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  • organ
  • Accumulating experimental and clinical data have established the importance of DAMPs, which signal through innate pattern recognition receptors (PRRs) or DAMP-specific receptors, in regulating the alloresponse to solid organ transplantation (SOT). (jci.org)
  • A growing understanding of the role of DAMPs in directing the immune response to transplantation has suggested novel avenues for the treatment or prevention of allograft rejection that complement contemporary immunosuppression and could lead to improved outcomes for solid organ recipients. (jci.org)
  • Solid organ transplantation (SOT) provides life-extending treatment for patients with advanced kidney, heart, liver, or lung failure. (jci.org)
  • DAMPs are of particular relevance in the context of organ transplantation because of the injury inherent in the removal of an organ from one individual and later implantation into another. (jci.org)
  • The current paradigm suggests that kidney-infiltrating T cells (KITs) are activated effector cells contributing to tissue damage and ultimately organ failure. (jci.org)
  • cells
  • Few subjects in biomedical science have captured the imagination of both the scientific community and the public as has the use of stem cells for the repair of damaged tissues. (jci.org)
  • Further understanding of the biology of angiogenic factors, as well as of the function of hematopoietic cells in tissue neovascularization, will lead to improved therapeutic strategies for the treatment of diseases ranging from ischemia to cancer. (jci.org)
  • 10 ) report a more complex role for this neurotrophic factor: BDNF can mobilize TrkB + hematopoietic precursor cells (HPCs) for both hematopoiesis and tissue neovascularization. (jci.org)
  • These findings suggest avenues for the treatment of autoimmunity based on selectively exploiting the exhausted phenotype of tissue-infiltrating T cells. (jci.org)
  • mouse
  • Notably, in spite of concurrent Akt hyperactivation in mouse brain lesions, single mTOR inhibition by rapamycin was sufficient to strongly impair mouse SEGA growth. (jci.org)
  • development
  • Tuberous sclerosis complex (TSC) is a dominantly inherited disease caused by hyperactivation of the mTORC1 pathway and characterized by the development of hamartomas and benign tumors, including in the brain. (jci.org)