Brain nuclear proteins. Medical search. Frequent questions

Brain tumor: immunohistochemical studies on the stress-response proteins, p53 protein and proliferating cell nuclear antigen. (elsevierpure.com)
This retrospective immunohistochemical study compares the expression of five stress-response (heat-shock) proteins (srp's) [srp 90, srp 72, srp 27, alpha B-crystallin and ubiquitin], p53 protein and proliferating cell nuclear antigen (PCNA) in 118 primary brain tumors and 21 carcinoma metastases to the central nervous system. (elsevierpure.com)
Dive into the research topics of 'Brain tumor: immunohistochemical studies on the stress-response proteins, p53 protein and proliferating cell nuclear antigen. (elsevierpure.com)

The scientists discovered that certain proteins, called extremely long-lived proteins (ELLPs), which are found on the surface of the nucleus of neurons, have a remarkably long lifespan. (sciencedaily.com)
Most cells, but not neurons, combat functional deterioration of their protein components through the process of protein turnover, in which the potentially impaired parts of the proteins are replaced with new functional copies," says Hetzer. (sciencedaily.com)
Nuclear transport protein RanGAP1 (red) clumps up with mutant Huntingtin protein (green) in neurons. (hopkinsmedicine.org)
Because of such clues from others' research, Grima took on the task of investigating whether problems with nuclear transport and the nuclear pores also happened in neurons with Huntington's disease. (hopkinsmedicine.org)
By using antibodies with glowing markers that bind to specific proteins and viewing the neurons under the microscope, Grima saw that the mutant Huntingtin protein clumped up in the same location of the cell as abnormal clumps of RanGAP1, the nuclear transport protein. (hopkinsmedicine.org)
Chromosome 21 aneuploid cells constitute ∼4% of the estimated one trillion cells in the human brain and include non-neuronal cells and postmitotic neurons identified by the neuronspecific nuclear protein marker. (jneurosci.org)
Together, these data demonstrate that human brain cells (both neurons and non-neuronal cells) can be aneuploid and that the resulting genetic mosaicism is a normal feature of the human CNS. (jneurosci.org)
Toward determining the presence of constitutional aneuploidy in the human brain, we report here an analysis of the frequency of chromosome 21 gain and loss among neurons and non-neuronal cells isolated from the cerebral cortex and hippocampus of normal individuals ranging from 2 to 86 years of age. (jneurosci.org)
To address the therapeutic hypothesis experimentally, we transduced UPS subunits into HD skin fibroblasts or HD mutant protein expressing striatum-derived neurons. (science20.com)
Abstract During maturation of the brain, neurons and glia are formed sequentially. (bartleby.com)
Salk Institute scientists have discovered that an interaction between two key proteins helps regulate and maintain the cells that produce neurons. (neurosciencenews.com)
The work, published in Cell Stem Cell on September 14, 2017, offers insight into why an imbalance between these precursor cells and neurons might contribute to mental illness or age-related brain disease. (neurosciencenews.com)
In 1998, Gage led a research team which discovered that adult brains do produce new neurons, contrary to decades of dogma saying we are born with all the neurons we will ever have. (neurosciencenews.com)
Gage's team conducted screens in cells from mice and rats to see which genes were being transcribed into proteins in precursor cells, immature neurons and astrocytes. (neurosciencenews.com)
MeCP2 is most highly expressed in neurons, and mice lacking this protein show symptoms that strikingly parallel those of Rett patients. (portlandpress.com)

In addition, the researchers demonstrated that these epigenetic modulators repressed the expression of nuclear genes encoding mitochondrial proteins by occupying the promoter regions and hence reduced mitochondrial function, a mechanism conserved in mouse brain tissues. (medicalxpress.com)

