Bone cell proliferation neoplasms plasma cell. Medical search. Frequent questions

Multiple myeloma (MM) , also known as plasma cell myeloma , is a multifocal proliferation of plasma cells based in the bone marrow . (radiopaedia.org)
Multiple myeloma accounts for one of the 'M's in the popular mnemonic for lucent bone lesions FEGNOMASHIC . (radiopaedia.org)
As per the WHO classification of tumors of hematopoietic and lymphoid tissues , multiple myeloma is called plasma cell myeloma 14 . (radiopaedia.org)
Multiple myeloma and osteosarcoma combined account for ~50% of all primary bone malignancies 7 . (radiopaedia.org)
Multiple myeloma is the most common primary malignant neoplasm of the skeletal system. (medscape.com)
[ 1 ] The etiology of multiple myeloma is the monoclonal proliferation of plasma B cells, with resultant marrow infiltration and increase of a single immunoglobulin and its fragments in the serum and urine. (medscape.com)
[ 8 ] Patients suspected of having multiple myeloma based on bone marrow aspirate results or hypergammaglobulinemia should undergo a radiographic skeletal survey. (medscape.com)
[ 9 ] MRI is the gold-standard imaging modality for detection of bone marrow involvement and the preferred imaging technique to rule out spinal cord compression in patients with multiple myeloma, whereas PET/CT provides valuable prognostic data and aids in assessment of response to therapy. (medscape.com)
range, 44-83 years) with multiple myeloma proven by bone marrow biopsy. (medscape.com)
Multiple myeloma (MM) is an incurable neoplasm caused by proliferation of malignant plasma cells in the bone marrow (BM). (huji.ac.il)
Plasmacytoma is a neoplastic proliferation of monoclonal plasma cells, which can present clinically as solitary bone neoplasm, extramedullary plasmacytoma, and multiple myeloma. (autopsyandcasereports.org)
Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells within the bone marrow. (oncotarget.com)
blood transfusion), spinal cord, lung cancer (oncology), respiratory cancer, radiology Background Multiple myeloma is a malignant proliferation of plasma cells mostly affecting the bone marrow and commonly presents with anaemia, hypercalcaemia, renal dysfunction, bone and skeletal involvement. (2011globalhealth.org)
Linden has continued doing research on multiple myeloma and other plasma cell neoplasms while translating that knowledge to clinical application through improved laboratory diagnoses, clinical monitoring, and prediction of disease resistance to therapy.Multiple myeloma is characterized by the proliferation of malignant plasma cells within the bone marrow. (umn.edu)
Multiple myeloma (MM) is a neoplastic, monoclonal proliferation of terminally differentiated plasma cells. (thejh.org)
Multiple myeloma (MM) is caused by the neoplastic proliferation of plasma cells. (jnccn.org)
These neoplastic plasma cells proliferate and produce monoclonal immunoglobulin in the bone marrow causing skeletal damage, a hallmark of multiple myeloma. (jnccn.org)
The NCCN Multiple Myeloma Panel members have developed guidelines for the management of patients with various plasma cell dyscrasias, including solitary plasmacytoma, smoldering myeloma, multiple myeloma, systemic light chain amyloidosis, and Waldenström's macroglobulinemia. (jnccn.org)
The NCCN Guidelines for Multiple Myeloma provide recommendations for diagnosis, initial workup, treatment, follow-up, and supportive care for patients with various plasma cell neoplasms, including multiple myeloma. (jnccn.org)
A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. (lookformedical.com)
651. Myeloma: Biology and Pathophysiology, excluding Therapy: The Role of the Bone Marrow Microenvironment in the Pathogenesis and Therapy of Multiple Myeloma and Waldenstrom's Macroglobulinemia. (confex.com)
Multiple myeloma (also known as MM , myeloma , plasma cell myeloma , or as Kahler's disease after Otto Kahler) is a presently incurable hematological malignancy of plasma cells, the cells of the immune system that produce antibodies. (the-medical-dictionary.com)
Multiple myeloma, a rare malignancy of plasma cells, was first described in 1950 as an abnormal production of immunoglobulins. (the-medical-dictionary.com)
Patients suffering from monoclonal gammopathy are at risk of developing Multiple Myeloma, a type of plasma cells cancer, or Amyloidosis, a group of disease in which abnormal proteins build up in body tissue. (editorproject.com)
Determine the characteristics of pre-malignant plasma cells in individuals at risk of developing multiple myeloma and amyloidosis. (editorproject.com)
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. (uams.edu)
ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. (uams.edu)
The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells. (uams.edu)
Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells. (uams.edu)

