• Cerebral Palsy
  • Common special needs include learning disabilities (such as dyslexia), communication disorders, emotional and behavioral disorders (such as ADHD and ADD), physical disabilities (such as Brittle Bone Disease, Cerebral Palsy, Muscular Dystrophy, Spinal Bifida, and Frederich's Ataxia), and developmental disabilities (such as autism spectrum disorders and intellectual disability). (wikipedia.org)
  • skeletal
  • Hemophilia , finally, is a generalized hereditary condition that affects the skeletal system only secondarily by bleeding in the bones and joints. (britannica.com)
  • This decrease in collagen secretion can lead to the bone defects that are also characteristic of the disease, such as skeletal dysplasia and under-ossification. (wikipedia.org)
  • FGD1 is expressed in areas of bone formation and post-natally in skeletal tissue, the perichondrium, joint capsule fibroblasts and resting chondrocytes. (wikipedia.org)
  • The embryo may also develop shorter bones, miss any skeletal elements, or lack multiple articulating joints. (wikipedia.org)
  • proteins
  • It localizes preferentially to the trans-Golgi network (TGN) of mammalian cells and regulates, for example, the secretory transport of bone-specific proteins from the Golgi complex. (wikipedia.org)
  • seizures
  • Disseminated disease occurs when the fungus has spread outside of the lungs and may include clinical signs such as lameness, pain, seizures, anterior uveitis, and localized swelling. (wikipedia.org)
  • Menkes Disease is also characterized by seizures, failure to thrive, subnormal body temperature, and strikingly peculiar hair, which is kinky, colorless or steel-colored, and easily broken. (wikipedia.org)
  • short stature
  • Albright's Hereditary Osteodystrophy is a rare autosomal dominant disease characterized by a constellation of physical features including short stature, central obesity, round face, brachydactyly, subcutaneous calcifications and mental retardation. (clinicaltrials.gov)
  • occur
  • It can also occur when the bone tissue in the neck of the femur is softer than normal, causing it to bend under the weight of the body. (wikipedia.org)
  • This is pertinent in humans as well, because many diseases stemming from organ fibrosis occur via the EMT process. (wikipedia.org)
  • deformity
  • Being the craniostenoses sutural basically a disease, the fact that the brain being trapped in an enclosure that does not have complacency required to accompany their growth constitutes the challenge of treatment, which aims to restore the complacency of the suture and correct the stenotic compensatory cranial deformity. (clinicaltrials.gov)
  • Paget's disease of bone), post-Perthes deformity, osteomyelitis, and post traumatic (due to improper healing of a fracture between the greater and lesser trochanter). (wikipedia.org)
  • The bone loss leads to some degree of collapse and deformity of the femoral head and sometimes secondary changes to the shape of the hip socket. (wikipedia.org)
  • treatment
  • Patients may continue treatment in the absence of toxicity and disease progression. (clinicaltrials.gov)
  • Secondary efficacy measures during Phase 2a include change in height SDS and change in bone age after 6 months VRS-317 treatment. (clinicaltrials.gov)
  • Though the children affected with CLSD will have problems throughout life, the treatment for this disease thus far is symptomatic. (wikipedia.org)
  • Atrimustine (INN) (developmental code name KM-2210), also known as bestrabucil or busramustine, is a nitrogen mustard alkylating antineoplastic drug that was under development in Japan by Kureha Chemicals (now Kureha Corporation) for the treatment of breast cancer and non-Hodgkin's lymphoma as well as for the prevention of graft-versus-host disease in bone marrow transplant recipients. (wikipedia.org)
  • Also in the treatment of tibial non-union, frequently in cases where a bone graft has failed. (wikipedia.org)
  • BMP7 also has the potential for treatment of chronic kidney disease. (wikipedia.org)
  • Kidney disease is characterized by derangement of the tubular architecture by both myofibroblast buildup and monocyte infiltration Because endogenous BMP-7 is an inhibitor of the TGF-β signaling cascade that induces fibrosis, the use of exogenous recombinant BMP-7 (rhBMP-7) could be a viable treatment of chronic kidney disease. (wikipedia.org)
