Bone lymphocytes cell proliferation. Medical search. Frequent questions

The finding of T cells bearing abnormal immunophenotype cluster of differentiation markers is critical to making the diagnosis. (wikipedia.org)
The cells were phenotypically categorized according to the expression of CD29, CD90, CD34 and CD45, and submitted to adipogenic and chondrogenic differentiation for 21 days and osteogenic differentiation for 7, 14 and 21 days. (scielo.br)
On days 7, 14 and 21 of osteogenic differentiation, the cultures were submitted to evaluations of MTT conversion in formazan, of alkaline phosphatase activity (AP), of collagen and mineralized matrix synthesis, evaluation of the number of cells per field and there was quantification of the gene transcripts for osterix, bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC). (scielo.br)
The number of cells per field, the AP activity, the collagen and mineralized matrix synthesis were higher in AT-MSC en differentiation, in relation to BM-MSC under the same conditions in all evaluated times. (scielo.br)
LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
Involvement of CD44 in mast cell proliferation during terminal differentiation. (southernbiotech.com)
Due to the rarity of these cells in the intestine, their development and differentiation remain yet to be fully understood. (bvsalud.org)
Mesenchymal stem cells (MSCs) have been widely tested for treating a variety of refectory medical indications such as type 1 diabetes mellitus, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease due to their multiple differentiation potentials and immunomodulation capability [1-5]. (researchsquare.com)
All- trans retinoic acid promotes smooth muscle cell differentiation of rabbit bone marrow-derived mesenchymal stem cells[J]. Journal of Zhejiang University Science B, 2010, 11(7): 489-496. (zju.edu.cn)
plays a key role in the development and differentiation of smooth muscle cells . (zju.edu.cn)
may serve as a potent agent for functional smooth muscle cell differentiation in tissue engineering. (zju.edu.cn)
All- trans retinoic acid regulates proliferation, migration, differentiation, and extracellular matrix turnover of human arterial smooth muscle cells. (zju.edu.cn)
Interleukin 13: novel role in direct regulation of proliferation and differentiation of primitive hematopoietic progenitor cells. (ox.ac.uk)
This novel effect on differentiation was directly mediated, shared with IL-4, and could not be observed on Lin-Sca-1- progenitor cells. (ox.ac.uk)
Lymphoplasmacytic lymphoma (LPL) is a neoplasm of mature B-cells exhibiting some plasmacytic differentiation. (hematology.org)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
Btk is required for the proliferation and differentiation of B lymphocytes. (medscape.com)
However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)
These malignancies are further characterized by the maturity and differentiation of the individual cell types and are divided into acute leukemias such as acute myeloid leukemia and acute lymphoblastic leukemia and chronic leukemias such as chronic myeloid leukemia and chronic lymphocytic leukemia. (medscape.com)
Different characteristics of the nuclei and cytoplasm of the cell allow differentiation by instrumentation and microscopy. (medscape.com)

B and T cells, type 2 dendritic cells, and natural killer (NK) cells share a common ancestor: common lymphoid progenitor (CLP). (medscape.com)
Memory cells travel to the primary follicle, where, after exposure to dendritic cells, they differentiate into centroblasts (immunoglobulin class-switch). (medscape.com)
Using single-cell RNA sequencing, we identify C5aR- and lysozyme-expressing dendritic cells (C5aR+ LysoDCs) in PP and examine their role in CD8+ T cell immune induction. (bvsalud.org)
Occurrence and function: CD19 is expressed only on B-cells and follicular dendritic cells. (nordiqc.org)
Tonsil and appendix are both appropriate controls: The mantle zone B-cells, the germinal centre B-cells and the follicular dendritic cells must show a strong staining reaction. (nordiqc.org)
Characterization of dendritic cells generated in vivo by an E. coli derived chimeric dual receptor agonist. (medscimonit.com)
Despite lower co-stimulatory molecule expression, ProGP-4-generated Class II+/CD11c+ cells stimulated proliferation of allogeneic T cells and an antigen-specific T cell hybridoma as efficiently as bone marrow derived dendritic cells from untreated mice. (medscimonit.com)
SL is an antigen-dependent process and requires the collaboration of antigen presenting cells (dendritic cells and macrophages), CD4 + T lymphocytes, and different cytokines. (medscape.com)
RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. (moviplans.com)
These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK+ T-cells, and regulate T-cell-dependent immune response. (moviplans.com)
Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)

