Bone marrow cell proliferation. Medical search. Frequent questions

Despite their crucial role as a link between innate and adaptive immunity, little is known about the modulation of pDC differentiation by other bone marrow (BM) cells. (nih.gov)
In this study, we investigated the modulation of pDC differentiation in Flt-3 ligand (Flt3L)-supplemented BM cultures, using highly purified mesenchymal stem cells (MSCs) that were FACS-isolated from murine BM based on surface marker expression and used after in vitro expansion. (nih.gov)
Bone marrow-derived hematopoietic and mesenchymal stem cells as targets for Histoplasma capulatum infection: implications for hematopoiesis, differentiation, and proliferation. (urosario.edu.co)
To determine whether the interaction of hematopoietic stem cells (HSCs) and bone marrow-derived mesenchymal stem cells (BMMSCs) with Histoplasma capsulatum affects hematopoiesis, differentiation and proliferation of these precursor cells. (urosario.edu.co)
BMMSCs) with Histoplasma capsulatum affects hematopoiesis, differentiation and proliferation of these precursor cells. (urosario.edu.co)
Stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, resulting in an increased production of platelets. (medscape.com)
Interacts with transmembrane domain of human TPO receptor and induces megakaryocyte proliferation and differentiation from bone marrow progenitor cells. (medscape.com)
Here we document the effects of specified PEMF parameters over mesenchymal stem cells (MSC) chondrogenic differentiation. (nature.com)
Mesenchymal stem cells (MSCs) support chondrogenic differentiation and are an attractive cell source for cartilage tissue engineering. (nature.com)
The protein produced from this gene is involved in regulating the growth and division (proliferation) and maturation (differentiation) of cells, particularly cells in the bone marrow that give rise to blood cells . (medlineplus.gov)
It is involved in cell differentiation, maintenance of cell differentiation state, tumorigenesis, and cell senescence, mainly through DNA methylation, histone acetylation, and RNA-related silencing [ 6 ]. (hindawi.com)
We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
Regeneration can occur in some simple glands by proliferation and differentiation of ductal cells. (iastate.edu)
Here are their technical properties: AECs have multipotent differentiation potential and expression of pluripotent stem cell specific transcription factors including Oct4 and Nanog. (parentsguidecordblood.org)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. (cancerindex.org)
There is clonal proliferation of malignant hematopoietic stem cells, dysregulated cellular differentiation, and compromised tissue function. (standardofcare.com)
Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation, differentiation, and immune regulation. (techscience.com)
While substantial progress has been made to delineate the developmental pathway of T-cell lineage commitment, still little is known about the relationship between differentiation competence and the remarkable expansion of the earliest (DN1 stage) T-cell progenitors. (lu.se)
To satisfy differentiation kinetics and overall cell yield data, our models require that adult DN1 cells divide multiple times before becoming competent to progress into DN2 stage. (lu.se)
Low-level laser therapy has been investigated as a possible stimulus for enhancement of proliferation and differentiation of various cell types, but few reports relate undifferentiated mouse pulp cells (OD-21) response to irradiation in in vitro models. (bvsalud.org)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
Osteocytes have recently been identified as a new regulator of bone remodeling, but the detailed mechanism of their differentiation from osteoblasts remains unclear. (lu.se)
The purpose of this study is to identify cell cycle regulators involved in the differentiation of osteoblasts into osteocytes and determine their physiological significance. (lu.se)
The study uses IDG-SW3 cells as a model for the differentiation from osteoblasts to osteocytes. (lu.se)
Among the major cyclin-dependent kinases (Cdks), Cdk1 is most abundantly expressed in IDG-SW3 cells, and its expression is down-regulated during differentiation into osteocytes. (lu.se)
Inhibition of CDK1 activity reduces IDG-SW3 cell proliferation and differentiation into osteocytes. (lu.se)
These results demonstrate that Cdk1 plays an essential role in the differentiation from osteoblast to osteocyte and the acquisition and maintenance of bone mass. (lu.se)
HQ reduced the proliferation and the differentiation and colony formation, but increased the apoptosis of both YS-HSCs and BM-HSCs. (cdc.gov)

It is also used to induce hypoxia-like environment in mesenchymal stem cells. (wikipedia.org)
The study also showed that the adult OCRs are distinct from mesenchymal stem cells (MSCs), which play a role in bone generation during development and adulthood. (sciencedaily.com)
Oct. 8, 2021 Researchers have identified a subpopulation of mesenchymal stem cells in the bone marrow that express the marker CD73. (sciencedaily.com)
Jan. 29, 2020 Scientists used molecular motors to manipulate the protein matrix on which bone marrow-derived mesenchymal stem cells are grown. (sciencedaily.com)
Mesenchymal Stem Cells (MSCs) have been successfully isolated from first-, second-, and third-trimester placental compartments, including the amnion, chorion, decidua parietalis and decidua basalis. (parentsguidecordblood.org)
BACKGROUND AND OBJECTIVES: Most studies in cardiac regeneration have explored bone marrow mesenchymal stem cells (BM-MSC) with variable therapeutic effects. (koreamed.org)
Immortalized murine pulp cells (OD-21)6 are considered as the major action mechanism of those lasers.11 undifferentiated mesenchymal stem cells derived from fetal Although this mechanism has not been fully clarified, the most molar papillae7. (bvsalud.org)

