Bound fas ligand protein. Medical search. Frequent questions

Fas ligand (FasL or CD95L or CD178) is a type-II transmembrane protein expressed on cytotoxic T lymphocytes and natural killer (NK) cells. (wikipedia.org)
Fas ligand or FasL is a homotrimeric type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. (wikipedia.org)
Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external matrix metalloproteinase MMP-7. (wikipedia.org)
DcR3: Decoy receptor 3 (DcR3) is a recently discovered decoy receptor of the tumor necrosis factor superfamily that binds to FasL, LIGHT, and TL1A. (wikipedia.org)
DcR3 is a soluble receptor that has no signal transduction capabilities (hence a "decoy") and functions to prevent FasR-FasL interactions by competitively binding to membrane-bound Fas ligand and rendering them inactive. (wikipedia.org)
Soluble FasL is less active than its membrane-bound counterpart and does not induce receptor trimerization and DISC formation. (wikipedia.org)
Inhibitory peptides and fragments of TSP1 bind to CD36, leading to the expression of FAS ligand (FasL), which activates the expression of Fas. (dadamo.com)
Its ligand (FasL), a member of the tumor necrosis factor (TNF) family, which includes two forms of a membrane-bound form and a soluble one, induces apoptosis of Fas-bearing cells through cytotoxic activity. (iomcworld.com)
Fas/FasL) that results in caspase-dependent apoptosis. (frontiersin.org)
The extrinsic pathway is mediated by a variety of death receptor ligands, including tumor necrosis factor (TNF) and Fas ligand (FaSL), that trigger apoptosis by binding to cell surface receptors. (cdc.gov)
whereas the other, death receptor pathway, involves the binding of a death ligand, such as Fas ligand (FasL), to Fas resulting in activation of caspase-8. (ac.ir)
Fas/APO-1/CD95, member of the tumor necrosis factor (TNF) receptor superfamily, is a widely expressed cell surface receptor that can initiate apoptosis when activated by its ligand (FasL). (ac.ir)
Death ligands are mainly members of the tumour necrosis factor (TNF) family, of which FasL is an important member. (bvsalud.org)
BACKGROUND: Fas ligand (FasL) is expressed by activated T cells and induces death in target cells upon binding to Fas. (bvsalud.org)
In contrast, heterozygous variants affected FasL function by reducing expression, impairing trimerization, or preventing Fas binding. (bvsalud.org)
The mammalian extrinsic apoptosis pathway is triggered by Fas ligand (FasL) and Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL). (deathbase.org)
In addition, oestradiol down-regulated the expression of Fas ligand (FasL) in activated SLE T cells at the both protein and mRNA levels. (elsevierpure.com)
The inhibitory effect of oestradiol on FasL expression was mediated through binding to its receptor, as co-treatment of tamoxifen, an oestrogen receptor inhibitor, completely nullified the oestradiol-induced decrease in FasL mRNA expression. (elsevierpure.com)
Moreover, pre-treatment of FasL-transfected L5178Y cells with either oestradiol or anti-FasL antibody inhibited significantly the apoptosis of Fas-sensitive Hela cells when two types of cells were co-cultured. (elsevierpure.com)
Among TNF family members, DcR3 was shown to bind with Fas ligand (FasL) and LIGHT and inhibit FasL- and LIGHT-induced apoptosis. (bio-techne.com)
Furthermore, Akt regulates cell success by phosphorylating forkhead the individual rhabdomyosarcoma transcription aspect to inhibit the translation of preapoptotic genes, such as for example cell loss of life Bcl-2 antagonist (Poor), Bcl-2-interacting cell loss of life mediator (BIM), and Fas ligands (FasL). (portefeuillessac.com)

Fas induces apoptosis by recruiting proteins that form the death inducing signaling complex DISC. (dtic.mil)
Similar to TNF and Fas ligand, TRAIL induces apoptosis and NF-κB activation in many tissues and cells. (il-10.com)