numerous tyrosine kinase cell signaling proteins are responsible for the growth and proliferation of eosinophils {see clonal eosinophilia}), methotrexate and Hydroxycarbamide (both are chemotherapy and immunosuppressant drugs), and Alemtuzumab (an antibody that binds to the CD52 antigen on mature lymphocytes thereby marking them for destruction by the body). (wikipedia.org)
Atypical lymphoid hyperplasia due to clonal expansion of B or T lymphocytes has been reported in as many as one third of patients with common variable immunodeficiency. (medscape.com)
The result is a lymphoma comprising of small B-lymphocytes, plasmacytoid B-cells with more abundant cytoplasm, as well as clonal plasma cells. (hematology.org)
Consid- (for biopsy taking), pathologist (for bi- clonal proliferations of lymphocytes. (who.int)

Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
Apoptosis was observed in alveolar epithelial cells, which is the major target cell type for the viral replication. (cdc.gov)
Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. (cdc.gov)
Infection of epithelial cells and lymphocytes has been shown to induce apoptosis in vitro ( 4 - 8 ). (cdc.gov)
Infection with virulent influenza (H5N1) virus was also shown to induce lymphopenia and lymphocyte apoptosis in vivo ( 14 ). (cdc.gov)

Spleens from ProGP treated mice were evaluated by immunocytochemistry and enriched CD11c+ populations were functionally assessed in a mixed lymphocyte assay and in an antigen dependent CTL assay. (medscimonit.com)
These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)

Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. (zju.edu.cn)
In this study we investigated for the first time the potential role of IL-13 in the regulation of the growth of hematopoietic progenitor cells. (ox.ac.uk)
IL-13 enhanced stem cell factor (SCF)-induced proliferation of Lin-Sca-1+ bone marrow progenitor cells more potently than IL-4. (ox.ac.uk)
In contrast, IL-13 had no synergistic activity on SCF-induced proliferation of the more mature Lin-Sca-1- progenitor cells. (ox.ac.uk)
Thus, the cloning frequency in response to SCF + IL-13 was at least 20-fold higher in the Lin-Sca-1+ than the Lin-Sca-1- progenitor cell population. (ox.ac.uk)
Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. (moviplans.com)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)

Echinacea can stimulate bone marrow cells to produce cytokines, promote the proliferation of B lymphocytes, and then inhibit the growth of tumor cells. (kitairu.net)
Mast cells are cells that reside in the connective tissue and contain a large number of granules, rich in histamine, heparin, chymase, serotonin, and also cytokines. (bvsalud.org)

These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
They are where proliferation and maturation of stem cell s into immunocompetent cells occur. (biologyonline.com)
Although defects may occur in many steps in B-cell development and maturation, resulting in agammaglobulinemia, the most common and well-described defect is the impaired maturation of the pro-B cells to pre-B cells. (medscape.com)
Decreased WBC count, leukopenia, is seen when supply is depleted by infection or treatment such as chemotherapy or radiation therapy, or when a hematopoietic stem cell abnormality does not allow normal growth/maturation within the bone marrow, such as myelodysplastic syndrome or leukemia. (medscape.com)

The background comprises prominent eosinophils with plasma cells and small lymphocytes. (radiopaedia.org)
The bone marrow demonstrated a diffuse proliferation of small lymphocytes admixed with plasmacytoid lymphocytes and clusters of plasma cells. (hematology.org)
Bone marrow aspirate smear shows increased small lymphocytes with clumped chromatin and scant cytoplasm (green arrow). (hematology.org)
A bone core biopsy shows diffuse infiltration by small lymphocytes and plasma cells (A). Dutcher bodies (intra-nuclear pseudo-inclusions comprised of immunoglobulin) are readily identified (B). (hematology.org)

CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. (southernbiotech.com)
The recently cloned interleukin 13 (IL-13) shares most investigated biological activities on B lymphocytes and monocytes with IL-4. (ox.ac.uk)
However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
The white blood cells (leukocytes) are further divided into phagocytes or myeloid (neutrophils, eosinophils, basophils, monocytes) and immunocytes or lymphoid (lymphocytes). (medscape.com)

