SodiumPolymerAntithrombotic effectNanoparticlesMoleculesFluorescein isothiocyanatePlateletPolysaccharideElevatesLinkagesMannose receptorsPolyanionsAntibodySucroseViscositySerum ironNanoparticleIsolationSynthesisCompetesTIBCParenteralMolecularFluorescentMiceVivoIncreasesSolubleInhibitionAffinityPromoterAntibodiesHeparinPorosityCovalentlyLigandLengthsProteinsFunctionalAntigenSuggestsBacteriaTherapeuticExhibitImmobilizationIronProteinGeneTypicallyChemicalBloodEffectsApplicationsGreaterCellAdministrationWaterVolumeAgentShown
Sodium7
- Solutions of fluorescently-labelled dextran can be perfused through engineered vessels to analyze vascular permeability Dextran is used to make microcarriers for industrial cell culture Orally-administered dextran sodium sulphate is used to induce colitis in animal models of inflammatory bowel disease. (wikipedia.org)
- However, the mechanism by which RUT ameliorates dextran sulfate sodium (DSS)-induced IBD is largely unknown. (nih.gov)
- In the present study we examined the protective potential of exogenously administered human umbilical cord derived mesenchymal stem cells (UCMSCs) against Dextran Sulfate Sodium (DSS) induced acute colitis in immunodeficient NOD.CB 17 - Prkdc scid /J mice with particular attention to endoplasmic reticulum (ER) stress. (biomedcentral.com)
- Agarose gel electrophoresis evaluation of binding tests demonstrated that after treatment with sodium periodate, Fe3O4-dextran-anti-HCG nanoparticles possess a reasonable potential to soak up DNA, as well as the protection test demonstrated that nanoparticles can secure DNA from DNase I digestion effectively. (fabretp.org)
- Frmd8 deficiency in mice accelerates azoxymethane/dextran-sodium-sulfate-induced colorectal adenoma formation. (bvsalud.org)
- Oral administration of C18-3OH decreased colitis induced by dextran sulfate sodium in mice. (bmj.com)
- Ferric carboxymaltose , sodium ferric gluconate, and iron sucrose are preferred to iron dextran , which has a higher incidence of anaphylaxis. (msdmanuals.com)
Polymer7
- This characteristic branching distinguishes a dextran from a dextrin, which is a straight chain glucose polymer tethered by α-1,4 or α-1,6 linkages. (wikipedia.org)
- Dextran is a polymer of anhydroglucose. (sigmaaldrich.com)
- In one embodiment, the nanocage is covalently attached to a polymer shell (e.g. a dextran shell). (justia.com)
- Finally we prepared the synthesis of dextran derivative possessing disialic acids via polymer reactions. (nii.ac.jp)
- This polymer is used as a binding agent in tablets and a suspending agent in other pharmaceutical preparations. (pharmacy180.com)
- Dextran is a complex, branched polymer or polysaccharide composed of glucose molecules. (pharmacy180.com)
- [ 1 , 2 ] PEG, a water-soluble linear polymer, appears to accelerate antibody-RBC binding by steric exclusion of water molecules in the diluents and to promote antibody detection. (medscape.com)
Antithrombotic effect1
- The antithrombotic effect of dextran is mediated through its binding of erythrocytes, platelets, and vascular endothelium, increasing their electronegativity and thus reducing erythrocyte aggregation and platelet adhesiveness. (wikipedia.org)
Nanoparticles14
- Dextran can be used as a stabilizing coating to protect metal nanoparticles from oxidation and improve biocompatibility. (wikipedia.org)
- Magnetic Composite Thin Films of Fe(x)O(y) Nanoparticles and Photocrosslinked Dextran Hydrogels. (mpg.de)
- No cytotoxicity was noticed when the focus of Fe3O4-dextran-anti-HCG nanoparticles was 37.5 g/mL. (fabretp.org)
- Aldehyde Fe3O4-dextran-anti-HCG nanoparticles can transfect reporter genes, as well as the transfection performance of the nanoparticles is certainly higher than that of liposomes ( 0.05). (fabretp.org)
- Fe3O4-dextran-anti-HCG nanoparticles can focus in choriocarcinoma cells and in transplanted choriocarcinoma tumors. (fabretp.org)
