• Avpr1a transcripts are diurnally expressed 12 hours out of phase from vasopressin expression in vasopressin and vasoactive intestinal polypeptide neurons of the suprachiasmatic nucleus in both vasopressin-normal Sprague-Dawley rats, as well as vasopressin-deficient Brattleboro rats. (wikipedia.org)
  • The TSRI researchers found large droplets of triglycerides within the neurons of mice modeling the disease. (news-medical.net)
  • We were able to show as well, using both light microscopy and electron microscopy, that droplets of triglyceride-rich fat are present in the neurons of DDHD2-knockout mice, in several brain regions, but are not present in normal mice,' said Inloes. (news-medical.net)
  • We identified BDNF as an important target of Sirt1 and TORC1 transcriptional activity in normal and HD neurons. (harvard.edu)
  • To better understand these imbalances, He and his team will study three lineages of mice in which ASH1L has been deleted in particular neuron types: cortical excitatory neurons, cortical inhibitory neurons, and astrocytes. (msu.edu)
  • Gonadotropin-releasing hormone (GnRH) neurons represent the final common output of signals from the brain that regulates reproductive function. (jneurosci.org)
  • GnRH mRNA levels were reduced in Jak2 G −/− mice when compared with controls, while the number of GnRH neurons was equivalent, indicating a reduction in GnRH gene expression. (jneurosci.org)
  • These results demonstrate an essential role for Jak2 signaling in GnRH neurons for normal reproductive development and fertility in female mice. (jneurosci.org)
  • Previously, it was thought that these cells were mainly used to support neurons, the brain cells that process information. (thenakedscientists.com)
  • Answers to these questions will fill prevailing knowledge gaps regarding how lncRNAs govern normal development of human neurons and lncRNA malfunction in brain disorders. (grantome.com)
  • In the January 18 issue, Small, Beth Stevens at Boston Children's Hospital, and colleagues reported that knocking out a different retromer protein, VPS35, in hippocampal neurons in mice not only jammed neuronal endosome traffic but also caused microglia to assume shapes resembling those seen in AD. (alzforum.org)
  • In cultured primary neurons from mice, fluorescent antibodies to VPS26a (blue) and 26b (red) detected two distinct retromer complexes. (alzforum.org)
  • To see which brain cells carried which VPS26, Simoes cultured primary mouse neurons, astrocytes, microglia, and endothelial cells separately. (alzforum.org)
  • By crossing AD model mice onto a CD45-deficient background, the researchers created a transgenic strain that fails to clear Aβ oligomers, overproduces the microglial proinflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-1β, and loses cortical neurons. (alzforum.org)
  • By immunohistochemistry and stereological analysis, neurons in the entorhinal cortex were injured and dying in eight-month-old CD45-deficient PSAPP mice. (alzforum.org)
  • Here, we present our analysis of p35 conditional KO mice (p35cKO) in hippocampal pyramidal neurons or forebrain GABAergic neurons using electrophysiological and behavioral methods. (biomedcentral.com)
  • CreER-p35cKO mice show reduced dendritic spine density in CA1 pyramidal neurons and impaired LTD induction in the hippocampus with impairment in spatial learning and memory and reduced anxiety-like behavior [ 11 ]. (biomedcentral.com)
  • Since these mice had p35 deletion in all cells, it was impossible to separate and analyze its functions in excitatory and inhibitory neurons. (biomedcentral.com)
  • In the present study, we created mice in which the p35 gene was deleted in hippocampal excitatory neurons (CaMKII-Cre p35cKO) or GABAergic inhibitory neurons (Dlx-Cre p35cKO). (biomedcentral.com)
  • ApoE is the main lipid carrier protein in the brain, and it is released by astrocytes in order to supply neurons with cholesterol. (spandidos-publications.com)
  • In paper №2, I describe how mesDA neurons transplanted in the adult SN of a PD mouse model, extended axons across millimetres into the striatum, functionally reforming the nigrostriatal pathway. (lu.se)
  • Adult ependyma-specific deletion of Ccn1 transiently enhanced NSC proliferation and reduced neuronal differentiation in mice, increasing the numbers of NSCs and NSC units. (stanford.edu)
  • To address this issue, we evaluated behavioral responses, assessed neuronal function and integrity, and conducted a comprehensive analysis of mitochondria-related parameters in selected brain regions of aged (24 months old) male rats supplemented with testosterone propionate (TP). (aging-us.com)
  • Preovulatory LH surge levels were blunted in Jak2 G −/− mice, which was correlated with reduced GnRH neuronal activation as assessed by c-Fos. (jneurosci.org)
  • The lncRNA Gomafu, a transcript initially identified to associate with myocardial infarction thus named MIAT, was recently found to be most abundant in the brain and implicated in normal neuronal development and cognitive conditions. (grantome.com)