Damage to the ELLPs weakens the ability of the three-dimensional transport channels that are composed of these proteins to safeguard the cell's nucleus from toxins, says Martin Hetzer, a professor in Salk's Molecular and Cell Biology Laboratory, who headed the research. (sciencedaily.com)
Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center - the nucleus - appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder. (hopkinsmedicine.org)
RanGAP1 in turn helps move molecules through nuclear pores that serve as passageways in the nucleus, letting proteins and genetic material flow in and out of it. (hopkinsmedicine.org)
One of the group's main areas of research was the nuclear pore complex - a large complex of proteins that allows the transport of molecules into and out of the cell's nucleus. (embl.org)
Interestingly, Nup153 levels are also known to be high in cells with elevated levels of a mobile protein called Sox2, a transcription factor that floats around the nucleus and binds to genes and turns them on or off. (neurosciencenews.com)
Western blot analysis of HD brain tissue shows full-length huntingtin protein in the nuclear fraction as well as abundant immunopositive bands at lower molecular weight, suggesting proteolytic products in the nucleus. (jci.org)
TMF1‐regulated nuclear protein 1 (Trnp1) has been shown to exert potent roles in neural development affecting neural stem cell self‐renewal and brain folding, but its molecular function in the nucleus is still unknown. (uni-muenchen.de)
Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
Both endogenous and enhanced green fluorescent protein (EGFP)-fused Gβ2 and Gγ2 proteins were detected in the nucleus at baseline, whereas a fraction of EGFP-Gβ2 and DsRed2-GR comigrated to the nucleus or the plasma membrane, depending on the exposure of cells to dexamethasone or somatostatin, respectively. (rupress.org)

Many of the most promising medicines under development are proteins, often antibodies, to help patients fight disease. (udel.edu)
We offer a fully equipped radiochemistry laboratory where we can label everything from liposomes, antibodies and proteins and all the way down to small molecules. (lu.se)

Working with Martin Hetzer, we decided to look at the brains of young and old rats. (embl.org)
Another Salk professor and a coauthor on the paper, Martin Hetzer, previously found that proteins in the nuclear membrane influence gene expression in different kinds of cancer cells. (neurosciencenews.com)

Grima also observed this same clumping of Huntingtin protein with RanGAP1 and nuclear pore proteins to the wrong place in the cell in brain tissue and cultured brain cells derived from deceased patients with Huntington's disease. (hopkinsmedicine.org)
In patients with Huntington's disease (HD), the proteolytic activity of the ubiquitin proteasome system (UPS) is reduced in the brain and other tissues. (science20.com)

These specific aspects are reviewed in this article, with separate attention being paid to small organic molecules and protein therapeutics. (snmjournals.org)
Although microdosing has been associated predominantly with small organic molecules and site-specific labeling, there is growing interest in applying the concept to protein therapeutics and in using some of the exclusive properties of proteins for nuclear imaging purposes. (snmjournals.org)
This article discusses the consequences of the facilitated regulations, the impact of performing studies at very low pharmacologic concentrations, and the differences in regulation and pharmacology between smaller (organic) molecules and larger (protein biologic) molecules. (snmjournals.org)
The mutant gene makes RNA molecules that stick to a transport protein, RanGAP1. (hopkinsmedicine.org)
The protein produced from this gene, called heterogenous nuclear ribonucleoprotein K (hnRNP K), attaches (binds) to DNA or its chemical cousin RNA and to other proteins, acting as a docking station for these molecules so they can interact. (medlineplus.gov)
After that, manifold proteins and their related molecules were demonstrated to participate in novel signaling pathways related to various cytokines in different types of cells. (novapublishers.com)
The large proteoglycan molecules made up of protein cores, and GAG branches are secreted by cells and constitute a significant fraction of the extracellular matrix of connective tissue. (medscape.com)
These radiation particles and rays carry enough energy to knock out electrons from atoms and molecules (such as water, protein, and DNA) that they hit or pass near. (cdc.gov)