A research team from the University Hospitals of Cleveland Medical Center in western Pennsylvania has discovered the existence of myeloid neoplasms (MNs) that can undergo plasmacytoid dendritic cell (PDC) differentiation. (news-medical.net)
The groups study present evidence of myeloid neoplasms derived from patients with acute leukemias which encompass a spectrum of PDC differentiation which result in outcomes that do not fit into the categories of MPD MN or BPDCN. (news-medical.net)
Both categories of cells resulting from atypical PDC differentiation are thought to represent two ends of a spectrum of maturation. (news-medical.net)
Leukemic myoblast differentiation into PDCs occurs as a result of sharing a common hematopoietic precursor to dendritic cells, monocytes, and myeloid cells. (news-medical.net)
Flt3 or CD135 signaling induces differentiation and proliferation of pDCs, although their mechanisms are not entirely understood. (wikipedia.org)
For example, the secretion of type 1 interferon triggers natural killer cells to produce IFNγ while also activating the differentiation of B cells. (wikipedia.org)
Lymphoplasmacytic lymphoma (LPL) is a neoplasm of mature B-cells exhibiting some plasmacytic differentiation. (hematology.org)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
Thus, the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs, significantly impacting MDS-MSCs differentiation. (techscience.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
However, the tumour cells have undergone hypermutation, 21 23 a feature of the GC reaction during B-cell activation and differentiation. (bmj.com)
There is clonal proliferation of malignant hematopoietic stem cells, dysregulated cellular differentiation, and compromised tissue function. (standardofcare.com)
Thrombopoiesis takes place primarily in the bone marrow through a series of cell differentiation and is influenced by several cytokines. (lecturio.com)
Decreased ferroportin promotes myeloma cell growth and osteoclast differentiation. (uams.edu)
Btk is required for the proliferation and differentiation of B lymphocytes. (medscape.com)
However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)

Clinical definitions of the various myeloma subtypes have been updated, as have the imaging definitions of what constitutes bone marrow disease and individual bony involvement. (medscape.com)
Standard 99m Tc bone scintigraphy should play no role in the routine staging of myeloma, and sequential dual-energy radiographic absorptiometry (DXA) scans are not recommended, according to the authors. (medscape.com)
Introduction: Myeloma is a form of blood cancer that affects the bone marrow. (peoplebeatingcancer.org)
A re-evaluation of solitary plasma cell myeloma of bone. (autopsyandcasereports.org)
Investigators use murine and human myeloma cell lines, xenograft models, and genetically engineered mice to identify the multiple genetic pathways involved in the pathobiology of the disease as well as mechanisms of drug resistance. (umn.edu)
Additional findings are: a raised calcium (when myeloma cells are breaking down bone, releasing calcium into the bloodstream) and decreased renal function, which may be due to paraprotein deposition in the kidney). (the-medical-dictionary.com)
Fibroblast activation protein (FAP) is upregulated in myelomatous bone and supports myeloma cell survival. (uams.edu)
Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance. (uams.edu)
Arsenic trioxide-mediated growth inhibition of myeloma cells is associated with an extrinsic or intrinsic signaling pathway through activation of TRAIL or TRAIL receptor 2. (uams.edu)
High expression of BCL3 in human myeloma cells is associated with increased proliferation and inferior prognosis. (uams.edu)
Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells. (uams.edu)
Myeloma cell-derived Runx2 promotes myeloma progression in bone. (uams.edu)

Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm characterized by the proliferation of abnormal plasma cells outside the bone marrow. (peoplebeatingcancer.org)
Edema builds up abnormal and excessive fluids that cause serious actions to the tissue cells. (jagomart.net)
These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin. (lookformedical.com)
Abnormal immunoglobulins synthesized by atypical cells of the MONONUCLEAR PHAGOCYTE SYSTEM. (lookformedical.com)
In patients with unexplained anemia, thrombocytopenia, or neutropenia without dysplasia in the bone marrow but with abnormal chromosome activity in 5, 7 or 13 the diagnosis is consistent with MDS and occurs in less than 10% of patients with MDS. (standardofcare.com)
The clonal outgrowth of mutant stem cells favors and abnormal hematopoietic stem cell niche. (standardofcare.com)
It is the abnormal growth and proliferation of lymphocytes. (medicalbiochemist.com)
HL is characterized by the presence of Reed-Sternberg cells, which are large, abnormal cells derived from B cells. (medicalbiochemist.com)
These are a group of disorders characterized by abnormal growth and development of cells in the myeloid lineage, which includes granulocytes, monocytes erythrocytes, platelets, etc. (medicalbiochemist.com)
The increment in erythrocyte mass in SP patients results from bone marrow stimulation by EPO or abnormal functioning of the mutant EPO receptor. (nature.com)
The term leukaemia comprehends a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. (editorproject.com)
This course presents the disease processes leading to abnormal white and red cell morphology, and white blood cell disorders, including both benign and malignant states. (iowacentral.edu)
Examine and identify normal and abnormal blood cell morphology on a peripheral blood smear. (iowacentral.edu)