  • On the contrary, p39 deficient mice do not exhibit detectable abnormalities in neuronal positioning. (biomedcentral.com)
  • The aim of this thesis was to understand how particular factors such as neuronal content, placement and cell source, affect functional outcome after transplantation into the rodent brain. (lu.se)
  • Scientists at The Scripps Research Institute (TSRI) have discovered that a gene mutation linked to hereditary spastic paraplegia, a disabling neurological disorder, interferes with the normal breakdown of triglyceride fat molecules in the brain. (news-medical.net)
  • To start, the researchers created a mouse model of DDHD2-related HSP, in which a targeted deletion from the DDHD2 gene eliminated the expression of the DDHD2 protein. (news-medical.net)
  • Cravatt's team compared the tissues of the no-DDHD2 mice to the tissues of mice with normal versions of the gene, and also found that the mutant mice had much higher levels of a type of fat molecule, principally in the brain. (news-medical.net)
  • Here we report successful gene editing of H3.3K27M and G34R point mutations in human normal brain and pediatric glioma cells, generating pairs of otherwise isogenic cell lines that allowed us to define epigenetic and transcriptomic changes contributing to gliomagenesis in the native genomic context. (nature.com)
  • ASH1L typically plays a role in gene expression by encoding a protein known as histone methyltransferase and is crucial in regulating gene expression in normal development. (msu.edu)
  • To date, He and his team have made significant discoveries by using innovative models that "knock out" the ASH1L gene in the brains of mice. (msu.edu)
  • Jeff mutant mouse is a mouse model for OM identified a single gene on the screen deaf as part of an ENU mutagenesis program at MRC Harwell. (mugen-noe.org)
  • Jason Gerstner, the author of the study, found that those with the normal version of the gene had a better night's sleep than those with a mutated or altered form of FABP7. (thenakedscientists.com)
  • Mice lacking the FABP7 gene (also known as "knockout mice" because the gene has been "knocked out") also had more disrupted sleep than animals with a working copy of the gene. (thenakedscientists.com)
  • Just like the mice, those with a mutated FABP7 gene slept more fitfully. (thenakedscientists.com)
  • A paired box gene 6 ( PAX6 ) missense mutation, p.T391A, has been described in a patient with bilateral ONA, nystagmus, and normal anterior eye segments. (molvis.org)
  • Pcp2 was first identified as a candidate gene to explain Purkinje cell degeneration in pcd mice (Nordquist, D. T., Kozak, C. A., and Orr, H. T. (1988) J. Neurosci. (embl-heidelberg.de)
  • FUNCTION: [Summary is not available for the mouse gene. (utsouthwestern.edu)
  • In a study of mice, some of which had the gene for the glutamate receptor subunit GLuR6 knocked out (i.e. production of the gene was artificially limited), the researchers found that the L-type dihydropyridine calcium channel blocker nimodipine decreased hyperactivity, amphetamine super-sensitivity, risk-taking behavior, and aggression in those with the gene removed. (bipolarnews.org)
  • Male knockout mice in Avpr1a have reduced anxiety-like behavior and greatly impaired social recognition abilities, without any defects in spatial and nonsocial olfactory learning and memory tasks, as measured by the elevated plus maze, light/dark box, Morris water maze, forced swim, baseline acoustic startle and prepulse inhibition (PPI), and olfactory habituation tests. (wikipedia.org)
  • The present study was designed to analyze whether the ARd changes in these and other brain areas, such as the medial amygdala (MeA) and lateral septum, ventral part (LSV), were associated with changes in sexual behavior following sexual satiety. (karger.com)
  • The results are discussed on the basis of the similarities and discrepancies between ARd in specific brain areas and male sexual behavior. (karger.com)
  • Notably, using a viral vector to reintroduce GIRK3 in the VTA of knockout mice rescued normal alcohol consumption behavior. (the-scientist.com)
  • However, the nuances of how Avp modulates behavior within specific brain regions via its two centrally expressed receptors, the Avp 1a (Avpr1a) and the Avp 1b receptor (Avpr1b), continues to be a robust and exciting area of research. (frontiersin.org)
  • Given the expression of IRAP in areas of the brain associated with oxytocin modulated maternal behavior, we also investigated whether the IRAP global knockout mice had improved maternal responses. (monash.edu)
  • Without ASH1L, mice displayed telltale signs of ASD including behavior and memory deficits. (msu.edu)
  • In both groups, offspring grew up normal , showing that IL-6 is necessary for the maternal poly(I:C) treatment to alter fetal brain development and subsequent behavior in the offspring. (foundmyfitness.com)