Through this interaction, mRNAs and their associative proteins form messenger ribonucleoprotein particles (mRNPs) that are actively transported along the cytoskeleton to intracellular destinations. (frontiersin.org)
The Salk scientists are the first to discover an essential intracellular machine whose components include proteins of this age. (sciencedaily.com)
To accomplish that, a number of intracellular systems work in concert to keep the cell healthy and from clogging up with damaged proteins. (science20.com)
When proteins or peptides mutate, they can present major problems to the clearing up of the intracellular environment. (science20.com)
Afterwards, calmodulin and protein kinase C were discovered as modulator proteins of intracellular calcium signaling in hormonal action. (novapublishers.com)

Additionally, he realized that other researchers previously showed that mutations in the nuclear pore protein NUP62 caused Huntington's disease-like pathology. (hopkinsmedicine.org)
This finding was quite tantalizing given the fact that mutations in the NUP62 protein were shown by other researchers to cause an infantile form of Huntington's disease called infantile bilateral striatal necrosis," says Grima. (hopkinsmedicine.org)
HNRNPK gene mutations that cause Au-Kline syndrome result in the production of little or no hnRNP K protein. (medlineplus.gov)

In order to explore the factors that regulate the nuclear import of TDP-43, we used a small interfering RNA library to silence 82 proteins involved in nuclear transport and found that knockdowns of karyopherin-beta1 and cellular apoptosis susceptibility protein resulted in marked cytoplasmic accumulation of TDP-43. (crick.ac.uk)
Recently, several chromatin-related proteins have been shown to regulate ESC pluripotency and/or differentiation, yet the role of the major heterochromatin proteins in pluripotency is unknown. (biomedcentral.com)
EGR-1 has also been found to regulate the expression of VAMP2 (a protein important for synaptic exocytosis ). (wikipedia.org)
By analyzing gene expression in the brains of AD patients, they found that the expression levels of BAZ2B and EHMT1 negatively correlate with the expression of key mitochondrial function-related genes, suggesting that BAZ2B and EHMT1 can regulate mitochondrial function in aging human brains. (medicalxpress.com)
The ability to regulate transgene expression will be crucial for development of gene therapy to the brain. (lu.se)
An aspect of gene delivery to the brain that is currently being regulate the endogenous GFAP expression in a lesioned brain. (lu.se)

The lilli gene encodes a nuclear protein related to the AF4/FMR2 family. (sdbonline.org)
A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. (bvsalud.org)

Grima used two mouse models of Huntington's disease: one with a human version of the mutant Huntingtin protein and another with an aggressive form of the disease that contains only the first portion of the mouse Huntingtin protein. (hopkinsmedicine.org)
In Huntington's disease (HD) brains and other tissues, UPS activity is inhibited and intraneuronal nuclear protein aggregates of mutant huntingtin in HD brains indicate dysfunction of the UPS. (science20.com)
The pathological hallmark of HD is the intraneuronal nuclear protein aggregates of mutant huntingtin. (science20.com)

It is a nuclear protein and functions as a transcriptional regulator. (wikipedia.org)
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)
However, the proteins needed for transcriptional control have been reported to be immunogenic and there is often a substantial leakage in the systems (Clackson, 2000). (lu.se)

Glioblastoma (GBM) is one of the most aggressive primary brain tumors, with a median survival time of about 14.6 months despite maximal therapy 1 . (nature.com)
Of the estimated 17,000 primary brain tumors diagnosed in the United States each year, approximately 60% are gliomas. (medscape.com)

By bringing certain proteins together with DNA or RNA, the hnRNP K protein helps control the activity of genes and the production of proteins. (medlineplus.gov)

Expression and estrogen sensitivity of target genes and nuclear receptor coregulators were altered at mRNA and protein levels in adult uterus, prostate and brain. (researchgate.net)
P-glycoprotein/MDR1, multidrug resistance-associated proteins), nuclear receptors (e.g., glucocorticoid nuclear receptor, pregnane xenobiotic nuclear receptor), and other regulatory factors that control pharmacokinetic and pharmacodynamic phenomena during drug biotransformation in disease states. (ccf.org)
Ghosh, C . Glucocorticoid Receptor beta Isoform Predominates in the Human Dysplastic Brain Region and Is Modulated by Age, Sex, and Antiseizure Medication. (ccf.org)
Achar A, Ghosh C . Multiple hurdle mechanism and blood-brain barrier in epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation. (ccf.org)
Ghosh, C. Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy. (ccf.org)
May be a nuclear hormone receptor coactivator. (lu.se)

