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  • multiple sclerosis
  • A vast amount research has been conducted in recent years for the use of MSCs to treat multiple sclerosis (MS). This form of treatment for the disease has been tested in many studies of experimental allergic encephalomyelitis, the animal model of MS, and several published and on-going phase I and phase II human trials. (wikipedia.org)
  • umbilical
  • Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. (wikipedia.org)
  • Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial. (wikipedia.org)
  • The FDA has approved five hematopoietic stem-cell products derived from umbilical cord blood, for the treatment of blood and immunological diseases. (wikipedia.org)
  • tissue
  • Bone marrow derived stem cells have been shown to promote anatomical and functional recovery in animal models of SCI by promoting tissue sparing, axonal regeneration, and remyelination. (clinicaltrials.gov)
  • Increasingly, it is recognized that it is extremely important to facilitate the attachment of osteoblasts on the implant so that a proper foundation of extracellular matrix (ECM) can be laid down for the growth of new bone tissue. (medsci.org)
  • 1 ) ESCs represent the ideal source of new osteoblasts for bone tissue engineering. (medsci.org)
  • Schwann cell-laden grafts and nerve conduits have shown promise for repairing nervous tissue and optic nerves, as have injections of adult stem cells, but the size and complexity of the spinal cord warrants the development of specialized constructs combining several technologies. (docplayer.net)
  • Accordingly, tissue engineering holds great potential to become the optimal approach for the repair of the spinal cord. (docplayer.net)
  • Yet their exact anatomy remained obscure due to the contrasting physical properties of bone and neural tissue. (wikipedia.org)
  • According to studies of bone cancer in mouse femur models, it has been determined that bone pain related to cancer occurs as a result of destruction of bone tissue. (wikipedia.org)
  • Stimulation of specialized pain-sensitive nerve fibers (nociceptors) that innervate bone tissue leads to the sensation of bone pain. (wikipedia.org)
  • Bone tissue is innervated by both myelinated (A beta and A delta fiber) and unmyelinated (C fiber) sensory neurons. (wikipedia.org)
  • Nociceptors responsible for bone pain can be activated via several mechanisms including deterioration of surrounding tissue, bone destruction, and physical stress which shears the bone, vascular, muscle, and nervous tissue. (wikipedia.org)
  • This would provide a radical new treatment approach to a wide variety of conditions where age, disease, or trauma has led to tissue damage or dysfunction. (wikipedia.org)
  • Because of their plasticity and potentially unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. (wikipedia.org)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • inflammatory
  • Gastrointestinal or systemic, such as celiac disease and non-celiac gluten sensitivity (both often occur without obvious digestive symptoms), inflammatory bowel disease (including Crohn's disease and ulcerative colitis). (wikipedia.org)
  • Inflammatory bowel disease. (wikipedia.org)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • differentiate
  • A particular field encouraged by the foundation is stem-cell research, with the great hope that it will result in the ability to get cells to differentiate into neurons and support cells to bridge the gap of a spinal cord injury. (thefutureofthings.com)
  • Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract and skin, which are derived from endoderm and mesoderm. (wikipedia.org)
  • Adult
  • Royan Institute for Stem Cell Biology and Technology (RI-SCBT) first, as the "Department of Stem Cells" was established in 2002 to advance researches on biology and technology of embryonic stem cells, induced pluripotent stem cells, germ line stem cells, adult stem cells, cancer stem cells, and cord blood stem cells. (wikipedia.org)
  • Stem-cell therapy for treatment of myocardial infarction usually makes use of autologous bone-marrow stem cells (a specific type or all), however other types of adult stem cells may be used, such as adipose-derived stem cells. (wikipedia.org)
  • Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007. (wikipedia.org)
  • tumors
  • Bone tumors are composed of a conglomeration of cell types including cancer and immune system cells. (wikipedia.org)
  • certain diseases
  • While you may indeed have a genetic tendency toward developing certain diseases and conditions, the latest research shows that by learning to change your neural wiring, it's possible to turn off those undesirable genes and to signal new, healthier genes to turn on. (mindbodygreen.com)
  • However, in certain diseases the endosteal and haversian nerve supply seems to play an important role, e.g. in osteomalacia, osteonecrosis, and other bone diseases. (wikipedia.org)
  • clinical
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • Canine coronavirus is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. (wikipedia.org)
  • Disseminated disease occurs when the fungus has spread outside of the lungs and may include clinical signs such as lameness, pain, seizures, anterior uveitis, and localized swelling. (wikipedia.org)
  • According to a study performed in the Tucson and Phoenix area, 28% of dogs will test positive for exposure to the fungus by two years of age, but only 6% of the dogs will be ill with clinical disease. (wikipedia.org)
  • Genetic
  • Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing. (wikipedia.org)
  • burden
  • He sees the diseases of an aging population - in the brain, spine, bones, joints and eyes - being cured, easing an enormous burden on patients, their families and the healthcare system. (wikipedia.org)
  • cells
  • This research investigates the use of autologous bone marrow stem cells in patients with spinal cord injury. (clinicaltrials.gov)
  • Other Name: BMMSC - Bone Marrow Mesenchymal Stem Cells. (clinicaltrials.gov)
  • In rodents, and even in some preliminary trials in humans, human embryonic stem cells have been shown to bridge gaps in spinal cord injuries , allowing restoration of motor functions. (thefutureofthings.com)
  • As embryonic stem cells (ESCs) are capable of differentiating into osteoblasts (bone forming cells) and are relatively immune-privileged. (medsci.org)
  • 3 NEW JERSEY COMMISSION ON SPINAL CORD RESEARCH GRANT AWARDS ONE-TIME GRANT FOR START-UP COSTS RECIPIENT: PRINCIPAL INVESTIGATOR Treena Arinzeh, Ph.D. Grant Award: - $686,463 Proposal Title: Neuronal Differentiation of Stem Cells on Nanomeshes In the United States, there are approximately 250,000 people living with spinal cord injuries, and 11,000 new injuries are reported every year. (docplayer.net)
  • 2004: Culture of Human Limbal Stem Cells on Chorionic Membrane and use them for corneal injuries 2005: Establishment of the first Private Cord Blood Bank in Iran (Royan Stem Cell Technology Co.) 2006: The first IVM-IVF sheep born in Iran 2006: Iran's first cloned sheep, named Royana. (wikipedia.org)
  • When the cancer cells have metastasized, the mechanical dynamics of the bone matrix become weaker as skeletal strength decreases. (wikipedia.org)
  • Some of the cell types that have or are currently being developed include cardiomyocytes (CM), neurons, hepatocytes, bone marrow cells, islet cells and endothelial cells. (wikipedia.org)
  • Research has shown that CD34+ cells are relatively more in men than in women in the reproductive age among Spinal Cord Injury victims. (wikipedia.org)
  • These agents, however, cannot discriminate between the leukaemia or neoplastic cells, and the hematopoietic stem cells within the bone marrow. (wikipedia.org)
  • research
  • Christopher Reeve and his wife, Dana, started a foundation that continues to encourage research in the field of spinal injuries, the Christopher Reeve Foundation . (thefutureofthings.com)
  • 2 NEW JERSEY COMMISSION ON SPINAL CORD RESEARCH This data was compiled in compliance with the New Jersey Commission on Spinal Cord Research's statutory mandate, N.J.S.A. 52:9E-1, to compile a directory of spinal cord research being conducted in the State. (docplayer.net)
  • In addition, institutions are not obligated to share their research information with the New Jersey Commission on Spinal Cord Research. (docplayer.net)