  • Moreover, the original study examined tube-test behavior in isolated mice 10 months of age. (bath.ac.uk)
  • Mice Genetically Depleted of Brain Serotonin Do Not Display a Depression-like Behavioral Phenotype. (technologynetworks.com)
  • Although Tmem45b-knockout mice showed normal responses to noxious heat and noxious mechanical stimuli under normal conditions, mechanical pain hypersensitivity was selectively impaired after inflammation and tissue incision, reproducing the pain phenotype of IB4 sensory neuron-ablated mice. (iasp-pain.org)
  • Besides impairing ATP production by compromising the normal function of the respiratory chain machinery, excessive ROS generation and the ensuing oxidative stress cause oxidative damage to proteins, lipids, and DNA, accelerating the aging phenotype [ 5 , 6 ]. (aging-us.com)
  • PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and display normal brain morphology. (utsouthwestern.edu)
  • We assessed the reproductive and maternal profile of global IRAP knock out mice. (monash.edu)
  • Interestingly, three days after inoculation intranasally of Fbxo11 tm2b / + mice with non-typeable Haemophilus influenzae (NTHI) proportion of them have been inflamed mucosa of the middle ear and accumulation of fluid in the ear indicates that Fbxo11 knock-out mice tend to NTHI induced inflammation of the middle ear. (mugen-noe.org)
  • Removing alpha-synuclein in mice (the knock-out mice) also resulted in increased DSBs, following bleomycin treatment. (parkinson.org)
  • Giving healthy human alpha-synuclein to the alpha-synuclein knock-out mice, restored the mice cells' DNA damage response to normal levels. (parkinson.org)
  • To determine its biological function in reproduction, we used Cre (cAMP response element)/LoxP technology to generate GnRH neuron-specific Jak2 conditional knock-out (Jak2 G −/− ) mice. (jneurosci.org)
  • We show that the conditional depletion of the m 6 A reader protein Ythdf2 in mice causes lethality at late embryonic developmental stages, with embryos characterized by compromised neural development. (biomedcentral.com)
  • Several lines of conditional Cdk5 knockout mice (KO) have been generated and have shown different outcomes for learning and memory. (biomedcentral.com)
  • In our previous study, we generated and analyzed CreER-p35 conditional knockout mice (cKO), in which p35 is inducibly deleted in the brain. (biomedcentral.com)
  • Simultaneous knockout of both IRP1 and IRP2 leads to embryonic lethality in mice. (nature.com)
  • The injection of oxytocin (OXT) vs. oxytocin antagonist (OTA) at birth has sexually dimorphic effects in prairie voles later on in life in various areas of the brain. (wikipedia.org)
  • Also, unlike vasopressin 1b receptor and oxytocin knockout mice, Avpr1a KO mice have a normal Bruce effect (appropriate failure of pregnancy in presence of novel male). (wikipedia.org)
  • Western blot analysis of HD brain tissue shows full-length huntingtin protein in the nuclear fraction as well as abundant immunopositive bands at lower molecular weight, suggesting proteolytic products in the nucleus. (jci.org)
  • Knocking it out in mice slowed glutamate receptor recycling and weakened synaptic transmission, but only in the transentorhinal cortex, hinting at why this region is so vulnerable to AD pathology in people. (alzforum.org)
  • Given the metabolic decline in the 12-month-old VPS26b knockouts, did synaptic signaling wane as well? (alzforum.org)
  • By studying and/or generating knockout mice, the lab is exploring a role for these molecules in synaptic plasticity, learning, memory and neurological disorders. (stanford.edu)
  • Intriguingly, LTP was normal in TEC slices from heterozygous knockouts of the alternate VPS26a subunit, whereas homozygous VPS26a knockouts died in utero. (alzforum.org)
  • Blocking this activity in utero, or preventing vision after birth, disrupts normal tuning up of circuits and brain wiring. (stanford.edu)
  • Vasopressin receptor 1A (V1AR), or arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major receptor types for vasopressin (AVPR1B and AVPR2 being the others), and is present throughout the brain, as well as in the periphery in the liver, kidney, and vasculature. (wikipedia.org)
  • Scientists at The Scripps Research Institute are reporting that mice created to lack a certain type of molecule known as an LPA receptor have fertility problems, which suggests that these receptors play a major role in conception. (sciencedaily.com)
  • The pathway that affects implantation involves a particular type of receptor molecule -- a protein called a lysophosphatidic acid (LPA) receptor that can be found on the surfaces of cells in the brains and in the uteruses of mammals, where it binds to LPA, one type of phospholipid. (sciencedaily.com)
  • Indeed, LTP weakened and glutamate receptor GluA1 expression was lower in TEC brain slices, while both were normal in the medial entorhinal cortex. (alzforum.org)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • 1999. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. (cdc.gov)