According to Dr. Gaya Dowling, a researcher with the National Institutes of Health, which is sponsoring the $300 million study, thinning of the cortex is thought to be part of the brain maturation process, so what these scans are showing is that this process is being sped up in children who get a lot of screen time 6 (7-plus hours a day). (consciouslifenews.com)

Huntington's disease is caused by a mutation in the Huntingtin protein, resulting in too many repeats of the amino acid glutamine in the protein's sequence, making the protein sticky and clumpy. (hopkinsmedicine.org)
The manuscript shows that cellular changes due to expression of huntingtin protein with longer CAG repeats can reduce the ubiquitin proteasome system (UPS) function in Huntington¡¦s disease cells. (science20.com)

To identify a nuclear marker pathognomonic of astrocytic phenotype, we assessed differential RNA expression by FACS-purified adult astrocytes and, on that basis, evaluated the expression of the transcription factor SOX9 in both mouse and human brain. (jneurosci.org)
We found that SOX9 is almost exclusively expressed by astrocytes in the adult brain except for ependymal cells and in the neurogenic regions, where SOX9 is also expressed by neural progenitor cells. (jneurosci.org)
The analysis showed that SOX9+ astrocytes constitute ∼10-20% of the total cell number in most CNS regions, a smaller fraction of total cell number than previously estimated in the normal adult brain. (jneurosci.org)
Based on SOX9 immunolabeling, we document that astrocytes constitute a smaller fraction of total cell number than previously estimated in the normal adult mouse brain. (jneurosci.org)

Funded by the Ellison Medical Foundation and the Glenn Foundation for Medical Research, Hetzer's research group is the only lab in the world that is investigating the role of these transport channels, called the nuclear pore complex (NPC), in the aging process. (sciencedaily.com)
The article is titled "Nuclear Accumulation of CHMP7 Initiates Nuclear Pore Complex Injury and Subsequent TDP-43 Dysfunction in Sporadic and Familial ALS. (bioquicknews.com)

EGR-1 (Early growth response protein 1) also known as ZNF268 (zinc finger protein 268) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene . (wikipedia.org)
The protein encoded by this gene belongs to the EGR family of Cys 2 His 2 -type zinc finger proteins. (wikipedia.org)

We conclude that primary and metastatic tumors of the brain produce one or more stress-related proteins, and that a variable proportion of the tumor cells have immunohistochemically-detectable p53, the expression of which may depend, at least in part, on the growth potential of a given tumor. (elsevierpure.com)
Within any tumor, nuclear size may vary, but uniformly, these tumors are of a high Fuhrman nuclear grade. (medscape.com)

We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e., putative protein mod- ifications. (lu.se)
The need to keep track of protein modifications is readily recognized by the proteomics community, and few repositories of known peptide modifications have been created. (lu.se)
These opportunities are surveyed here against a background of the immunobiology of allergic sensitization and current state-of-the-art approaches to measurement of peptide/protein reactivity. (cdc.gov)

The existence of mRNAs retaining both nuclear cap binding protein and EJC in the distal sites of neuronal processes suggests that some localized mRNAs have not yet undergone the "very first translation," which contribute to the spatio-temporal regulation of gene expression. (frontiersin.org)
Our results also suggest that nuclear pore deterioration might be a general aging mechanism leading to age-related defects in nuclear function, such as the loss of youthful gene expression programs," he adds. (sciencedaily.com)

The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
Buffy often acts opposite to Debcl , the other Drosophila Bcl-2-family protein. (sdbonline.org)
These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)