Their function is regulated by the activation of a number of activating and inhibitory receptors that bind to specific ligands expressed on the surface of target cells. (frontiersin.org)
The signaling events initiated by the binding of peptide-MHC complexes to T cell receptors (signal 1). (nih.gov)
The exogenous pathway mediated by death receptors and death ligands is a very important pathway for cell apoptosis. (bvsalud.org)
This selection removes the T or B cell clones before they attain maturation if they possess receptors that recognize self-antigens and bind to them with strong affinity. (tutorialspoint.com)
It is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. (il-10.com)
Its receptors include the death domain containing proteins DR4 and DR5, both of which mediate TRAIL induced cell death. (il-10.com)
These ligands and their receptors are involved in the development of autoimmune diseases as well as cancer. (toll-likereceptors.com)
Ligand binding to cognate receptors activates initiator caspases directly in a death-inducing signaling complex. (deathbase.org)
Studies with three Apo2L/TRAIL homologs demonstrated that they bind the receptors zHDR (previously linked to hematopoiesis) and ovarian TNFR (zOTR). (deathbase.org)
The phosphorylation of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] forms phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] via growth factor G and receptors protein-coupled receptors. (portefeuillessac.com)
During vesiculation, bioactive lipids and receptors re- main associated with vesicle membranes, and cytosolic proteins and nucleic acids are contained within the vesicles [11]. (unicyte.ch)

Some reports have suggested that the extrinsic Fas pathway is sufficient to induce complete apoptosis in certain cell types through DISC assembly and subsequent caspase-8 activation. (wikipedia.org)
In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
It has been shown that the Fas pathway is functional in cardiac myocytes and plays a critical role in myocardial death due to ischemia-reperfusion in vivo [ 4 ]. (ac.ir)
In lpr mice, a naturally occurring mutant deficient in Fas, there is marked reduction in infarct size and abundance of apoptotic cardiac myocytes following ischemia and reperfusion that also signifies the importance of Fas pathway in ischemia-reperfusion injury [ 5 ]. (ac.ir)
and the intrinsic pathway, which is activated by cellular stress and is regulated primarily at the level of mitochondria by the Bcl-2 family of proteins ( Fig. 1 ). (biologists.com)
The intrinsic apoptotic pathway is initiated in response to a variety of stress signals ( Willis and Adams, 2005 ), and a complex interplay of Bcl-2 proteins relays this signal to the mitochondrial outer membrane (OM) to initiate Bak and Bax activation, oligomerisation and OM damage ( Fig. 1 ). (biologists.com)
However, in certain cell types, the extrinsic pathway also induces mitochondrial damage by cleaving the pro-apoptotic Bcl-2 family protein Bid to its activated truncated form (tBid), which leads to Bak and Bax activation. (biologists.com)
Similar to course I PI3Ks, Vps34 can control cell development by regulating the mammalian rapamycin complicated 1 (mTORC1)/ribosomal proteins S6 kinase 1 (S6K1) pathway, which regulates proteins synthesis in response to amino acidity availability. (portefeuillessac.com)
Furthermore to Akt, effectors downstream of PI3K consist of Ras-related C3 botulinum toxin substrate 1 (Rac1) and Proteins kinase C (PKC), but of the numerous of PI3K signaling pathways, the PI3K/Akt pathway is most linked to atherosclerosis. (portefeuillessac.com)

A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS . (online-medical-dictionary.org)
1987 ). This superfamily of proteases is defined by the presence of a Zn 2+ ion at the catalytic center, which is coordinated by three histidine residues in the zinc-binding consensus sequence HExxHxxGxxH that is present in all proteolytically active metzincins, and a characteristic, strictly conserved methionine-containing tight 1,4 beta turn forming a hydrophobic cleft for the catalytic zinc ion (Bode et al. (evelinvahter.com)

FLIP, Fas-associated death domain-like interleukin-1β converting enzyme-like inhibitory protein. (cdc.gov)
Under conditions that sensitize the cell to death, a cell death-inducing complex of RIPK1, Fas-associated protein via death domain (FADD), caspase-8, and cellular FLICE-like inhibitory protein (cFLIP) is formed. (bioradiations.com)

Fas forms the death-inducing signaling complex (DISC) upon ligand binding. (wikipedia.org)
Interestingly, breast cancer cells often highly express the Fas CD95APO-1 receptor, which is well established as an activator of apoptosis programmed cell death upon ligand binding. (dtic.mil)