  • 1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)
  • Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice. (lu.se)
  • The purpose of this study was to demonstrate experimentally that alterations of in vivo transporter function at the blood-brain barrier (BBB) in disease and during pharmacotherapy can be reconstructed from in vitro data based on our established pharmacoproteomic concept of reconstructing in vivo function by integrating intrinsic transport activity per transporter molecule and absolute protein expression level at the BBB. (aspetjournals.org)
  • Alcohol hits a lot of different targets in our brain, which makes disentangling the in vivo effects of alcohol quite complicated," coauthor Candice Contet, a biologist at the Scripps Research Institute in La Jolla, California, said in a statement . (the-scientist.com)
  • In both human cells in a dish (in vitro) and living mouse brains (in vivo) alpha-synuclein was present in the exact same location as the DNA repair proteins, suggesting alpha-synuclein binds directly to DSBs, and helps repair those breaks. (parkinson.org)
  • To identify major effectors, we used CRISPR-Cas9 to introduce H3.3K27M and G34R mutations into previously H3.3-wildtype brain cells, while in parallel reverting the mutations in glioma cells back to wildtype. (nature.com)
  • To find out, first authors Yuyan Zhu and Huayan Hou crossed PSAPP mice (which overexpress human amyloid precursor protein and presenilin-1 with familial AD-linked mutations) with CD45-knockout mice, and analyzed their progeny at four or eight months of age. (alzforum.org)
  • Professor Gronostajski's lab uses mouse Embryonic Stem Cells (mES) to make mice with mutations in the genes for the Nuclear Factor I transcription factors. (ny.gov)
  • Iron regulatory protein 2 (IRP2) is a key factor in regulating brain iron homeostasis. (nature.com)
  • Although the role of abnormal prion protein (PrP) conformation in generating infectious brain diseases (transmissible spongiform encephalopathy) has been recognized, the function of PrP in the normal brain remains mostly unknown. (amrita.edu)
  • Quantitative targeted absolute proteomic analysis of 31 membrane proteins showed that P-glycoprotein (P-gp/mdr1a) protein expression levels were significantly increased in brain capillaries of PTZ (129%), EL (143%), and PHT mice (192%) compared with controls. (aspetjournals.org)
  • WIKIMEDIA, TIIA MONTO Mice lacking a subunit of a G protein-gated inwardly rectifying potassium (GIRK) channel drank more ethanol than their wild-type counterparts when given access to the beverage for only two hours a day during a time when they would be most likely to drink-a test intended to mirror a bar's happy hour. (the-scientist.com)
  • And boosting expression of the protein in wild-type mice resulted in even less binge drinking. (the-scientist.com)
  • In this work, we explore the gaps in the spatial pattern of expression and extracellular matrix, adhesion and gap junction protein between wild-type and Nkx2-5 + / RG mutant mice. (mugen-noe.org)
  • Misfolded protein can grow and fragment, creating seeds that spread throughout the brain to form new clusters. (economystep.com)
  • By feeding these mice food containing an antibiotic (doxycycline), we were able to knock out TDP-43 protein expression and they became normal. (economystep.com)
  • The latter is a neurodegenerative disease, which is characterized by dementia, along with a dense deposition of amyloid-β (Aβ) protein in senile plaques in the brain, hyperphosphorylated tau protein and neuron loss. (spandidos-publications.com)
  • iv) Brain cholesterol affects the Aβ formation from amyloid precursor protein (APP) ( 13 , 14 ). (spandidos-publications.com)
  • We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
  • A mouse model study implicated alterations in bivalent genes in mutant H3.3 downstream function 20 . (nature.com)
  • Gronostajski's lab is culturing mouse neural stem cells (NSC) to assess changes in NSC number in some of our NFI knockout mice and investigating the effect of loss of NFI genes on the differentiation of NSCs into neural and glial cells. (ny.gov)
  • The dihydropyridine-type drugs like nimodipine also decreased stress-related immobilization in the wild type (the animal with normal genes) but not the knockout animals (the ones lacking GLuR6). (bipolarnews.org)
  • Our research includes the use of knockout mice and zebrafish as laboratory models. (ncl.ac.uk)
  • As an optically transparent model organism with an endothelial blood-brain barrier (BBB), zebrafish offer a powerful tool to study the vertebrate BBB. (elifesciences.org)
  • Our findings indicate a conserved developmental program of barrier acquisition between zebrafish and mice. (elifesciences.org)
  • Nicotine is thought to act on brain monoamine systems that normally mediate diverse motivational behaviors. (uthscsa.edu)
