TumorsTumorSarcomaHemangiomaSclerosing epithelioid fibrosarcomaAngiosarcomaEndothelialHaemangioendotheliomaLesionsOsteosarcomaSubcutaneousImmunohistochemistryHemangiomasLiverCellsNeoplasmLong bonesLungPrecursorsTissueLymphCancerGeneticInvolvementRecurrenceObjectivePresentation2002ArticularVascularityUnusualVariantSingle boneCortex
Tumors15
- [ 13 ] The WWTR1-CAMTA1 fusion was used in a retrospective study with good results to reinforce prior data that epithelioid hemangiomas are benign lesions and not low-grade malignant soft-tissue tumors. (medscape.com)
- Ewing sarcoma includes several types of bone tumors. (dana-farber.org)
- Ewing sarcoma tumors usually form in the hip bones, the ribs, or in the middle of long bones. (dana-farber.org)
- Ewing tumors are most common in bone but can also form in soft tissue. (dana-farber.org)
- WHO Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone. (neoplasiaresearch.com)
- Malignant vascular tumors: Epithelioid Hemangioendothelioma. (neoplasiaresearch.com)
- BACKGROUND: Sexual hormones have an important role in many hormone-dependent tumors like breast and prostate carcinomas, and also a relationship has been found with bone metabolism and bone tumors. (bvsalud.org)
- We found that certain lesions of bone often regarded as tumors should be classified as malformations. (unibas.ch)
- These tumors have a high risk of recurring where they start and can also travel to liver, bone, lung, and other sites. (sarctrials.org)
- Malignant vascular tumors of bone occur less frequently than hemangiomas. (basicmedicalkey.com)
- Their behavior ranges from that of indolent, low-grade tumors, such as epithelioid hemangioendothelioma, to that of lethal, high-grade angiosarcomas or hemangiopericytomas. (basicmedicalkey.com)
- As for the initial treatment, curettage and bone cementing were performed for the epiphyseal tumor of the right femur, followed by surgical resections of the other tumors. (tottori-u.ac.jp)
- Examples of vascular tumors include infantile hemangioma, kaposiform hemangioendothelioma (KH), and tufted angioma (TA). (e-acfs.org)
- Malignant vascular tumors (MVTs), mainly composed of angiosarcoma (AS) and hemangioendothelioma (HE), are considered one of the rarest soft tissue neoplasms in contrast to their benign counterparts. (turkjpath.org)
- The commonly used immunohistochemical panel includes CD31 and CD34 which lack adequate sensitivity and specificity, especially in tumors with epithelioid morphology 2 - 5 . (turkjpath.org)
Tumor13
- Epithelioid hemangioendothelioma (EHE) is a rare tumor, first characterized by Sharon Weiss and Franz Enzinger in 1982 that both clinically and histologically is intermediate between angiosarcoma and hemangioma. (wikipedia.org)
- Before the initial description of Weiss, the tumor had been reported under a variety of other names, including histiocytoid hemangioendothelioma, intravascular bronchoalveolar tumor (in the lung), and sclerosing cholangiocarcinoma. (wikipedia.org)
- Some have argued that epithelioid hemangiomas are not a distinct clinicopathologic entity but rather a misdiagnosed hemangioendothelioma, which is a tumor with malignant potential, unlike hemangioma. (medscape.com)
- Hemangioendothelioma is a vascular tumor with several different morphologic patterns that can include a component of ovoid or spindled cells, but generally lacks an inflammatory component. (neoplasiaresearch.com)
- We present a challenging lymphocyte-rich soft tissue lesion that was not recognized to be an unusual hemangioendothelioma until after several recurrences in the arm of a 63 year-old male, which was originally diagnosed as a follicular dendritic cell tumor instead. (neoplasiaresearch.com)
- The most recent tumor consisted predominantly of epithelioid spindled cells with moderate amounts of bubbly pale to eosinophilic cytoplasm with rare discrete cytoplasmic vacuoles, admixed with a prominent lymphoid infiltrate and occasional erythrocytes. (neoplasiaresearch.com)
- Epithelioid Hemangioendothelioma: A distinctive vascular tumor often mistaken for carcinoma. (neoplasiaresearch.com)
- As its name implies, epithelioid hemangioendothelioma is an angiocentric vascular tumor with metastatic potential…These lesions may appear as a solitary, slightly painful mass in either superficial or deep soft tissue. (medicallessons.net)
- In the tumor category, hemangioendothelioma and epithelioid hemangioma were the most common. (unibas.ch)
- Many of these sarcomas have some (but not all) features in common with their bone-tumor equivalents, and each has unique characteristics that must be considered in their treatment. (sarctrials.org)
- Histologically, the tumor was discerned as EHE with a spectrum of endothelial tumor, with the added feature of epithelioid hemangioma in a limited area. (tottori-u.ac.jp)
