Human transferrin is encoded by the TF gene and produced as a 76 kDa glycoprotein. (wikipedia.org)
Lactoferrin (Lf) is an 80-kDa glycoprotein that belongs to the transferrin family and is abundant in the colostrum and milk of mammals. (springer.com)
A glycoprotein albumin from hen's egg white with strong iron-binding affinity. (lookformedical.com)
Ferric ions1
Serum transferrin binds ferric ions in the bloodstream and transports them to cells, where they are released in a process involving receptor-mediated endocytosis. (rcsb.org)
To help define the steps in iron release, we have determined the three-dimensional structure of the iron-free (apo) form of the recombinant N-lobe half-molecule of human serum transferrin (ApoTfN) by X-ray crystallography. (rcsb.org)
Mice bearing LC-06-JCK were administered rat anti-mouse IL-6 receptor antibody MR16-1 and their serum hepcidin levels and hematological parameters were determined. (biomedcentral.com)
Endocytosis1
When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell, e.g., erythroid precursors in the bone marrow, it binds to it and is transported into the cell in a vesicle by receptor-mediated endocytosis. (wikipedia.org)
Protein6
An increased plasma transferrin level is often seen in patients with iron deficiency anemia, during pregnancy, and with the use of oral contraceptives, reflecting an increase in transferrin protein expression. (wikipedia.org)
Kada transferinski protein napunjen gvožđem naiđe na transferinski receptor na površini ćelije , npr. (wikipedia.org)
The current taxonomic entity of FPV shares with CPV (Tattersall, 2006) wherein after crossing species barriers, CPVs evolved from FPV by acquiring five or six amino acid changes in the capsid protein gene (Truyen, 1999) (Appel, Scott et al. (bioguardlabs.com)
In particular, two ironligands, Asp 63 and His 249, change conformation to form salt bridges, with Lys 296 and Glu 83, respectively, in the binding cleft of the apo protein. (rcsb.org)
The results of recently conducted clinical trials suggest that lactoferrin, an iron-binding protein that is abundant in mammalian colostrum and milk, may be an effective agent in preventing sepsis in newborns. (springer.com)
Hits common to both data sets indicate disrupted cellular metabolism, calcium signaling, protein stability, DNA binding, and cytoskeletal cell structure. (biomedcentral.com)
Uptake2
The receptor with its ligand bound transferrin is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. (wikipedia.org)
Upon Fe3+ uptake, transferrins undergo a large scale conformational transition: the apo structure with an opening of the interdomain cleft is transformed into the closed holo structure, implying initial Fe3+ binding in the open form. (lookformedical.com)
Transferrins are not limited to only binding to iron but also to different metal ions. (wikipedia.org)
The pH of the vesicle is reduced by hydrogen ion pumps (H+ ATPases) to about 5.5, causing transferrin to release its iron ions. (wikipedia.org)
Proteins2
Some invertebrates have proteins that act like transferrin found in the hemolymph. (wikipedia.org)
CDKs are cyclin-dependent serine-/threonine-specific proteins kinases, the experience of which depends upon cyclin binding. (niepokorny.org)
Secretion2
A major source of transferrin secretion in the brain is the choroid plexus in the ventricular system. (wikipedia.org)
A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
Lactoferrin1
Lactoferrin that was not bound to its cognate receptor was able to bind and neutralize lipopolysaccharide. (springer.com)
Decreases3
The affinity of transferrin for Fe(III) is extremely high (association constant is 1020 M−1 at pH 7.4) but decreases progressively with decreasing pH below neutrality. (wikipedia.org)
Transferrin glycoproteins bind iron tightly, but reversibly. (wikipedia.org)
Transmembrane1
IL-6 exerts various biological activities on responding cell populations through its binding to transmembrane IL-6 receptor as well as to soluble IL-6 receptor. (biomedcentral.com)
Residues2
Predicated on series evaluation and a 3D style of pUL97, the viral kinase displays structural similarity to CDK2 in the catalytic middle and in functionally essential residues from the ATP binding site [16]. (niepokorny.org)
Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this domain, termed 'Site #1', can also bind additional LRRK2 substrates, Rab8A and Rab10. (stanford.edu)