  • Infection-induced interleukin-6 secretion in mice increases the risk for schizophrenia- and autism-like behaviors in offspring. (foundmyfitness.com)
  • The team tried injecting the pregnant mice with individual cytokines, rather than with poly(I:C). It turned out that after a single dose of a specific cytokine known as interleukin-6 (or IL-6), a mouse would give birth to offspring who, at maturity, exhibited the familiar schizophrenia- and autism-like behaviors . (foundmyfitness.com)
  • In addition, Gomafu knockout mice display anxiety-like behaviors. (grantome.com)
  • Taken together, these data suggest future research on Grb10 +/p mice should focus on the stability of social behaviors, rather than dominance per se. (bath.ac.uk)
  • Some studies have shown Avpr1a knockout mice to have deficits in their circadian rhythms and olfaction. (wikipedia.org)
  • OTUD3 knockout mice display nigral iron accumulation, motor deficits, and nigrostriatal dopaminergic neurodegeneration, which resembles the pathology of PD. (nature.com)
  • These findings suggest that testosterone supplementation may be a viable approach to ameliorating brain mitochondrial dysfunction and thus prevent or treat cognitive-behavioral deficits and neurodegenerative conditions associated with aging. (aging-us.com)
  • Furthermore, when administered a histone deacetylase inhibitor postnatally, autistic-like deficits were seen to be lessened in young mice, raising exciting possibilities for therapeutics and a future human cure. (msu.edu)
  • More recently, CRISPR-mediated knockout of the mutant H3F3A allele in two H3.3K27M glioma lines restored more normal histone mark deposition and reduced tumorigenesis 9 . (nature.com)
  • Consistently, decreased levels of OTUD3 are detected in transgenic PD mice expressing A53T mutant of human α-synuclein. (nature.com)
  • One study reported elevated levels of an unknown fat molecule in the brains of DDHD2-mutant HSP patients. (news-medical.net)
  • In contrast, Maoa-KO mice were normal in their behavioral response to a novel, inescapable open field and in their preference for a novel place. (uthscsa.edu)
  • In contrast, 12-month-old knockouts had less metabolic activity than controls in the same region. (alzforum.org)
  • In contrast, Dlx-p35cKO mice showed no abnormalities in behavioral tasks and electrophysiological analysis in their hippocampal slices. (biomedcentral.com)
  • GIRK3 knockout mice did not drink to the point of intoxication when given continuous access to alcohol, however, suggesting this subunit specifically affects the tendency to binge drink, according to a study published this week (May 11) in PNAS . (the-scientist.com)
  • These data suggest that alterations in a subunit of the dihydropyridine-responsive L-type calcium channel are a risk factor for bipolar illness, a brain abnormality in those who have the illness, and relevant to behavioral/pharmacological models. (bipolarnews.org)
  • We examined the impact of constitutive monoamine oxidase A (MAOA) deficiency in mice on nicotine reward and responses to novel stimuli. (uthscsa.edu)
  • The observed phenotypes suggest that a constitutive deficiency of MAOA reduces the rewarding effects of nicotine without altering behavioral responses to novel stimuli in mice. (uthscsa.edu)
  • They assessed fibrillar Aβ burden by staining mouse brain sections with thioflavin S, and Aβ oligomers with Charles Glabe's OC antibody. (alzforum.org)
  • Inhibition of EGFR signaling prevented expansion of the NSC population observed in CCN1 deficient mice. (stanford.edu)
  • Herein, we show that chemical ablation of isolectin B4-binding (IB4) afferents by IB4-saporin injection into sciatic nerves completely and selectively inhibited inflammation- and tissue injury-induced mechanical pain hypersensitivity while thermal and mechanical pain hypersensitivities were normal following nerve injury. (iasp-pain.org)
  • vi) APP transgenic mice with apolipoprotein E (ApoE) deficiency had increased atherosclerosis and vascular inflammation ( 16 ). (spandidos-publications.com)
  • Subchronic phencyclidine (PCP) treatment (which induces symptoms similar to those of schizophrenia) reduces Avpr1a density in many brain regions, implying there might be a role for AVPR1A in schizophrenia. (wikipedia.org)
  • Importantly, Gomafu dysregulation is detected in cortical grey matters and interneurons of post-mortem brains derived from schizophrenia patients. (grantome.com)
  • Successful completion of the proposed studies will greatly advance our current knowledge regarding how noncoding RNA-mediated epigenetic regulation governs normal human neuron development and their contribution to the complex etiology of various cognitive and neurological diseases, which is a critical prerequisite for developing novel diagnosis biomarkers and/or therapeutic strategies against brain illnesses. (grantome.com)
  • I also describe the development of a novel behavioural task that is predictive of mesDA neuron cell loss in mice. (lu.se)