  • This includes providing therapeutic treatment in circumstances where movement and function are threatened by aging, injury, disease or environmental factors. (wikipedia.org)
  • Stem cell transplantation may be used if the disease recurs following standard treatment. (wikipedia.org)
  • Marfan Syndrome
  • TGF-β levels play a major role in the pathogenesis of Marfan syndrome, a disease characterized by disproportionate height, long extremities, lens dislocation in the eyes and heart complications such as mitral valve prolapse and aortic enlargement increasing the likelihood of aortic dissection. (clinicaltrials.gov)
  • femoral
  • Over time, healing occurs by new blood vessels infiltrating the dead bone and removing the necrotic bone which leads to a loss of bone mass and a weakening of the femoral head. (wikipedia.org)
  • Legg believed the cause was impairment of blood supply to the femoral epiphysis, Calve believed rickets, and Perthes deduced an infection possibly causing degenerative arthritis leads to LCP disease. (wikipedia.org)
  • The disease is theorized to include the artery of the ligmentum teres femoris being constricted or even blocked too early, not allowing for time when the medial circumflex femoral artery takes over. (wikipedia.org)
  • soft tissue
  • One millimetre a day is commonly the amount of distraction, however the soft tissue increases in length at a slower pace than the bone which leads to soft tissue tension. (clinicaltrials.gov)
  • humans
  • Some of these diseases are unique to dogs or closely related species, while others are found in other animals, including humans. (wikipedia.org)
  • Rabies (hydrophobia) is a fatal viral disease that can affect any mammal, although the close relationship of dogs with humans makes canine rabies a zoonotic concern. (wikipedia.org)
  • Rocky Mountain spotted fever* is a rickettsial disease that occurs in dogs and humans. (wikipedia.org)
  • Blastomycosis* is a fungal disease caused by Blastomyces dermatitidis that affects both dogs and humans. (wikipedia.org)
  • Histoplasmosis* is a fungal disease caused by Histoplasma capsulatum that affects both dogs and humans. (wikipedia.org)
  • Sporotrichosis is a fungal disease caused by Sporothrix schenckii that affects both dogs and humans. (wikipedia.org)
  • joints
  • It is characterized by calcium deposits in a bone at the base of the skull (occipital bone), coarse hair, loose skin, and joints. (wikipedia.org)
  • After the development of orthopedics in the eighteenth century, machines like the Gymnasticon were developed to treat gout and similar diseases by systematic exercise of the joints, similar to later developments in physical therapy. (wikipedia.org)
  • protein
  • Noggin, also known as NOG, is a protein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones. (wikipedia.org)
  • It is released from the notochord and regulates bone morphogenic protein (BMP4) during development. (wikipedia.org)
  • In the Golgi apparatus, ATP7A protein provides copper to certain enzymes that are critical for the structure and function of bone, skin, hair, blood vessels, and the nervous system. (wikipedia.org)
  • clinical
  • Compare the number of adverse events or clinical manifestations of disease progression occurring in these patients. (clinicaltrials.gov)
  • Principal objective: To evaluate in Marfan patients, if FBN1 expression level (non-mutated or mutated allele) modulates the clinical expression of the disease. (clinicaltrials.gov)
  • Canine coronavirus is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. (wikipedia.org)
  • According to a study performed in the Tucson and Phoenix area, 28% of dogs will test positive for exposure to the fungus by two years of age, but only 6% of the dogs will be ill with clinical disease. (wikipedia.org)
  • progression
  • Although the available treatments (beta-blockers, BBs) improve the evolution of the disease, they do not protect MFS patients from progression of ARD and dissection. (clinicaltrials.gov)
  • If disease progression is diagnosed in the control group, patients will then receive interferon gamma in combination with calcitriol. (clinicaltrials.gov)