- Conclusions: The outcomes concur that Fe3O4-dextran-anti-HCG nanoparticles possess potential being a protected, effective, and choriocarcinoma-specific concentrating on gene vector. (fabretp.org)
- Outcomes size and Morphology of Fe3O4-dextran-anti-HCG nanoparticles Fe3O4-dextran-anti-HCG nanoparticle option is Furosemide atramentous and transparent. (fabretp.org)
- Open up in another window Body 1 Transmitting electron micrograph of magnetic iron oxide (Fe3O4)-dextran-anti-HCG nanoparticles. (fabretp.org)
- The iron content material of Fe3O4-dextran-anti-HCG nanoparticles is certainly 37.5 g/mL. (fabretp.org)
- Toxicity of Fe3O4-dextran-anti-HCG nanoparticles As proven in Desk 1, the inhibitory price of nanoparticles at 56.25 and 75 g/mL is greater than control ( 0.05). (fabretp.org)
- Desk 2 Transfection performance of anti-HCG monoclonal antibody destined to nanoparticle 0.05) (Desk 3), indicating that Fe3O4-dextran-anti-HCG nanoparticles work being a gene vector. (fabretp.org)
- Oddly enough, the performance of gene transfection using Fe3O4-dextran-anti-HCG nanoparticles is certainly greater than that noticed using liposomes ( 0.05). (fabretp.org)
- These results indicate that Fe3O4-dextran-anti-HCG nanoparticles are even more soaked up by choriocarcinoma cells readily. (fabretp.org)
- In collaborating with BIND, we will be able to leverage their accomplished R&D team who has strong track record for advancing targeted nanoparticles from concept into the clinic. (businesswire.com)
Molecules7
- citation needed] Dextran can be used in an ATPS for PEGylation Dextran is used in the osmotic stress technique for applying osmotic pressure to biological molecules. (wikipedia.org)
- Dextran coupled with a fluorescent molecule such as fluorescein isothiocyanate can be used to create concentration gradients of diffusible molecules for imaging and allow subsequent characterization of gradient slope. (wikipedia.org)
- As the MW increases, dextran molecules attain greater symmetry. (sigmaaldrich.com)
- FITC-Dextran 250 (FD 250) may be used as a model compound for development of methods to deliver molecules into protoplasts and to study drug release from structures such as hydrogels and liposomes. (sigmaaldrich.com)
- The dextran molecules bind to the conA molecules. (technovelgy.com)
- However, when glucose enters the picture, it competes with dextran, displacing the dextran molecules and binding to the conA. (technovelgy.com)
- Use of various capture molecules, linkers and spacers in a Molecular Net may confer unique binding properties to a Molecular Net. (justia.com)
Fluorescein isothiocyanate1
- Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals. (sigmaaldrich.com)
Platelet3
- Dextrans also reduce factor VIII-Ag Von Willebrand factor, thereby decreasing platelet function. (wikipedia.org)
- CONCLUSIONS: These data are consistent with a rise in plasmin due to dextran blockade of tPA uptake in vivo, leading to enhanced fibrinolysis, cleavage of vWF and of the platelet protease-activated receptor-1 (PAR-1) thrombin receptor. (reading.ac.uk)
- This suggests that dextran exerts a combined therapeutic effect, enhancing endogenous fibrinolysis, whilst also reducing platelet adhesion to vWF and platelet activation by thrombin. (reading.ac.uk)
Polysaccharide1
- Dextran is a complex branched glucan (polysaccharide derived from the condensation of glucose), originally derived from wine. (wikipedia.org)
Elevates2
- Dextran is a complicating contaminant in the refining of sugar because it elevates the viscosity of sucrose solutions and fouls plumbing. (wikipedia.org)
- Iron dextran elevates serum iron levels several weeks. (medscape.com)
Linkages1
- The remaining (163) linkages account for the branching of dextran. (sigmaaldrich.com)
Mannose receptors1