MPNs are characterized by the neoplastic proliferation of multipotent myeloid stem cells in the bone marrow. (medicalbiochemist.com)

Solitary extramedullary plasmacytoma (SEP) describes solid plasma cell tumours of soft-tissue origin as opposed to solitary plasmacytoma of bone. (2011globalhealth.org)
The extension of bone marrow and extramedullary involvement should be carefully evaluated to establish prognosis and clinical management [ 4 ]. (hindawi.com)
Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. (lookformedical.com)
Dimopoulos MA, Kiamouris C, Moulopoulos LA. Solitary plasmacytoma of bone and extramedullary plasmacytoma. (najms.com)

It can cause lesions to grow in the bones and spinal column, which can lead to fractures and even death. (peoplebeatingcancer.org)
M-protein), and the presence of end organ damage which may include lytic bone lesions [ 1 ]. (oncotarget.com)
While MM presents with a variety of disease-related complications, the most common complications include the following: hypercalcemia, renal insufficiency, anemia, and bone lesions [ 2 , 3 ]. (thejh.org)
Additional information could be provided by computed tomography (CT) and magnetic resonance imaging (MRI), while conventional bone scintigraphy is affected by low sensitivity because of inadequate osteoblastic activity in MM lesions [ 1 - 3 ]. (hindawi.com)
These methods demonstrated a greater diagnostic accuracy compared to whole-body X-ray in diagnosing lytic bone lesions. (hindawi.com)
The CD19 reactivity patterns differ from those of CD20 in several B-cell lesions: In plasma cells neoplasms with t(11;14) the expression of CD19 and CD20 is mutually exclusive, the majority of cases are CD20+ while only a small fraction of these tumours expresses CD19. (nordiqc.org)

Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
The result is a lymphoma comprising of small B-lymphocytes, plasmacytoid B-cells with more abundant cytoplasm, as well as clonal plasma cells. (hematology.org)
Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. (bmj.com)
1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
Large B-cell lymphoma is positive in 24-50% of the cases, another 14% are negative. (nordiqc.org)
CD19 is generally weakly expressed in B-cell prolymphocytic leukaemia, splenic lymphoma with villous lymphocytes and mantle cell lymphoma. (nordiqc.org)
Hodgkin and Reed-Sternberg cells in classical Hodgkin Lymphoma are generally CD19 negative, while around 40% are positive for CD20. (nordiqc.org)
Lymphocytic-Histiocytic (L&H) cells of nodular lymphocytic predominant Hodgkin lymphoma are negative, while staining for CD20 is positive as a rule. (nordiqc.org)
CD20 is strongly expressed in T-cell rich B-cell lymphoma, B-cell prolymphocytic leukaemia, splenic lymphoma with villous lymphocytes and mantle cell lymphoma as opposed to a weaker CD19 reaction mentioned above. (nordiqc.org)
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
EDITOR will focus on Follicular Lymphoma (FL) - FL is a systemic indolent neoplasm of the lymphoid tissue and represents 20-25% of all new non-Hodgkin lymphoma (NHL) diagnoses. (editorproject.com)
Extranodal NK/T cell lymphoma is a rare non-Hodgkin lymphoma mainly involving the upper aerodigestive tract, even rarer is primary extranasal disease involving the intestine. (frontiersin.org)
We present a case of primary intestinal NK/T cell lymphoma with diagnostic challenge, which eventually developed into multiple intestinal perforations. (frontiersin.org)
The surgical samples underwent pathological analysis, and a diagnosis of extranodal NK/T cell lymphoma nasal type was confirmed. (frontiersin.org)
Early diagnosis of primary intestinal NK/T cell lymphoma is frequently difficult. (frontiersin.org)
Extranodal NK/T cell lymphoma nasal type (ENKTL) is a subtype of non-Hodgkin lymphoma (NHL). (frontiersin.org)
It is an invasive lymphoma derived from NK cells or cytotoxic T cells, which is related to Epstein-Barr virus infection. (frontiersin.org)
Diffuse large B-cell lymphoma is the most common histologic subtype of NHL, with ENKTL of the large bowel being less frequent ( 4 ). (frontiersin.org)