  • This is a randomized, double-blind, placebo-controlled study comparing the safety and efficacy of 2 dosage regimens of palovarotene versus placebo in preventing disease progression in pediatric subjects with multiple osteochondromas (MO). (clinicaltrials.gov)
  • pulmonary
  • Some people with LSDhave enlarged livers (hepatomegaly) and enlarged spleens (splenomegaly), pulmonary and cardiac problems, and bones that grow abnormally. (wikipedia.org)
  • defect
  • The primary defect lies in the growth zone of the long bones. (britannica.com)
  • This form of osteotomy was therefore chosen by the authors to induce bone compliance areas of secondary defect that should expand or compress indirectly during the process of dynamic remodeling of primary defect with springs. (clinicaltrials.gov)
  • tissues
  • It is the benzoate ester of an ester conjugate of estradiol and chlorambucil, which results in targeted/site-directed DNA alkylating activity toward estrogen receptor-positive tissues such as breast and bone. (wikipedia.org)
  • Excessive
  • The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, and platelets. (wikipedia.org)
  • fibrous
  • It is most commonly a sequela of osteogenesis imperfecta, Pagets disease, osteomyelitis, tumour and tumour-like conditions (e.g. fibrous dysplasia). (wikipedia.org)
  • Onset
  • Onset of the disease is in neonatal development and infancy, and symptoms tend to become evident soon after birth. (wikipedia.org)
  • autosomal
  • Most of these disorders are autosomal recessively inherited such as Niemann-Pick disease, type C, but a few are X-linked recessively inherited, such as Fabry disease and Hunter syndrome (MPS II). (wikipedia.org)
  • Canine
  • Canine distemper is an often fatal infectious disease that mainly has respiratory and neurologic signs. (wikipedia.org)
  • Canine influenza is a newly emerging infectious respiratory disease. (wikipedia.org)
  • Infectious canine hepatitis is a sometimes fatal infectious disease of the liver. (wikipedia.org)
  • Canine herpesvirus is an infectious disease that is a common cause of death in puppies less than three weeks old. (wikipedia.org)
  • Canine minute virus is an infectious disease that can cause respiratory and gastrointestinal signs in young puppies. (wikipedia.org)
  • noggin
  • Experiments in mice have shown that noggin also plays a role in learning, cognition, bone development, and neural tube fusion. (wikipedia.org)
  • Therapeutic
  • Ambroxol has recently been shown to increase activity of the lysosomal enzyme glucocerebrosidase, so it may be a useful therapeutic agent for both Gaucher disease and Parkinson's disease. (wikipedia.org)
  • known
  • Although no one has identified the cause of Perthes disease, a reduction in blood flow to the joint is known. (wikipedia.org)
  • reduction
  • In addition, substrate reduction therapy, a method used to decrease the production of storage material, is currently being evaluated for some of these diseases. (wikipedia.org)
  • blood
  • At the screening visit, participants will have a physical examination and medical history, provide blood and urine samples, have an oral glucose tolerance test (to check blood sugar levels), and have an x-ray of the left hand to check bone age. (clinicaltrials.gov)
  • X-rays may show an increased density in the medullary cavity of the affected bones, often near the nutrient foramen (where the blood vessels enter the bone). (wikipedia.org)
  • Due to the lack of blood flow, the bone dies (osteonecrosis or avascular necrosis) and stops growing. (wikipedia.org)
  • The decreased supply of copper can reduce the activity of numerous copper-containing enzymes that are necessary for the structure and function of bone, skin, hair, blood vessels and the nervous system such as lysyl oxidase. (wikipedia.org)
  • Christ, B (1997), "On the bifurcation of blood vessels-Wilhelm Roux's doctoral thesis (Jena 1878)--a seminal work for biophysical modelling in developmental biology. (wikipedia.org)
  • In addition, umbilical cord blood transplantation is being performed at specialized centers for a number of these diseases. (wikipedia.org)
  • often
  • Trevor disease can often mimic posttraumatic osseous fragments, synovial chondromatosis, ostechondroma, or anterior spur of ankle. (wikipedia.org)
  • Children affected by LCP disease often display uneven gait and limited range of motion, and they experience mild to severe pain in the groin area. (wikipedia.org)