Previous exposure to chemotherapy drugs (eg, alkylating agents) - These agents may be used in the treatment of Hodgkin lymphoma , multiple myeloma , bone marrow transplant , ovarian cancer , breast cancer , and nonneoplastic disorders (eg, collagen-vascular disease ). (medscape.com)
People with multiple myeloma develop tumors in more than one location inside and sometimes outside of the bone marrow, hence the name 'multiple' myeloma. (lls.org)
Virtually all MM cases begin as the pre-malignant plasma cell disorders monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM) and usually neither of them presents with symptoms. (lls.org)
One of the more recent approvals for MM came July 2019, when Xpovio (Selinexor) was approved for relapsed or refractory multiple myeloma (R/R MM). This drug has received extensive support from LLS: over $4M in 9 grants for acute myeloid leukemia, chronic lymphocytic leukemia, diffuse large B-cell lymphoma and for multiple myeloma. (lls.org)
Multiple myeloma (MM) is an incurable plasma cell malignancy of the bone marrow. (snmjournals.org)
Multiple myeloma (MM) is an incurable malignancy characterized by clonal proliferation of plasma cells in the bone marrow microenvironment. (snmjournals.org)
Recent studies have demonstrated that pharmacological inhibition of the Notch pathway with γ-secretase inhibitor (GSI) induces apoptosis of multiple myeloma (MM) cells via upregulation of the proapoptotic protein Noxa. (aacrjournals.org)
Cilta-cel is an investigational B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR)-T cell therapy for the treatment of adults with relapsed or refractory multiple myeloma who have received at least three prior therapies, including a proteasome inhibitor (PI), an immunomodulatory agent (IMiD), and an anti-CD38 antibody. (pharmiweb.com)
Today's submission is an encouraging step in our mission to provide a potentially transformative cell therapy option to patients with multiple myeloma," said Ying Huang, PhD, CEO and CFO of Legend Biotech. (pharmiweb.com)
Cilta-cel is an investigational chimeric antigen receptor T cell (CAR-T) therapy, formerly identified as JNJ-4528 in the U.S. and Europe and LCAR-B38M CAR-T cells in China, that is being studied in a comprehensive clinical development program for the treatment of patients with relapsed or refractory multiple myeloma and in earlier lines of treatment. (pharmiweb.com)
Multiple myeloma, an incurable blood cancer that starts in the bone marrow and is characterized by an excessive proliferation of plasma cells. (pharmiweb.com)
6 , 7 While some patients with multiple myeloma have no symptoms at all, most patients are diagnosed by symptoms that can include bone problems, low blood counts, calcium elevation, kidney problems or infections. (pharmiweb.com)
Angiogenesis is important for the proliferation and survival of multiple myeloma (MM) cells. (koreamed.org)
NXC-201 (formerly HBI0101) is a BCMA-targeted investigational chimeric antigen receptor T (CAR-T) cell therapy that is being studied in a comprehensive clinical development program for the treatment of patients with relapsed/refractory multiple myeloma and relapsed/refractory AL amyloidosis across 58 patients. (biospace.com)
Multiple myeloma (MM) is an incurable cancer in which uncontrolled plasma cell proliferation disrupts the bone marrow environment and impairs immune function. (hrb.ie)
Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of malignant plasma cells in the bone marrow microenvironment. (confex.com)

While some assays utilize antibodies to study cell health, proliferation, cell cycle or apoptosis, other types of experiments can rely on non-antibody based methods of assessment, often called non-antibody chemical probes. (biolegend.com)
Cellular division for any cell type is dependent on the inherent function, location and the response of cells to repair, apoptosis, or death. (biolegend.com)
Oppositely, expression of mutated myocilin sensitizes cells to apoptosis induced by oxidative stress. (nih.gov)
The MDS cell of origin is a hematopoetic stem cell that proliferates and escapes apoptosis. (standardofcare.com)
ABT-737, a novel BH3 mimetic, was shown to block Bcl-2 and Bcl-xL and induce MM cell apoptosis. (aacrjournals.org)
Signaling through the receptor/transcriptional regulator Notch plays an important role in the survival of tumor cells and their protection from apoptosis induced by chemotherapeutic agents. (aacrjournals.org)
STAT3 is upregulated in MM and increases the expression of genes involved proliferation, angiogenesis and evasion of apoptosis. (confex.com)
VP79s was found to induce apoptosis in NCI-H929 and U266B1 MM cell lines in a dose- and time-dependent manner. (confex.com)
Combining VP79s with bortezomib synergistically enhanced apoptosis in MM cells compared with single agent treatment. (confex.com)

Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
VP79s was shown to overcome adhesion mediated drug resistance in MM cells in a co-culture model system with bone marrow stromal cells which induces MM cell resistance to treatment with the proteasome inhibitor bortezomib. (confex.com)
The Ewing s sarcoma cell line TC71 overexpresses vascular endothelial growth factor isoform 165 (VEGF165), a potent proangiogenic molecule that induces endothelial cell proliferation, migration, and chemotaxis. (conicet.gov.ar)

Bone marrow aspiration and biopsy are critical in making the diagnosis of acute erythroleukemia (see the image below, and Workup ). (medscape.com)
There is no end organ damage in MGUS or in a more progressed condition called smoldering MM. Accordingly, MGUS and smoldering MM are usually not treated, but there are investigational chemoprevention trials attempting to halt the progression to symptomatic MM. In smoldering MM, bone marrow biopsy shows a 10%-60% diffuse infiltration of plasma cells, and the infiltration is less than 10% in MGUS. (snmjournals.org)
Corticosteroids have a cytotoxic effect on lymphoma cells and can induce a radiographic response in up to half of patients, which limits the sensitivity of diagnostic tools like biopsy or lumbar puncture. (medscape.com)
[ 6 ] Additionally, a biopsy of lymphoma pre-treated with corticosteroids may reveal only gliosis or lymphocytic and histiocytic infiltrates without identifiable neoplastic cells. (medscape.com)
Most patients are diagnosed by bone marrow biopsy. (bvsalud.org)

Transplanted murine bone marrow (BM) progenitor cells stimulate endogenous beta cell proliferation and insulin production. (uwo.ca)
Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow. (cdc.gov)

CBR3-AS1 Accelerates the Malignant Proliferation of Gestational Choriocarcinoma Cells by Stabilizing SETD4. (nih.gov)
Blood and blood marrow cancers are characterized by alterations in blood production and the rapid proliferation of malignant cells throughout the body. (bvsalud.org)

MSCs can be differentiated along different cell lineages of mesodermal origin including osteoblasts, chondrocytes, skeletal myocytes or visceral stromal cells 9 . (nature.com)
Researchers presumed that MSCs were the origin of all bone, cartilage, and fat, but recent studies have shown that these cells do not generate young bone and cartilage. (sciencedaily.com)
The CUMC study suggests that OCR stem cells actually fill this function and that both OCR stems cells and MSCs contribute to bone maintenance and repair in adults. (sciencedaily.com)
The MSCs represent less than 1% of the cells present in the placenta, while the average yield of MSCs from chorions and amnions is between 1 to 10 million per gram of tissue. (parentsguidecordblood.org)
Chorionic and amniotic MSCs suppress T cell proliferation to the same extent as bone marrow derived MSCs. (parentsguidecordblood.org)
Unlike MSCs, which are all plastic adherent, primary AECs have three subpopulations of cells that are adherent, loosely adherent, and free-floating. (parentsguidecordblood.org)
The effect of antioxidant trolox on biological characteristics of MSCS, including aging, proliferation, and gene expression, was examined. (techscience.com)
The results demonstrated that trolox can resist aging, promote proliferation, and enhance PGE-2 secretion of MSCs without affecting their surface marker expression. (techscience.com)

MM bone loss is due to complex interactions between the tumor and the bone marrow microenvironment leading to both osteoclastic stimulation and inhibition of osteoblastic function. (snmjournals.org)
The bone marrow microenvironment and inflammatory signaling can also determine the rate of development and progression of MDS. (standardofcare.com)
However, despite the effectiveness of the first-line treatments, patients invariably relapse and become drug refractory due to genetic heterogeneity and induction of prosurvival signalling cascades in the bone marrow microenvironment. (confex.com)
The Janus kinase (JAK)/Signal transducer and activator of transcription 3 (STAT3) pathway in MM can be both constitutively active due to autonomous mutations or activated by growth and survival factors, such as interleukin-6 (IL-6), secreted by bone marrow stromal cells and other cells within the bone marrow microenvironment. (confex.com)