3) Different forms of physical activity alleviate the symptoms of PD through different mechanisms, including reducing the accumulation of α -syn protein, inflammation, and oxidative stress, while enhancing BDNF activity, nerve regeneration, and mitochondrial function. (nih.gov)
Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-XL ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy. (ccf.org)
This newly discovered epigenetic regulation of mitochondrial function is critical for achieving healthy aging of the brain. (medicalxpress.com)
Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
90% of mitochondrial proteins are coded by nuclear genes. (msdmanuals.com)
High-energy tissues (eg, muscle, heart, brain) are particularly at risk of malfunction due to mitochondrial abnormalities. (msdmanuals.com)

Because all three cell types have roughly the same number of nuclear pores, the team concluded that Nup153 levels influence cell type and that a high level is necessary to maintain cells' precursor status. (neurosciencenews.com)
Proteins can creep into the pores of resin beads used to perform ion-exchange chromatography and bind on the walls, based on charge. (udel.edu)

3 Henan International Joint Laboratory of Nuclear Protein Regulation, Kaifeng 475004, China. (nih.gov)
Research from my lab has found that the nuclear membrane is a dynamic structure that plays a key role in developmental gene regulation," says Hetzer, Salk's chief science officer and holder of the Jesse and Caryl Philips Foundation Chair. (neurosciencenews.com)
Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)

These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins. (biomedcentral.com)
Trnp1 interacts with factors located in several nuclear membrane‐less organelles, the nucleolus, nuclear speckles, and condensed chromatin. (uni-muenchen.de)
It is a nuclear protein that is largely chromatin-bound and has a strong preference for binding to methylated DNA sequences in vivo . (portlandpress.com)

We first genetically engineered proteasome activators involved in either non-ubiquitinated protein degradation pathways (PA28ƒ×) or subunits of PA700, the 26S proteasome ubiquitinated pathway (S5a) into transducible lentiviral vectors. (science20.com)
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (gentaur.com)

LMNB1 encodes for Lamin B1, a protein of the nuclear lamina. (raredis.org)
Nevertheless, Lamin B1 together with the other lamins that constitute the nuclear lamina has firstly the key role of maintaining the nuclear structure. (raredis.org)

After college, he conducted research on the human nuclear membrane protein Emerin. (rochester.edu)

In Xp11.2 translocation-associated renal cell carcinoma, tumor cells with abundant eosinophilic cytoplasm and high nuclear grade are often arranged in large nests with a delicate, intervening vascular stroma. (medscape.com)

By analyzing published databases, the researchers found that the expression levels of their human homologues BAZ2B and EHMT1 increase with age in human brains, and positively correlate with Alzheimer's disease (AD) progression. (medicalxpress.com)
By understanding and exploiting protein surface diffusion in ion-exchange chromatography, researchers can build upon this work and develop methods to reduce waste during the expensive drug manufacturing process. (udel.edu)
Researchers can also build upon this new fundamental understanding of protein diffusion and perhaps apply it to other problems. (udel.edu)
These approaches promise to enable researchers to assess, on a large scale, both expression level and functional state of the proteins that carry out most functions in a cell. (lu.se)

Analysis of the expression of chosen nuclear import factors in post-mortem brain samples from patients with TDP-43 positive frontotemporal lobar degeneration, and spinal cord samples from patients with amyotrophic lateral sclerosis, revealed a considerable reduction in expression of cellular apoptosis susceptibility protein in frontotemporal lobar degeneration. (crick.ac.uk)
We propose that cellular apoptosis susceptibility protein associated defective nuclear transport may play a mechanistic role in the pathogenesis of the TDP-43 positive frontotemporal lobar degeneration. (crick.ac.uk)
Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)

Applications for supercomputers beyond demonstration of national technological prowess include modeling weather, nuclear explosions, proteins and chunks of rat brain . (chinadigitaltimes.net)
It's imaging the broader physiological activity - respiration, oxygen flux, vascular changes - in small chunks of the brain. (freethoughtblogs.com)