The bone marrow demonstrated a diffuse proliferation of small lymphocytes admixed with plasmacytoid lymphocytes and clusters of plasma cells. (hematology.org)
Bone marrow aspirate smear shows increased small lymphocytes with clumped chromatin and scant cytoplasm (green arrow). (hematology.org)
Plasmacytoid lymphocytes (red arrow) and atypical plasma cells (black arrow) are seen. (hematology.org)
A bone core biopsy shows diffuse infiltration by small lymphocytes and plasma cells (A). Dutcher bodies (intra-nuclear pseudo-inclusions comprised of immunoglobulin) are readily identified (B). (hematology.org)
Transgenic mice over-expressing CD19 show reciprocal phenotype with increase in peritoneal B-1 lymphocytes, increase B-cell proliferation, reduction of number of B-cells exiting bone marrow, reduced surface IgM, and elevated humoral immune responses. (nordiqc.org)

This work builds on existing knowledge that PDCs can be divided into two categories: mature PDC proliferations which result in myeloid neoplasms (MPDMN) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). (news-medical.net)
pDCs that undergo malignant transformation cause a rare hematologic disorder, blastic plasmacytoid dendritic cell neoplasm. (wikipedia.org)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare type of myeloid cancer in which malignant pDCs infiltrate the skin, bone marrow, central nervous system, and other tissues. (wikipedia.org)
Blastic plasmacytoid dendritic cell neoplasm has a high rate of recurrence following initial treatments with various chemotherapy regimens. (wikipedia.org)

This case highlights the importance of genetic counseling in patients with hematopoietic neoplasms with high clinical suspicion for carrying cancer susceptibility gene mutations, which require timely diagnosis and personalized management. (frontiersin.org)

Images of peripheral blood and/or bone marrow of blood disorders and normal hematopoiesis. (hematology.org)
Complete cases of common blood disorders (peripheral blood, bone marrow, and diagnostic studies). (hematology.org)
In B-cell lymphoproliferative disorders, the neoplastic B-cell population shares the same Ig rearrangement pattern and serves as a marker for monoclonality that can be detected by PCR and capillary electrophoresis. (cellnetix.com)
Clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias. (standardofcare.com)
A heterogenous group of myeloid disorders characterized by somatically mutated hematopoietic stem cells,the presence of variable peripheral cytopenias, and a broad risk of progression to acute myeloid leukemia (AML). (standardofcare.com)
The differential diagnosis of a mediastinal mass includes benign and malignant etiologies like lymphomas, thymic tumors, thyroid goiter, infections such as tuberculosis, chronic granulomatous disorders such as sarcoidosis, germ cell tumors, among others. (scientificarchives.com)
MDS refers to a group of disorders characterized by ineffective blood cell production in the bone marrow, leading to low blood counts. (medicalbiochemist.com)

Unlike conventional dendritic cells (cDCs) that leave the bone marrow as precursors, pDCs leave the bone marrow to go to the lymphoid organs and peripheral blood upon completing development. (wikipedia.org)
Define the cellular origin of WM by comparing the genetic landscape of WM cells to that of CD34+ HPC, B cell precursors and residual normal B cells. (confex.com)
We used FACSorting to isolate 57 cell subsets from bone marrow (BM) aspirates of 10 WM patients: CD34+ HPC, B cell precursors, residual normal B cells (if detectable), WM B cells, plasma cells (PCs) and T cells (germline control). (confex.com)
In parallel, MYD88 p.L252P (orthologous position of the human L265P mutation) transgenic mice were crossed with conditional Sca1 Cre , Mb1 Cre , and Cγ1 Cre mice to selectively induce in vivo expression of MYD88 mutation in CD34+ HPC, B cell precursors and germinal center B cells, respectively. (confex.com)
Notably, we found MYD88 L265P in B cell precursors from 1/10 cases and in residual normal B cells from 4/10 patients, which were confirmed by ASO-PCR and ddPCR. (confex.com)
Indeed, these more sensitive methods detected MYD88 L265P in B cell precursors from 6/10 cases and in residual normal B cells from 6/10 patients. (confex.com)
CXCR4 was simultaneously mutated in B cell precursors and WM B cells from one patient. (confex.com)
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. (curehunter.com)
The paradox is that the mutation provides advantage at the stem cell level and progenitor cells, with a disadvantage at the level of hematopoietic precursors. (standardofcare.com)
These cells are believed to be the precursors of neuroblastomas and ganglioneuromas. (medscape.com)

Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs). (msdmanuals.com)
10. Which of the following is a common finding in myeloproliferative neoplasms (MPNs)? (medicalbiochemist.com)

It accounts for 1% of all malignancies and 10-15% of all hematological neoplasms 12,14 . (radiopaedia.org)
Ayvakit is already approved for advanced SM, SM with associated hematological neoplasms, aggressive SM, mast cell leukemia and unresectable or metastatic gastrointestinal stromal tumor. (biospace.com)