- Hepatic epithelioid hemangioendothelioma (HEHE) is a rare liver tumor, which is usually diagnosed by pathological examination, since the diagnostic imaging criteria remain to be defined. (spandidos-publications.com)
- Epithelioid sarcoma (ES) is a rare, malignant soft tissue tumor. (logicalimages.com)
Sarcoma2
- The situation has been further complicated by the human immunodeficiency virus (HIV) pandemic and its associated vascular lesions in bone, such as bacillary angiomatosis and Kaposi's sarcoma. (basicmedicalkey.com)
- MVTs showing variable morphologic characteristics may be misdiagnosed as carcinomas or epithelioid sarcoma, especially when epithelioid morphology dominates. (turkjpath.org)
Hemangioma1
- Hemangioma of bone may be symptomatic or may be purely an incidental finding. (medscape.com)
Sclerosing epithelioid fibrosarcoma1
- The main differential diagnoses are osteosarcoma (both primary of bone and extraosseous) and sclerosing epithelioid fibrosarcoma. (bvsalud.org)
Angiosarcoma2
- They include less aggressive (epithelioid hemangioendothelioma or EHE) and more aggressive forms (angiosarcoma)s. (sarctrials.org)
- We collected 11 angiosarcoma (AS) and 16 hemangioendothelioma (HE) cases from the archives between the years 1982 and 2007. (turkjpath.org)
Endothelial1
- Epithelioid hemangioendothelioma (EHE) is a rare type of cancer made up of endothelial cells, the specialized cells normally found on the inside of blood vessels. (mypathologyreport.ca)
Haemangioendothelioma1
- Background Epithelioid haemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that can arise in the lung, liver, soft tissues or, less commonly, bone. (uni-luebeck.de)
Lesions7
- Vascular lesions of bone are rare and their terminology is not standardized. (unibas.ch)
- All lesions were either restricted to bone or had minimal contiguous soft tissue involvement with the exception of some multifocal lymphatic lesions that extensively affected soft tissue and/or viscera. (unibas.ch)
- Utilizing the ISSVA approach, the diverse and often contradictory terminology of vascular lesions of bone can be largely eliminated. (unibas.ch)
- Standardized nomenclature is critical for scientific communication and patient management, and we hereby recommend the ISSVA classification be applied to vascular lesions of bone, just as for skin, soft tissue, and viscera. (unibas.ch)
- Despite the rich vascularity of bone, skeletal vascular lesions are rare, and consequently knowledge of their clinical and pathologic features is still limited. (basicmedicalkey.com)
- Solitary hemangiomas are the most common vascular lesions of bone. (basicmedicalkey.com)
- Plain x-rays revealed multiple osteolytic lesions involving the navicular bone with osteoporosis and intact articular surface without collapse (Fig. 1). (jocr.co.in)
Osteosarcoma2
- Osteosarcoma is the most common bone cancer. (dana-farber.org)
- Osteosarcoma of the jaw bones. (nih.gov)
Subcutaneous2
- They can affect numerous tissue types (individually or in combination), including skin, subcutaneous tissue, viscera, muscle, synovium, and bone, but they do not spread to avascular tissue such as cartilage. (medscape.com)
- and subcutaneous models provide crucial cell RO4929097 biology and response data but do not capture the important relationships happening between HCC cells and the inflammatory local and 'distant' (bone marrow-derived) stroma. (researchatlanta.org)
Immunohistochemistry1
- CD31, CD34 and Fli-1 positive immunohistochemistry is strongly indicative of epithelioid lineage. (uni-luebeck.de)
Hemangiomas2
- Hemangiomas of the deep soft tissues and bone are most commonly treated by orthopedists. (medscape.com)
- Soft-tissue hemangiomas may cause benign-appearing periosteal reaction, or chronic cortical thickening and remodeling in adjacent bone, as in the image below. (medscape.com)
Liver2
- In addition to liver and lungs, bones and skin have been the most frequent organs. (wikipedia.org)
- While it does not appear particularly aggressive under the microscope, it travels very early to other sites of the body, including lung, chest cavity, liver, and bone, and occasionally to the brain. (sarctrials.org)
Cells4
- It starts in bone cells that make new bone tissue. (dana-farber.org)
- Histologic evaluation of the thyroid nodule showed multinodular proliferation of oval to polygonal-shaped epithelioid cells with oval nuclei and eosinophilic cytoplasm arranged in sheet- or cord-like patterns, accompanied by fibrous stroma and marked osseous metaplasia. (springeropen.com)
- Multinodular proliferations, composed of comparatively rich spindle cells with nuclear blebs, are observed between the trabecular bone structures. (springeropen.com)
- Histology showed a nodular structure with clusters of epithelioid and spindled cells with a low proliferative index and mitotic count, suspended in a sclerotic stroma. (uni-luebeck.de)
Neoplasm3