  • iii) In a transgenic mouse model of AD (B6Tg2576), early atherosclerosis lesions were detected and were positively correlated with cerebral β amyloid deposits when mice were fed a normal diet ( 11 ) or atherogenic diets ( 12 ). (spandidos-publications.com)
  • In this study, we investigated the effects of N-butyldeoxygalacto-nojirimycin (N B-DGJ), an imino sugar that inhibits ganglioside biosynthesis, in normal C57BL/6J mice and in beta-gal knockout (beta-gal-/-) mice from postnatal day 9 (p-9) to p-15. (wikigenes.org)
  • This led us to investigate whether FXI deficiency in elderly ApoE knockout (KO) mice would decrease pathological alterations compatible with atherosclerosis and AD. (spandidos-publications.com)
  • However, neither atherosclerosis nor AD‑associated pathological alterations in the elderly mice brains were observed in either the DKO mice or the ApoE KO mice. (spandidos-publications.com)
  • Furthermore, NMDAR-dependent long-term depression (LTD) induction by low-frequency stimuli in hippocampal slices from CamkII-p35cKO mice was impaired compared to that in control mice. (biomedcentral.com)
  • In the journal ACS Chemical Neuroscience , scientists report that mice lacking the ability to make serotonin in their brains (and thus should have been "depressed" by conventional wisdom) did not show depression-like symptoms. (technologynetworks.com)
  • In the latest issue of the journal Nature, the scientists detail how mice that lack LPA receptors, which normally appear on the surface of cells in a mouse's womb, have fertility problems. (sciencedaily.com)
  • To probe VPS26b's role in brain function, the scientists turned to VPS26b knockout mice. (alzforum.org)
  • At the third postnatal week, when PrP expression would normally attain mature levels, PrP0/0 mice showed low performance in the accelerating rotarod and runway tests and the functioning of 40% of granule cells was abnormal. (amrita.edu)
  • These mice showed symptoms similar to those of HSP patients, including abnormal gait and lower performance on tests of movement and cognition,' said Inloes. (news-medical.net)
  • Female Jak2 G −/− mice exhibited significantly delayed puberty and first estrus, abnormal estrous cyclicity, and impaired fertility. (jneurosci.org)
  • In diseased human cells and mice carrying the abnormal form of alpha-synuclein, the laser-induced DSBs, impaired alpha-synuclein from moving to the site of DNA damage. (parkinson.org)
  • We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)
  • Glioma lines that were edited to correct the pathogenic H3F3A mutation exhibited less invasiveness and growth in xenografted mice than their mutated counterparts. (nature.com)
  • To see whether these defects stemmed from faulty microglia, the authors stained brain sections with anti-Aβ antibodies and looked to see whether the amyloid clumps also lit up with microglial activation markers (Iba1, CD11b, or CD40), as this would indicate that the phagocytes were reaching their desired target. (alzforum.org)
  • Although evidence suggests that the two phenomena are interrelated, it is unclear whether testosterone supplementation ameliorates mitochondrial dysfunction in the aging male brain. (aging-us.com)
  • No differences in the reproductive profile were observed, with normal gestational period, litter size and parturition recorded. (monash.edu)
  • We examined both male and female mice to account for sex differences and tested cohorts aged 2, 6 and 10 months to examine any developments related to age. (bath.ac.uk)
  • No significant differences in the prepatent period and the appearance of asexual-stage parasites in mice intravenously infected with defined numbers of PbWT and PbAAT1KO sporozoites. (pberghei.eu)
  • Mitochondrial dysfunction is a common feature of normal aging and is closely associated with the development of age-related neurodegenerative disease [ 1 - 3 ]. (aging-us.com)
  • Thus, ensuring normal mitochondrial function is critical for delaying aging and reducing the risk of age-related neurodegenerative disease [ 4 , 7 , 8 ]. (aging-us.com)
  • Indeed, lncRNA dysregulation is observed in autism, intellectual disability, epilepsy, neurodegenerative disorders and neuropsychiatric diseases, suggesting that lncRNA dysregulation contributes to the pathogenesis of various brain illnesses. (grantome.com)
  • The accumulation of waste proteins begins early in the neurodegenerative disease process - well before the onset of symptoms and brain loss. (economystep.com)
  • In paper №1, I detail the neurodegenerative and behavioural outcomes in a mouse lesion model of PD, which can be used as a platform for the development of novel therapeutic strategies. (lu.se)
  • One of the most consistent findings in biological psychiatry is that levels of intracellular calcium in blood elements (platelets and white cells) are higher than normal in patients with mood disorders, particularly bipolar disorder . (bipolarnews.org)