1) It accounts for approximately 10 to 15% of all hematologic malignancies, 1% of all malignant neoplasms in whites and 2% in blacks, and 2% of deaths from all malignancies. (the-medical-dictionary.com)

A bone marrow study with biopsy is performed. (hematology.org)
Immunohistochemical stains on the core biopsy showed diffuse infiltration of CD20-positive B-cells, and increased kappa-restricted CD138-positive plasma cells. (hematology.org)
A bone marrow biopsy is usually performed to estimate the percentage of bone marrow occupied by plasma cells. (the-medical-dictionary.com)
Diagnosis is based on peripheral blood analysis and bone marrow biopsy findings. (lecturio.com)
Bone marrow biopsy shows hypercellularity with increased granulocytes and megakaryocytes. (medicalbiochemist.com)
A subsequent complete work up for systemic disease revealed normal bone marrow biopsy, normal flow cytometry, and negative skeletal survey. (najms.com)
Pre-treatment biopsy demonstrates bland spindle cell proliferation and irregular bony trabeculae resembling fibrous dysplasia. (medscape.com)
Pre-treatment biopsy at higher power demonstrates malignant cells with round and spindle nuclei infiltrating irregular bony trebeculae with evidence of osteoid formation. (medscape.com)
However, biopsy of lymphoid tissue and bone marrow examination are not currently performed in the workup of most cases of XLA. (medscape.com)

In addition, none of the PDC proliferations satisfied the clinical or pathological criteria for BPDCN. (news-medical.net)
Additional groups of 10 male and 10 female rats (clinical pathology study) and five male and five female rats (plasma concentration study) were administered the same doses, 5 days per week for up to 14 weeks. (nih.gov)
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia. (lookformedical.com)
Diagnosing hematolymphoid neoplasm by evaluating fine-needle aspiration (FNA) cytology sample is controversial and requires experience and clinical skills. (cytojournal.com)
Pheochromocytomas and catecholamine-secreting paragangliomas have a similar clinical presentation, but the risk for associated neoplasms, risk for malignancy, and genetic testing is different between the tumors. (medscape.com)
Analyzing samples from 805 children with newly diagnosed ALL from three consecutive clinical trials, we determined the ex vivo sensitivity of primary leukemia cells to 18 therapeutic agents across 23 molecular subtypes defined by leukemia genomics. (cdc.gov)

Recently, shared mutations between clonal B cells in MBL/CLL and CD34+ hematopoietic progenitor cells (HPC) have been identified. (confex.com)
26 27 In contrast, the chromosomal breakpoint in sBL and HIV-associated BL occurs most commonly in the class switch region, 28 but since both somatic hypermutation and class switching are events that are normally confined to GC B cells and GC centroblast markers are expressed on BL cells, the BL progenitor cells most likely arise from B cells subjected to chromosomal rearrangements in the GC. (bmj.com)
The mutation occurs in hematopoetic stem cells capable of self renewal and additional mutations are associated with clonal progression may occur in progenitor cells conferring a self renewal capability. (standardofcare.com)

Plasmacytoma is a clonal proliferation and neoplastic of plasma cells. (bvsalud.org)

Investigations On admission the patients blood count was normal: haemoglobin 138 g/L, white cell count 5.14109/L with a normal differential and platelets 256109/L. Chemistry was normal with no evidence of renal failure or hypercalcaemia. (2011globalhealth.org)
EPO-secreting tumors EPO-secreting tumors Polycythemia Vera , such as renal cell carcinoma Renal cell carcinoma Renal cell carcinoma (RCC) is a tumor that arises from the lining of the renal tubular system within the renal cortex. (lecturio.com)
Renal cell carcinoma is responsible for 80%-85% of all primary renal neoplasms. (lecturio.com)

BPDCNs commonly infiltrate the skin and bone marrow, disseminate, and display an aggressive phenotype. (news-medical.net)

MRI can provide information that is complementary to a skeletal survey and was recommended for use in patients with normal radiographic images and in all patients with an apparently solitary plasmacytoma of bone. (medscape.com)
It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. (lookformedical.com)

It has also been described in hematologic malignancies such as acute leukemia and following bone marrow transplantation [ 5 , 6 ]. (thejh.org)
NHL encompasses a diverse group of lymphoid malignancies that can arise from B cells, T cells, or natural killer (NK) cells. (medicalbiochemist.com)

PDC progenitors are in common with monocytic and myeloid cell progenitors. (news-medical.net)
In the bone marrow, common dendritic cell progenitors expressing Flt3 (CD135) receptors are able to give rise to pDCs. (wikipedia.org)

