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  • high
  • The latter found in high amounts in added sugars such as sucrose and high fructose corn syrup (HFCS). (mdpi.com)
  • Fish oil supplementation maintains proper insulin signaling in the brain, ameliorates NAFLD and decreases the risk to metabolic syndrome suggesting that adequate levels of omega-3 fatty acids in the diet can cope with the metabolic challenges imposed by high fructose intake in Western diets which is of major public health importance. (mdpi.com)
  • So how can we stay away from foods high in fructose? (dietsinreview.com)
  • When choosing minimally processed foods, such as bread, crackers and cereal, read the ingredient list on the food label and avoid products that list high fructose corn syrup as one of the first three ingredients . (dietsinreview.com)
  • It's obvious that different forms of sugar are not similar to each other, debunking the phrase "sugar is sugar" that big companies use to support the inclusion of high fructose corn syrup in their products from soda to cough syrup. (dietsinreview.com)
  • Schober concluded this won't be the last study we'll see that shows high fructose corn syrup is highly dangerous for our bodies. (dietsinreview.com)
  • In animal models, the effects of a high fructose diet on fat distribution are inconclusive in that some studies find increases in body mass and lipids while others find no effect. (gsu.edu)
  • The following experiments tested the hypotheses that a high fructose diet alters fat distribution rather than total body mass and impairs hippocampal-dependent memory. (gsu.edu)
  • Results indicated that the high fructose diet did not affect fat distribution, but did increase plasma triacylglycerides. (gsu.edu)
  • These results indicate that a high fructose diet impairs brain function. (gsu.edu)
  • mechanisms
  • There are two classes of fructose-bisphosphate aldolases with different catalytic mechanisms: class I enzymes [ PMID: 3355497 ] do not require a metal ion, and are characterised by the formation of a Schiff base intermediate between a highly conserved active site lysine and a substrate carbonyl group, while the class II enzymes require an active-site divalent metal ion. (ebi.ac.uk)
  • Purnell
  • It implies that fructose, at least with regards to promoting food intake and weight gain, is a bad actor compared to glucose," said Purnell. (saukvalley.com)
  • Cook more at home and limit processed foods containing fructose and high-fructose corn syrup, Purnell suggested. (saukvalley.com)
  • We know from animal models that the brain responds uniquely to different nutrients and that these responses can determine how much they eat," said Jonathan Purnell, M.D., an associate professor of medicine (endocrinology, diabetes and clinical nutrition) in the OHSU School of Medicine. (healthcanal.com)
  • testis
  • Though the PFKM subunit majorly incorporates into muscle and erythrocyte PFKs, PFKM also is expressed in the heart, brain, and testis. (wikipedia.org)
  • enzyme
  • PFKFB3 is a gene that encodes the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 enzyme in humans. (wikipedia.org)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene. (wikipedia.org)
  • Glycation (sometimes called non-enzymatic glycosylation) is the result of the covalent bonding of a sugar molecule, such as glucose or fructose, to a protein or lipid molecule, without the controlling action of an enzyme. (wikipedia.org)
  • In particular increased fructose-1,6-bisphophate accumulation can have inhibitory effects on glucose-6-phosphate dehydrogenase, an essential enzyme of this pathway. (wikipedia.org)
  • intake
  • The brain itself consumes about 18% of the basal metabolic rate: on a total intake of 1800 kcal/day, this equates to 324 kcal, or about 80 g of glucose. (wikipedia.org)
  • regions of the brain that regulate
  • An analysis of the MRIs in fact showed that the two types of sugar differed greatly in terms of network activation within the hippocampus and amygdala areas of the limbic system, i.e. the regions of the brain that regulate emotions and impulses. (healthcanal.com)
  • ALDOC
  • ALDOC is found to be upregulated in the brains of schizophrenia (SCZ) patients. (wikipedia.org)
  • Furthermore, ALDOC is reported to undergo oxidation in brains affected by mild cognitive impairment (MCI) and Alzheimer's disease (AD). (wikipedia.org)
  • Mole Rats
  • Now this is where it becomes interesting, mole rats show much higher levels of fructose than mice during anoxia in many organs and in blood. (wordpress.com)
  • What is interesting is the difference in how mole rats brain and heart differ from mice in terms of fructose activity. (wordpress.com)
  • When administered fructose over glucose, mole rats organs know to switch between the two sugars to gets its energy. (wordpress.com)
  • This entry was posted in Neurosciences , Sciences , Uncategorized and tagged Fructose , Mole Rats , Neurosciences , Sciences by BBBScientist . (wordpress.com)
  • To continue creating the energy needed for cells to survive in vital organs such as the brain and heart -- and keeping them functioning -- the mole-rats were using a different form of fuel, one where l ack of incoming oxygen is irrelevant. (cnn.com)
  • sweeteners
  • Nonetheless, the USDA's Economic Research Service identifies the United States as the world's largest consumer of sweeteners, including high-fructose corn syrup. (eurekalert.org)
  • For consumers, our findings support current recommendations that people be conscious of sweeteners added to their drinks and meals and not overindulge on high-fructose, processed foods. (healthcanal.com)
  • tissue
  • During short periods of energy abstinence, the human body burns primarily free fatty acids from body fat stores, along with small amounts of muscle tissue to provide required glucose for the brain. (wikipedia.org)