The aim of this study was to compare the osteogenic potential of mesenchymal stem cells obtained from bone marrow (BM-MSC) with those extracted from adipose tissue (AT-MSC) of adult dogs. (scielo.br)
In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
Bone marrow mesenchymal stem cells (BMSCs) have potential therapeutic benefits for the treatment of endometrial diseases and injury. (biologists.com)
Mesenchymal stem cells (MSCs) are the most commonly used cells in tissue engineering and regenerative medicine. (frontiersin.org)
There are significant differences on the biological characteristics of bone marrow mesenchymal stem cells (BMMSCs), immunological response, and antigen-presenting functions between patients with psoriasis and normal subjects, but there are no significant differences in aborted fetuses. (geneticsmr.com)
Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
bone marrow-derived mesenchymal stem cells are multipotent stem cells, an attractive resource for regenerative medicine. (zju.edu.cn)
increased the expression of myocardin, caldesmon, 22-kDa smooth muscle cell-specific protein (SM22α), and SM-myosin heavy chains in rabbit bone marrow-derived mesenchymal stem cells , as detected by reverse transcription polymerase chain reaction (PCR). (zju.edu.cn)
In addition, more than 47% of bone marrow-derived mesenchymal stem cells demonstrated the contractile phenotype of smooth muscle cells . (zju.edu.cn)

Lymphocyte-variant hypereosinophilia is a rare disorder in which eosinophilia or hypereosinophilia (i.e. a large or extremely large increase in the number of eosinophils in the blood circulation) is caused by an aberrant population of lymphocytes. (wikipedia.org)
The overly stimulated CFU-Eos cells mature to apparently normal appearing but possibly overactive eosinophils which enter the circulation and may accumulate in and damage various tissues. (wikipedia.org)
Correlation of hyaluronan deposition with infiltration of eosinophils and lymphocytes in a cockroach-induced murine model of asthma. (southernbiotech.com)

Histopathologic diagnosis is based on biopsy of lymph node or tissue from another suspected disease site, such as the bone marrow. (msdmanuals.com)
Patients should also have bone marrow biopsy, cerebrospinal fluid cytology, and laboratory studies to include lactate dehydrogenase (LDH). (msdmanuals.com)
A bone marrow study with biopsy is performed. (hematology.org)
Immunohistochemical stains on the core biopsy showed diffuse infiltration of CD20-positive B-cells, and increased kappa-restricted CD138-positive plasma cells. (hematology.org)
However, biopsy of lymphoid tissue and bone marrow examination are not currently performed in the workup of most cases of XLA. (medscape.com)

Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm characterized by monoclonal proliferation and accumulation of B lymphocytes in the blood, bone marrow, and lymphoid tissues [ 1 ]. (biomedcentral.com)
Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (msdmanuals.com)
Burkitt lymphoma is the most rapidly growing human tumor, and pathology reveals a high mitotic rate, a monoclonal proliferation of B cells, and a "starry-sky" pattern of benign macrophages that have engulfed apoptotic malignant lymphocytes. (msdmanuals.com)

Employing in vitro cell culture of inherited mitochondrial disease and an in vivo animal experimental model of low-grade inflammation (high fat feeding), we show human-derived MSCs to alter mitochondrial function. (frontiersin.org)
Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
In vitro organoid analysis of RankL treated organoid showed an increase of mature marker GP2 expression and other M cell-associated markers. (bvsalud.org)
We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)

MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
Many affected individuals have widespread disease at diagnosis, with involved regions often including multiple lymph nodes, the spleen, and, potentially, the bone marrow, the liver, and/or regions of the digestive (gastrointestinal) tract. (rarediseases.org)
Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes. (rarediseases.org)
Lymphocytes are stored within lymph nodes and may also be found in other lymphatic tissues. (rarediseases.org)
[4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)
[9] If enlarged lymph nodes are caused by infiltrating CLL-type cells, a diagnosis of small lymphocytic lymphoma (SLL) is made. (wikipedia.org)
We also found suppression of CD4+CD25+ and stimulation CD4+ CD8+ cells in the spleen, blood, mesenteric lymph nodes (MLNs), and Peyer's patches (PPs) of the treated mice. (bvsalud.org)

Multiple myeloma (MM) is a malignant plasma cell disorder with debilitating symptoms related to anemia, immunosuppression, bone destruction, and renal failure. (haematologica.org)
Multiple myeloma, extramedullary plasmacytoma and solitary bone plasmacytoma all are the three subgroup of plasma cell tumor [3].We present a case of plasmacytoma present in frontoparietal region. (olitespublishing.com)