Inclusion of at least these bones is important for both diagnosis and staging . (medscape.com)
A diagnosis of LPL with bone marrow involvement along with IgM paraprotein is termed Waldenström's macroglobulinemia (WM). (hematology.org)
To confirm the diagnosis proceeded immunohistochemistry evaluation which showed positivity for Plasma Cell and Lambda and negativity of Kappa. (bvsalud.org)
Criteria for diagnosis of MDS consist of anemia, thrombocytopenia, or neutropenia that persist for six months or longer, dysplasia greater than 10% in at least one bone marrow cell lineage, and MDS associated clonal cytogenetic abnormalities or molecular markers. (standardofcare.com)
A frozen section diagnosis of "unclassified neoplasm, defer to permanent sections" was made. (najms.com)

It is the most common primary malignant bone neoplasm in adults. (radiopaedia.org)

FL is considered incurable and is preceded by an asymptomatic preclinical phase in which premalignant B cells carrying a t(14;18) chromosomal translocation accumulate additional genetic alterations. (editorproject.com)

One of the most notable changes is an expanded bone marrow space, which leads to the thinning of the bone cortex. (passmed.uk)

Throughout the lifetime of patients with an FA gene mutation, DNA damage increasing accumulates, which would lead to a complex clinically and genetically heterogeneous disorder characterized by developmental abnormalities, bone marrow failure (BMF), immune deficiency, and a high risk of developing various cancers (e.g. (frontiersin.org)
Some clinically benign proliferations could have a clonal origin (e.g. benign monoclonal gammopathies). (cellnetix.com)
When the bone marrow hematopoietic cells are mostly clonally derived cells, the disease is clinically manifested as cytopenia and morphologic dysplasia. (standardofcare.com)

Histopathology (HE) was identified a malignant neoplasm characterized by proliferation of plasmacytoid cells intensely hyperchromatic and pleomorphic. (bvsalud.org)
On touch prep, naked nuclei with homogenous/salt and pepper chromatin, mild crush artifacts and rare plasmacytoid cells were noted. (najms.com)

They develop from bone marrow hematopoietic stem cells and constitute (wikipedia.org)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) is a disease characterized by increased absolute red blood cell mass caused by stimulation of red blood cell production. (nature.com)

There is a growing literature that tumor cells release biologically active microvesicles (MVs) that modify both local and distant microenvironments. (oncotarget.com)
A cell line derived from cultured tumor cells. (lookformedical.com)
1 paraffin embedded tissue block or 6 unstained 7-micron slides with an additional H&E stained slide containing at least 50% tumor cells. (cellnetix.com)
Immunohistochemical analysis on permanent sections showed that tumor cells were positive for CD138, CD56, kappa light chain, BCL-1 and negative for chromogranin A and lambda light chain. (najms.com)

Currently, whole-body X-ray scan is the most commonly used diagnostic tool in the evaluation of bone involvement in patients with MM, due to the rare occurrence of extraosseous sites. (hindawi.com)
Infection, bone marrow aplasia, or lung involvement (acute chest syndrome) can develop acutely and be fatal. (msdmanuals.com)

We present a functional analysis of TRIM13 using a loss-of-function approach, and demonstrate that TRIM13 downregulation decreases tumour cell survival as well as cell cycle progression and proliferation of MM cells. (huji.ac.il)
The observation of this intercellular communication and that MM cells modify the microenvironment is highly suggestive that one of the first biologically relevant changes necessary for progression of MGUS or SMM to MM is for a member(s) of the clone to evolve and acquire the molecular changes needed to reprogram its immediate microenvironment into a supportive, growth-promoting microenvironment. (oncotarget.com)
Bone marrow loss and a high proclivity to leukemic progression are the characteristics of myelodysplastic syndrome (MDS). (techscience.com)
A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
They were nanoscale membrane vesicles that were generated by most types of cells, which can convey information in the tumor microenvironment by transferring cargos such as DNA, RNA, proteins and lipids, therefore they are critical to tumor progression [ 5 ]. (biomedcentral.com)
The bone marrow microenvironment and inflammatory signaling can also determine the rate of development and progression of MDS. (standardofcare.com)

Only 13% of marginal zone B-cell lymphomas are positive. (nordiqc.org)
The expression of CD19 is diminished in about 1/3 of cases of all B-cell lymphomas when compared with normal B-cells. (nordiqc.org)
In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
mature T/NK-cell lymphomas (C84. (who.int)