Erythroleukemia is a subtype of acute myeloid leukemia ( AML ) that is distinguished by erythroblastic proliferation. (medscape.com)
Calpin C, Dick P, Poon A, Feldman W. Is bone marrow aspiration needed in acute childhood idiopathic thrombocytopenic purpura to rule out leukemia? (medscape.com)
Next, we used methylation-specific polymerase chain reaction (MSP) technology for detecting the methylation of GRHL2 in clinical samples with acute leukemia and cell lines. (hindawi.com)
Then we investigated the demethylating effect of arsenic trioxide and 5-azacitidine on the mRNA and protein expression levels of GRHL2 in cell lines of acute leukemia. (hindawi.com)
We found a lower level of GRHL2 expression not only in acute leukemia patients but also in cell lines when compared with normal controls. (hindawi.com)
The methylation level of the GRHL2 promoter region in acute leukemia patients and cell lines was significantly higher than the normal control group, and we found the elevated mRNA and protein levels of GRHL2 in acute leukemia cell lines after the use of the demethylation drug arsenic trioxide and 5-azacitidine. (hindawi.com)
At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF- β signaling pathway-linked proteins, including TGF- β , Smad2, Smad3, and Smad4. (hindawi.com)
A heterogenous group of myeloid disorders characterized by somatically mutated hematopoietic stem cells,the presence of variable peripheral cytopenias, and a broad risk of progression to acute myeloid leukemia (AML). (standardofcare.com)
In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans. (researchgate.net)

Exposure to 2-nitrotoluene has also been associated with non-cancer effects in experimental animals, including developmental and reproductive effects as well as effects in the lungs, liver, spleen, bone marrow and the hematopoietic system. (gc.ca)

We report that BM B cells isolated from RA patients express TLR9 at the mRNA and protein levels acquired at the stage of preB/immature B-cell maturation. (nih.gov)
Most of the MM CAR-T cell therapies that are under investigation are directed against the B-cell maturation antigen (BCMA) - a protein found on the surface of most myeloma cells. (lls.org)

CAR-T therapy involves genetically engineering the patient's own T-cells to recognize and kill the patient's tumor cells. (lls.org)
Studies suggest that the SAMD9L protein acts as a tumor suppressor, keeping cells from growing and dividing too rapidly or in an uncontrolled way. (medlineplus.gov)
This tumor-induced diffuse bone loss compounds the treatment-induced bone loss from frequent use of high-dose glucocorticoid medications (typically dexamethasone), leading to severe osteoporosis. (snmjournals.org)
Signaling through the receptor/transcriptional regulator Notch plays an important role in tumor cell survival. (aacrjournals.org)
Although the cells of origin are lymphocytes, PCNSL should be considered a brain tumor, because the therapeutic challenges resemble those of other brain tumors. (medscape.com)
We used a transplant model to determine whether CD341 cells migrate from the bone marrow to Ewing s sarcoma tumors and participate in the neovascularization process that supports tumor growth. (conicet.gov.ar)
Seven days later, the mice were injected subcutaneously with TC71 tumor cells. (conicet.gov.ar)
The tumor sections expressed both human VE-cadherin and mouse CD31, indicating involvement of donor-derived human cells in the tumor vessels. (conicet.gov.ar)
The resulting VEGF165-deficient tumor cells had normal growth rates in vitro, but had delayed growth when implanted into mice. (conicet.gov.ar)
These data show that bone marrow stem cells contribute to the growing tumor vasculature in Ewing s sarcoma and that VEGF165 is critical for the migration of CD341 cells from the bone marrow into the tumor. (conicet.gov.ar)

The extension of bone marrow and extramedullary involvement should be carefully evaluated to establish prognosis and clinical management [ 4 ]. (hindawi.com)
MM has 3 components: diffuse marrow infiltration, focal bone lesions, and soft-tissue (extramedullary) disease. (snmjournals.org)

We employed in vitro cultures and two in vivo models to investigate whether androgens exert these effects directly on marrow lymphoid precursors or whether actions on marrow stromal elements are required. (jci.org)
Erythroleukemia is a neoplastic proliferation of erythroid and myeloid precursors of bone marrow hematopoietic stem cells . (medscape.com)
The paradox is that the mutation provides advantage at the stem cell level and progenitor cells, with a disadvantage at the level of hematopoietic precursors. (standardofcare.com)

[ 1 ] Patients usuallly present with nonspecific signs and symptoms from the anemia, thrombocytopenia, and leukopenia resulting from the replacement of bone marrow by leukemic cells (see Presentation ). (medscape.com)
frequent infections due to low numbers of white blood cells (neutropenia), and abnormal bleeding due to low numbers of platelets (thrombocytopenia). (medlineplus.gov)
Criteria for diagnosis of MDS consist of anemia, thrombocytopenia, or neutropenia that persist for six months or longer, dysplasia greater than 10% in at least one bone marrow cell lineage, and MDS associated clonal cytogenetic abnormalities or molecular markers. (standardofcare.com)
In patients with unexplained anemia, thrombocytopenia, or neutropenia without dysplasia in the bone marrow but with abnormal chromosome activity in 5, 7 or 13 the diagnosis is consistent with MDS and occurs in less than 10% of patients with MDS. (standardofcare.com)

ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)