- Based on the expression of CD206 mannose receptors on disease-associated macrophages, BIND and Macrophage plan to conduct joint research to develop a CD206 targeted Accurin nanoparticle that is capable of concentrating various therapeutic payloads to the tumor microenvironment. (businesswire.com)
Polyanions2
- All anti prion polyanions seem to inhibit the binding of PrPc to heparin sepharose, demonstrating a clear connection between the heparin binding activity of PrPc and inhibition of prion replication. (europa.eu)
- Reports also indicate that DAPI will bind to polyphosphates and other polyanions (ref.10), dextran sulfate (ref.11) and SDS (ref.12). (thermofisher.com)
Antibody4
- These unique micropolymers allow a higher density of enzymes per antibody to bind the target with minimal interference. (vectorlabs.com)
- AHG is an animal antibody that binds to the F c portion of human immunoglobulin. (medscape.com)
- The AHG detects bound RBC antibodies that do not produce direct agglutination (sensitizing antibody). (medscape.com)
- The presence of agglutination with the addition of AHG indicates antibody binding to a specific red cell antigen. (medscape.com)
Sucrose1
- Dextran is now produced from sucrose by certain lactic acid bacteria of the family lactobacillus. (wikipedia.org)
Viscosity1
- The MW of dextran is measured by one or more of the following methods: low angle laser light scattering, size exclusion chromatography, copper-complexation and anthrone reagent colorometric reducing-end sugar determination and viscosity. (sigmaaldrich.com)
Serum iron4
- Iron stores are assessed using serum iron, total iron-binding capacity, and serum ferritin. (msdmanuals.com)
- The amount of circulating iron bound to transferrin is reflected by the serum iron level. (medscape.com)
- Parenteral injection of iron dextran may result in high serum iron levels (eg, 500-1000 µg/dL) for several weeks. (medscape.com)
- When screening for hereditary hemochromatosis, serum iron, iron-binding capacity, and transferrin saturation may be helpful. (medscape.com)
Nanoparticle2
- Desk 1 Inhibitory price of Fe3O4-dextran-anti-HCG nanoparticle to JEG-3 cells 0.05) (Desk 2). (fabretp.org)
- An Accurin nanoparticle that binds to CD206 positive macrophages could be a valuable asset in the armament against multiple cancers and disease states. (businesswire.com)
Isolation1
- Some bacteria coproduce fructans, which can complicate isolation of the dextrans. (wikipedia.org)
Synthesis1
- Functional dextran-based hydrogels: synthesis and biomedical applications. (mpg.de)
Competes1
- FRMD8 competes with MDM2 to bind RB and attenuates MDM2-mediated RB degradation. (bvsalud.org)
TIBC2
- Total iron binding capacity (TIBC): indirect measurement of serum transferrin. (magistras.eu)
- The circulating transferrin is indirectly measured by the total iron-binding capacity (TIBC). (medscape.com)
Parenteral1
- Intravenous solutions with dextran function both as volume expanders and means of parenteral nutrition. (wikipedia.org)
Molecular5
- Dextrans are available in multiple molecular weights ranging from 3 kDa to 2 MDa. (wikipedia.org)
- Native dextran has been found to have a molecular weight (MW) in the range of 9 million to 500 million. (sigmaaldrich.com)
- Porosity, binding affinity, size exclusion abilities, filtration abilities, concentration abilities and signal amplification abilities of a Molecular Net may be varied and depend on the nature of components used in its fabrication. (justia.com)
- Molecular docking in silico and SPR assays indicated that RUT interacted with kelch-like ECH-associated protein 1 (KEAP1), and extracellular incubation studies revealed that RUT bound to the KEAP1 kelch domain with a calculated equilibrium dissociation constant K d of 19.6 μM. (nih.gov)
- Molecular docking analysis revealed that PPI exhibited a higher binding affinity with GRP78. (bvsalud.org)
Fluorescent3
- fluorescent-labelled dextran can be used to visualize these endosomes under a microscope. (wikipedia.org)
- FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination. (sigmaaldrich.com)
- DAPI (diamidino-2-phenylindole) is a blue fluorescent probe that fluoresces brightly upon selectively binding to the minor groove of double stranded DNA, where its fluorescence is approximately 20-fold greater than in the nonbound state. (thermofisher.com)
Mice1
- Using stereomicroscopy and microscopic examination of plastic sections, dextran dyes dispersed in SNOT are demonstrated in the neuroepithelium of the nose and olfactory bulb of B6;129P2-Omp(tm3Mom)/MomJ mice after intranasal instillation in SNOT. (cdc.gov)
Vivo1
- In vivo, FITC-dextran is stable for more than 24 hours. (sigmaaldrich.com)
Increases1
- Dextran also increases blood sugar levels. (wikipedia.org)
Soluble1
- In conclusion, S. aureus adhesion on fibronectin-coated biomaterials can be efficiently blocked in vitro by soluble compounds such as dextran derivatives. (unige.ch)
Inhibition3
- 20%) adhesion inhibition at 1 mg/ml, dextrans increasingly substituted with carboxylic and benzylamide groups (CMBD) exhibited increasing anti-adhesive activities. (unige.ch)
- Another category of substituted dextrans having a variable proportion (2-26%) of sulfonated benzylamide groups (CMBDS) produced active inhibition of S. aureus adhesion. (unige.ch)
- In comparison to these heparin-like dextran derivatives, native heparin produced inhibition values of S. aureus adhesion which were intermediate between those of CMBD and CMBDS compounds. (unige.ch)
Affinity2
- For chemokines binding with high affinity to sugar residues, immobilization can even lead to the formation of stable solid phase gradients, which induce a variant of haptotaxis 9 . (nature.com)
- After having captured antigen in non-lymphoid tissues, DCs migrate along immobilized gradients of the high affinity sugar-binding chemokine (C-C motif) ligand21 (CCL21) towards lymphatic vessels, from where they are flushed into the sinus of lymph nodes. (nature.com)
Promoter1
- Mechanistically, chromatin immunoprecipitation (ChIP) assays indicated that the transcription factor TCF4 directly binds to the promoter region of ERLR and promotes its transcription. (stanford.edu)
Antibodies1
- The associators, such as aptamers or antibodies, bind their targets, when such targets are present in a fluid sample from a pregnant woman, to produce a detectable signal. (justia.com)
Heparin1
- METHODS: Twenty patients undergoing endovascular stenting for abdominal aortic aneurysm were randomized to receive 100 mL of 10% dextran-40 or saline, over 1 hour, during their operation in addition to heparin. (reading.ac.uk)
Porosity1
- FITC-dextran has been used to study plant cell wall porosity and capillary permeability. (sigmaaldrich.com)
Covalently1
- The sample was manufactured to be 5 nm wide and up to 200 m long, with ~50% purity covalently bound with hexagonal boron nitride (hBN) in the sample. (cdc.gov)
Ligand1
- Additional reported applications (for the relevant formats) include: blocking of ligand binding 1-3 , immunohistochemical staining of paraformaldehyde fixed frozen sections 13 , and spatial biology (IBEX) 15,16 . (biolegend.com)
Lengths1
- Dextran chains are of varying lengths (from 3 to 2000 kilodaltons). (wikipedia.org)
Proteins1
- Plasma proteins have been shown not to bind to FITC-dextran. (sigmaaldrich.com)
Functional1
- 05). The postoperative level of functional VWF was significantly lower in the dextran-treated group vs controls. (reading.ac.uk)
Antigen1
- Prostate Specific Antigen Biosensor Based on Long Range Surface Plasmon-Enhanced Fluorescence Spectroscopy and Dextran Hydrogel Binding Matrix. (mpg.de)
Suggests1
- Transferrin saturation in excess of 50% suggests a disproportionate amount of iron bound to transferrin is being delivered to nonerythroid tissues. (medscape.com)
Bacteria2
- Dextran was discovered by Louis Pasteur as a microbial product in wine, but mass production was only possible after the development by Allene Jeanes of a process using bacteria. (wikipedia.org)