The disease is a malignancy of plasma cells. (medscape.com)

pDC maturation is initiated when the cell comes in contact with a virus, prompting the upregulation of MHC class I and MHC class II, co-stimulatory molecules CD80, CD86, CD83, and c-c chemokine receptor 7 (CCR7) and interferon production gradually decreases. (wikipedia.org)
Upon stimulation and subsequent activation of TLR7 and TLR9, these cells produce large amounts (up to 1,000 times more than other cell type) of type I interferon (mainly IFN-α and IFN-β), which are critical anti-viral compounds mediating a wide range of effects and induce maturation of the pDC. (wikipedia.org)
A pDC's ability to stimulate T cells is heightened following maturation. (wikipedia.org)
As mentioned earlier, maturation also induces the expression of both MHC Class I and Class II molecules in pDCs as well, which allows the cell to optimize its antigen-presenting abilities. (wikipedia.org)
Accordingly, the clonotypic BCR detected in WM cells was unbiasedly investigated in all B cell maturation stages defined according to their molecular phenotype. (confex.com)
During normal B-cell development and maturation, the immunoglobulin (Ig) heavy-and light-chain (Kappa and Lambda) genes undergo a series of rearrangements to produce a unique antigen receptor with specificity to a discrete antigen. (cellnetix.com)
Although defects may occur in many steps in B-cell development and maturation, resulting in agammaglobulinemia, the most common and well-described defect is the impaired maturation of the pro-B cells to pre-B cells. (medscape.com)

The drugs administered cause DNA damage of cancer cells, making them unable to survive. (peoplebeatingcancer.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
The transformation from a normal to a cancer cell is driven by the multistep acquisition of genetic alterations. (confex.com)
Non-FA (or underlying FA) patients harboring heterozygous germline FA gene mutations may also face an increased risk of developing bone marrow failure, primary immunodeficiency disease, and hereditary cancer predisposition syndromes. (frontiersin.org)
Consequently, she developed ovarian cancer and secondary t-CMML and then suffered from BMF and delayed post−chemotherapy bone marrow recovery after several chemotherapy courses. (frontiersin.org)
Modulation and response of the immune system are of interest in cancer treatment due to the success of immunotherapy in the treatment of various neoplasms. (spandidos-publications.com)

Solitary bone plasmacytoma of the maxilla- a rare case report. (autopsyandcasereports.org)

The soft tissue filling the cavities of bones. (lookformedical.com)
Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. (lookformedical.com)
Later came to be used to describe all forms of lymphoid neoplastic proliferations that arise as discrete tissue masses. (fdocuments.net)
In the absence of mature B cells, patients lack lymphoid tissue and fail to develop plasma cells, the cells that manufacture antibodies. (medscape.com)
Germinal centers where B cells proliferate and differentiate are poorly developed in all lymphoid tissue, including the spleen. (medscape.com)

EDITOR will focus on two types of leukemic blood cancers that affect the immature cells within the bone marrow: myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). (editorproject.com)

The group analyzed seven MN patients who presented with PDC proliferations comprising 5-26% of that blood cell or bone marrow. (news-medical.net)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Most SM patients have non-advanced-or indolent-disease, which is associated with a broad range of severe, chronic and often unpredictable symptoms such as anaphylaxis, pruritus, diarrhea, fatigue and bone pain. (biospace.com)
In the primary prevention component of the Helsinki Heart Study, in which 4081 male patients between the ages of 40 and 55 were studied in a randomized, double-blind, placebo-controlled fashion, gemfibrozil therapy was associated with significant reductions in total plasma triglycerides and a significant increase in high density lipoprotein cholesterol. (nih.gov)
Among Fredrickson types, during the 5-year double-blind portion of the primary prevention component of the Helsinki Heart Study, the greatest reduction in the incidence of serious coronary events occurred in Type IIb patients who had elevations of both LDL-cholesterol and total plasma triglycerides. (nih.gov)
This subgroup of Type Iib gemfibrozil group patients had a lower mean HDL-cholesterol level at baseline than the Type Iia subgroup that had elevations of LDL-cholesterol and normal plasma triglycerides. (nih.gov)
Single-cell RNA and B-cell receptor sequencing (scRNA/BCRseq) was performed in total BM B cells and PCs (n=32,720) from 3 IgM MGUS and 2 WM patients. (confex.com)
Thus, the few WM subclonal mutations observed in patients' lymphopoiesis could not result from contamination during FACSorting since in such cases, WM clonal mutations would become detectable in normal cells. (confex.com)
Conditions associated with bone marrow failure such as aplastic anemia with hypocellular marrow, typical bone marrow findings of MDS are a hypercellular marrow for a persons age, dysplasia in 1 to 3 lineages manifested by pseudo Pelger-Huet nuclei, hypogranular neutrophils, micro megakaryocytes, and/or ringed sideroblasts, glass Siri glass, and increased myeloblasts in a subset of patients. (standardofcare.com)
Here we reported that SP patients exhibited decreased plasma levels of, IL-17A, IFN-γ, IL-12p70 and TNF-α when compared with PV patients, suggesting that analysis of the cytokine production profile may be an useful diagnostic biomarker to distinguish PV from SP patients. (nature.com)
To date, no randomized studies were conducted to analyze whether the morbidity and/or mortality rates in SP patients correlate with the increased red blood cell volume and thrombosis 7 . (nature.com)