This disease is characterized by the uncontrolled proliferation of abnormal monoclonal plasma cells in the bone marrow. (lls.org)
As these abnormal cells grow in excess, they disrupt normal cell production, which can result in a range of complications, particularly in the bones, blood, kidney and immune system. (lls.org)
The clonal outgrowth of mutant stem cells favors and abnormal hematopoietic stem cell niche. (standardofcare.com)
Langerhans cell granulomatosis cells are abnormal and coexpress S100 and CD1a, and these markers are used to separate this subpopulation of dendritic cells from other histiocyte-like cells. (medscape.com)
attributed to procoagulant properties of The underlying pathophysiology of sickle red blood cells and their abnormal many of the clinical complications of SCA adherence to vascular endothelium as well is poorly understood. (who.int)
viscosity, reduced red cell deformability, The main objectives of this study were abnormal red cell adhesive properties, en- to assess platelet aggregation patterns and dothelial intimal proliferation, bone marrow levels of PC, PS and AT III in SCA patients or fat embolism and a chronic hypercoagula- in the steady state and in vaso-occlusive ble state [6]. (who.int)

Jubelirer SJ, Harpold R. The role of the bone marrow examination in the diagnosis of immune thrombocytopenic purpura: case series and literature review. (medscape.com)
The surgical samples underwent pathological analysis, and a diagnosis of extranodal NK/T cell lymphoma nasal type was confirmed. (frontiersin.org)
Early diagnosis of primary intestinal NK/T cell lymphoma is frequently difficult. (frontiersin.org)
Indolent SM, which is characterized by both gastrointestinal and cutaneous symptoms in the absence of bone marrow suppression, is extremely rare and often missed due to the complexity of the diagnosis. (bvsalud.org)
These lesions as well as the rare multicentric reticulohistiocytosis (MRH), a systemic monocytoid/histiocytic disorder with multinucleated giant cells, polyarthritis, and papulonodular skin lesions, should be considered in the differential diagnosis. (medscape.com)
conversely, a bone marrow aspirate lacking hemophagocytosis does not rule out the diagnosis of HLH. (cdc.gov)

The bone-regeneration kit relies on a collagen platform seeded with particles containing the genes needed for producing bone. (sciencedaily.com)
We delivered the DNA to the cells, so that the cells produce the protein and that's how the protein is generated to enhance bone regeneration," explains Aliasger Salem, professor in the College of Pharmacy and a co-corresponding author on the paper, published in the journal Biomaterials . (sciencedaily.com)
When cells migrate into the scaffold, they meet with the plasmid, they take up the plasmid, and they get the encoding to start producing PDGF-B, which enhances bone regeneration. (sciencedaily.com)
Transplantation of ALDHhl mixed progenitor cells or culture- expanded multipotent stromal cells (MSC) into streptozotocin-treated NOD/SCID mice revealed endogenous islet regeneration occurred via distinct mechanisms. (uwo.ca)

The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
The stromal cell products responsible for these effects of estrogens have not been identified. (jci.org)

SET Domain-Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence. (nih.gov)
SET domain-containing Protein 4 (SETD4) is a Newly Identified Cytosolic and Nuclear Lysine Methyltransferase involved in Breast Cancer Cell Proliferation. (nih.gov)
They prevent an overactive SAMD9L protein from excessively restricting cell proliferation, which reduces the severity of pancytopenia in affected individuals. (medlineplus.gov)
The cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. (sciencedaily.com)
Laboratory tests showed leukocytosis (20.79 × 10 9 /L), moderate anemia (69 g/L), increased percent of neutrophils (91.6%), increased C-reactive protein (CRP) (80.90 mg/L), procalcitonin (PCT) (5.87 ng/ml) and erythrocyte sedimentation rate (ESR) (106.0 mm/h) level, and mild hypoalbuminemia (31.0 g/L). Stool routine revealed Leukocyte ++++/HP, pus cell ++++/HP, stool blood was positive. (frontiersin.org)
Secondly, we employed qRT-PCR and Western blotting to detect the mRNA and protein levels of GRHL2 in leukemia cell lines. (hindawi.com)
Much of the morbidity in MM results from insufficiency fractures from the profound bone loss seen in MM. Because the dickkopf 1 protein secreted by MM destroys the osteoblast progenitors ( Fig. 2 ), focal osteolytic bone lesions from MM never heal ( 7 , 9 ). (snmjournals.org)
OBJECTIVE: To assess the efficacy of osteogenic protein-1 (OP-1) for long bone nonunion. (who.int)
Sickle-cell anaemia (SCA) was first rec- aggregability, elevated beta thromboglobu- ognized as a haematological disorder more lin, reduced levels of protein C (PC) and than 90 years ago [1]. (who.int)
The sickle-cell gene, protein S (PS). (who.int)
DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)

Clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias. (standardofcare.com)
The mutation occurs in hematopoetic stem cells capable of self renewal and additional mutations are associated with clonal progression may occur in progenitor cells conferring a self renewal capability. (standardofcare.com)
Langerhans cell granulomatosis (LCG) is a clonal disorder characterized by lesions containing histiocyte-like cells, giant cells, and eosinophils. (medscape.com)

1988. Species-specific response to the rodent carcinogens 1,2-dimethylhydrazine and 1,2-dibromo-3-chloropropane in rodent bone-marrow micronucleus assays. (cdc.gov)

Achievement of a complete response on 18 F-FDG PET before stem-cell transplantation correlates with a superior outcome. (snmjournals.org)
In recent years, with a combination of autologous stem-cell transplantation and modern chemotherapy, the 10-y survival of patients presenting at an age less than 60 y is approximately 30% ( 1 , 2 ). (snmjournals.org)
We are interested in investigating the potential neuroprotective benefits of stem cell transplantation, which has produced encouraging results in different models of CNS degeneration. (nih.gov)
Transplantation of ALDHhl cells improved systemic hyperglycemia via increased islet vascularization and proliferation resulting in increased islet size, but not islet number. (uwo.ca)
Contrary to mixed-progenitor cells, transplantation of cultured MSC stably reduced hyperglycemia via an increase in islet number directly associated with the ductal epithelium without evidence of NGN3+ endocrine precursor activation. (uwo.ca)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

This inhibition was cell contact-dependent and soluble factor-independent, as indicated by trans-well experiments. (nih.gov)

To enrich for analogous human progenitor cells, we purified human umbilical cord blood (UCB) and BM based on high aldehyde dehydrogenase activity (ALDHhl), a conserved function in multiple progenitor lineages. (uwo.ca)

The classic imaging finding in MM is one or more focal osteolytic lesions seen on radiographs ( Fig. 1 ) or CT, but there is also a systemic bone loss leading to diffuse osteopenia or osteoporosis ( 7 , 8 ). (snmjournals.org)
PURPOSE: Fluorodeoxyglucose (FDG) uptake of bone marrow (BM) and adipose tissue is known to reflect systemic inflammatory response to cancer cell. (koreamed.org)
AL amyloidosis is a rare systemic disorder caused by an abnormality of plasma cells in the bone marrow. (biospace.com)
The homeostasis of bone tissue is influenced by systemic factors of nutritional, pharmacological, endocrine and pathological origin. (bvsalud.org)

Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Re-evaluation of 1,2-dimethylhydrazine in the mouse bone marrow micronucleus assay: Observation of a positive response. (cdc.gov)

Stimulation of BM CD20(+) B cells by CpG-containing oligodeoxynucleotide-enhanced expression of activation markers (CD86 and CD54) triggered IL-6 and TNF-alpha secretion and cell proliferation. (nih.gov)

Bone marrow (BM) microvessel density (MVD) is a useful marker of angiogenesis and an increase in MVD. (koreamed.org)

The fetal membranes - amnion and chorion - also contain stem cells and stem cell-like cells that can be isolated and banked for clinical use. (parentsguidecordblood.org)
Legend Biotech is a global, clinical-stage cell therapy company dedicated to treating, and one day curing, life-threatening diseases. (pharmiweb.com)
BACKGROUND: Bone marrow oedema (BMO) in children/adolescents is a rare clinical condition without an etiologic cause. (koreamed.org)
Most clinical trials which utilize ADSCs for OA treatment have been based on the autologous cells from the stromal vascular fraction, as have most of the in vivo studies ( 6 , 7 ). (spandidos-publications.com)
The Phase 1b portion of the ongoing Phase 1b/2a clinical trial has been successful in determining the recommended Phase 2 dose (RP2D) of 800 million CAR+T cells. (biospace.com)
Its effectiveness in reducing bone resorption has been proven in comparative clinical studies after a period of 24 months administering the drug 6-7 . (bvsalud.org)

Although MM can arise de novo, it usually progresses in a stepwise fashion from MGUS or smoldering MM. If marrow infiltration with plasma cells exceeds 60%, or if end organ damage is present, the patient is diagnosed with active MM ( 1 , 2 ). (snmjournals.org)
Immunohistochemical analysis revealed decreased infiltration of CD341 cells into both VEGF165-deficient tumors. (conicet.gov.ar)
Histiocytic infiltration and proliferation within the synovium is a common finding associated with inflammatory processes. (medscape.com)

The amnion dressings promote cell growth, modulate inflammation and recruit endogenous (local) stem cells to facilitate wound repair. (parentsguidecordblood.org)
In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)

Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)