The expression of B7 proteins on an antigen-presenting cell is induced by pathogens during the innate response to an infection. (nih.gov)
Effector T cells act back to promote the expression of B7 proteins on antigen-presenting cells, creating a positive feedback loop that amplifies the T cell response. (nih.gov)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. (tgf-a.com)
Although the lupus band appears to colocalize with type VII collagen, the noncollagenous-1 (NC1) domain of this protein does not represent the target antigen for circulating antibodies in systemic lupus erythematosus patients without clinical blistering. (medscape.com)
TNFRFSF6/Fas-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T cells, or both. (lu.se)

Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
Membrane rupture leads to the spilling of intracellular content into the organ and the release of damage-associated molecular patterns (DAMPs), such as interleukin (IL)-1α, IL-β, IL-33, and high-mobility group protein 1, into the extracellular space. (bioradiations.com)
Both of these proteins contain an extracellular TRAIL binding domain but lack intracellular signaling domains. (il-10.com)
Selective compounds have been developed that target either the extracellular ligand-binding region of the EGFR (including a number of monoclonal antibodies [MAbs], immunotoxins, and ligand-binding cytotoxic agents) or the intracellular tyrosine kinase region (including various small-molecule inhibitors). (medscape.com)
In this study, we compared how different signaling pathways determine extracellular nucleotide pools in control Jurkat cells versus Jurkat lines that lack the Fas-associated death domain (FADD) or receptor-interacting protein kinase 1 (RIP1) cell death regulatory proteins. (aspetjournals.org)

Necroptosis is a programmed form of necrotic cell death that is dependent on activation of receptor interacting protein kinase-3 (RIPK3) and occurs when caspase activation is insufficient or blocked. (bioradiations.com)

This allows the adaptor molecule Fas-associated death domain (FADD) to bind the death domain of Fas through its own death domain. (wikipedia.org)
FADD also contains a death effector domain (DED) near its amino terminus, which facilitates binding to the DED of FADD-like ICE (FLICE), more commonly referred to as caspase-8. (wikipedia.org)

Thrombospondins (TSP) are secreted proteins with the ability to inhibit angiogenesis. (dadamo.com)
Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells. (bio-techne.com)

RÉSUMÉ L'objectif de l'étude était d'évaler l'importance clinique du ligand de CD40 soluble (sCD40L) chez des patients atteints d'un carcinome hépatocellulaire (CHC) associé au virus de l'hépatite C (VHC). (who.int)

Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates based on a conserved mechanism involving activation of an active site-bound water molecule by a Zn 2+ ion. (evelinvahter.com)
1993 ). Catalysis of protein substrates is (most probably) carried out via a general base mechanism involving activation of a zinc-bound water molecule by the carboxylate group of the conserved glutamate residue in the catalytic pocket followed by attack of water on the polarized carbonyl group in the substrate's scissile bond (Browner et al. (evelinvahter.com)
At the heart of the pathogenesis of lymphedema lies the appearance of chronic high-protein edema, characterized by the pathological accumulation of intercellular fluid with large-molecule proteins in the interstitial space due to a defect in lymphatic drainage caused by congenital malformation (primary lymphedema), lymphatic obstruction or by the destruction of lymphatic vessels (secondary lymphedema). (biomedcentral.com)
In addition, this molecule was capable of transmitting apoptotic signals mediated through not only Fas but also the TNF receptor in mouse Casp8-deficient cells. (deathbase.org)
Thus, in addition to DcR1, DcR2 and OPG, DcR3 is another TNFR family molecule which modulates ligands that induce apoptosis. (bio-techne.com)
We recently reported that a key step leading to Bak homo-oligomerisation following an apoptotic stimulus involves transient exposure of the Bak BH3 domain before it binds to the hydrophobic groove of another activated Bak molecule to form a novel symmetric dimer. (biologists.com)

Like osteoprotegerin (OPG), DcR3 lacks a transmembrane sequence and is a secreted protein. (bio-techne.com)
Binding to the decoy receptor TNFRSF6b/dcr3 modulates its effects. (lu.se)