In many clinical settings, however, studies on the T cell receptor and IL-5 are not available and therefore not routine parts of the diagnostic work-up or criteria for the disease. (wikipedia.org)
Following B-cell receptor activation, 2 waves of tyrosine kinase phosphorylation occur. (medscape.com)
X-linked agammaglobulinemia (XLA), also known as Bruton agammaglobulinemia, results from a mutation of the BTK gene, which encodes the pre-B-cell receptor (Pre-BCR) and BCR. (medscape.com)
The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
A mature M cell expresses a receptor Gp2 which binds to pathogens and aids in the uptake. (bvsalud.org)
The development, homeostasis and function of B lymphocytes involve multiple rounds of B cell receptor (BCR)-controlled proliferation and prolonged maintenance. (gsea-msigdb.org)
Thus, Zfx restrains the stress response and couples antigen receptor signaling to B cell expansion and maintenance during development and peripheral homeostasis. (gsea-msigdb.org)
It is a part of B-cell Receptor Complexes (BCR) on the cell surface together with CD21, CD81 and CD225. (nordiqc.org)
Design and Methods OPM2 and high-risk primary myeloma tumors were grown in human fetal bone implanted into non-obese diabetic severe combined immunodeficiency mice with a deficient interleukin-2 receptor gamma chain. (haematologica.org)
Expanded natural killer cells killed both allogeneic and autologous primary myeloma cells avidly via a perforin-mediated mechanism in which the activating receptor NKG2D, natural cytotoxicity receptors, and DNAX-accessory molecule-1 played a central role. (haematologica.org)
RESULTS: Administration of this dual receptor agonist to mice resulted in dose-dependent increases in the numbers of total white blood cells and Class II+/CD11c+ cells in spleen and peripheral blood. (medscimonit.com)
The B-cell receptor is formed from the noncovalent association between surface IgM or IgD and 2 transmembrane proteins, IgA and immunoglobulin B. The presence of CD22 and CD19/CD21 on the cell surface, playing the role of coreceptorlike molecules, is necessary for the activation of the receptor. (medscape.com)
RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. (moviplans.com)
Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)

Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
The stromal cell products responsible for these effects of estrogens have not been identified. (jci.org)
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. (zju.edu.cn)

Large granular lymphocyte leukemia (LGLL) is a chronic lymphoproliferative disorder characterized by the proliferation of T or NK cytotoxic cells in the peripheral blood, the spleen and the bone marrow. (nih.gov)
In C5-deficient mice, oral co-administration of C5a and Listeria enhances Listeria-specific cytotoxic T cell levels. (bvsalud.org)
Patients with an absence of cytotoxic T lymphocyte (CTL) function have a high risk for developing HLH, and could therefore benefit the most from early hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)

Both continue their development in the bone marrow through an antigen-independent process called primary lymphopoiesis (PL). Recognized stages of PL are pro-B cell, pre-B cell, immature B cell, and mature B cell. (medscape.com)
The device may also have the capability to flag, count, or classify immature or abnormal hematopoietic cells of the blood, bone marrow, or other body fluids. (medicregister.com)
The primary lymphoid organs, also called central lymphoid organs, are the organs wherein immature lymphocyte s develop. (biologyonline.com)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)

Possible pathogenetic mechanisms may include chronic antigenic stimulation of lymphocytes, proliferation of EBV-infected B lymphocytes, and direct mutagenic effects of metallic ions. (karger.com)
Stimulation of C5aR+ LysoDCs by C5a increases reactive oxygen species levels, leading to efficient antigen cross-presentation, which elicits an antigen-specific CD8+ T cell response. (bvsalud.org)
Stimulation of innate immunity receptors on the dendritic cell by the pathogen promotes phagocytosis by the dendritic cell and the display of antigens with MHC class II molecules. (vumc.org)
The effect of graded amounts of dietary lactalbumin (L) and casein (C) hydrolyzates on the immune responsiveness of C3H/HeN and DBA/2 strain mice has been investigated by measuring both the specific humoral immune response to sheep red blood cells (SRBC) and the nonspecific splenic cell responsiveness to phytohemagglutinin, concanavalin A and Escherichia coli lipopolysaccharide after stimulation with Mycobacteriurn bovis, strain BCG. (immunehealthscience.com)
Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)