- Furthermore, the anti-adhesive activity was still expressed when substituted dextrans were preincubated with fibronectin-coated PMMA but washed away at the time when radiolabeled bacteria were added to the adhesion assay. (unige.ch)
Therapeutic2
- We are pleased to work with BIND Therapeutics to explore the therapeutic potential of our two complementary technology platforms," said Michael M. Goldberg, M.D., CEO of Macrophage Therapeutics and Director of Navidea. (businesswire.com)
- The proven antithrombotic efficacy of low-dose dextran in carotid surgery may be applicable to wider therapeutic use. (reading.ac.uk)
Exhibit3
- Lower MW dextrans will exhibit slightly less branching and have a more narrow range of MW distribution. (sigmaaldrich.com)
- Dextrans with MW of 2,000 to 10,000, exhibit the properties of an expandable coil. (sigmaaldrich.com)
- We screened the potential anti-adhesive properties of a group of substituted dextrans, previously shown to exhibit potent anticoagulant and anticomplementary activities. (unige.ch)
Immobilization1
- Dextran has been used as an immobilization agent in biosensors. (wikipedia.org)
Iron2
- and in certain intravenous fluids to solubilize other factors, such as iron (in a solution known as Iron Dextran). (wikipedia.org)
- The iron-binding capacity is increased. (medscape.com)
Protein1
- ERLR mediates EMT by directly binding to MYH9 protein and increasing its stability. (stanford.edu)
Gene1
- Finally, using TR-FRET binding assay and gene expression analysis, we demonstrated that the C18-3OH is an agonist of peroxisome proliferator activated receptor gamma. (bmj.com)
Typically1
- Sigma typically tests the solubility of FITC dextrans in water at concentrations at or above 25 mg/ml. (sigmaaldrich.com)
Chemical1
- Through chemical modification of dextran, the primary amino group (-NH 2 ) are joined to the magnetic beads through a short hydrophilic linker. (gbiosciences.com)
Blood2
- The hemodilution caused by volume expansion with dextran use improves blood flow, thus further improving patency of microanastomoses and reducing thrombosis. (wikipedia.org)
- The larger dextrans (>60,000 Da) are excreted poorly from the kidney, so remain in the blood for as long as weeks until they are metabolized. (wikipedia.org)
Effects2
- This indicates that the anti-adhesive effects of CMBDS could be exerted at the level of the S. aureus binding site of fibronectin. (unige.ch)
- Dextrans are thought to have antithrombotic and antiplatelet effects. (reading.ac.uk)
Applications1
- Dextran has also been used in bead form to aid in bioreactor applications. (wikipedia.org)
Greater1
- Dextrans with MW greater than 10,000 behave as if they are highly branched. (sigmaaldrich.com)
Cell2
- FITC-dextran is used extensively in microcirculation and cell permeability research utilizing microfluorimetry. (sigmaaldrich.com)
- Photocrosslinkable dextran hydrogel films as substrates for osteoblast and endothelial cell growth. (mpg.de)
Administration1
- Still, no difference has been detected in antithrombotic effectiveness in comparison of intra-arterial and intravenous administration of dextran. (wikipedia.org)
Water1
- It forms a viscous gum on binding with water. (pharmacy180.com)
Volume1
- Already at a dextran volume fraction of 14%, we find a 30-fold increase of the decamer population and 5105-fold increase of the association constant. (lu.se)
Agent1
- It is also used as binding and granulating agent for tablets and as a vehicle for drugs such as penicillin, cortisone, procaine, and insu-lin to delay their absorption and prolong their action. (pharmacy180.com)
Shown1
- Heparan sulfate has been shown to be a component of every brain amyloid, and interestingly, the amyloid binding dye CR, a known amyloid stain, is among the most effective anti prion agents. (europa.eu)