Additionally the Fas receptor has recently been shown to activate the nonapoptotic NF- B and MAP kinase pathways upon receptor stimulation in either Type I or Type II cells. (dtic.mil)
Phosphorylation of RIPK3 leads to recruitment and subsequent phosphorylation of mixed lineage kinase domain-like protein (MLKL), which translocates to intracellular and plasma membranes and induces membrane permeabilization and rupture, either through calcium or sodium influx through ion channels or direct binding to membrane phosphatidylinositol phosphates (this is still controversial among experts). (bioradiations.com)
PI3K and its own Downstream Effectors AKT, referred to as proteins kinase B (PKB), may be the primary effector that's downstream of PI3K. (portefeuillessac.com)
PIP3 is normally another messenger that activates downstream protein, being among the most essential of which is normally phosphoinositide-dependent proteins kinase-1 (PDK1), which handles the activation of PKB/AKT indication transduction. (portefeuillessac.com)
Activated Akt activates or inhibits the downstream focus on proteins Poor, Caspase9, nuclear factor-kappa B (NF- B), and glycogen synthase kinase-3 (GSK3) through phosphorylation, regulating cell proliferation thus, differentiation, migration and apoptosis. (portefeuillessac.com)
Previously, we have shown in a mouse model that exposure to hog dust extract (HDE) collected from a CAFO results in the activation of protein kinase C (PKC), elevated lavage fluid cytokines/chemokines including interleukin-6 (IL-6), and the development of significant lung pathology. (cdc.gov)

Evidence for crosstalk between the extrinsic and intrinsic pathways exists in the Fas signal cascade. (wikipedia.org)
Consequently dimerization of Fas complexes does not induce internalization of Fas nor apoptosis but is sufficient to induce nonapoptotic-signaling pathways and increases motility and invasiveness of tumor cells. (dtic.mil)
In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. (kamiyabio.com)
NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. (tgf-a.com)
Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)

Upregulation of Fas expression in myocardial ischemia-reperfusion can induce cardiomyocyte apoptosis, and atorvastatin can significantly inhibit cardiomyocyte apoptosis by inhibiting Fas expression. (ac.ir)
In contrast, inflammatory pathologies, such as multiple sclerosis, myocardial ischemia-reperfusion injury, inflammatory bowel disease, and chronic obstructive pulmonary disease, are associated with elevated expression of necroptotic signaling proteins. (bioradiations.com)

In Drosophila, TNF ligand binding activates initiator caspases indirectly, through JNK. (deathbase.org)

BH-3 only members of the Bcl-2 family engage exclusively anti-apoptotic members of the family (Bcl-2, Bcl-xL), allowing Bak and Bax to translocate to the outer mitochondrial membrane, thus permeabilizing it and facilitating release of pro-apoptotic proteins such as cytochrome c and Smac/DIABLO, an antagonist of inhibitors of apoptosis proteins (IAPs). (wikipedia.org)

NFPs are mainly found in bacteria where formyl modified methionine initiates protein synthesis [ 7 ]. (nature.com)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)

T cells are initially resistant to Fas-mediated apoptosis during clonal expansion, but become progressively more sensitive the longer they are activated, ultimately resulting in activation-induced cell death (AICD). (wikipedia.org)

Apoptosis-inducing Fas receptor is dubbed isoform 1 and is a type 1 transmembrane protein. (wikipedia.org)

With the overexpression of the recombinant protein pcDNA3 1- ChFasL, the activity of p53 and p21 significantly increased, showing a positive regulatory effect. (bvsalud.org)

BRDs can act as scaffolds that enable the recruitment of large protein complexes or they can act as transcription factors themselves. (frontiersin.org)

Humans and mice with deleterious mutations of Fas or Fas ligand develop an accumulation of aberrant T-cells, leading to lymphadenopathy, splenomegaly, and lupus erythematosus. (wikipedia.org)
Loss-of-function FAS or FASLG mutations cause autoimmune-lymphoproliferative syndrome (ALPS) characterized by expanded double-negative T cells (DNT) and elevated serum biomarkers. (bvsalud.org)
While most ALPS patients carry heterozygous FAS mutations, FASLG mutations are rare and usually biallelic. (bvsalud.org)

Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. (wikipedia.org)

10] The cartilage matrix protein (CMP) subdomain of the NC1 domain has been shown to bind to antibodies from patients with epidermolysis bullosa acquisita and systemic lupus erythematosus, suggesting this subdomain serves as an immunodominant antigenic epitope. (medscape.com)

It is associated with a complex of invariant transmembrane proteins called CD3 , which transduces the binding of the peptide- MHC complex into intracellular signals ( Figure 24-63 ). (nih.gov)

Bromodomains are proteins that contain modules of ~110 amino acids that recognize and bind acetylated lysine residues in histones and other proteins. (frontiersin.org)
I am trying to stabilize a protein-protein interface by using charged residues at the periphery. (rosettacommons.org)

