• multiple sclerosis
  • A vast amount research has been conducted in recent years for the use of MSCs to treat multiple sclerosis (MS). This form of treatment for the disease has been tested in many studies of experimental allergic encephalomyelitis, the animal model of MS, and several published and on-going phase I and phase II human trials. (wikipedia.org)
  • tissue
  • Increasingly, it is recognized that it is extremely important to facilitate the attachment of osteoblasts on the implant so that a proper foundation of extracellular matrix (ECM) can be laid down for the growth of new bone tissue. (medsci.org)
  • 1 ) ESCs represent the ideal source of new osteoblasts for bone tissue engineering. (medsci.org)
  • Schwann cell-laden grafts and nerve conduits have shown promise for repairing nervous tissue and optic nerves, as have injections of adult stem cells, but the size and complexity of the spinal cord warrants the development of specialized constructs combining several technologies. (docplayer.net)
  • Accordingly, tissue engineering holds great potential to become the optimal approach for the repair of the spinal cord. (docplayer.net)
  • This is the only organization that focuses on the understanding and treatment of disease by probing into the characteristics of adipose tissue and its rich repository of stem cells. (prweb.com)
  • Yet their exact anatomy remained obscure due to the contrasting physical properties of bone and neural tissue. (wikipedia.org)
  • According to studies of bone cancer in mouse femur models, it has been determined that bone pain related to cancer occurs as a result of destruction of bone tissue. (wikipedia.org)
  • Stimulation of specialized pain-sensitive nerve fibers (nociceptors) that innervate bone tissue leads to the sensation of bone pain. (wikipedia.org)
  • Bone tissue is innervated by both myelinated (A beta and A delta fiber) and unmyelinated (C fiber) sensory neurons. (wikipedia.org)
  • Nociceptors responsible for bone pain can be activated via several mechanisms including deterioration of surrounding tissue, bone destruction, and physical stress which shears the bone, vascular, muscle, and nervous tissue. (wikipedia.org)
  • This would provide a radical new treatment approach to a wide variety of conditions where age, disease, or trauma has led to tissue damage or dysfunction. (wikipedia.org)
  • Because of their plasticity and potentially unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. (wikipedia.org)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • differentiate
  • A particular field encouraged by the foundation is stem-cell research, with the great hope that it will result in the ability to get cells to differentiate into neurons and support cells to bridge the gap of a spinal cord injury. (thefutureofthings.com)
  • When a stem cell divides, each new cell can either remain a stem cell or differentiate into a more specialized cell such as nerve, blood, bone or muscle. (prweb.com)
  • Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract and skin, which are derived from endoderm and mesoderm. (wikipedia.org)
  • Adult
  • Royan Institute for Stem Cell Biology and Technology (RI-SCBT) first, as the "Department of Stem Cells" was established in 2002 to advance researches on biology and technology of embryonic stem cells, induced pluripotent stem cells, germ line stem cells, adult stem cells, cancer stem cells, and cord blood stem cells. (wikipedia.org)
  • Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007. (wikipedia.org)
  • Acute
  • Acute rheumatic fever, a very dangerous disease that can cause permanent cardiac damage. (wikipedia.org)
  • Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. (wikipedia.org)
  • tumors
  • Bone tumors are composed of a conglomeration of cell types including cancer and immune system cells. (wikipedia.org)
  • clinical
  • the Krembil is also one of the largest research institutes in Canada focusing on human neurological disease from both a basic science and clinical research perspective. (wikipedia.org)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • Canine coronavirus is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. (wikipedia.org)
  • Disseminated disease occurs when the fungus has spread outside of the lungs and may include clinical signs such as lameness, pain, seizures, anterior uveitis, and localized swelling. (wikipedia.org)
  • According to a study performed in the Tucson and Phoenix area, 28% of dogs will test positive for exposure to the fungus by two years of age, but only 6% of the dogs will be ill with clinical disease. (wikipedia.org)
  • treatment
  • a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. (wikipedia.org)
  • this process can go too far, however, leading to graft vs host disease, the most serious side effect of this treatment. (wikipedia.org)
  • certain diseases
  • While you may indeed have a genetic tendency toward developing certain diseases and conditions, the latest research shows that by learning to change your neural wiring, it's possible to turn off those undesirable genes and to signal new, healthier genes to turn on. (mindbodygreen.com)
  • However, in certain diseases the endosteal and haversian nerve supply seems to play an important role, e.g. in osteomalacia, osteonecrosis, and other bone diseases. (wikipedia.org)
  • cells
  • In rodents, and even in some preliminary trials in humans, human embryonic stem cells have been shown to bridge gaps in spinal cord injuries , allowing restoration of motor functions. (thefutureofthings.com)
  • As embryonic stem cells (ESCs) are capable of differentiating into osteoblasts (bone forming cells) and are relatively immune-privileged. (medsci.org)
  • 3 NEW JERSEY COMMISSION ON SPINAL CORD RESEARCH GRANT AWARDS ONE-TIME GRANT FOR START-UP COSTS RECIPIENT: PRINCIPAL INVESTIGATOR Treena Arinzeh, Ph.D. Grant Award: - $686,463 Proposal Title: Neuronal Differentiation of Stem Cells on Nanomeshes In the United States, there are approximately 250,000 people living with spinal cord injuries, and 11,000 new injuries are reported every year. (docplayer.net)
  • 2004: Culture of Human Limbal Stem Cells on Chorionic Membrane and use them for corneal injuries 2005: Establishment of the first Private Cord Blood Bank in Iran (Royan Stem Cell Technology Co.) 2006: The first IVM-IVF sheep born in Iran 2006: Iran's first cloned sheep, named Royana. (wikipedia.org)
  • When the cancer cells have metastasized, the mechanical dynamics of the bone matrix become weaker as skeletal strength decreases. (wikipedia.org)
  • Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing. (wikipedia.org)
  • Some of the cell types that have or are currently being developed include cardiomyocytes (CM), neurons, hepatocytes, bone marrow cells, islet cells and endothelial cells. (wikipedia.org)
  • Research has shown that CD34+ cells are relatively more in men than in women in the reproductive age among Spinal Cord Injury victims. (wikipedia.org)
  • Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. (wikipedia.org)
  • These agents, however, cannot discriminate between the leukaemia or neoplastic cells, and the hematopoietic stem cells within the bone marrow. (wikipedia.org)
  • research
  • Christopher Reeve and his wife, Dana, started a foundation that continues to encourage research in the field of spinal injuries, the Christopher Reeve Foundation . (thefutureofthings.com)
  • 2 NEW JERSEY COMMISSION ON SPINAL CORD RESEARCH This data was compiled in compliance with the New Jersey Commission on Spinal Cord Research's statutory mandate, N.J.S.A. 52:9E-1, to compile a directory of spinal cord research being conducted in the State. (docplayer.net)
  • In addition, institutions are not obligated to share their research information with the New Jersey Commission on Spinal Cord Research. (docplayer.net)
  • suffer
  • Doctors have long known that black people are more likely than white people to suffer from diseases such as high blood pressure. (wesa.fm)
  • It occurs as a result of a wide range of diseases and/or physical conditions and may severely impair the quality of life for patients who suffer from it. (wikipedia.org)
  • renal
  • A number of diseases can cause bone pain, including the following: Endocrine, such as hyperparathyroidism, osteoporosis, renal failure. (wikipedia.org)