- A primary or metastatic malignant neoplasm affecting the bone or articular cartilage. (nih.gov)
- Subsequent Malignant Neoplasm of Bone in Children and Adolescent-Possibility of Multimodal Treatment. (nih.gov)
- Primary malignant bone neoplasm: a case report of dedifferentiated chondrosarcoma in the rib and review of the literature. (nih.gov)
Long bones2
- It usually forms at the end of long bones, such as the leg bones, but can form in any bone. (dana-farber.org)
- Some studies have demonstrated that the expression of hormonal receptors (HR) in osteosarcomas (OS) of long bones is associated with gender, histological grade, histological type, and a possibly may be connection with pathogenesis and evolution. (bvsalud.org)
Lung2
- International- Poster Presentation: "Epitheloid Hemangio-endothelioma of bone with Lung Metastasis" at 17th Asian Musculoskeletal Conference, 2015. (medicoverhospitals.in)
- Regional lymph node involvement and distant metastases to the lung, bones, brain, and other organs, and spread along connective tissue planes and neurovascular bundles, have been reported. (logicalimages.com)
Precursors1
- Various theories involve hormone and cytokine stimulation of osteoclast function, with heightened sensitivity of osteoclast precursors to interleukin (IL)-6 leading to increased bone resorption locally. (medscape.com)
Tissue6
- Devaney et al defined skeletal-extraskeletal angiomatosis as a benign vascular proliferation involving the medullary cavity of bone and at least one other type of tissue. (medscape.com)
- Our group is also dedicated to clinical research to develop innovative treatment strategies for soft tissue and bone malignancies. (dana-farber.org)
- Soft-tissue sarcomas are more common than bone sarcomas. (sarctrials.org)
- Some sarcomas that arise in soft tissue mimic those that typically arise in cartilage or bone. (sarctrials.org)
- Internal exposure to cheat is linked to bone cancer, cancer of the soft tissue near the bone, and leukemia. (steelwood.cz)
- There was sinus tract lined by granulation tissue extending from wooden splinter (foreign body) to the exterior on medial aspect on navicular bone perforating the bone itself. (jocr.co.in)
Lymph1
- The soft tissues of the body include the muscles, tendons (bands of fiber that connect muscles to bones), fat, blood vessels, lymph vessels, nerves, and tissues around joints. (dana-farber.org)
Cancer2
- There are several types of bone cancer. (dana-farber.org)
- He is co-director of the Georgetown University Medical Center Adult Hemophilia Treatment Center and has particular clinical and research interest in bleeding and clotting disorders, bone failure and aplastic anemia, leukemia, and genetic syndromes of cancer predisposition. (medstarhealth.org)
Genetic1
- [ 12 ] Identification of WWTR1-CAMTA1 fusion as the genetic hallmark of epithelioid hemangioendothelioma, regardless of anatomic location, provides an objective and powerful diagnostic tool that can be used to distinguish the two entities. (medscape.com)
Involvement2
- Epithelioid hemangioendothelioma can be isolated or associated with internal visceral involvement. (steelwood.cz)
- CT-scan was done rule out adjacent bone involvement (Fig.2) Surgical exploration was done through two incisions. (jocr.co.in)
Recurrence1
- At 18 months follow up, patient had painless foot with no recurrence or collapse of navicular bone. (jocr.co.in)
Objective1
- However, to our knowledge there are no studies of HR in osteosarcomas of craniofacial bones (OS-CF). OBJECTIVE: To assess the expression of hormonal receptors in OS-CF. MATERIAL AND METHODS: Twenty one cases of OS-CF were included in this study. (bvsalud.org)
Presentation1
- On presentation, there was discharging sinus over medial border of mid foot corresponding to navicular bone with mild swelling and tenderness over plantar aspect without any antecedent systemic symptoms. (jocr.co.in)
20021
- J Bone Miner Res 2002 Mar;17(3):465-71. (nih.gov)
Articular1
- Of particular note is that the articular edge of the cartilage is identifiable even when the cartilage is superimposed by bone due to the positioning of the joint in relation to the x-ray beam. (co.ke)
Vascularity1
- Its etiology is thought to be related to excess vascularity of the involved bone. (medscape.com)
Unusual1
- This represents an unusual and potentially confusing pattern of hemangioendothelioma that is not previously well described in the literature. (neoplasiaresearch.com)
Variant1
- 15: Puls F, Niblett A, Clarke J, Kindblom LG, McCulloch T. YAP1-TFE3 epithelioid hemangioendothelioma: a case without vasoformation and a new transcript variant. (cancercentrum.se)
Single bone1
- This process may affect a single bone or may cross joint spaces. (medscape.com)
Cortex1
- In bone, the nutrient arteries penetrate the cortex and branch into an abundant network of small arteries and capillaries. (basicmedicalkey.com)