A key target in this respect is natural killer (NK) cells in order to generate an anticancer-immune response. (academicjournals.org)
The switch in a mother's immune system during pregnancy is largely mediated by regulatory T cells in the maternal bloodstream. (parentsguidecordblood.org)
The HLA-G molecule plays a major role in immune tolerance during pregnancy, particularly at the maternal-fetal interface, where HLA-G inhibits the migration and proliferation of maternal immune cells. (parentsguidecordblood.org)
Dendritic cell as sentinel of the immune system plays an irreplaceable role. (medsci.org)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)

Using this marker, the researchers found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes. (sciencedaily.com)
Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
5 demonstrated, in a study carried out using osteoblastic cells, that bisphosphonates do not cause cytotoxic action when administered to the cell culture in the period between 24 and 72 hours, and are capable of reversing the harmful effects of glycation in osteoblasts in patients with osteoporosis and diabetes mellitus. (bvsalud.org)

Our findings raise the possibility that drugs or other therapies can be developed to stimulate the production of OCR stem cells and improve the body's ability to repair bone injury--a process that declines significantly in old age," says Timothy C. Wang, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine at CUMC, who initiated this research. (sciencedaily.com)

In vivo work showed that the outcomes of disease (erythroid, myeloid, or both) depend on the driving oncogene and the hematopoietic target cell in which it is aberrantly expressed. (medscape.com)

It is believed that benzene and its metabolites target hematopoietic stem cells (HSCs) to cause toxicity and cancer in the hematopoietic system. (cdc.gov)

It also stimulated new growth in human bone marrow stromal cells in lab experiments. (sciencedaily.com)
The researchers believe that OCR stem cells will be found in human bone tissue, as mice and humans have similar bone biology. (sciencedaily.com)

Amnion Epithelial Cells (AECs) are a stem-like cell that can be isolated in large numbers (150 to 200 million per gram) from full-term placentae. (parentsguidecordblood.org)

This represents an important step forward in the planned U.S. expansion of the Company's ongoing Phase 1b/2a NEXICART-1 (NCT04720313) study of its novel BCMA-targeted chimeric antigen receptor T (CAR-T) cell therapy NXC-201. (biospace.com)
and, in response to antigen, are subsequently secreted by plasma cells. (msdmanuals.com)
[ 1 ] Antigen-presenting cells or histiocyte-like cells containing Birbeck granules have been identified within inflamed synovial tissues. (medscape.com)

The use of NO synthesis inhibitors may be a new therapeutic strategy for septic bone-marrow failure. (tum.de)
Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. (medsci.org)
VP79s was more potent in inducing cell death in a panel of drug sensitive and drug resistant MM cell lines compared to standard and emerging therapeutic agents for MM. VP79s rapidly inhibited both constitutively active and IL-6-induced STAT3 signalling in MM cells. (confex.com)
VP79s showed selective cytotoxicity in patient derived MM cells compared to normal donor lymphocytes and reduced the viability of MM patient samples in a dose-responsive manner suggesting its potential as an anti-MM therapeutic. (confex.com)
The findings contribute to a better understanding of the mechanisms of bone mass regulation and can help develop efficient therapeutic strategies for osteoporosis treatment. (lu.se)

CD341 bone marrow stem cells can differentiate into endothelial and hematopoietic cells. (conicet.gov.ar)

Conditions associated with bone marrow failure such as aplastic anemia with hypocellular marrow, typical bone marrow findings of MDS are a hypercellular marrow for a persons age, dysplasia in 1 to 3 lineages manifested by pseudo Pelger-Huet nuclei, hypogranular neutrophils, micro megakaryocytes, and/or ringed sideroblasts, glass Siri glass, and increased myeloblasts in a subset of patients. (standardofcare.com)

The plasmid-seeded bio patch grew 44-times more bone and soft tissue in the affected area than with the scaffold alone, and was 14-fold higher than the affected area with no manipulation. (sciencedaily.com)
The researchers also suspect that OCR cells may play a role in soft tissue cancers. (sciencedaily.com)
However, since there are many different non-muscle cell populations that reside within the tissue, these experiments cannot easily distinguish true myonuclei from those of neighboring mononuclear cells. (frontiersin.org)
Sample suitability indicates whether this reagent can be used to label already fixed tissue sections or single cells in suspension or cell culture. (biolegend.com)
There can be symmetrical or asymmetrical division depending on the cell and tissue type. (biolegend.com)
A more realistic service is offered by a few cord blood banks that preserve the stem cells from placental blood and placental tissue. (parentsguidecordblood.org)
Fu Q, Saiz E, Rahaman MN, Tomsia AP (2011) Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives. (springer.com)

Tumoral cells overexpress surface GLUTs and have a higher glycolitic activity than normal cells corresponding to an increased FDG uptake. (hindawi.com)
In addition, the activation of haematopoiesis after antitumoral therapies could increase bone marrow FDG uptake diffusely. (hindawi.com)

These methods demonstrated a greater diagnostic accuracy compared to whole-body X-ray in diagnosing lytic bone lesions. (hindawi.com)