NDN odes for the protein Necdin, which, in rodents, interacts with neurotrophin receptors in a way that is not completely understood to promote normal cognitive development. (bartleby.com)

We use multifaceted approaches to study the neurovascular properties ex vivo and in vitro using a humanized dynamic neurovascular unit established with primary brain cells isolated from resected brain tissues post-epilepsy surgery, and in vivo by using rodent models of seizure/epilepsy. (ccf.org)
Importantly, Trnp1 co‐regulates the architecture and function of these nuclear compartments in vitro and in the developing brain in vivo. (uni-muenchen.de)

It also clumped up in the same location as abnormal clumps of nuclear pore proteins NUP88 and NUP62. (hopkinsmedicine.org)
From these results, we hypothesized that enhancing UPS function would improve catalytic degradation of abnormal proteins in HD. (science20.com)
These remarkable results demonstrate for the first time that it is possible to intervene therapeutically in the proteolytic pathways and organelles that participate in the specific degradation of misfolded and abnormal proteins. (science20.com)
To investigate stimulation effects and disease-related brain activity, he focuses on the development of stimulation methods that cause a sustained neural desynchronization by an unlearning of abnormal synaptic interactions. (stanford.edu)

Mitochondria contain DNA in a single circular chromosome containing 37 genes that code for 13 proteins, various RNAs, and several regulating enzymes. (msdmanuals.com)
The transcription factor NF-E2-related factor 2 (Nrf2) plays a critical role in the mammalian response to chemical and oxidative stress through induction of phase II detoxification enzymes and oxidative stress response proteins. (cdc.gov)

Now scientists report that they have discovered a weakness in a component of brain cells that may explain how the aging process occurs in the brain. (sciencedaily.com)
Easing cellular traffic jams may save brain cells. (hopkinsmedicine.org)
Huntington's disease is a relatively rare fatal inherited condition that gradually kills off healthy nerve cells in the brain, leading to loss of language, thinking and reasoning abilities, memory, coordination and movement. (hopkinsmedicine.org)
Not only tumor borders but also the tumor core was composed of highly dynamic cells, with no clear correlation to the ability to spread into the brain. (nature.com)
So we are eager to understand how specific brain cells develop, what keeps them healthy and why advancing age or other factors can lead to disease. (neurosciencenews.com)
The Gage team sought the expertise of the Hetzer lab to explore whether something similar was at play in brain cells. (neurosciencenews.com)
Amyotrophic lateral sclerosis ( ALS ) (Lou Gehrig's disease) is a rapidly progressive and fatal degenerative disease affecting the nerve cells in the brain and spinal cord responsible for controlling voluntary muscle movement. (bioquicknews.com)
Deltamethrin exposure promoted free radical formation in rat brain and reactive oxygen species generation in PC12 cells. (cdc.gov)
In animals receiving excitotoxic lesions of the striatum we detected an eightfold increase of green ¯uorescent protein (GFP)-expressing cells. (lu.se)
There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)
These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)

Isoform 3 interacts with HCV core protein. (lu.se)

However, no study has examined Nrf2 nuclear translocation and free radical production, two hallmarks of oxidative stress, in the mammalian brain in vivo. (cdc.gov)

Heterogeneous population of RNA granules serve as motile units to translocate, store, translate, and degrade mRNAs in the dendrites contain cis -elements and trans -acting factors such as RNA-binding proteins and microRNAs to convey stimulus-, transcript-specific local translation. (frontiersin.org)
1) Risk factors of PD include dairy products, pesticides, traumatic brain injury, and obesity. (nih.gov)

