The results suggest that histamine inhibits serotonin release in the rat brain cortex via histamine H3 receptors, which may be located presynaptically. (springer.com)
Arrang J-M, Garbarg M, Schwartz J-C (1985) Autoregulation of histamine release in brain by presynaptic H 3 -receptors. (springer.com)
Schwartz J-C, Arrang J-M, Garbarg M (1986) Three classes of histamine receptors in brain. (springer.com)
Using positron emission tomography and the selective 5-HT1A receptor radioligand [11C]WAY100635, we previously demonstrated a preferential occupancy of 5-HT1A autoreceptors, compared to postsynaptic receptors by pindolol in healthy volunteers. (ox.ac.uk)
The discovery of extrasynaptic receptors by Miledi (1960) , was followed by observations by Dun and Minota (1982) of peripheral neuronal responses that could be attributed to somatic exocytosis of signaling molecules upon electrical stimulation. (frontiersin.org)
The effect of age on the response to stimulation of postsynaptic dopamine receptors is more difficult to predict. (baillement.com)
Our observations suggest that there is an age-related decline in the functional response to stimulation of dopamineautoreceptors and postsynaptic D2 receptors, although postsynaptic responses to mixed D1/D2 stimulation are increased. (baillement.com)
Electrical stimulation1
van der Werf JF, Bast A, Bijloo GJ, Van der Vliet A, Timmerman H (1987) HA autoreceptor assay with superfused slices of rat brain cortex and electrical stimulation. (springer.com)
Postsynaptic1
On the other hand, the results of receptor binding studies would predict decreased responsiveness to postsynaptic dopamine receptor stimulation in aged rats. (baillement.com)
Responses3
Events lasting for seconds or less may change the responses of our brain circuits for hours or longer. (frontiersin.org)
In view of the known loss of nigrostriatal dopamineneurons and decreases in striatal dopamine that occur with ageing, we predicted a decrement in apomorphine-induced yawning and penile grooming , responses that are thought to result from stimulation of autoreceptors located on dopamine nerve terminals. (baillement.com)
This particular experimental paradigm was chosen in order to complement other work from our laboratory on the responses to continuous, selective D2 stimulation. (baillement.com)
Release4
Arrang J-M, Garbarg M, Schwartz J-C (1983) Auto-inhibition of brain histamine release mediated by a novel class (H 3 ) of histamine receptor. (springer.com)
Schlicker E, Classen K, G6thert M (1984) GABAB receptor-mediated inhibition of serotonin release in the rat brain. (springer.com)
Schlicker, E., Betz, R. & Göthert, M. Histamine H 3 receptor-mediated inhibition of serotonin release in the rat brain cortex. (springer.com)
On the other hand, the results may also reflect the fact that terminal 5 HTid autoreceptors have little influence on 5 HT release in vivo, at the very least in the guinea pig. (hsp70inhibitor.com)
Effect2
Rat brain cortex slices preincubated with 3 H-serotonin were superfused with physiological salt solution (containing citalopram, an inhibitor of serotonin uptake) and the effect of histamine on the electrically (3 Hz) evoked 3 H overflow was studied. (springer.com)
Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression? (ox.ac.uk)