Moreover, RA BM B cells exerted higher expression of CD86 than their osteoarthritis counterparts, suggesting their in situ activation via TLR9. (nih.gov)
citation needed] Deferoxamine may modulate expression and release of inflammatory mediators by specific cell types. (wikipedia.org)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)

While toxic for MM cells, the combination of GSI and ABT-737 did not affect survival of peripheral blood mononuclear cells isolated from healthy donors. (aacrjournals.org)

Plasmacytoid dendritic cells (pDCs) are rare central regulators of antiviral immunity and unsurpassed producers of interferon-α (IFN-α). (nih.gov)
We focus on the essential functions of dendritic cell in severe SARS-CoV-2 infection. (medsci.org)
Basis of treatment based dendritic cells to combat coronavirus infections is summarized. (medsci.org)
Histiocytic/dendritic proliferations involving the synovial tissues are not uncommon. (medscape.com)
The cellular makeup of these monocytoid/histocytic cells is heterogeneous and ranges from cells of lymphoid, histiocytic, and dendritic origin. (medscape.com)
[ 3 , 4 ] Langerhans cells are stellate dendritic cells that arise from CD34-positive bone marrow stem cells [ 5 ] and are not a member of the mononuclear phagocytic system. (medscape.com)
It emphasizes the importance of immunocytochemistry to separate this histiocyte-like cell proliferation from true histiocytic and other dendritic cell types. (medscape.com)

Bone biopsies conducted on patients who, over a long period, have been given bisphosphonates for treatment of osteoporosis and who had suffered fractures, detected the presence of giant osteoclasts suggesting that prolonged use could cause osteoclastic mutations and bone fractures 8 . (bvsalud.org)

Treatment with iron-chelating drugs such as deferoxamine reduces mortality in persons with sickle cell disease or β‐thalassemia who are transfusion dependent. (wikipedia.org)

Bone marrow examination showed the proliferation of hematopoietic cells were active, mainly granulocytes, and immature granulocytes increased. (frontiersin.org)

Furthermore, chitosan/β-TCP composite coating improves the interaction between osteoblast-like cells and the polymeric scaffolds and accelerates the rate of cell proliferation. (springer.com)

In the current study, we compared the effects of hydroquinone (HQ), a major metabolite of benzene in humans and animals, on mouse embryonic yolk sac hematopoietic stem cells (YS-HSCs) and adult bone marrow hematopoietic stem cells (BM-HSCs). (cdc.gov)

These experiments showed that the two DN1 sub-populations divided with similar rates, but progressed to the DN2 stage with different rates, thus providing experimental evidence that DN1 cells increase their commitment probability in a cell-intrinsic manner as they undergo cell division. (lu.se)

The upregulation of miR‑145 and miR‑221 was associated with the enhanced proliferation of periosteal cells and chondrogenic potential, respectively. (spandidos-publications.com)

Moreover, cell viability was assessed by SaOS-2 cells. (springer.com)
Cell growth and viability were assessed after 7 and 10 days. (bvsalud.org)
001). Cell viability in all the groups was over 80%, except in group IV at day 7. (bvsalud.org)
Irradiation time of group I influenced positively the proliferation and viability of OD-21 cells in late cell culture period. (bvsalud.org)

Further study could provide greater understanding of how to prevent and treat osteoporosis, osteoarthritis, or bone fractures. (sciencedaily.com)

The discovery has implications for bone repair, the scientists say. (sciencedaily.com)
In: Chemically induced cell proliferation: Implications for risk assessment. (cdc.gov)

We discovered that myocilin increased cell proliferation and survival. (nih.gov)

The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

Anatomy43

Organisms19

Diseases31

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes58

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Named Groups1

Health Care1

Differentiation29

Mesenchymal Stem7

Multiple myeloma16

Apoptosis9

Induces3

Biopsy5

Murine2

Malignant2

MSCs8

Microenvironment4

Acute9

Spleen1

Maturation2

Tumor10

Extramedullary2

Precursors3

Thrombocytopenia4

Abstract1

Abnormal6

Diagnosis6

Regeneration4

Stromal cell2

Protein11

Clonal3

Assays1

Transplantation6

Inhibition1

Progenitor1

Systemic4

Mouse bone2

Secretion1

Angiogenesis1

Clinical6

Infiltration3

Inflammation2

Adipose tissue2

Immune6

Osteoblasts3

Stimulate1

Myeloid1

Hematopoietic system1

Human bone2

Epithelial Cells1

Antigen3

Therapeutic5

Differentiate1

Aplastic1

Tissue7

Uptake2

Lytic bone lesions1

Expression3

Peripheral1

Dendritic7

Biopsies1

Sickle cell di1

Examination1

Accelerates1

HSCs1

Populations1

Chondrogenic1

Viability4

Fractures1

Implications2

Survival1

Receptor1