Fresh-frozen samples of postmortem brain tissue from normal cerebral cortices and hippocampi were obtained from the Harvard Brain Bank (United States Public Health Service MH/NS 31862) and from the University of Miami/University of Maryland Brain and Tissue Bank (National Institute of Child Health and Human Development NO1-HD-8-3284). (jneurosci.org)
Intrinsically, ischemic stroke indicates the cascade of congesting events, i.e., thrombus formation and embolism, that ultimately decreases the local blood flow and cause oxygen deprivation in affected brain tissue. (hindawi.com)

Differential promoter methylation and histone modification contribute to the brain specific expression of the mouse Mbu-1 gene. (nih.gov)
promoter in the intact brain and after different lesions to the brain. (lu.se)

In Huntington's disease (HD) the disease provoking mutation in the huntingtin gene eventually causes the cell to build up intranuclear and cellular inclusions of protein-aggregates, made up primarily of huntingtin. (science20.com)
One cellular organelle with a central role of clearing such protein build up in the cell is the ubiquitin proteasome system (UPS). (science20.com)

The encoded protein is likely to be a nuclear transcription factor. (nih.gov)
The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain. (cdc.gov)

Protein synthesis, folding. (msdmanuals.com)

It has an essential role in brain neuron epigenetic reprogramming. (wikipedia.org)

The methyl-CpG-binding protein MeCP2 was discovered over 15 years ago as part of a search for proteins that selectively bind methylated DNA. (portlandpress.com)

One such mechanism may be defective nuclear import of TDP-43 protein, as a disruption of its nuclear localization signal leads to mislocalization and aggregation of TDP-43 in the cytoplasm. (crick.ac.uk)

PTMs from this list in conjunction with a protein sequence and a few precursor masses. (lu.se)

The fundamental defining feature of aging is an overall decline in the functional capacity of various organs such as the heart and the brain," says Hetzer. (sciencedaily.com)
they are instead due to the circuitry and functional organization of the brain, as well as to inappropriate experimental protocols that ignore this organization. (freethoughtblogs.com)
Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)

Finally, we showed that Bonus SUMOylation is mediated by the SUMO E3-ligase Su(var)2-10, revealing that although SUMOylation of TIF1 proteins is conserved between insects and mammals, both the mechanism and specific site of modification is different in the two taxa. (elifesciences.org)

Here, using double-label fluorescence in situ hybridization for the autosome chromosome 21 (chromosome 21 point probes combined with chromosome 21 "paint" probes), along with immunocytochemistry and cell sorting, we present evidence for chromosome gain and loss in the human brain. (jneurosci.org)
The human EGR-1 protein contains (in its unprocessed form) 543 amino acids with a molecular weight of 57.5 kDa , and the gene is located on the chromosome 5 . (wikipedia.org)

Here we report a class of mRNA granules in human neuronal processes that are enriched in the nuclear cap-binding protein complex (CBC) and exon junction complex (EJC) core components, Y14 and eIF4AIII. (frontiersin.org)
ELISA kit, ELISA, ELISAs Enzyme-linked immunosorbent assay 90320007 SNOMED code are used by the medical researcher for detection of human, mouse, … proteins are supplied in coated 96 well plates to be stored at +4°C. ELISA test kits can be sandwich ELISA. (gentaur.com)
ELISA tests are enzyme linked immunoassays to detect human, mouse or other proteins in serum, plasma, urine or biological fluids. (gentaur.com)
Orthologous to human CSRNP3 (cysteine and serine rich nuclear protein 3). (nih.gov)
The use of viral vectors to deliver foreign genes to the brain is highly logical states in the human brain (Eng et al. (lu.se)

E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene. (wikipedia.org)
Polyglutamine-binding protein 1 ( PQBP1 ) is an RNA-splicing factor that, when mutated, in humans causes Renpenning syndrome, an X-linked intellectual disability disease characterized by severe cognitive impairment, but also by physical defects that suggest PQBP1 has broader functions in embryonic development. (xenbase.org)

The matching is com- plicated by the fact that there are protein modifications and the sequence databases store the unmodified sequences. (lu.se)

It performs the third step (ligation) in binding ubiquitin to proteins in a process called ubiquitination which tags the proteins for disposal. (wikipedia.org)