The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)
Herein, we report morphologic, phenotypic and functional evaluation of Class II+/CD11c+ cells generated by in vivo administration of ProGP-4. (medscimonit.com)
Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)
Analyzing samples from 805 children with newly diagnosed ALL from three consecutive clinical trials, we determined the ex vivo sensitivity of primary leukemia cells to 18 therapeutic agents across 23 molecular subtypes defined by leukemia genomics. (cdc.gov)

[18] CLLs are, in virtually all cases, preceded by a particular subtype of monoclonal B-cell lymphocytosis (MBL). (wikipedia.org)

Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
For the gene family, see B-cell CLL/lymphoma . (wikipedia.org)
Primary lymphoma of bone is extremely rare. (karger.com)
There are increasing reports of lymphoma arising in bone adjacent to metallic prostheses. (karger.com)
Herein, we describe the case of a 76-year-old man who developed diffuse large B cell lymphoma in the tibia 3 years after total knee arthroplasty for osteoarthritis. (karger.com)
To our knowledge this is the first reported case of a primary lymphoma arising in bone adjacent to a knee prosthesis. (karger.com)
Lima FP, Bousquet M, Gomez-Brouchet A, de Paiva GR, Amstalden EM, Soares FA, Dastugue N, Vassallo J, Brousset P: Primary diffuse large B-cell lymphoma of bone displays preferential rearrangements of the c-MYC or BCL2 gene. (karger.com)
Cheuk W, Chan AC, Chan JK, Lau GT, Chan VN, Yiu HH: Metallic implant-associated lymphoma: a distinct subgroup of large B-cell lymphoma related to pyothorax-associated lymphoma? (karger.com)
Hsieh TC, Kao CH, Yen KY, Sun SS: Osteomyelitis-mimicking primary bone lymphoma at hip prosthetic site. (karger.com)
Ganapathi M, Lake DN, Griffiths AP: Periprosthetic high-grade B-cell lymphoma complicating an infected revision total hip arthroplasty. (karger.com)
Syed AA, Agarwal M, Fenelon G, Toner M: Osseous malignant non-Hodgkin's B-cell lymphoma associated with total hip replacement. (karger.com)
Recent regimens, including kinase inhibitors targeting Bruton tyrosine kinase (BTK) and phosphatidylinositol 3-kinase, as well as B cell lymphoma 2 (BCL2) antagonists, have transitioned treatments from chemotherapy-based to molecular-targeting due to improved survival and better side effect profiles [ 10 ]. (biomedcentral.com)
Large B-cell lymphoma is positive in 24-50% of the cases, another 14% are negative. (nordiqc.org)
CD19 is generally weakly expressed in B-cell prolymphocytic leukaemia, splenic lymphoma with villous lymphocytes and mantle cell lymphoma. (nordiqc.org)
Hodgkin and Reed-Sternberg cells in classical Hodgkin Lymphoma are generally CD19 negative, while around 40% are positive for CD20. (nordiqc.org)
Lymphocytic-Histiocytic (L&H) cells of nodular lymphocytic predominant Hodgkin lymphoma are negative, while staining for CD20 is positive as a rule. (nordiqc.org)
CD20 is strongly expressed in T-cell rich B-cell lymphoma, B-cell prolymphocytic leukaemia, splenic lymphoma with villous lymphocytes and mantle cell lymphoma as opposed to a weaker CD19 reaction mentioned above. (nordiqc.org)
Burkitt lymphoma is an aggressive B-cell non-Hodgkin lymphoma occurring in children and adults. (msdmanuals.com)
This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
NK-cell lineages all of which are further incidence of leukaemia and lymphoma, and radiodiagnosis physician (for imag- classified as distinct entities including it is important to investigate whether ing). (who.int)

Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
MSCs could be derived from a series of tissues including but not limited to umbilical cord, placenta, adipose tissue, bone marrow, gingiva, and dental pulp [5-12]. (researchsquare.com)
Organs are made up of tissues, which are groups of cells that work together to perform a specific function. (vumc.org)
For example, the liver is an organ that is made up of several different types of tissues, including hepatocytes (liver cells), Kupffer cells (immune cells), and bile ducts (tubes that transport bile). (vumc.org)