Its functions include: T-cell homeostasis: the activation of T-cells leads to their expression of the Fas ligand. (wikipedia.org)
Additionally, BRDs contain several catalytic domains that enable them to act as methyltransferases, ATP-dependent re-modellers or histone acetyltransferases and helicases ( 8 ) Bromodomain and extra-terminal domain (BET) proteins are a family of transcriptional mediators that regulate gene expression ( 8 , 9 ). (frontiersin.org)
Inhibition of Fas expression prevents I/R induced apoptosis. (ac.ir)
However, the influence of atorvastatin on Fas expression in I/R injury was not studied. (ac.ir)
Therefore, we designed this study to see the influence of atorvastatin on cardiomyocyte apoptosis and Fas expression following acute I/R in vivo. (ac.ir)
To detect the expression of Fas in the cardiomyocytes, immunohistochemistry method was used. (ac.ir)
Fas expression was significantly higher in the ischemia-reperfusion group as compared to sham-operated group, but was decreased significantly in atorvastatin treated group as compared with I/R group. (ac.ir)
We evaluated a next generation therapeutic peptide, HTL-001, capable of targeting HOX gene over-expression in GBM by disrupting the interaction between HOX proteins and their co-factor, PBX. (biomedcentral.com)
Several cancers, including breast and ovarian cancers, melanoma, and leukemia, are characterized by low expression and activity of necroptotic signaling proteins. (bioradiations.com)
The expression position of ChFasL in HEK293T cells was also located by subcellular localization, and the effect of increased recombinant protein content on the activity of reporter genes p53 and p21 was studied by dual-fluorescence reporter gene. (bvsalud.org)
P. gingivalis HSP60 at a concentration of 10 ng/l significantly decreased the expression levels of VE‑cadherin and eNOS protein at 24 h stimulation, whereas no difference in these proteins was identified following a low dose of P. gingivalis HSP60 (1 ng/l). (spandidos-publications.com)
P. gingivalis HSP60 at 100 ng/l significantly downregulated the expression levels of VE‑cadherin and eNOS protein at 12 h in HUVECs. (spandidos-publications.com)
Ectopic expression of these ligands during embryogenesis induced apoptosis in erythroblasts and notochord cells. (deathbase.org)
C1QBP promoted the mRNA and protein expression of hypoxanthine catabolic enzyme XDH. (medsci.org)
C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)
Real-time PCR and Western blot analyses were used to evaluate gene and protein expression levels. (wjgnet.com)
It is a defect in the expression of ligands for selectins due to lack of enzymes required for expression of selectin ligands. (medscape.com)

Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. (wikipedia.org)
Complement component 1 Q subcomponent binding protein (C1QBP) plays a vital role in the progression and metabolism of cancer. (medsci.org)

KSHV is a herpesvirus , and is a large double-stranded DNA virus with a protein covering that packages its nucleic acids, called the virion , which is then surrounded by an amorphous protein layer called the tegument , and finally enclosed in a lipid envelope derived in part from the cell membrane. (wikidoc.org)

Cytokine that binds to TNFRSF6/Fas, a receptor that transduces the apoptotic signal into cells. (lu.se)

This event is also mimicked by binding of an agonistic Fas antibody, though some evidence suggests that the apoptotic signal induced by the antibody is unreliable in the study of Fas signaling. (wikipedia.org)

Inhibition of zHDR, zOTR, the adaptor zFADD, or caspase-8-like proteases blocked ligand-induced apoptosis, as did antiapoptotic Bcl-2 family members. (deathbase.org)

Another (useful if you're looking at protein-ligand and protein-DNA binding) is to turn off protein-protein hack_elec interactions. (rosettacommons.org)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

Type I cells form large amounts of the DISC and internalize Fas, whereas in Type II cells Fas does not internalize and the DISC is almost undetectable. (dtic.mil)