Steroid1
In addition, calcitriol has rapid effects that are independent of gene transcription regulation, which are defined as non-genomic effects and not mediated directly through steroid receptor-ligand-DNA interaction. (jcancer.org)
Anion2
For the iron ion to bind, an anion is required, preferably carbonate (CO2− 3). (wikipedia.org)
There is, however, no clear interaction between the nitrilotriacetate anion and the synergistic anion binding site, Arg121. (lookformedical.com)
Pathways1
In genomic pathways, calcitriol binds to intracellular vitamin D receptor (VDR), which subsequently heterodimerizes with another nuclear receptor retinoid X receptor (RXR). (jcancer.org)
The main role of transferrin is to deliver iron from absorption centers in the duodenum and white blood cell macrophages to all tissues. (wikipedia.org)
The heterodimer binds to vitamin D response element in target genes and leads to gene transcription regulation ( 1 ). (jcancer.org)
Genes1
Drosophila melanogaster has three transferrin genes and is highly divergent from all other model clades, Ciona intestinalis one, Danio rerio has three highly divergent from each other, as do Takifugu rubripes and Xenopus tropicalis and Gallus gallus, while Monodelphis domestica has two divergent orthologs, and Mus musculus has two relatively close and one more distant ortholog. (wikipedia.org)
Organs1
Brain capillaries also possess few fenestrae and few endocytic vesicles, compared with the capillaries of other organs ( Pardridge, 1999 ). (aspetjournals.org)
Cleft1
Comparison with the holo form (FeTfN) shows that a large rigid-body domain movement of 63 degrees has occurred in ApoTfN, to give an open binding cleft. (rcsb.org)
Amino1
In humans, transferrin consists of a polypeptide chain containing 679 amino acids and two carbohydrate chains. (wikipedia.org)
Concentrations1
The receptor helps maintain iron homeostasis in the cells by controlling iron concentrations. (wikipedia.org)
Liver1
liver can here bind characterized by either COMT or wide variety. (erik-mill.de)
Involves1
In the structure, both empty iron binding clefts are in the open conformation, lending weight to the theory that Fe(3+) binding or release in transferrin proceeds via a mechanism that involves domain opening and closure. (lookformedical.com)
Biological1
Transferrins are glycoproteins that are often found in biological fluids of vertebrates. (wikipedia.org)
Human2
Although both are similar in structure, TfR1 can only bind specifically to human TF where TfR2 also has the capability to interact with bovine TF. (wikipedia.org)
To clarify the hypothesis that overproduction of IL-6 elevates hepcidin levels and contributes to the development of cancer-related anemia, we evaluated anti-IL-6 receptor antibody treatment of cancer-related anemia in an IL-6-producing human lung cancer xenograft model. (biomedcentral.com)
Aprotinin transcytosis across bovine brain capillary endothelial cell (BBCEC) monolayers is at least 10-fold greater than that of holo-transferrin. (aspetjournals.org)
Transferrins are glycoproteins found in vertebrates which bind and consequently mediate the transport of iron (Fe) through blood plasma. (wikipedia.org)
Although iron bound to transferrin is less than 0.1% (4 mg) of total body iron, it forms the most vital iron pool with the highest rate of turnover (25 mg/24 h). (wikipedia.org)
The N- and C- terminal sequences are represented by globular lobes and between the two lobes is an iron-binding site. (wikipedia.org)
It enables ligand bonding to the transferrin, as each monomer can bind to one or two atoms of iron. (wikipedia.org)
It is found in the mucosa and binds iron, thus creating an environment low in free iron that impedes bacterial survival in a process called iron withholding. (wikipedia.org)
[18] The N- and C- terminal sequences are represented by globular lobes and between the two lobes is an iron-binding site. (wikipedia.org)
Domains1
The shape of a transferrin receptor resembles a butterfly based on the intersection of three clearly shaped domains. (wikipedia.org)
Alpha1
Myelinating OLs originate from parenchymal precursors expressing the neuron-glia antigen 2 (NG2) chondroitin sulphate proteoglycan and the platelet derived growth factor receptor alpha (PDGFRα), commonly referred to as oligodendrocyte progenitor cells (OPCs) 4 . (nature.com)
Found1
We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)