Astrocytes may be recognized as such by their expression of glial fibrillary acidic protein, glutamine synthetase, glutamate transporter 1 (GLT1), aquaporin-4, aldehyde dehydrogenase 1 family member L1, and other proteins. (jneurosci.org)
It has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. (wikipedia.org)
In our lesioned brain and a substantially less pronounced expression in the laboratory, we have investigated the characteristics of lentiviral vec- normal, intact brain. (lu.se)
Efforts have therefore, designed a study to compare the expression of green ¯uor- been made to develop systems based on different drugs or hormones escent protein (GFP) and GDNF under the control of the hGFAP including tetracycline, rapamycine and progestrone (Clackson, 2000). (lu.se)

The success of proteomics experiments, such as studies of protein function and cell signaling pathways, ultimately de- pends on how well the protein content in samples is identified and annotated. (lu.se)

However, these proteins may all be regulated both developmentally and functionally, restricting their utility. (jneurosci.org)
In zebrafish mutants in which a particular BMP protein is functionally reduced, there was a resulting increase in Lim1+ interneurons (medial interneurons) post-mitotically (Nguyen et al. (bartleby.com)

In the precursors, they discovered high numbers of a protein called Nup153, which is part of a multiprotein complex that forms a gatekeeping pore in the nuclear membrane, controlling what goes in or out. (neurosciencenews.com)

His interests in neurosurgery include endovascular techniques and traumatic brain injury. (rochester.edu)

Recent research in several laboratories has linked breakdown of protein homeostasis to declining cell function. (sciencedaily.com)
To function, each living cell needs both to build new and to degrade old or damaged proteins. (science20.com)
We determined how to enhance UPS function and influence catalytic protein degradation and cell survival in HD. (science20.com)
1 Laboratory of Brain Function and Disease, Institute for Brain Sciences Research, School of Life Sciences, Henan University, China. (nih.gov)
Our laboratory conducts cerebrovascular research to better understand brain physiology and function in neurological disorders (e.g., epilepsy and epilepsy with other comorbidities such as stroke or depression), with a focus on the blood-brain barrier. (ccf.org)
By regulating certain genes and proteins, the hnRNP K protein plays a role in the normal development and function of several body systems, including the brain. (medlineplus.gov)
Huntingtin contains a few domains that suggest particular functions, including WW domains and caspase cleavage sites ( 7 , 8 ), but the function of the protein remains unknown. (jci.org)
Future studies of MeCP2 promise to shed light upon brain function, neurological disease and the biology of DNA methylation. (portlandpress.com)

Anatomy34

Organisms17

Diseases15

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Psychiatry and Psychology4

Phenomena and Processes67

Disciplines and Occupations1

Information Science4

Health Care1

Proliferating cell nu3

Neurons15

Genes encoding1

Nucleus9

Antibodies2

Martin Hetzer2

Patients with Huntington's disease2

Molecules8

Intracellular5

Mutations3

Regulate6

Encodes a nuclear2

Mutant huntingtin3

Transcriptional3

Primary brain tumors2

Certain proteins1

Receptor6

Maturation1

Huntingtin protein2

Adult4

Pore complex2

Zinc2

Tumors2

Peptide3

Gene expression2

Drosophila4

Mitochondrial6

Pores2

Regulation3

Chromatin3

Subunits2

Lamina2

Membrane protein1

Tumor cells1

Researchers4

Apoptosis3

Chunks2

Receptors1

Vitro2

Abnormal4

Enzymes2

Cells11

Interacts1

Oxidative stress1

Factors2

Tissue2

Promoter2

Cellular2

Transcription factor2

Synthesis1

Epigenetic1

Selectively1

Localization1

Precursor1

Functional3

Mechanism1

Chromosome2

Human5

Humans2

Sequences1

Ubiquitin1

Expression4

Pathways1

Functionally2

Complex1

Traumatic brain1

Function8