  • At first, the brain continues to use glucose, because, if a non-brain tissue is using fatty acids as its metabolic fuel, the use of glucose in the same tissue is switched off. (wikipedia.org)
  • metabolic
  • Analyzing the data, the scientists realized the animals were switching from a glucose-based metabolic system, which requires oxygen to release energy, to one based on fructose, which doesn't need oxygen. (cnn.com)
  • He also wonders whether extreme divers, who survive for relatively long periods of time without taking in any oxygen, may have unwittingly taught their bodies how to switch from using glucose to fructose in the metabolic process. (cnn.com)
  • Ketone bodies are short-chain derivatives of fatty acids, which, since they can cross the blood-brain barrier, can be used by the brain as an alternative metabolic fuel. (wikipedia.org)
  • substrate
  • Slight differences in isozyme structure result in different activities for the two substrate molecules: FBP and fructose 1-phosphate. (wikipedia.org)
  • rats
  • A week later, the rats were anesthetized and underwent a brief pulse of fluid to the head to reproduce aspects of human traumatic brain injury. (eurekalert.org)
  • corn
  • The main source of fructose in processed foods in the US is high fructose corn syrup, which is also used to improve the appearance of baked goods because it produces a more consistent browning. (medicalnewstoday.com)
  • A more recent study by the University of Oxford and the University of Southern California suggests countries that use large amounts of high fructose corn syrup in their food may be helping to fuel the global epidemic of type 2 diabetes . (medicalnewstoday.com)
  • High-fructose corn syrup is 55 percent fructose and 45 percent glucose. (saukvalley.com)
  • FILE - In this Sept. 15, 2011, file photo, high fructose corn syrup is listed as an ingredient on a can of soda in Philadelphia. (pottsmerc.com)
  • Americans consume most of their fructose from processed foods sweetened with high-fructose corn syrup," said Fernando Gomez-Pinilla, a professor of neurosurgery and integrative biology and physiology at UCLA's David Geffen School of Medicine. (eurekalert.org)
  • The fructose was crystallized from corn in a dose simulating a human diet high in foods and drinks sweetened with high-fructose corn syrup. (eurekalert.org)
  • The average American consumed roughly 27 pounds of high-fructose corn syrup in 2014 -- or just shy of eight teaspoons per day, according to the U.S. Department of Agriculture. (eurekalert.org)
  • It is also present in the form of refined sugars including granulated sugars (white crystalline table sugar, brown sugar, confectioner's sugar, and turbinado sugar), refined crystalline fructose and as high fructose corn syrups. (wikipedia.org)
  • sugars
  • However, activity in the cortical brain control areas showed the opposite response during infusions of the sugars. (healthcanal.com)
  • Endogenous glycations occur mainly in the bloodstream to a small proportion of the absorbed simple sugars: glucose, fructose, and galactose. (wikipedia.org)
  • drinks
  • For the study, scientists used magnetic resonance imaging, or MRI, scans to track blood flow in the brain in 20 young, normal-weight people before and after they had drinks containing glucose or fructose in two sessions several weeks apart. (saukvalley.com)
  • Various diseases have been attributed to industrial fructose in sugary drinks and ready meals. (healthcanal.com)
  • Research is increasingly finding indications that isolated, industrially manufactured fructose - which is increasingly used in sugary drinks, sweets and ready meals - is problematic for the human body. (healthcanal.com)
  • genes
  • By revealing the function of "head genes" in Nematostella, we now understand better how and from where the head and brain of higher animals evolved", Sinigaglia and Rentzsch explain. (scitechdaily.com)
  • Yale University
  • Scans showed that drinking glucose "turns off or suppresses the activity of areas of the brain that are critical for reward and desire for food," said one study leader, Yale University endocrinologist Dr. Robert Sherwin. (saukvalley.com)
  • molecules
  • Because of the blood-brain barrier, getting nutrients to the human brain is especially dependent on molecules that can pass this barrier. (wikipedia.org)
  • schizophrenia
  • The findings in this paper lend more credence to the idea that a subset of schizophrenia may be caused by an immune attack on the brain. (blogspot.com)
  • hypothalamic
  • The patient was a 10-year-old girl who for three years had been treated medically for precocious (premature) puberty due to the presence of a hypothalamic hamartoma (HH), a noncancerous lesion in the brain. (medicalxpress.com)
  • A hypothalamic hamartoma (HH) is a rare, congenital, disorganized collection of normal brain cells (glia and neurons) located in or around the hypothalamus. (medicalxpress.com)
  • satiety
  • Unlike glucose, fructose is less effective at creating feelings of satiety and stimulating the reward system in the brain. (healthcanal.com)
  • The study may provide the first key findings about the lack of satiety and rewarding effects triggered by fructose," state lead authors Dr Bettina Wölnerhanssen and Dr Anne Christin Meyer-Gerspach. (healthcanal.com)
  • Dopamine acts primarily through the reward centers of the brain, whereas serononin primarily acts through effects on neuropeptide Y (NPY)/agouti-related peptide (AgRP) [stimulate appetite] and proopiomelanocortin (POMC) [induce satiety] neurons located in the arcuate nucleus. (wikipedia.org)
  • appetite
  • The arcuate nucleus of the hypothalamus, a part of the brain, is the main regulatory organ for the human appetite. (wikipedia.org)
  • Many brain neurotransmitters affect appetite, especially dopamine and serotonin. (wikipedia.org)