These cells are dubbed Type 1 cells and are characterized by the inability of anti-apoptotic members of the Bcl-2 family (namely Bcl-2 and Bcl-xL) to protect from Fas-mediated apoptosis. (wikipedia.org)
Unlike necrosis, an unregulated form of cell death caused by external physicochemical stress, necroptosis is highly regulated and acts as a defense mechanism or escape route for cells infected with viruses that inhibit apoptosis signaling proteins (examples of these viruses include the murine cytomegalovirus, West Nile virus, human immunodeficiency virus-1 (HIV-1), and herpes simplex virus). (bioradiations.com)
The aim of the present study was to identify whether P. gingivalis heat‑shock protein 60 (HSP60) induced the dysfunction of human umbilical vein endothelial cells (HUVECs) in vitro. (spandidos-publications.com)
For cells, cell lines and tissues in culture till half confluency.Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (tgf-a.com)
This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)

Signal 2 is provided by costimulatory proteins, especially the B7 proteins (CD80 and CD86), which are recognized by the co-receptor protein CD28 on the surface of the T cell. (nih.gov)

Its binding with Fas receptor (FasR) induces programmed cell death in the FasR-carrying target cell. (wikipedia.org)
FasR: The Fas receptor (FasR), or CD95, is the most intensely studied member of the death receptor family. (wikipedia.org)
Apoptosis is a genetically programmed form of cell death that is mediated by the activation of the caspase cascade and results in the cleavage of protein substrates and oligonucleosomal fragmentation of DNA. (ac.ir)
It was shown that functional Fas system contributes to apoptotic myocardial cell death in response to ischemia/reperfusion injury [ 4 , 5 ]. (ac.ir)
Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
TNFα binds to TNFR1 on the plasma membrane, which leads to recruitment of TNF receptor-associated death domain (TRADD) and, in turn, RIPK1. (bioradiations.com)

Although the catalytic domain of MMPs is structurally highly similar, there are many differences with respect to substrate specificity, cellular and tissue localization, membrane binding and regulation that make this a very versatile family of enzymes with a multitude of physiological functions, many of which are still not fully understood. (evelinvahter.com)

Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. (wikipedia.org)
It plays an important role in immune homeostasis and cell -mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS . (online-medical-dictionary.org)
Both proteins stimulate B cell proliferation, humoral immune responses, NF-κB activation, and apoptosis. (toll-likereceptors.com)

Disturbance of drainage function of lymphatic vessels leads to accumulation of fluid rich in proteins under the epidermis. (biomedcentral.com)

Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (bio-techne.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (bio-techne.com)

This peptide-MHC complex signals through the T cell receptor and its associated proteins. (nih.gov)

Fas is type I membrane protein, expressed on various tissue including hematopoietic cell. (iomcworld.com)
Long existence of the high-protein edema causes chronic inflammation leading to the replacement of adipose tissue with connective tissue, increasing the volume of connective tissue matrix, which subsequently leads not only to an increase in size of body parts, but also to a secondary disturbance of lymphatic transport and drainage [ 2 ]. (biomedcentral.com)

Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)

The thrombospondins (TSP) are a family of multifunctional proteins. (dadamo.com)
The family consists of thrombospondins 1-5 and can be divided into 2 subgroups: A, which contains TSP-1 and -2, and B, which contains TSP-3, -4 and -5 (also designated cartilage oligomeric protein or COMP). (dadamo.com)
In this Commentary, we discuss the implications of these findings for the regulation of apoptosis by Bcl-2 family proteins. (biologists.com)
The current development of anti-cancer agents that target the Bcl-2 protein family is showing considerable promise, although how this targeting triggers Bak and Bax to perform their crucial function of mitochondrial outer membrane permeabilisation (MOMP) is not clear. (biologists.com)
1994). High-res- belongs to the family of intracellular lipid bind- olution crystal structures (Sacchetti ni et al. (lu.se)

Anatomy2

Diseases2

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

FasL21

Induces apoptosis2

Receptors11

Pathway9

Superfamily2

Inhibitory protein2

Upon ligand2

Antigen6

Extracellular5

Receptor-interacting pr1

FADD2

Ability to inhibit2

Soluble1

Molecule6

DcR32

Kinase6

Pathways6

Myocardial ischemia-reperfusion2

Activates1

Apoptosis proteins1

Synthesis2

Resistant1

Transmembrane protein1

Overexpression1

Complexes1

Mutations3

Trimerization1

Shown to bind1

Intracellular signals1

Residues2

Expression17

Progression2

Nucleic acids1

Transduces1

Apoptotic signal1

Adaptor1

Interactions2

Undetectable1

Cells5

CD801

Death7

Localization1

Immune3

Accumulation1

Recombinant protein2

Signals1

Tissue2

Patients1

Family5