Similarly, a HPC origin of BRAF V600E mutations in hairy cell leukemia (HCL) has been uncovered, strengthening the notion that at least a fraction of somatic mutations may occur in CD34+ HPC before the malignant transformation of some B cell neoplasms. (confex.com)
Importantly, clonal mutations in WM B cells were undetectable in normal cells. (confex.com)
Targeted next-generation sequencing (NGS) of a panel of 80 genes was performed on her initial bone marrow aspirate sample and identified PTPN11, NRAS , and DNMT3A somatic mutations. (frontiersin.org)

It is caused by homozygous inheritance of genes for hemoglobin (Hb) S. Sickle-shaped red blood cells cause vaso-occlusion and are prone to hemolysis, leading to severe pain crises, organ ischemia, and other systemic complications. (msdmanuals.com)

Slowly growing metastases to bone, liver, lymph nodes, and lung can arise from malignant tumors. (medscape.com)

Three months later, follow-up radiographs demonstrated changes consistent with a more aggressive neoplasm. (medscape.com)

Bone marrow examination showed the proliferation of hematopoietic cells were active, mainly granulocytes, and immature granulocytes increased. (frontiersin.org)

Plasma cell tumors of the skull base: four case reports and literature review. (najms.com)
The biosynthesis and storage of catecholamines in chromaffin cell tumors may differ from the biosynthesis and storage in the normal medulla. (medscape.com)
Trial organizers announced that the first participant had been treated using immune cells with four base-edited genes, equipping the cells to better target and destroy tumors. (cdc.gov)

The peripheral blood and bone marrow are most commonly involved. (hematology.org)
Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts. (uams.edu)

1] The etiology of the disease is the monoclonal proliferation of plasma B cells, with resultant marrow infiltration and increase of a single immunoglobulin and its fragments in the serum and urine. (medscape.com)
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. (lookformedical.com)
A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. (lookformedical.com)

The disease may also present as a pDC leukemia, i.e. increased levels of malignant pDC in blood (i.e. >2% of nucleated cells) and bone marrow and evidence (i.e. cytopenias) of bone marrow failure. (wikipedia.org)

Over the last decade, significant investigation in the MM field has demonstrated that the interaction of malignant PCs with BM stromal cells within the microenvironment is essential for survival of the PC clone [ 5 , 6 ]. (oncotarget.com)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)

The bone marrow often shows increased mast cells. (hematology.org)
Mast cells are also increased (A, black circles). (hematology.org)
SM is a rare, genetic condition characterized by the frenzied and uncontrollable activation and proliferation of mast cells, a type of white blood cell. (biospace.com)
In this way, Ayvakit suppresses the proliferation of mast cells bearing the D816V mutation. (biospace.com)
Blueprint backed Ayvakit's supplemental NDA with data from the PIONEER trial , which found that the drug significantly and rapidly reduced all main measures of pathological mast cell compared to placebo. (biospace.com)

Anatomy46

Organisms13

Diseases40

Chemicals and Drugs82

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes45

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Multiple myeloma29

Differentiation16

Myeloma12

Abnormal13

Neoplastic proliferation1

Extramedullary4

Lesions6

Lymphoma22

Lymphocytes5

Blastic4

Hematopoietic neoplasms1

Disorders7

Precursors10

Myeloproliferative Neoplasms2

Hematological neoplasms2

Malignant neoplasms1

Biopsy9

Clinical6

Progenitor cells3

Clonal proliferation1

Renal3

Infiltrate the skin1

Skeletal2

Malignancies2

Progenitors2

Diagnosis5

Primary malignant1

Incurable1

Expanded bone marrow1

Clinically3

Plasmacytoid cells2

Stem cells3

Tumor cells4

Involvement2

Progression6

Lymphomas4

Malignancy of plasma cells1

Maturation7

Cancer7

Solitary1

Tissue5

Myelodysplastic Syndromes1

Patients11

Mutations3

Systemic1

Arise1

Aggressive1

Marrow examination1

Tumors3

Peripheral blood2

Immunoglobulin3

Cytopenias1

Microenvironment2

Mast5