Immunological parameters such as hematological parameters, delayed-type hypersensitivity (DTH), hemagglutination titer (HA), spleen cellularity, splenocytes proliferation, as well as spleen and bone marrow histopathological assessment were evaluated. (biomedcentral.com)
Our findings showed that melittin has no gross pathological effect on the spleen and bone marrow. (biomedcentral.com)
In adults, disease may be bulky and generalized, often with massive involvement of liver, spleen, and bone marrow. (msdmanuals.com)

Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)

Neoplastic proliferations of white blood cells also cause leukocytosis. (medscape.com)

In addition, Echinacea can also promote the production of interleukin and interferon, achieve the effect of anti-virus, and directly inhibit the effect of tumor cells. (kitairu.net)
It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development. (southernbiotech.com)
Tumor is a result of the proliferation of cells and extra mass formed by tissue growth in any tissue in the body. (innovacare.com.tr)
Plasmacytoma is a tumor arising from plasma cell, which mainly grows within soft tissue or within axial skeleton. (olitespublishing.com)
We did fronto parietal craniectomy and complete resection of tumor with bone margin subsequent cranioplasty also done.Histopathology of which revealed plasmacytoma. (olitespublishing.com)
At 4th post-operative day, en bloc removal of tumor without any residual tumor with cranioplasty. (olitespublishing.com)
Histopathology revealed plasmacytoma .his post-operative period was uneventful, as there was no other site of lytic lesion and we removed tumor in en bloc with part of dura so radiotherapy was not performed. (olitespublishing.com)
ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)

These pluripotent hematopoietic stem cells can divide and mature into one of a number of different types of cells. (vumc.org)

One specificity of LGLL is its frequent association with auto-immune disorders, among them first and foremost rheumatoid arthritis, and other hematologic diseases, including pure red cell aplasia and bone marrow failure. (nih.gov)

Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body, such as the skin, small intestine, liver, and other organs. (rarediseases.org)
[18] Whereas, with CLL, diseased cells propagate from within the bone marrow, in SLL they propagate from within the lymphatic tissue. (wikipedia.org)
Pediatric oncological situations represent a group of diseases, which together with the proliferation of abnormal cells in any tissue, metastasize to another part of the body with blood or lymphatic flow and impair body health. (innovacare.com.tr)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

B-cell disorders are divided into defects of B-cell development/immunoglobulin production ( immunodeficiencies ) and excessive/uncontrolled proliferation ( lymphomas , leukemias ). (medscape.com)
Lymphomas are cancers that involve white blood cells, and can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. (rarediseases.org)
Only 13% of marginal zone B-cell lymphomas are positive. (nordiqc.org)
The expression of CD19 is diminished in about 1/3 of cases of all B-cell lymphomas when compared with normal B-cells. (nordiqc.org)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)

Notably, PDE inhibition also enhanced the enrichment of human Foxp3(+) CD4(+) T cells driven by allogeneic APCs. (lu.se)

Images of peripheral blood and/or bone marrow of blood disorders and normal hematopoiesis. (hematology.org)

After birth, the bone marrow becomes the exclusive production site for lymphoid progenitors. (medscape.com)
CLP differentiates into 2 intermediate progenitors: early B cells and T/NK/dendritic trilineage cells. (medscape.com)
Single cell experiments suggested that the synergistic effect of IL-13 on Lin-Sca-1+ progenitors was directly mediated. (ox.ac.uk)
Furthermore, IL-13 but not IL-4 synergistically enhanced colony formation of Lin-Sca-1+ progenitors in response to granulocyte/macrophage colony-stimulating factor (GM-CSF) (threefold), whereas both IL-4 and IL-13 enhanced G-CSF-induced colony formation (threefold), and neither of the two significantly affected CSF-1 and IL-3-induced proliferation. (ox.ac.uk)
TLR9 is expressed in cells of the innate immune system, as well as in B lymphocytes and their progenitors. (pasteur.fr)

At the same time, it strengthened the epithelial barrier, evidenced by substantially increasing the number of the goblet and Paneth cells and upregulation of tight junction and adhesion molecules. (bvsalud.org)
Intestinal microfold cells (M cells) are a dynamic lineage of epithelial cells that initiate mucosal immunity in the intestine. (bvsalud.org)
We previously demonstrated in an autopsy case that alveolar epithelial cells are the major target cell type of this virus ( 3 ). (cdc.gov)

Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
Mitochondrial function or the ability to generate energy through OXPHOS (oxidative phosphorylation) is vital for cell homeostasis and its dysfunction has been linked to the pathogenesis of nearly all chronic diseases ( Pieczenik and Neustadt, 2007 ). (frontiersin.org)
Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with a predilection for older individuals. (biomedcentral.com)
Chronic Lymphocytic Leukemia Treatment Cost in India : Chronic Lymphocytic Leukemia (CLL) affects the bone marrow and blood in our body. (indiamedassist.com)
Chronic lymphocytic B-cell leukaemia is positive in 36% of the cases. (nordiqc.org)
The aim of the present study was to locate mast cells in chronic periapical lesions (granulomas and cysts) by using histochemical techniques and toluidine blue staining. (bvsalud.org)

CD19 is found on majority of B-cell neoplasms with some exceptions. (nordiqc.org)
The CD19 reactivity patterns differ from those of CD20 in several B-cell lesions: In plasma cells neoplasms with t(11;14) the expression of CD19 and CD20 is mutually exclusive, the majority of cases are CD20+ while only a small fraction of these tumours expresses CD19. (nordiqc.org)
CD19 is useful in identification of B-cell lineage of majority of B-cell neoplasms but appears to be less useful in subclassifying of B-cell neoplasms in histological material. (nordiqc.org)
These are the malignant proliferations of abnormal clones of white blood cells within the bone marrow that are broadly categorized into lymphoid and myeloid neoplasms depending on the type of white cell proliferation. (medscape.com)

People with low immunity can use Echinacea to enhance their immunity, because Echinacea can promote the proliferation of lymphocytes, enhance the immune system, and then enhance immunity. (kitairu.net)
Whether observed apoptotic cells were a direct result of the viral replication or a consequence of an overactivation of the immune system requires further studies. (cdc.gov)

Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)
8. Wright MH, Calcagno AM, Salcido CD, Carlson MD, Ambudkar SV, Varticovski L. Brca1 breast tumors contain distinct CD44 + /CD24 - and CD133 + cells with cancer stem cell characteristics. (southernbiotech.com)
The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
Our hospital is approved to be qualified for implementing stem cell clinic trials by government agencies [19]. (researchsquare.com)
We analyzed the role of transcription factor Zfx, a recently identified regulator of stem cell maintenance, in B cell development and homeostasis. (gsea-msigdb.org)
1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)

Primary B-cell immunodeficiencies refer to diseases resulting from impaired antibody production due to either molecular defects intrinsic to B-cells or a failure of interaction between B-cells and T-cells. (medscape.com)
Centroblasts progress to centrocytes with high-affinity antibody production, then differentiate further to long-term memory cells and plasmablasts. (medscape.com)

A critical length of telomere repeats is required to ensure proper telomere function and avoid the activation of DNA damage pathways that result in replicative senescence or cell death. (nature.com)
It is considered a positive regulator of both intrinsic and stimulus-dependent pathways in B-lymphocytes. (nordiqc.org)
In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
These pathways converge toward the activation of transcription factors, resulting in B-cell activation and proliferation. (medscape.com)

In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
By disrupting cellular DNA, cyclophosphamide is able to kill the cell. (marvistavet.com)

Secondary lymphopoiesis (SL) begins when mature B cells enter the extrafollicular area of lymphoid tissue and differentiate into short-lived plasma cells and memory cells after being stimulated by antigen-presenting cells. (medscape.com)
In the absence of mature B cells, patients lack lymphoid tissue and fail to develop plasma cells, the cells that manufacture antibodies. (medscape.com)
Germinal centers where B cells proliferate and differentiate are poorly developed in all lymphoid tissue, including the spleen. (medscape.com)

Microscopy: two core biopsies of skeletal muscle and fibrous tissue which are infiltrated by a lymphoid proliferation comprising large malignant cells. (radiopaedia.org)

Zfx-deficient B cells showed normal proximal BCR signaling, but impaired BCR-induced proliferation and survival. (gsea-msigdb.org)