  • Overall, our findings highlight the importance of TEs as regulatory agents and their dynamic activity during development, adult life, and disease in the human brain. (lu.se)
  • We conduct studies of early human brain development. (ncl.ac.uk)
  • A quantitative understanding of how the molecular transport systems at the human BBB are altered in diseases is essential not only to elucidate the pathophysiological roles of the BBB in human brain, but also to aid development of effective drugs and appropriate pharmacotherapies for CNS diseases. (aspetjournals.org)
  • These studies suggest a key role of Sirt1 in transcriptional networks in normal and HD brain and offer an opportunity for therapeutic development. (harvard.edu)
  • Electron microscopy studies further reveal high levels of transcytosis in brain endothelium early in development that are suppressed later. (elifesciences.org)
  • Barrier properties of brain endothelial cells are induced by extrinsic signals from other cells in the surrounding microenvironment during development ( Stewart and Wiley, 1981 ). (elifesciences.org)
  • Mutation of ZEB1 is associated with human diseases and defective brain development. (stanford.edu)
  • and report here a role for the Jak2 signaling molecule in the regulation of reproductive development and function in female mice. (jneurosci.org)
  • The transcription factor Nfix is essential for normal brain development. (ny.gov)
  • Taken together, our results suggest that post-transcriptional mechanisms play an important role in the brain both during development and in the adult brain. (lu.se)
  • Though there might be some disagreement over what it means for a mouse to be schizophrenic, these abnormalities are generally marked by inappropriateness of response and difficulty in coping. (foundmyfitness.com)
  • Younger CD45-deficient transgenic mice and PSAPP mice with normal CD45 did not show these abnormalities. (alzforum.org)
  • We found group-housed Grb10 +/p mice do not show evidence of enhanced social dominance, but cages containing Grb10 +/p and wild-type mice lacked the normal correlation between three different measures of social rank. (bath.ac.uk)
  • In previous mice studies, a loss of ASH1L was seen to spur neural hyperactivity, and an excitation/inhibition imbalance in the brain. (msu.edu)
  • Even before birth and long before vision, the eye spontaneously generates and sends coordinated patterns of neural activity to the brain. (stanford.edu)
  • Behavioral tests were conducted with adult male mice of 8-25 weeks of age, using either p35f/f mice and CamkII-Cre p35cKO or Dlx-Cre p35cKO littermates, according to previously described methods. (biomedcentral.com)
  • WB: Mouse liver tissue lysate. (abcam.com)
  • Spurred into action, these phagocytes can chew up Aβ plaques in the brain, but they also dish out a proinflammatory concoction that destroys local tissue. (alzforum.org)
  • They are progressive and relentless, resulting in a gradual loss of brain tissue. (economystep.com)
  • Interestingly, the mice were compulsive and extremely aggressive, but didn't show signs of depression-like symptoms. (technologynetworks.com)
  • We show that under normal conditions Sirt1 deacetylates and activates TORC1 by promoting its dephoshorylation and interaction with CREB. (harvard.edu)
  • However, feeding mosquitoes with PbAAT1KO-infected mice on day 12 post-infection (p.i.) did not show a significant decrease in the formation of ookinetes. (pberghei.eu)
  • Over time, the mice show the classic signs of ALS, including progressive muscle dysfunction and brain atrophy. (economystep.com)
  • CD45-deficient PSAPP mice had more Aβ oligomers at four months, and greater fibrillar Aβ load at eight months, compared to PSAPP littermates. (alzforum.org)
  • Blood vessels in the vertebrate brain are composed of a single layer of endothelial cells that possess distinct functional properties that allow the passage of necessary nutrients yet prevent unwanted entry of specific toxins and pathogens into the brain. (elifesciences.org)
  • The latest funding from the NIH will support an examination of the particular brain and molecular mechanisms at play in relation to ASH1L and ASD. (msu.edu)
  • Now Chun and his colleagues have discovered a new molecular pathway that influences fertility, at least in mice -- and one that directly affects the ability of mouse embryos to implant in their mother's womb. (sciencedaily.com)
  • These mice are able to produce eggs normally, so that the eggs can be fertilized, but the resulting embryos, which are otherwise healthy, have problems implanting in the womb -- the last step in conception. (sciencedaily.com)
  • Western analysis also showed elevated levels of dimeric and oligomeric Aβ in brain extracts, both extracellular and intracellular, from CD45-/- PSAPP mice. (alzforum.org)
  • The mechanism by which ApoE KO protects against brain pathology should be further studied as it may prove helpful for future treatment of senile dementia. (spandidos-publications.com)
