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  • regulation
  • In addition, interactions between epithelial ion channels and actin or actin-binding/scaffolding proteins play a role in the regulation of channel activity and in their intracellular trafficking. (physiology.org)
  • Due to its exocytotic role in platelets, immune cells, neurons, and insulin regulation, downregulation of Ral may lead to pathological conditions such as thrombosis and metabolic syndrome. (wikipedia.org)
  • actin
  • Through the recent application of molecular and proteomic approaches, we now know that the interactions between epithelial ion channels and actin can either be direct or indirect, the latter being mediated through scaffolding or actin-binding proteins that serve as links between the channels and the actin-based cytoskeleton. (physiology.org)
  • The clustering and retention of ion channels within a particular plasma membrane domain are, in part, mediated through interactions with actin, actin-binding proteins, or scaffolding proteins. (physiology.org)
  • Na + /H + exchanger regulatory factors (NHERFs)] or actin-binding proteins (e.g., α-actinin, spectrin) that serve as a link between the channel and the actin-based cytoskeleton ( Table 1 ). (physiology.org)
  • residues
  • Mutational studies were performed to investigate the contribution of selected interface residues to the binding affinity. (embl.de)
  • 2002
  • 0\QQa The U n i v e r s i t y o f B r i t i s h Vancouver, Canada & XrnfTt O O p l Columbia http://www.library.ubc.ca/spcoll/thesauth.html 8/15/2002 ABSTRACT Ras and members of the Ras-related family of small GTP-binding proteins are involved in many biological functions. (ubc.ca)
  • kinase
  • Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase. (embl.de)
  • Here we show that Ral-GEF stimulation by EGF involves an additional mechanism, PI3-K-dependent kinase 1 (PDK1)-induced enhancement of Ral-GEF catalytic activity. (ad-astra.ro)
  • RasGTP
  • Adenylyl cyclase molecules carrying these mutations are rendered unactivatable by Ras in vitro with the Ras-associating domain-RA, not all RA domains bind RasGTP it is a primary Ras-binding site. (wikipedia.org)
  • have shown that not all RA domains bind RasGTP. (embl.de)
  • Predicted RA domains in PLC210 and nore1 found to bind RasGTP. (embl.de)
  • stimulation
  • 3 The immature MEG-01 cells already show an increase in cytosolic Ca 2+ concentration, [Ca 2+ ] i , on stimulation by thrombin and platelet-activating factor. (ahajournals.org)
  • domain
  • Instead, the non-catalytic N-terminus of PDK1 mediates the formation of an EGF-induced complex with the N-terminus of the Ral-GEF, Ral-GDS, thereby relieving its auto-inhibitory effect on the catalytic domain of Ral-GDS. (ad-astra.ro)
  • AND-34 binds by its GDP exchange factor domain to the C terminus of HEF1, a region of HEF1 previously implicated in apoptotic, adhesion, and cell cycle-regulated signaling. (jimmunol.org)
  • affinity
  • Furthermore, we could convert an intrabody which does not bind RAS in mammalian cells into a high‐affinity reagent capable of inhibiting RAS‐mediated NIH 3T3 transformation by exchanging VH and VL complementarity‐determining regions onto its consensus scaffold. (embopress.org)
  • molecules
  • p130Cas and HEF1 are a structurally related pair of such docking molecules that localize to the focal adhesion complex, assembling members of adhesion and growth factor-related signaling cascades ( 10 , 11 ). (jimmunol.org)
  • functions
  • While the above functions appear to be shared between the two Ral isoforms, their differential subcellular localizations result in their differing involvement in certain biological processes. (wikipedia.org)
  • activity
  • After size fractionation of FCS and analysis of the lipids that bound to serum albumin, the lysophosphatidic acid (LPA) was found to be responsible for the serum activity that induced stress fibre formation. (wikipedia.org)