• syndrome
  • However, the discovery of loss-of-function mutations in genes of the telomerase complex (TERC, TERT) established a genetic etiology for telomere attrition in some patients with marrow failure who did not have the stigmata associated to an inherited bone marrow failure syndrome. (clinicaltrials.gov)
  • peripheral blood
  • In vitro studies suggest that telomere length could, in theory, be modulated with sex hormones.15 Exposure of normal peripheral blood lymphocytes and human bone marrow derived CD34+ cells to androgens increased telomerase activity in vitro and androgens increased low baseline telomerase activity in individuals carrying a loss-of-function TERT mutation to normal levels. (clinicaltrials.gov)
  • metastatic
  • citation needed] Currently, the most common cause is displacement of bone marrow by metastatic cancer (extramedullary hematopoiesis tends to be modest). (wikipedia.org)
  • aspirate
  • The aspirate yields semi-liquid bone marrow, which can be examined by a pathologist under a light microscope and analyzed by flow cytometry, chromosome analysis, or polymerase chain reaction (PCR). (wikipedia.org)
  • An aspirate needle is inserted through the skin using manual pressure and force until it abuts the bone. (wikipedia.org)
  • Once the needle is in the marrow cavity, a syringe is attached and used to aspirate ("suck out") liquid bone marrow. (wikipedia.org)
  • Clinical
  • Detection and analysis of autoantigens targeted by autoantibodies in immunorelated pancytopenia," Clinical and Developmental Immunology , vol. 2013, Article ID 297678, 7 pages, 2013. (hindawi.com)
  • This study suggests that the bone marrow pathology and clinical signs associated with BNP are related to an insult which compromises the pluripotential progenitor cell within the first 24 hours of life but that this does not initially include all cell types. (biomedcentral.com)
  • radiographic
  • Malignant infantile osteopetrosis, also known as infantile autosomal recessive osteopetrosis or simply infantile osteopetrosis is a rare osteosclerosing type of skeletal dysplasia that typically presents in infancy and is characterized by a unique radiographic appearance of generalized hyperostosis - excessive growth of bone. (wikipedia.org)
  • patients
  • Study on quantity and function of bone marrow macrophages in patients with BMMNC-Coombs Test(+) pancytopenia]," Zhonghua Xue Ye Xue Za Zhi , vol. 30, no. 8, pp. 538-542, 2009. (hindawi.com)
  • Quantity and apoptosis-related protein level of B lymphocyte in patients with immunorelated pancytopenia," Zhonghua Xue Ye Xue Za Zhi , vol. 23, no. 5, pp. 236-238, 2002. (hindawi.com)
  • Furthermore, our laboratory data (unpublished) shows that similar chromosome instability occurs in bone marrow cells of mutant patients, confirming the experimental data. (clinicaltrials.gov)
  • Patients treated with drugs compromising bone marrow function (e.g. cytostatics) should be treated carefully. (wikipedia.org)
  • causes
  • Such studies support the hypothesis that maternally derived colostral alloantibody targeting a bovine antigen (or antigens) causes the bone marrow pathology in calves. (biomedcentral.com)
  • blood cells
  • Intact females, if not mated, will remain in heat, and after some time the high levels of estrogen will cause the bone marrow to stop producing red blood cells. (wikipedia.org)
  • cells
  • H. He, Z. H. Shao, and R. Fu, "Hemocytopenia related to immunity detected by modified Coombs test for measuring autoantibody of bone marrow mononuclear cells," Blood , vol. 100, article 136b, 2002. (hindawi.com)
  • These cells descend from the primitive reticulum cells, which are found in the stroma of the marrow. (wikipedia.org)
  • involvement
  • This primary bone involvement helps to differentiate Eosinophilic Granuloma from other forms of Langerhans Cell Histiocytosis (Letterer-Siwe or Hand-Schüller-Christian variant. (wikipedia.org)