Therapies for these disorders (eg, intravenous immunoglobulin [IVIG], bone marrow transplantation, gene therapy) are very costly and require highly advanced facilities. (medscape.com)
Significant similarities in gene expression profiles between calorie restricted WT cells and a non-restricted ade4 mutant suggested the possibility of common gene expression biomarkers of all chronologically long lived cells that could also provide insights into general mechanisms of lifespan extension. (refine.bio)
Using these varied methods to extend CLS, we compared gene expression profiles in the aging cells (at day 8) to identify functionally relevant biomarkers of longevity. (refine.bio)
Patients who have common variable immunodeficiency and autoimmune conditions appear to have very low numbers of isotype-switched memory B cells in peripheral blood and are more likely to have a mutation in the gene that encodes TACI ( TNFRST13B ). (medscape.com)
Non-XLA is the result of mu heavy-chain gene deficiency that leads to abortive production of IgM and failure of B-cell development. (medscape.com)
Determined by its dose-dependent ability to induce reporter gene in HT-29 NF-κB Luc reporter cells. (moviplans.com)

Complete cases of common blood disorders (peripheral blood, bone marrow, and diagnostic studies). (hematology.org)
The peripheral blood and bone marrow are most commonly involved. (hematology.org)
ProGP-4 possesses cross-species activity and treatment of mice with ProGP-4 results in increases in the number of WBC and Class II+/CD11c+ cells in both spleen and peripheral blood. (medscimonit.com)

however, the level of telomerase activity is low or absent in the majority of stem cells regardless of their proliferative capacity. (nature.com)
Telomeric DNA consists of short guanine-rich repeat sequences in all eukaryotes with linear chromosomes, and its length in human somatic cells is remarkably heterogeneous among individuals ranging from 5 to 20 kb, according to age, organ, and the proliferative history of each cell ( Wright and Shay, 2005 ). (nature.com)
As stem cells have elongated proliferative capacity, they should have a mechanism that maintains telomere length through many cell divisions. (nature.com)
Azathioprine inhibits DNA synthesis and, as a purine antimetabolite, exerts its effect on activated lymphocytes, which requires purines during their proliferative phase. (illnesshacker.com)

CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification. (nordiqc.org)

KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4 + T cells. (southernbiotech.com)

Bone marrow transplantation for leukaemia in Europe. (thieme-connect.de)

The cytoplasmic domain serves as a signal transducing element amplifying B-lymphocyte signal by regulating Src family of tyrosine kinases. (nordiqc.org)

Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)

Transgenic mice over-expressing CD19 show reciprocal phenotype with increase in peritoneal B-1 lymphocytes, increase B-cell proliferation, reduction of number of B-cells exiting bone marrow, reduced surface IgM, and elevated humoral immune responses. (nordiqc.org)

CpG DNA inhibits the proliferation of pro-B, but not pre-B, cells by inducing caspase-independent cell death through a pathway that requires the expression of cathepsin B. This pathway is operative in Rag-deficient mice carrying an SP6 transgene, in which B lymphopoiesis is compromised, to reduce the size of the B lymphocyte precursor compartments in the bone marrow. (pasteur.fr)

Although T-cell functions are the primary targets for this drug, inhibition of /(natural killer cells)/ NK function and macrophage activities have also been reported. (illnesshacker.com)

Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)

Interleukin-21 (IL-21) is produced by activated T cells and it plays many diverse roles by regulating the functions of normal and abnormal cells. (intechopen.com)

Anatomy51

Organisms16

Diseases16

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes54

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Differentiation20

Dendritic cells11

Clonal4

Apoptosis6

Mixed lymphocyte assay2

Progenitor8

Cytokines2

Maturation4

Small lymphocytes4

Monocytes4

Mesenchymal11

Eosinophils3

Biopsy5

Monoclonal proliferation3

Vitro4

Lymph7

Multiple Myeloma2

Receptor14

Stromal6

Cytotoxic3

Immature4

Stimulation5

Vivo4

Lymphocytosis1

Lymphoma21

Tissues5

Spleen and bone marrow3

Populations1

Neoplastic1

Tumor8

Hematopoietic1

Rheumatoid arthritis1

Lymphatic4

Lymphomas5

Allogeneic1

Hematopoiesis1

Progenitors5

Epithelial3

Chronic6

Neoplasms4

Immune system2

Stem cell6

Antibody production2

Pathways4

Cellular3

Lymphoid tissue3

Malignant cells1

Survival1

Gene6

Peripheral blood3

Proliferative4

Regulates1

Splenic1

Leukaemia1

Tyrosine kinases1

Prominent1

Peritoneal1

Inhibits1

Inhibition1

Murine model1

Abnormal cells1