• receptors
  • Accumulating experimental and clinical data have established the importance of DAMPs, which signal through innate pattern recognition receptors (PRRs) or DAMP-specific receptors, in regulating the alloresponse to solid organ transplantation (SOT). (jci.org)
  • cellular
  • in the eye this can have disastrous consequences for vision - mechanically disrupting the visual axis or sufficiently disturbing the tissue microenvironment such that proper cellular functioning is no longer possible. (jci.org)
  • signals
  • These photoreceptors are the site at which photons of light are converted into electrical signals that are transmitted to the visual cortex of the brain by a complex series of synaptic transmissions (Figure 1 ). (jci.org)
  • complex
  • Tuberous sclerosis complex (TSC) is a dominantly inherited disease caused by hyperactivation of the mTORC1 pathway and characterized by the development of hamartomas and benign tumors, including in the brain. (jci.org)
  • lead
  • A growing understanding of the role of DAMPs in directing the immune response to transplantation has suggested novel avenues for the treatment or prevention of allograft rejection that complement contemporary immunosuppression and could lead to improved outcomes for solid organ recipients. (jci.org)
  • Disruption of the highly ordered tissue architecture in the eye caused by vascular leakage, hemorrhage, and concomitant fibrosis can lead to mechanical disruption of the visual axis and/or biological malfunctioning. (jci.org)
  • cells
  • Few subjects in biomedical science have captured the imagination of both the scientific community and the public as has the use of stem cells for the repair of damaged tissues. (jci.org)
  • mouse
  • Notably, in spite of concurrent Akt hyperactivation in mouse brain lesions, single mTOR inhibition by rapamycin was sufficient to strongly impair mouse SEGA growth. (jci.org)