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  • novel
  • AND-34, a novel GDP exchange factor, is expressed constitutively at significant levels in murine splenic B cells, but not in murine splenic T cells or thymocytes. (jimmunol.org)
  • amino acid
  • This domain, which could be narrowed down to 100 amino acid residues, associated in vitro with human Ha-Ras in a GTP-dependent manner and competed with yeast adenylyl cyclase for binding Ha-Ras. (embl-heidelberg.de)
  • The Ral isoforms share an 80% overall match in amino acid sequence and 100% match in their effector-binding region. (wikipedia.org)
  • A single amino acid substitution, and in particular a single nucleotide substitution, is responsible for an activating mutation. (wikipedia.org)
  • actin
  • Through the recent application of molecular and proteomic approaches, we now know that the interactions between epithelial ion channels and actin can either be direct or indirect, the latter being mediated through scaffolding or actin-binding proteins that serve as links between the channels and the actin-based cytoskeleton. (physiology.org)
  • The clustering and retention of ion channels within a particular plasma membrane domain are, in part, mediated through interactions with actin, actin-binding proteins, or scaffolding proteins. (physiology.org)
  • Na + /H + exchanger regulatory factors (NHERFs)] or actin-binding proteins (e.g., α-actinin, spectrin) that serve as a link between the channel and the actin-based cytoskeleton ( Table 1 ). (physiology.org)
  • affinity
  • Mutational studies were performed to investigate the contribution of selected interface residues to the binding affinity. (embl-heidelberg.de)
  • Furthermore, we could convert an intrabody which does not bind RAS in mammalian cells into a high‐affinity reagent capable of inhibiting RAS‐mediated NIH 3T3 transformation by exchanging VH and VL complementarity‐determining regions onto its consensus scaffold. (embopress.org)
  • domain
  • Instead, the non-catalytic N-terminus of PDK1 mediates the formation of an EGF-induced complex with the N-terminus of the Ral-GEF, Ral-GDS, thereby relieving its auto-inhibitory effect on the catalytic domain of Ral-GDS. (ad-astra.ro)
  • AND-34 binds by its GDP exchange factor domain to the C terminus of HEF1, a region of HEF1 previously implicated in apoptotic, adhesion, and cell cycle-regulated signaling. (jimmunol.org)
  • cascades
  • p130Cas and HEF1 are a structurally related pair of such docking molecules that localize to the focal adhesion complex, assembling members of adhesion and growth factor-related signaling cascades ( 10 , 11 ). (jimmunol.org)
  • Cdc42
  • They promote the exchange of GDP for GTP to generate the activated form of CDC42 capable of recognizing downstream targets [ 4 ]. (bio-rad.com)
  • activity
  • After size fractionation of FCS and analysis of the lipids that bound to serum albumin, the lysophosphatidic acid (LPA) was found to be responsible for the serum activity that induced stress fibre formation. (wikipedia.org)