  • the other consisted of so-called IL-6 knockout mice (mice whose genetic makeup prevents them from synthesizing IL-6). (foundmyfitness.com)
  • More so, TEs are a rich source of genetic variation, which makes them an intriguing research avenue to investigate humanspecific traits, including their impact on human brain evolution and their relevance in disease. (lu.se)
  • The WSU team first looked into the sleep cycle of mice and added either the mutated or normal form of FABP7 to star-shaped cells found in the brain called astrocytes. (thenakedscientists.com)
  • These effects were consistent with improved mitochondrial function, reflected by testosterone-induced increases in mitochondrial membrane potential (MMP), antioxidant enzyme (GSH-PX, catalase, and Mn-SOD) expression/activity, and mitochondrial respiratory complex activities in both brain regions. (aging-us.com)
  • Although testosterone supplementation in male patients was shown to improve cognitive function in AD [ 12 , 13 ], and to relieve motor and nonmotor symptoms in PD [ 14 , 15 ], it remains unclear whether testosterone beneficially influences mitochondrial function in the aging brain. (aging-us.com)
  • Finding this across humans, mice and flies is important as it helps us determine the function of sleep," says Gerstner. (thenakedscientists.com)
  • This latest discovery opens new studies into our brain's function, and the effect disrupted sleep can have on learning ability, long-term memory and brain ageing. (thenakedscientists.com)
  • These discoveries together suggest that Gomafu plays essential roles in governing normal brain function. (grantome.com)
  • Mouse VPS26b knockouts had more Aβ, less entorhinal cortex neurotransmission, and worse memory function. (alzforum.org)
  • But it switches on during sleep to disperse compounds essential for brain function and to get rid of toxic waste. (economystep.com)
  • Using magnetic resonance imaging (MRI) to see brain structure, we examined glymphatic function in these mice just three weeks after turning on TDP-43 expression. (economystep.com)
  • Research has relevance not only for understanding brain wiring and developmental disorders such as Autism and Schizphrenia, but also for understanding how the nervous and immune systems interact. (stanford.edu)
  • Tmem45b expression was barely detected in the spinal cord and brain. (iasp-pain.org)
  • But when the mice are switched to normal food, TDP-43 expression is turned on and misfolded proteins begin to accumulate. (economystep.com)
  • Thus, ependyma-derived CCN1 restricts NSC expansion in the adult brain to maintain the proper niche capacity of the V-SVZ. (stanford.edu)
  • In conclusion, the physiological significance of circulating IRAP during human pregnancy cannot be addressed by investigations on mice. (monash.edu)
  • The researchers conducted a series of sophisticated tests in both living mouse brains and human cells to see if this chain of events was taking place. (parkinson.org)
  • They tested this in two groups of live mice and live human cells: 1. (parkinson.org)
  • Lastly, they tried adding healthy human alpha-synuclein back into the mice without alpha-synuclein to see if it might restore the normal DNA damage response. (parkinson.org)
  • In both healthy human cells and living mouse brains, the laser-induced DSBs, triggered alpha-synuclein to move to the site of DNA damage. (parkinson.org)
  • The lncRNA transcriptome is strikingly expanded in human during evolution and most abundantly expressed in the brain. (grantome.com)
  • The complexity of human lncRNAs is thought to underlie the major architect of cognitive evolution but also introduce vulnerabilities for various brain diseases. (grantome.com)
  • Using a multi-omics approach, we demonstrate that TEs introduce a layer of transcriptome complexity to the human brain. (lu.se)
  • These clumping proteins are called Lewy Bodies that can be found in an area of the brain stem where dopamine cells die. (parkinson.org)
  • To search for novel proteins that interact with Galphao, a mouse brain library was screened using the yeast two-hybrid interaction system. (embl-heidelberg.de)
  • We also see waste proteins accumulating in the brain. (economystep.com)
  • The glymphatic system removes waste products, including toxic proteins, from the brain. (economystep.com)
  • New evidence puts into doubt the long-standing belief that a deficiency in serotonin - a chemical messenger in the brain - plays a central role in depression. (technologynetworks.com)
  • We previously demonstrated that factor XI (FXI) deficiency in mice reduced the atherosclerotic plaque area in coronary sinuses and the aortic arch. (spandidos-publications.com)
  • In mice, the association between ApoE deficiency and AD is not clear ( 17 - 26 ). (spandidos-publications.com)
  • Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). (foundmyfitness.com)