A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (lookformedical.com)
Mice8
While less commonly used for research than laboratory mice, rats have served as an important animal model for research in psychology and biomedical science. (wikipedia.org)
Inbred strains are also available, but are not as commonly used as inbred mice. (wikipedia.org)
This was the first in a series of developments that have begun to make rats tractable as genetic research subjects, although they still lag behind mice, which lend themselves better to the embryonic stem cell techniques typically used for genetic manipulation. (wikipedia.org)
Many investigators who wish to trace observations on behavior and physiology to underlying genes regard aspects of these in rats as more relevant to humans and easier to observe than in mice, giving impetus to the development of genetic research techniques applicable to rats. (wikipedia.org)
one estimate of mice and rats used in the US alone in 2001 was 80 million. (wmflabs.org)
Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
In both live and fixed brain preparations from these mice, detailed microanatomical features of EGFP-expressing interneurons were readily observed. (jneurosci.org)
Laboratory9
Laboratory rats or lab rats are strains of the subspecies Rattus norvegicus domestica which are bred and kept for scientific research. (wikipedia.org)
The first time one of these albino mutants was brought into a laboratory for a study was in 1828 for an experiment on fasting. (wikipedia.org)
Over the next 30 years, rats were used for several more experiments and eventually the laboratory rat became the first animal domesticated for purely scientific reasons. (wikipedia.org)
As there is evidence that the hooded rat was known as the "Japanese rat" in the early 20th century, Kuramoto concluded that one or more Japanese hooded rats might have been brought to Europe or the Americas and an albino rat that emerged as a product of the breeding of these hooded rats was the common ancestor of all the albino laboratory rats in use today. (wikipedia.org)
Laboratory rats are frequently subject to dissection or microdialysis to study internal effects on organs and the brain, such as for cancer or pharmacological research. (wikipedia.org)
Laboratory rats not sacrificed may be euthanized or, in some cases, become pets. (wikipedia.org)
In October 2003, researchers succeeded in cloning two laboratory rats by nuclear transfer. (wikipedia.org)
However, compared to traditional laboratory animals like rats, very little is known about its behavior, either in the wild or in a laboratory setting. (researchgate.net)
Rats, Inbred WF are a strain of laboratory rats that are commonly used in medical research due to their consistent genetic makeup and susceptibility to various diseases. (lookformedical.com)
Rattus5
In 18th-century Europe, wild brown rats (Rattus norvegicus) ran rampant and this infestation fueled the industry of rat-catching. (wikipedia.org)
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). (lookformedical.com)
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. (lookformedical.com)
Mutant strain of Rattus norvegicus which is used as a disease model of kernicterus. (lookformedical.com)
A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT). (lookformedical.com)
Testicular2
All but one of the testicular tumors occurred in the rats from a single supplier. (wikipedia.org)
L. C. Dunn breeds Strain 129, which later proves to have a high incidence of testicular cancer. (jax.org)
Genes1
Rats bearing mutant genes which are phenotypically expressed in the animals. (lookformedical.com)
Tumors2
There were even significant variations in the incidences of adrenal medulla tumors among rats from the same source raised in different laboratories. (wikipedia.org)
L. C. Strong breeds a Bagg albino with an albino from Little 's stock and starts the first of many tumor-prone strains, called the A strain, known for mammary and lung tumors. (jax.org)
Commonly1
Rat-catchers would not only make money by trapping the rodents, but also by selling them for food or, more commonly, for rat-baiting. (wikipedia.org)
Behavioral3
We conclude that although rats and opossums share many similar characteristics, including ecological niche, their divergent evolutionary heritage results in vastly different behavioral capabilities. (researchgate.net)
Halsey Bagg develops the BALB /c ( Bagg albino) mouse for behavioral experiments. (jax.org)
With collaborators, we are exploring the behavioral and anatomic consequences of induced malformations by testing rats in various auditory discrimination paradigms and subsequent examination of their brains. (dyslexialab.net)
Hippocampus1
Rutin caused attenuation of streptozotocin-induced inflammation by decreasing the activity of the glial fibrillary acidic protein, interleukin-8, cyclooxygenase-2, inducible nitric oxide synthase and nuclear factor-kB and thereby prevented gross anatomical changes in rat hippocampus. (fuqna.com)
Embryonic1
The anterior of the three primitive cerebral vesicles of the embryonic brain arising from the NEURAL TUBE. (lookformedical.com)
Differences1
One area of concentration has been on the investigation of animal models of the differences that have been noted between the brains of dyslexics and those of normal readers. (dyslexialab.net)
Brown1
Clarence Cook Little begins to develop the first inbred strain, designated DBA for dilute, brown, and non-agouti. (jax.org)
Research2
The first rat colony in America used for nutrition research was started in January 1908 by Elmer McCollum and then, nutritive requirements of rats were used by Thomas Burr Osborne and Lafayette Mendel to determine the details of protein nutrition. (wikipedia.org)
My research interests centers on the genetic and epigenetic factors that play a role in shaping the architecture of the brain. (dyslexialab.net)
Important1
Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. (lookformedical.com)
Major1
For every major excitatory pathway of the brain, there appears to be associated inhibitory pathways ( Buzsáki and Chrobak, 1995 ). (jneurosci.org)