • His research demonstrated the first indications that neurogenesis occurs in the brain of adult mammals using light and electron microscopy, but was curtailed by this prevailing dogma within the scientific community at the time. (wikipedia.org)
  • In the mid 1970s and the early 1980s, Michael Kaplan and his colleagues reexamined the initial observations using the electron microscope and added substantial confidence that neurogenesis could occur in the adult brain. (wikipedia.org)
  • reduces
  • Radenović L, Vasiljević I, Selaković V, Jovanović M. (2003): 7-Nitroindazole reduces nitrite concentration in rat brain after intrahippocampal kainate-induced seizure. (of.by)
  • adult brain
  • In the 1960s Joseph Altman and coworkers published a series of papers reporting that some dividing cells in the adult brain survived and differentiated into cells with morphology similar to neurons. (wikipedia.org)
  • severe
  • Delayed physiological responses post-TBI can lead to neurodegeneration in various parts of the brain in both chronic and severe cases in children. (wikipedia.org)
  • cortex
  • 1988 H3 receptor found to mediate inhibition of serotonin release in rat brain cortex. (wikipedia.org)
  • Phenylpiracetam binds to α4β2 nicotinic acetylcholine receptors in the mouse brain cortex with IC50 = 5.86 μM. (wikipedia.org)
  • For instance, when focused on the motor cortex of mice, TPU has been shown to induce paw movements without changing the structure or function of that area of the brain. (wikipedia.org)
  • neurons
  • The blood brain barrier and meninges may be damaged in the primary injury, and neurons may die. (wikipedia.org)
  • In addition, the concept that there may be brain stem cells that could proliferate, migrate, and then differentiate into new neurons had not yet been introduced. (wikipedia.org)
  • injury
  • Pediatric acquired brain injury (PABI) is the number one cause of death and disability for children and young adults in the United States. (wikipedia.org)
  • Patients
  • Selakovic V, Raicevic R, Radenovic L. (2009): Temporal patterns of soluble adhesion molecules in cerebrospinal fluid and plasma in patients with the acute brain infraction. (of.by)
  • neural
  • The malleable brain: plasticity of neural circuits and behavior - A review from students to students. (gov.pl)
  • The pediatric brain undergoes dramatic changes and significant pruning of neural networks throughout development. (wikipedia.org)
  • lead
  • In Wistar rats with gravitational cerebral ischemia, Phenylpiracetam reduced the extent of neuralgic deficiency manifestations, retained the locomotor, research, and memory functions, increased the survival rate, and lead to the favoring of local cerebral flow restoration upon the occlusion of carotid arteries to a greater extent than did piracetam. (wikipedia.org)
  • If intracranial pressure gets too high, it can lead to deadly brain herniation, in which parts of the brain are squeezed past structures in the skull. (wikipedia.org)
  • structures
  • The circle of Willis (also called Willis' circle, loop of Willis, cerebral arterial circle, and Willis polygon) is a circulatory anastomosis that supplies blood to the brain and surrounding structures. (wikipedia.org)
  • result
  • Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison their healthy counterparts. (wikipedia.org)
  • Unlike
  • Unlike in most forms of trauma a large percentage of the people killed by brain trauma do not die right away but rather days to weeks after the event. (wikipedia.org)
  • improve
  • Dr. Tyler and his team still continue to improve their knowledge of brain stimulation therapy and hope to provide a strong foundation in the implementation of such methods. (wikipedia.org)
  • proven
  • Scientists have discovered that focusing on targeted brain regions in animals has been proven to alter their behavior, their cells' electrical properties (electrophysiology), and their synaptic plasticity, which is essentially the neuron's ability to function. (wikipedia.org)
  • areas
  • Sound waves would target specific areas of the brain to stimulate activity in regions only a few cubic millimeters in size. (wikipedia.org)
  • different
  • Janac B, Radenovic L, Selakovic V, Prolic Z. (2006): Time course of motoric behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia. (of.by)
  • Janac B, Selakovic V, Radenovic L. (2008) Temporal patterns of motor behavioural improvements by MK-801 in Mongolian gerbils submitted to different duration of global cerebral ischemia. (of.by)
  • activity
  • They discovered that this low-power ultrasound is able to stimulate high neuron activity which allows for the manipulation of the brain waves through an external source. (wikipedia.org)
  • This proves that this method is capable of controlling brain activity at a high cognitive level. (wikipedia.org)
  • shown
  • It has also been shown that more immature brains have an enlarged extracellular space volume and a decreased expression of glial aquaporin 4 leading to an increased incidence of brain swelling after TBI. (wikipedia.org)
  • term
  • The mechanism for this action is thought to be through promoting the induction of long-term potentiation between synapses in the brain. (wikipedia.org)
  • science
  • Although this technology holds great potential to introducing new and beneficial alternatives to conventional brain manipulation, it is a relatively young science and has certain obstructions to its full development such as a lack of complete understanding and control of every safety measure. (wikipedia.org)
  • Rethinking the Brain, How the Songs of Canaries Upset a Fundamental Principle of Science. (wikipedia.org)